APC c.379_380delinsGC ;(p.S127A)

Variant ID: 5-112103044-AG-GC

NM_000038.5(APC):c.379_380delinsGC;(p.S127A)

This variant was identified in 18 publications

View GRCh38 version.




Publications:


TROP2 Represents a Negative Prognostic Factor in Colorectal Adenocarcinoma and Its Expression Is Associated with Features of Epithelial-Mesenchymal Transition and Invasiveness.

Cancers
Švec, Jiří J; Šťastná, Monika M; Janečková, Lucie L; Hrčkulák, Dušan D; Vojtěchová, Martina M; Onhajzer, Jakub J; Kříž, Vítězslav V; Galušková, Kateřina K; Šloncová, Eva E; Kubovčiak, Jan J; Pfeiferová, Lucie L; Hrudka, Jan J; Matěj, Radoslav R; Waldauf, Petr P; Havlůj, Lukáš L; Kolář, Michal M; Kořínek, Vladimír V
Publication Date: 2022-08-26

Variant appearance in text: APC: S127A
PubMed Link: 36077674
Variant Present in the following documents:
  • Main text
  • cancers-14-04137.pdf
View BVdb publication page



Targeting the IL-6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis.

Annals Of The Rheumatic Diseases
Symons, Rebecca A RA; Colella, Fabio F; Collins, Fraser L FL; Rafipay, Alexandra J AJ; Kania, Karolina K; McClure, Jessica J JJ; White, Nathan N; Cunningham, Iain I; Ashraf, Sadaf S; Hay, Elizabeth E; Mackenzie, Kevin S KS; Howard, Kenneth A KA; Riemen, Anna H K AHK; Manzo, Antonio A; Clark, Susan M SM; Roelofs, Anke J AJ; De Bari, Cosimo C
Publication Date: 2022-02

Variant appearance in text: APC: S127A
PubMed Link: 34844926
Variant Present in the following documents:
  • annrheumdis-2021-220875supp001.pdf
View BVdb publication page



Targeting the IL-6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis.

Annals Of The Rheumatic Diseases
Symons, Rebecca A RA; Colella, Fabio F; Collins, Fraser L FL; Rafipay, Alexandra J AJ; Kania, Karolina K; McClure, Jessica J JJ; White, Nathan N; Cunningham, Iain I; Ashraf, Sadaf S; Hay, Elizabeth E; Mackenzie, Kevin S KS; Howard, Kenneth A KA; Riemen, Anna H K AHK; Manzo, Antonio A; Clark, Susan M SM; Roelofs, Anke J AJ; De Bari, Cosimo C
Publication Date: 2021-11-29

Variant appearance in text: APC: S127A
PubMed Link: 34844926
Variant Present in the following documents:
  • annrheumdis-2021-220875supp001.pdf
View BVdb publication page



Reconciling the Biological and Transcriptional Variability of Hepatoblastoma with Its Mutational Uniformity.

Cancers
Prochownik, Edward V EV
Publication Date: 2021-04-21

Variant appearance in text: APC: S127A
PubMed Link: 33919162
Variant Present in the following documents:
  • Main text
View BVdb publication page



miR-582-5p Is a Tumor Suppressor microRNA Targeting the Hippo-YAP/TAZ Signaling Pathway in Non-Small Cell Lung Cancer.

Cancers
Zhu, Bowen B; V, Mitheera M; Finch-Edmondson, Megan M; Lee, Yaelim Y; Wan, Yue Y; Sudol, Marius M; DasGupta, Ramanuj R
Publication Date: 2021-02-11

Variant appearance in text: APC: S127A
PubMed Link: 33670427
Variant Present in the following documents:
  • Main text
  • cancers-13-00756.pdf
View BVdb publication page



YAP/TAZ Signalling in Colorectal Cancer: Lessons from Consensus Molecular Subtypes.

Cancers
Mouillet-Richard, Sophie S; Laurent-Puig, Pierre P
Publication Date: 2020-10-28

Variant appearance in text: APC: S127A
PubMed Link: 33126419
Variant Present in the following documents:
  • Main text
View BVdb publication page



The potential role of YAP in head and neck squamous cell carcinoma.

Experimental & Molecular Medicine
Shin, Eunbie E; Kim, Joon J
Publication Date: 2020-08

Variant appearance in text: APC: S127A
PubMed Link: 32859951
Variant Present in the following documents:
  • Main text
  • 12276_2020_Article_492.pdf
View BVdb publication page



The Hippo Pathway and YAP Signaling: Emerging Concepts in Regulation, Signaling, and Experimental Targeting Strategies With Implications for Hepatobiliary Malignancies.

Gene Expression
Werneburg, Nathan N; Gores, Gregory J GJ; Smoot, Rory L RL
Publication Date: 2020-06-12

Variant appearance in text: APC: S127A
PubMed Link: 31253203
Variant Present in the following documents:
  • Main text
View BVdb publication page



Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling.

Cancer Research
D'Agostino, Luca L; Nie, Yingchao Y; Goswami, Sayantani S; Tong, Kevin K; Yu, Shiyan S; Bandyopadhyay, Sheila S; Flores, Juan J; Zhang, Xiao X; Balasubramanian, Iyshwarya I; Joseph, Ivor I; Sakamori, Ryotaro R; Farrell, Victoria V; Li, Qi Q; Yang, Chung S CS; Gao, Bin B; Ferraris, Ronaldo P RP; Yehia, Ghassan G; Bonder, Edward M EM; Goldenring, James R JR; Verzi, Michael P MP; Zhang, Lanjing L; Ip, Y Tony YT; Gao, Nan N
Publication Date: 2019-08-15

Variant appearance in text: APC: S127A
PubMed Link: 31239271
Variant Present in the following documents:
  • Main text
View BVdb publication page



YAP and the Hippo pathway in cholangiocarcinoma.

