Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.
Molecular Neurodegeneration
Sampognaro, Paul J PJ; Arya, Shruti S; Knudsen, Giselle M GM; Gunderson, Emma L EL; Sandoval-Perez, Angelica A; Hodul, Molly M; Bowles, Katherine K; Craik, Charles S CS; Jacobson, Matthew P MP; Kao, Aimee W AW
Analysis of rare Parkinson's disease variants in millions of people.
Research Square
Pitz, Vanessa V; Makarious, Mary M; Bandrés-Ciga, Sara S; Iwaki, Hirotaka H; Singleton, Andrew A; Nalls, Mike M; Heilbron, Karl K; Blauwendraat, Cornelis C
Graph theoretical network analysis, in silico exploration, and validation of bioactive compounds from Cynodon dactylon as potential neuroprotective agents against α-synuclein.
In Silico Study of the Interactions of Anle138b Isomer, an Inhibitor of Amyloid Aggregation, with Partner Proteins.
International Journal Of Molecular Sciences
Kondratyev, Maxim S MS; Rudnev, Vladimir R VR; Nikolsky, Kirill S KS; Petrovsky, Denis V DV; Kulikova, Liudmila I LI; Malsagova, Kristina A KA; Stepanov, Alexander A AA; Kopylov, Arthur T AT; Kaysheva, Anna L AL
N-Terminal Acetylation of α-Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates.
Biochemistry
Bell, Rosie R; Thrush, Rebecca J RJ; Castellana-Cruz, Marta M; Oeller, Marc M; Staats, Roxine R; Nene, Aishwarya A; Flagmeier, Patrick P; Xu, Catherine K CK; Satapathy, Sandeep S; Galvagnion, Celine C; Wilson, Mark R MR; Dobson, Christopher M CM; Kumita, Janet R JR; Vendruscolo, Michele M
A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity.
Science Advances
Kumar, Senthil T ST; Mahul-Mellier, Anne-Laure AL; Hegde, Ramanath Narayana RN; Rivière, Gwladys G; Moons, Rani R; Ibáñez de Opakua, Alain A; Magalhães, Pedro P; Rostami, Iman I; Donzelli, Sonia S; Sobott, Frank F; Zweckstetter, Markus M; Lashuel, Hilal A HA
Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor impairment and cortical dysfunction, independent of protein aggregation.
Human Molecular Genetics
Geertsma, Haley M HM; Suk, Terry R TR; Ricke, Konrad M KM; Horsthuis, Kyra K; Parmasad, Jean-Louis A JA; Fisk, Zoe A ZA; Callaghan, Steve M SM; Rousseaux, Maxime W C MWC
Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.
Acta Neuropathologica
de Boni, Laura L; Watson, Aurelia Hays AH; Zaccagnini, Ludovica L; Wallis, Amber A; Zhelcheska, Kristina K; Kim, Nora N; Sanderson, John J; Jiang, Haiyang H; Martin, Elodie E; Cantlon, Adam A; Rovere, Matteo M; Liu, Lei L; Sylvester, Marc M; Lashley, Tammaryn T; Dettmer, Ulf U; Jaunmuktane, Zane Z; Bartels, Tim T
Novel engineered nanobodies specific for N-terminal region of alpha-synuclein recognize Lewy-body pathology and inhibit in-vitro seeded aggregation and toxicity.
The Febs Journal
Hmila, Issam I; Vaikath, Nishant N NN; Majbour, Nour K NK; Erskine, Daniel D; Sudhakaran, Indulekha P IP; Gupta, Vijay V; Ghanem, Simona S SS; Islam, Zeyaul Z; Emara, Mohamed M MM; Abdesselem, Houari B HB; Kolatkar, Prasanna R PR; Achappa, Devaya K DK; Vinardell, Tatiana T; El-Agnaf, Omar M A OMA