Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation.
Science Signaling
Panneer Selvam, Shanmugam S; De Palma, Ryan M RM; Oaks, Joshua J JJ; Oleinik, Natalia N; Peterson, Yuri K YK; Stahelin, Robert V RV; Skordalakes, Emmanuel E; Ponnusamy, Suriyan S; Garrett-Mayer, Elizabeth E; Smith, Charles D CD; Ogretmen, Besim B
Human telomerase model shows the role of the TEN domain in advancing the double helix for the next polymerization step.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Steczkiewicz, Kamil K; Zimmermann, Michael T MT; Kurcinski, Mateusz M; Lewis, Benjamin A BA; Dobbs, Drena D; Kloczkowski, Andrzej A; Jernigan, Robert L RL; Kolinski, Andrzej A; Ginalski, Krzysztof K