Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization in macaques and protection in hamsters.
Communications Medicine
Berry, Catherine C; Pavot, Vincent V; Anosova, Natalie G NG; Kishko, Michael M; Li, Lu L; Tibbitts, Tim T; Raillard, Alice A; Gautheron, Sylviane S; Cummings, Sheila S; Bangari, Dinesh S DS; Kar, Swagata S; Atyeo, Caroline C; Deng, Yixiang Y; Alter, Galit G; Gutzeit, Cindy C; Koutsoukos, Marguerite M; Chicz, Roman M RM; Lecouturier, Valerie V
Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection.
Nature Communications
Pieren, Daan K J DKJ; Kuguel, Sebastián G SG; Rosado, Joel J; Robles, Alba G AG; Rey-Cano, Joan J; Mancebo, Cristina C; Esperalba, Juliana J; Falcó, Vicenç V; Buzón, María J MJ; Genescà, Meritxell M
Homologous Ad26.COV2.S vaccination results in reduced boosting of humoral responses in hybrid immunity, but elicits antibodies of similar magnitude regardless of prior infection.
Medrxiv : The Preprint Server For Health Sciences
Moyo-Gwete, Thandeka T; Richardson, Simone I SI; Keeton, Roanne R; Hermanus, Tandile T; Spencer, Holly H; Manamela, Nelia P NP; Ayres, Frances F; Makhado, Zanele Z; Motlou, Thopisang T; Tincho, Marius B MB; Benede, Ntombi N; Ngomti, Amkele A; Baguma, Richard R; Chauke, Masego V MV; Mennen, Mathilda M; Adriaanse, Marguerite M; Skelem, Sango S; Goga, Ameena A; Garrett, Nigel N; Bekker, Linda-Gail LG; Gray, Glenda G; Ntusi, Ntobeko A B NAB; Riou, Catherine C; Burgers, Wendy A WA; Moore, Penny L PL
Shark nanobodies with potent SARS-CoV-2 neutralizing activity and broad sarbecovirus reactivity.
Nature Communications
Chen, Wei-Hung WH; Hajduczki, Agnes A; Martinez, Elizabeth J EJ; Bai, Hongjun H; Matz, Hanover H; Hill, Thomas M TM; Lewitus, Eric E; Chang, William C WC; Dawit, Layla L; Peterson, Caroline E CE; Rees, Phyllis A PA; Ajayi, Adelola B AB; Golub, Emily S ES; Swafford, Isabella I; Dussupt, Vincent V; David, Sapna S; Mayer, Sandra V SV; Soman, Sandrine S; Kuklis, Caitlin C; Corbitt, Courtney C; King, Jocelyn J; Choe, Misook M; Sankhala, Rajeshwer S RS; Thomas, Paul V PV; Zemil, Michelle M; Wieczorek, Lindsay L; Hart, Tricia T; Duso, Debora D; Kummer, Larry L; Yan, Lianying L; Sterling, Spencer L SL; Laing, Eric D ED; Broder, Christopher C CC; Williams, Jazmean K JK; Davidson, Edgar E; Doranz, Benjamin J BJ; Krebs, Shelly J SJ; Polonis, Victoria R VR; Paquin-Proulx, Dominic D; Rolland, Morgane M; Reiley, William W WW; Gromowski, Gregory D GD; Modjarrad, Kayvon K; Dooley, Helen H; Joyce, M Gordon MG
Antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages is reduced in convalescent sera regardless of infecting variant.
Cell Reports. Medicine
Richardson, Simone I SI; Kgagudi, Prudence P; Manamela, Nelia P NP; Kaldine, Haajira H; Venter, Elizabeth M EM; Pillay, Thanusha T; Lambson, Bronwen E BE; van der Mescht, Mieke A MA; Hermanus, Tandile T; Balla, Sashkia R SR; de Beer, Zelda Z; de Villiers, Talita R TR; Bodenstein, Annie A; van den Berg, Gretha G; du Pisanie, Marizane M; Burgers, Wendy A WA; Ntusi, Ntobeko A B NAB; Abdullah, Fareed F; Ueckermann, Veronica V; Rossouw, Theresa M TM; Boswell, Michael T MT; Moore, Penny L PL
The second COVID-19 mRNA vaccine dose enhances the capacity of Spike RBD-specific memory B cells to bind Omicron BA.2.
Allergy
Hartley, Gemma E GE; Edwards, Emily S J ESJ; Varese, Nirupama N; Boo, Irene I; Aui, Pei M PM; Bornheimer, Scott J SJ; Hogarth, P Mark PM; Drummer, Heidi E HE; O'Hehir, Robyn E RE; van Zelm, Menno C MC
Asymptomatic or symptomatic SARS-CoV-2 infection plus vaccination confers increased adaptive immunity to variants of concern.
Iscience
Sun, Peifang P; Ramos, Irene I; Coelho, Camila H CH; Grifoni, Alba A; Balinsky, Corey A CA; Vangeti, Sindhu S; Tarke, Alison A; Bloom, Nathaniel I NI; Jani, Vihasi V; Jakubski, Silvia J SJ; Boulifard, David A DA; Cooper, Elizabeth E; Goforth, Carl W CW; Marayag, Jan J; Marrone, Amethyst A; Nunez, Edgar E; White, Lindsey L; Porter, Chad K CK; Sugiharto, Victor A VA; Schilling, Megan M; Mahajan, Avinash S AS; Beckett, Charmagne C; Sette, Alessandro A; Sealfon, Stuart C SC; Crotty, Shane S; Letizia, Andrew G AG
An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS-CoV-2.
