Mutational Heterogeneity in APC and KRAS Arises at the Crypt Level and Leads to Polyclonality in Early Colorectal Tumorigenesis.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Gausachs, Mireia M; Borras, Ester E; Chang, Kyle K; Gonzalez, Sara S; Azuara, Daniel D; Delgado Amador, Axel A; Lopez-Doriga, Adriana A; San Lucas, F Anthony FA; Sanjuan, Xavier X; Paules, Maria J MJ; Taggart, Melissa W MW; Davies, Gareth E GE; Ehli, Erik A EA; Fowler, Jerry J; Moreno, Victor V; Pineda, Marta M; You, Y Nancy YN; Lynch, Patrick M PM; Lazaro, Conxi C; Navin, Nicholas E NE; Scheet, Paul A PA; Hawk, Ernest T ET; Capella, Gabriel G; Vilar, Eduardo E
Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing.
Molecular Cancer
Kovaleva, Valentina V; Geissler, Anna-Lena AL; Lutz, Lisa L; Fritsch, Ralph R; Makowiec, Frank F; Wiesemann, Sebastian S; Hopt, Ulrich T UT; Passlick, Bernward B; Werner, Martin M; Lassmann, Silke S