The comparative effect of exposure to various risk factors on the risk of hyperuricaemia: diet has a weak causal effect.
Arthritis Research & Therapy
Topless, Ruth K G RKG; Major, Tanya J TJ; Florez, Jose C JC; Hirschhorn, Joel N JN; Cadzow, Murray M; Dalbeth, Nicola N; Stamp, Lisa K LK; Wilcox, Philip L PL; Reynolds, Richard J RJ; Cole, Joanne B JB; Merriman, Tony R TR
Genetically Determined Uric Acid and the Risk of Cardiovascular and Neurovascular Diseases: A Mendelian Randomization Study of Outcomes Investigated in Randomized Trials.
Tin, Adrienne A; Li, Yong Y; Brody, Jennifer A JA; Nutile, Teresa T; Chu, Audrey Y AY; Huffman, Jennifer E JE; Yang, Qiong Q; Chen, Ming-Huei MH; Robinson-Cohen, Cassianne C; Macé, Aurélien A; Liu, Jun J; Demirkan, Ayşe A; Sorice, Rossella R; Sedaghat, Sanaz S; Swen, Melody M; Yu, Bing B; Ghasemi, Sahar S; Teumer, Alexanda A; Vollenweider, Peter P; Ciullo, Marina M; Li, Meng M; Uitterlinden, André G AG; Kraaij, Robert R; Amin, Najaf N; van Rooij, Jeroen J; Kutalik, Zoltán Z; Dehghan, Abbas A; McKnight, Barbara B; van Duijn, Cornelia M CM; Morrison, Alanna A; Psaty, Bruce M BM; Boerwinkle, Eric E; Fox, Caroline S CS; Woodward, Owen M OM; Köttgen, Anna A
Genetics of serum urate concentrations and gout in a high-risk population, patients with chronic kidney disease.
Scientific Reports
Jing, Jiaojiao J; Ekici, Arif B AB; Sitter, Thomas T; Eckardt, Kai-Uwe KU; Schaeffner, Elke E; Li, Yong Y; Kronenberg, Florian F; Köttgen, Anna A; Schultheiss, Ulla T UT
Mendelian randomization study shows no causal relationship between circulating urate levels and Parkinson's disease.
Annals Of Neurology
Kia, Demis A DA; Noyce, Alastair J AJ; White, Jon J; Speed, Doug D; Nicolas, Aude A; , ; Burgess, Stephen S; Lawlor, Debbie A DA; Davey Smith, George G; Singleton, Andrew A; Nalls, Mike A MA; Sofat, Reecha R; Wood, Nicholas W NW
MR-PheWAS: exploring the causal effect of SUA level on multiple disease outcomes by using genetic instruments in UK Biobank.
Annals Of The Rheumatic Diseases
Li, Xue X; Meng, Xiangrui X; Spiliopoulou, Athina A; Timofeeva, Maria M; Wei, Wei-Qi WQ; Gifford, Aliya A; Shen, Xia X; He, Yazhou Y; Varley, Tim T; McKeigue, Paul P; Tzoulaki, Ioanna I; Wright, Alan F AF; Joshi, Peter P; Denny, Joshua C JC; Campbell, Harry H; Theodoratou, Evropi E
Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants.
Genome Medicine
Nagy, Reka R; Boutin, Thibaud S TS; Marten, Jonathan J; Huffman, Jennifer E JE; Kerr, Shona M SM; Campbell, Archie A; Evenden, Louise L; Gibson, Jude J; Amador, Carmen C; Howard, David M DM; Navarro, Pau P; Morris, Andrew A; Deary, Ian J IJ; Hocking, Lynne J LJ; Padmanabhan, Sandosh S; Smith, Blair H BH; Joshi, Peter P; Wilson, James F JF; Hastie, Nicholas D ND; Wright, Alan F AF; McIntosh, Andrew M AM; Porteous, David J DJ; Haley, Chris S CS; Vitart, Veronique V; Hayward, Caroline C
Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps.