Journal Of Gastroenterology
Sugihara, Takaaki T; Isomoto, Hajime H; Gores, Gregory G; Smoot, Rory R
Publication Date: 2019-06

Variant appearance in text: APC: S127A
PubMed Link: 30815737
Variant Present in the following documents:
  • Main text
  • 535_2019_Article_1563.pdf
View BVdb publication page



YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration.

Cell Stem Cell
Yui, Shiro S; Azzolin, Luca L; Maimets, Martti M; Pedersen, Marianne Terndrup MT; Fordham, Robert P RP; Hansen, Stine L SL; Larsen, Hjalte L HL; Guiu, Jordi J; Alves, Mariana R P MRP; Rundsten, Carsten F CF; Johansen, Jens V JV; Li, Yuan Y; Madsen, Chris D CD; Nakamura, Tetsuya T; Watanabe, Mamoru M; Nielsen, Ole H OH; Schweiger, Pawel J PJ; Piccolo, Stefano S; Jensen, Kim B KB
Publication Date: 2018-01-04

Variant appearance in text: APC: S127A
PubMed Link: 29249464
Variant Present in the following documents:
  • Main text
  • mmc3.pdf
View BVdb publication page



DNAJB1-PRKACA fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Kastenhuber, Edward R ER; Lalazar, Gadi G; Houlihan, Shauna L SL; Tschaharganeh, Darjus F DF; Baslan, Timour T; Chen, Chi-Chao CC; Requena, David D; Tian, Sha S; Bosbach, Benedikt B; Wilkinson, John E JE; Simon, Sanford M SM; Lowe, Scott W SW
Publication Date: 2017-12-12

Variant appearance in text: APC: S127A
PubMed Link: 29162699
Variant Present in the following documents:
  • Main text
View BVdb publication page



NHERF1/EBP50 Suppresses Wnt-β-Catenin Pathway-Driven Intestinal Neoplasia.

Neoplasia (New York, N.Y.)
Georgescu, Maria-Magdalena MM; Gagea, Mihai M; Cote, Gilbert G
Publication Date: 2016-08

Variant appearance in text: APC: S127A
PubMed Link: 27566107
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



The two SAMP repeats and their phosphorylation state in Drosophila Adenomatous polyposis coli-2 play mechanistically distinct roles in negatively regulating Wnt signaling.

Molecular Biology Of The Cell
Kunttas-Tatli, Ezgi E; Von Kleeck, Ryan A RA; Greaves, Bradford D BD; Vinson, David D; Roberts, David M DM; McCartney, Brooke M BM
Publication Date: 2015-12-01

Variant appearance in text: APC: S127A
PubMed Link: 26446838
Variant Present in the following documents:
  • Main text
  • 4503.pdf
View BVdb publication page



Cross-talk between Wnt/β-catenin and Hippo signaling pathways: a brief review.

Bmb Reports
Kim, Minseong M; Jho, Eek-Hoon EH
Publication Date: 2014-10

Variant appearance in text: APC: S127A
PubMed Link: 25154721
Variant Present in the following documents:
  • Main text
  • BMB-47-540.pdf
View BVdb publication page



Twist1 controls a cell-specification switch governing cell fate decisions within the cardiac neural crest.

Plos Genetics
Vincentz, Joshua W JW; Firulli, Beth A BA; Lin, Andrea A; Spicer, Douglas B DB; Howard, Marthe J MJ; Firulli, Anthony B AB
Publication Date: 2013-03

Variant appearance in text: APC: S127A
PubMed Link: 23555309
Variant Present in the following documents:
  • Main text
View BVdb publication page



Restriction of intestinal stem cell expansion and the regenerative response by YAP.

Nature
Barry, Evan R ER; Morikawa, Teppei T; Butler, Brian L BL; Shrestha, Kriti K; de la Rosa, Rosemarie R; Yan, Kelley S KS; Fuchs, Charles S CS; Magness, Scott T ST; Smits, Ron R; Ogino, Shuji S; Kuo, Calvin J CJ; Camargo, Fernando D FD
Publication Date: 2013-01-03

Variant appearance in text: APC: S127A
PubMed Link: 23178811
Variant Present in the following documents:
  • Main text
  • nihms-416427.pdf
  • NIHMS416427-supplement-1.pdf
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The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Lamar, John M JM; Stern, Patrick P; Liu, Hui H; Schindler, Jeffrey W JW; Jiang, Zhi-Gang ZG; Hynes, Richard O RO
Publication Date: 2012-09-11

Variant appearance in text: APC: S127A
PubMed Link: 22891335
Variant Present in the following documents:
  • Main text
View BVdb publication page



Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Zhou, Dawang D; Zhang, Yongyou Y; Wu, Hongtan H; Barry, Evan E; Yin, Yi Y; Lawrence, Earl E; Dawson, Dawn D; Willis, Joseph E JE; Markowitz, Sanford D SD; Camargo, Fernando D FD; Avruch, Joseph J
Publication Date: 2011-12-06

Variant appearance in text: APC: Ser127Ala
PubMed Link: 22042863
Variant Present in the following documents:
  • Main text
View BVdb publication page