Embo Molecular Medicine
Zhang, Lianghui L; Narayanan, Krishna K KK; Cooper, Laura L; Chan, Kui K KK; Skeeters, Savanna S SS; Devlin, Christine A CA; Aguhob, Aaron A; Shirley, Kristie K; Rong, Lijun L; Rehman, Jalees J; Malik, Asrar B AB; Procko, Erik E
Protective antibodies and T cell responses to Omicron variant after the booster dose of BNT162b2 vaccine.
Cell Reports. Medicine
Naaber, Paul P; Tserel, Liina L; Kangro, Kadri K; Punapart, Marite M; Sepp, Epp E; Jürjenson, Virge V; Kärner, Jaanika J; Haljasmägi, Liis L; Haljasorg, Uku U; Kuusk, Marilin M; Sankovski, Eve E; Planken, Anu A; Ustav, Mart M; Žusinaite, Eva E; Gerhold, Joachim M JM; Kisand, Kai K; Peterson, Pärt P
Conformational flexibility in neutralization of SARS-CoV-2 by naturally elicited anti-SARS-CoV-2 antibodies.
Communications Biology
Li, Ruofan R; Mor, Michael M; Ma, Bingting B; Clark, Alex E AE; Alter, Joel J; Werbner, Michal M; Lee, Jamie Casey JC; Leibel, Sandra L SL; Carlin, Aaron F AF; Dessau, Moshe M; Gal-Tanamy, Meital M; Croker, Ben A BA; Xiang, Ye Y; Freund, Natalia T NT
Functional Profiling of In Vitro Reactivated Memory B Cells Following Natural SARS-CoV-2 Infection and Gam-COVID-Vac Vaccination.
Cells
Astakhova, Ekaterina A EA; Byazrova, Maria G MG; Yusubalieva, Gaukhar M GM; Kulemzin, Sergey V SV; Kruglova, Natalia A NA; Prilipov, Alexey G AG; Baklaushev, Vladimir P VP; Gorchakov, Andrey A AA; Taranin, Alexander V AV; Filatov, Alexander V AV
Nanobodies Protecting From Lethal SARS-CoV-2 Infection Target Receptor Binding Epitopes Preserved in Virus Variants Other Than Omicron.
Frontiers In Immunology
Casasnovas, José M JM; Margolles, Yago Y; Noriega, María A MA; Guzmán, María M; Arranz, Rocío R; Melero, Roberto R; Casanova, Mercedes M; Corbera, Juan Alberto JA; Jiménez-de-Oya, Nereida N; Gastaminza, Pablo P; Garaigorta, Urtzi U; Saiz, Juan Carlos JC; Martín-Acebes, Miguel Ángel MÁ; Fernández, Luis Ángel LÁ
Vaccine-induced T-cell responses against SARS-CoV-2 and its Omicron variant in patients with B cell-depleted lymphoma after CART therapy.
Blood
Atanackovic, Djordje D; Luetkens, Tim T; Omili, Destiny D; Iraguha, Thierry T; Lutfi, Forat F; Hardy, Nancy M NM; Fan, Xiaoxuan X; Avila, Stephanie V SV; Saharia, Kapil K KK; Husson, Jennifer S JS; Niederhaus, Silke V SV; Margiotta, Philip P; Lee, Seung T ST; Law, Jennie Y JY; Mannuel, Heather D HD; Vander Mause, Erica E; Bauman, Sherri S; Lesho, Patricia P; Hankey, Kim K; Baddley, John J; Kocoglu, Mehmet M; Yared, Jean A JA; Rapoport, Aaron P AP; Dahiya, Saurabh S
An engineered ACE2 decoy receptor can be administered by inhalation and potently targets the BA.1 and BA.2 omicron variants of SARS-CoV-2.
Biorxiv : The Preprint Server For Biology
Zhang, Lianghui L; Narayanan, Krishna K KK; Cooper, Laura L; Chan, Kui K KK; Devlin, Christine A CA; Aguhob, Aaron A; Shirley, Kristie K; Rong, Lijun L; Rehman, Jalees J; Malik, Asrar B AB; Procko, Erik E
Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine.
Biorxiv : The Preprint Server For Biology
Goel, Rishi R RR; Painter, Mark M MM; Lundgreen, Kendall A KA; Apostolidis, Sokratis A SA; Baxter, Amy E AE; Giles, Josephine R JR; Mathew, Divij D; Pattekar, Ajinkya A; Reynaldi, Arnold A; Khoury, David S DS; Gouma, Sigrid S; Hicks, Philip P; Dysinger, Sarah S; Hicks, Amanda A; Sharma, Harsh H; Herring, Sarah S; Korte, Scott S; Kc, Wumesh W; Oldridge, Derek A DA; Erickson, Rachel I RI; Weirick, Madison E ME; McAllister, Christopher M CM; Awofolaju, Moses M; Tanenbaum, Nicole N; Dougherty, Jeanette J; Long, Sherea S; D'Andrea, Kurt K; Hamilton, Jacob T JT; McLaughlin, Maura M; Williams, Justine C JC; Adamski, Sharon S; Kuthuru, Oliva O; Drapeau, Elizabeth M EM; Davenport, Miles P MP; Hensley, Scott E SE; Bates, Paul P; Greenplate, Allison R AR; Wherry, E John EJ