Nature Genetics
Iotchkova, Valentina V; Huang, Jie J; Morris, John A JA; Jain, Deepti D; Barbieri, Caterina C; Walter, Klaudia K; Min, Josine L JL; Chen, Lu L; Astle, William W; Cocca, Massimilian M; Deelen, Patrick P; Elding, Heather H; Farmaki, Aliki-Eleni AE; Franklin, Christopher S CS; Franberg, Mattias M; Gaunt, Tom R TR; Hofman, Albert A; Jiang, Tao T; Kleber, Marcus E ME; Lachance, Genevieve G; Luan, Jian'an J; Malerba, Giovanni G; Matchan, Angela A; Mead, Daniel D; Memari, Yasin Y; Ntalla, Ioanna I; Panoutsopoulou, Kalliope K; Pazoki, Raha R; Perry, John R B JRB; Rivadeneira, Fernando F; Sabater-Lleal, Maria M; Sennblad, Bengt B; Shin, So-Youn SY; Southam, Lorraine L; Traglia, Michela M; van Dijk, Freerk F; van Leeuwen, Elisabeth M EM; Zaza, Gianluigi G; Zhang, Weihua W; , ; Amin, Najaf N; Butterworth, Adam A; Chambers, John C JC; Dedoussis, George G; Dehghan, Abbas A; Franco, Oscar H OH; Franke, Lude L; Frontini, Mattia M; Gambaro, Giovanni G; Gasparini, Paolo P; Hamsten, Anders A; Issacs, Aaron A; Kooner, Jaspal S JS; Kooperberg, Charles C; Langenberg, Claudia C; Marz, Winfried W; Scott, Robert A RA; Swertz, Morris A MA; Toniolo, Daniela D; Uitterlinden, Andre G AG; van Duijn, Cornelia M CM; Watkins, Hugh H; Zeggini, Eleftheria E; Maurano, Mathew T MT; Timpson, Nicholas J NJ; Reiner, Alexander P AP; Auer, Paul L PL; Soranzo, Nicole N
Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study.
Journal Of The American College Of Cardiology
Keenan, Tanya T; Zhao, Wei W; Rasheed, Asif A; Ho, Weang K WK; Malik, Rainer R; Felix, Janine F JF; Young, Robin R; Shah, Nabi N; Samuel, Maria M; Sheikh, Nasir N; Mucksavage, Megan L ML; Shah, Omar O; Li, Jin J; Morley, Michael M; Laser, Annika A; Mallick, Nadeem Hayat NH; Zaman, Khan Shah KS; Ishaq, Mohammad M; Rasheed, Syed Zahed SZ; Memon, Fazal-Ur-Rehman FU; Ahmed, Faisal F; Hanif, Bashir B; Lakhani, Muhammad Shakir MS; Fahim, Muhammad M; Ishaq, Madiha M; Shardha, Naresh Kumar NK; Ahmed, Naveeduddin N; Mahmood, Khalid K; Iqbal, Waseem W; Akhtar, Saba S; Raheel, Rabia R; O'Donnell, Christopher J CJ; Hengstenberg, Christian C; März, Winifred W; Kathiresan, Sekar S; Samani, Nilesh N; Goel, Anuj A; Hopewell, Jemma C JC; Chambers, John J; Cheng, Yu-Ching YC; Sharma, Pankaj P; Yang, Qiong Q; Rosand, Jonathan J; Boncoraglio, Giorgio B GB; Kazmi, Shahana Urooj SU; Hakonarson, Hakon H; Köttgen, Anna A; Kalogeropoulos, Andreas A; Frossard, Philippe P; Kamal, Ayeesha A; Dichgans, Martin M; Cappola, Thomas T; Reilly, Muredach P MP; Danesh, John J; Rader, Daniel J DJ; Voight, Benjamin F BF; Saleheen, Danish D
Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis.
