Publications:

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An engineered activated factor V for the prevention and treatment of acute traumatic coagulopathy and bleeding in mice.

Blood Advances

Joseph, Bilgimol Chumappumkal BC; Miyazawa, Byron Y BY; Esmon, Charles T CT; Cohen, Mitchell J MJ; von Drygalski, Annette A; Mosnier, Laurent O LO

Publication Date: 2022-02-08

Variant appearance in text: APC: S2183A

PubMed Link: 34861695

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• Main text
• advancesADV2021005257.pdf

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Improved coagulation and haemostasis in haemophilia with inhibitors by combinations of superFactor Va and Factor VIIa.

Thrombosis And Haemostasis

Bhat, Vikas V; von Drygalski, Annette A; Gale, Andrew J AJ; Griffin, John H JH; Mosnier, Laurent O LO

Publication Date: 2016-03

Variant appearance in text: APC: S2183A

PubMed Link: 26466980

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An engineered factor Va prevents bleeding induced by anticoagulant wt activated protein C.

Plos One

von Drygalski, Annette A; Bhat, Vikas V; Gale, Andrew J AJ; Burnier, Laurent L; Cramer, Thomas J TJ; Griffin, John H JH; Mosnier, Laurent O LO

Publication Date: 2014

Variant appearance in text: APC: S2183A

PubMed Link: 25127130

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• pone.0104304.pdf

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Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant.

Journal Of Thrombosis And Haemostasis : Jth

von Drygalski, A A; Cramer, T J TJ; Bhat, V V; Griffin, J H JH; Gale, A J AJ; Mosnier, L O LO

Publication Date: 2014

Variant appearance in text: APC: S2183A

PubMed Link: 24818532

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Factor V is an anticoagulant cofactor for activated protein C during inactivation of factor Va.

Pathophysiology Of Haemostasis And Thrombosis

Cramer, Thomas J TJ; Griffin, John H JH; Gale, Andrew J AJ

Publication Date: 2010

Variant appearance in text: APC: Ser2183Ala

PubMed Link: 20501981

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Prothrombin amino terminal region helps protect coagulation factor Va from proteolytic inactivation by activated protein C.

Thrombosis And Haemostasis

Yegneswaran, Subramanian S; Nguyen, Phuong M PM; Gale, Andrew J AJ; Griffin, John H JH

Publication Date: 2009-01

Variant appearance in text: APC: S2183A

PubMed Link: 19132189

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Interdomain engineered disulfide bond permitting elucidation of mechanisms of inactivation of coagulation factor Va by activated protein C.

Protein Science : A Publication Of The Protein Society

Gale, Andrew J AJ; Xu, Xiao X; Pellequer, Jean-Luc JL; Getzoff, Elizabeth D ED; Griffin, John H JH

Publication Date: 2002-09

Variant appearance in text: APC: S2183A

PubMed Link: 12192065

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