The H50Q mutation induces a 10-fold decrease in the solubility of α-synuclein.
The Journal Of Biological Chemistry
Porcari, Riccardo R; Proukakis, Christos C; Waudby, Christopher A CA; Bolognesi, Benedetta B; Mangione, P Patrizia PP; Paton, Jack F S JF; Mullin, Stephen S; Cabrita, Lisa D LD; Penco, Amanda A; Relini, Annalisa A; Verona, Guglielmo G; Vendruscolo, Michele M; Stoppini, Monica M; Tartaglia, Gian Gaetano GG; Camilloni, Carlo C; Christodoulou, John J; Schapira, Anthony H V AH; Bellotti, Vittorio V