The Lancet. Diabetes & Endocrinology
White, Jon J; Sofat, Reecha R; Hemani, Gibran G; Shah, Tina T; Engmann, Jorgen J; Dale, Caroline C; Shah, Sonia S; Kruger, Felix A FA; Giambartolomei, Claudia C; Swerdlow, Daniel I DI; Palmer, Tom T; McLachlan, Stela S; Langenberg, Claudia C; Zabaneh, Delilah D; Lovering, Ruth R; Cavadino, Alana A; Jefferis, Barbara B; Finan, Chris C; Wong, Andrew A; Amuzu, Antoinette A; Ong, Ken K; Gaunt, Tom R TR; Warren, Helen H; Davies, Teri-Louise TL; Drenos, Fotios F; Cooper, Jackie J; Ebrahim, Shah S; Lawlor, Debbie A DA; Talmud, Philippa J PJ; Humphries, Steve E SE; Power, Christine C; Hypponen, Elina E; Richards, Marcus M; Hardy, Rebecca R; Kuh, Diana D; Wareham, Nicholas N; Ben-Shlomo, Yoav Y; Day, Ian N IN; Whincup, Peter P; Morris, Richard R; Strachan, Mark W J MW; Price, Jacqueline J; Kumari, Meena M; Kivimaki, Mika M; Plagnol, Vincent V; Whittaker, John C JC; , ; Smith, George Davey GD; Dudbridge, Frank F; Casas, Juan P JP; Holmes, Michael V MV; Hingorani, Aroon D AD; ,
Uric Acid and Cardiovascular Events: A Mendelian Randomization Study.
Journal Of The American Society Of Nephrology : Jasn
Kleber, Marcus E ME; Delgado, Graciela G; Grammer, Tanja B TB; Silbernagel, Günther G; Huang, Jie J; Krämer, Bernhard K BK; Ritz, Eberhard E; März, Winfried W
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
Nature Genetics
Köttgen, Anna A; Albrecht, Eva E; Teumer, Alexander A; Vitart, Veronique V; Krumsiek, Jan J; Hundertmark, Claudia C; Pistis, Giorgio G; Ruggiero, Daniela D; O'Seaghdha, Conall M CM; Haller, Toomas T; Yang, Qiong Q; Tanaka, Toshiko T; Johnson, Andrew D AD; Kutalik, Zoltán Z; Smith, Albert V AV; Shi, Julia J; Struchalin, Maksim M; Middelberg, Rita P S RP; Brown, Morris J MJ; Gaffo, Angelo L AL; Pirastu, Nicola N; Li, Guo G; Hayward, Caroline C; Zemunik, Tatijana T; Huffman, Jennifer J; Yengo, Loic L; Zhao, Jing Hua JH; Demirkan, Ayse A; Feitosa, Mary F MF; Liu, Xuan X; Malerba, Giovanni G; Lopez, Lorna M LM; van der Harst, Pim P; Li, Xinzhong X; Kleber, Marcus E ME; Hicks, Andrew A AA; Nolte, Ilja M IM; Johansson, Asa A; Murgia, Federico F; Wild, Sarah H SH; Bakker, Stephan J L SJ; Peden, John F JF; Dehghan, Abbas A; Steri, Maristella M; Tenesa, Albert A; Lagou, Vasiliki V; Salo, Perttu P; Mangino, Massimo M; Rose, Lynda M LM; Lehtimäki, Terho T; Woodward, Owen M OM; Okada, Yukinori Y; Tin, Adrienne A; Müller, Christian C; Oldmeadow, Christopher C; Putku, Margus M; Czamara, Darina D; Kraft, Peter P; Frogheri, Laura L; Thun, Gian Andri GA; Grotevendt, Anne A; Gislason, Gauti Kjartan GK; Harris, Tamara B TB; Launer, Lenore J LJ; McArdle, Patrick P; Shuldiner, Alan R AR; Boerwinkle, Eric E; Coresh, Josef J; Schmidt, Helena H; Schallert, Michael M; Martin, Nicholas G NG; Montgomery, Grant W GW; Kubo, Michiaki M; Nakamura, Yusuke Y; Tanaka, Toshihiro T; Munroe, Patricia B PB; Samani, Nilesh J NJ; Jacobs, David R DR; Liu, Kiang K; D'Adamo, Pio P; Ulivi, Sheila S; Rotter, Jerome I JI; Psaty, Bruce M BM; Vollenweider, Peter P; Waeber, Gerard G; Campbell, Susan S; Devuyst, Olivier O; Navarro, Pau P; Kolcic, Ivana I; Hastie, Nicholas N; Balkau, Beverley B; Froguel, Philippe P; Esko, Tõnu T; Salumets, Andres A; Khaw, Kay Tee KT; Langenberg, Claudia C; Wareham, Nicholas J NJ; Isaacs, Aaron A; Kraja, Aldi A; Zhang, Qunyuan Q; Wild, Philipp S PS; Scott, Rodney J RJ; Holliday, Elizabeth G EG; Org, Elin E; Viigimaa, Margus M; Bandinelli, Stefania S; Metter, Jeffrey E JE; Lupo, Antonio A; Trabetti, Elisabetta E; Sorice, Rossella R; Döring, Angela A; Lattka, Eva E; Strauch, Konstantin K; Theis, Fabian F; Waldenberger, Melanie M; Wichmann, H-Erich HE; Davies, Gail G; Gow, Alan J AJ; Bruinenberg, Marcel M; , ; Stolk, Ronald P RP; Kooner, Jaspal S JS; Zhang, Weihua W; Winkelmann, Bernhard R BR; Boehm, Bernhard O BO; Lucae, Susanne S; Penninx, Brenda W BW; Smit, Johannes H JH; Curhan, Gary G; Mudgal, Poorva P; Plenge, Robert M RM; Portas, Laura L; Persico, Ivana I; Kirin, Mirna M; Wilson, James F JF; Mateo Leach, Irene I; van Gilst, Wiek H WH; Goel, Anuj A; Ongen, Halit H; Hofman, Albert A; Rivadeneira, Fernando F; Uitterlinden, Andre G AG; Imboden, Medea M; von Eckardstein, Arnold A; Cucca, Francesco F; Nagaraja, Ramaiah R; Piras, Maria Grazia MG; Nauck, Matthias M; Schurmann, Claudia C; Budde, Kathrin K; Ernst, Florian F; Farrington, Susan M SM; Theodoratou, Evropi E; Prokopenko, Inga I; Stumvoll, Michael M; Jula, Antti A; Perola, Markus M; Salomaa, Veikko V; Shin, So-Youn SY; Spector, Tim D TD; Sala, Cinzia C; Ridker, Paul M PM; Kähönen, Mika M; Viikari, Jorma J; Hengstenberg, Christian C; Nelson, Christopher P CP; , ; , ; , ; , ; Meschia, James F JF; Nalls, Michael A MA; Sharma, Pankaj P; Singleton, Andrew B AB; Kamatani, Naoyuki N; Zeller, Tanja T; Burnier, Michel M; Attia, John J; Laan, Maris M; Klopp, Norman N; Hillege, Hans L HL; Kloiber, Stefan S; Choi, Hyon H; Pirastu, Mario M; Tore, Silvia S; Probst-Hensch, Nicole M NM; Völzke, Henry H; Gudnason, Vilmundur V; Parsa, Afshin A; Schmidt, Reinhold R; Whitfield, John B JB; Fornage, Myriam M; Gasparini, Paolo P; Siscovick, David S DS; Polašek, Ozren O; Campbell, Harry H; Rudan, Igor I; Bouatia-Naji, Nabila N; Metspalu, Andres A; Loos, Ruth J F RJ; van Duijn, Cornelia M CM; Borecki, Ingrid B IB; Ferrucci, Luigi L; Gambaro, Giovanni G; Deary, Ian J IJ; Wolffenbuttel, Bruce H R BH; Chambers, John C JC; März, Winfried W; Pramstaller, Peter P PP; Snieder, Harold H; Gyllensten, Ulf U; Wright, Alan F AF; Navis, Gerjan G; Watkins, Hugh H; Witteman, Jacqueline C M JC; Sanna, Serena S; Schipf, Sabine S; Dunlop, Malcolm G MG; Tönjes, Anke A; Ripatti, Samuli S; Soranzo, Nicole N; Toniolo, Daniela D; Chasman, Daniel I DI; Raitakari, Olli O; Kao, W H Linda WH; Ciullo, Marina M; Fox, Caroline S CS; Caulfield, Mark M; Bochud, Murielle M; Gieger, Christian C
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.
Plos Genetics
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