A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Jang, H Josh HJ; Hostetter, Galen G; MacFarlane, Alexander W AW; Madaj, Zachary Z; Ross, Eric A EA; Hinoue, Toshinori T; Kulchycki, Justin R JR; Burgos, Ryan S RS; Tafseer, Mahvish M; Alpaugh, R Katherine RK; Schwebel, Candice L CL; Kokate, Rutika R; Geynisman, Daniel M DM; Zibelman, Matthew R MR; Ghatalia, Pooja P; Nichols, Peter W PW; Chung, Woonbok W; Madzo, Jozef J; Hahn, Noah M NM; Quinn, David I DI; Issa, Jean-Pierre J JJ; Topper, Michael J MJ; Baylin, Stephen B SB; Shen, Hui H; Campbell, Kerry S KS; Jones, Peter A PA; Plimack, Elizabeth R ER
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.
Nature Genetics
Shrine, Nick N; Izquierdo, Abril G AG; Chen, Jing J; Packer, Richard R; Hall, Robert J RJ; Guyatt, Anna L AL; Batini, Chiara C; Thompson, Rebecca J RJ; Pavuluri, Chandan C; Malik, Vidhi V; Hobbs, Brian D BD; Moll, Matthew M; Kim, Wonji W; Tal-Singer, Ruth R; Bakke, Per P; Fawcett, Katherine A KA; John, Catherine C; Coley, Kayesha K; Piga, Noemi Nicole NN; Pozarickij, Alfred A; Lin, Kuang K; Millwood, Iona Y IY; Chen, Zhengming Z; Li, Liming L; , ; Wijnant, Sara R A SRA; Lahousse, Lies L; Brusselle, Guy G; Uitterlinden, Andre G AG; Manichaikul, Ani A; Oelsner, Elizabeth C EC; Rich, Stephen S SS; Barr, R Graham RG; Kerr, Shona M SM; Vitart, Veronique V; Brown, Michael R MR; Wielscher, Matthias M; Imboden, Medea M; Jeong, Ayoung A; Bartz, Traci M TM; Gharib, Sina A SA; Flexeder, Claudia C; Karrasch, Stefan S; Gieger, Christian C; Peters, Annette A; Stubbe, Beate B; Hu, Xiaowei X; Ortega, Victor E VE; Meyers, Deborah A DA; Bleecker, Eugene R ER; Gabriel, Stacey B SB; Gupta, Namrata N; Smith, Albert Vernon AV; Luan, Jian'an J; Zhao, Jing-Hua JH; Hansen, Ailin F AF; Langhammer, Arnulf A; Willer, Cristen C; Bhatta, Laxmi L; Porteous, David D; Smith, Blair H BH; Campbell, Archie A; Sofer, Tamar T; Lee, Jiwon J; Daviglus, Martha L ML; Yu, Bing B; Lim, Elise E; Xu, Hanfei H; O'Connor, George T GT; Thareja, Gaurav G; Albagha, Omar M E OME; , ; Suhre, Karsten K; Granell, Raquel R; Faquih, Tariq O TO; Hiemstra, Pieter S PS; Slats, Annelies M AM; Mullin, Benjamin H BH; Hui, Jennie J; James, Alan A; Beilby, John J; Patasova, Karina K; Hysi, Pirro P; Koskela, Jukka T JT; Wyss, Annah B AB; Jin, Jianping J; Sikdar, Sinjini S; Lee, Mikyeong M; May-Wilson, Sebastian S; Pirastu, Nicola N; Kentistou, Katherine A KA; Joshi, Peter K PK; Timmers, Paul R H J PRHJ; Williams, Alexander T AT; Free, Robert C RC; Wang, Xueyang X; Morrison, John L JL; Gilliland, Frank D FD; Chen, Zhanghua Z; Wang, Carol A CA; Foong, Rachel E RE; Harris, Sarah E SE; Taylor, Adele A; Redmond, Paul P; Cook, James P JP; Mahajan, Anubha A; Lind, Lars L; Palviainen, Teemu T; Lehtimäki, Terho T; Raitakari, Olli T OT; Kaprio, Jaakko J; Rantanen, Taina T; Pietiläinen, Kirsi H KH; Cox, Simon R SR; Pennell, Craig E CE; Hall, Graham L GL; Gauderman, W James WJ; Brightling, Chris C; Wilson, James F JF; Vasankari, Tuula T; Laitinen, Tarja T; Salomaa, Veikko V; Mook-Kanamori, Dennis O DO; Timpson, Nicholas J NJ; Zeggini, Eleftheria E; Dupuis, Josée J; Hayward, Caroline C; Brumpton, Ben B; Langenberg, Claudia C; Weiss, Stefan S; Homuth, Georg G; Schmidt, Carsten Oliver CO; Probst-Hensch, Nicole N; Jarvelin, Marjo-Riitta MR; Morrison, Alanna C AC; Polasek, Ozren O; Rudan, Igor I; Lee, Joo-Hyeon JH; Sayers, Ian I; Rawlins, Emma L EL; Dudbridge, Frank F; Silverman, Edwin K EK; Strachan, David P DP; Walters, Robin G RG; Morris, Andrew P AP; London, Stephanie J SJ; Cho, Michael H MH; Wain, Louise V LV; Hall, Ian P IP; Tobin, Martin D MD
Network expansion of genetic associations defines a pleiotropy map of human cell biology.
Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Publication Date: 2023-02-23
Variant appearance in text: ADRB2: 491C>T; Thr164Ile
Immunogenomic analysis of human brain metastases reveals diverse immune landscapes across genetically distinct tumors.
Cell Reports. Medicine
Álvarez-Prado, Ángel F ÁF; Maas, Roeltje R RR; Soukup, Klara K; Klemm, Florian F; Kornete, Mara M; Krebs, Fanny S FS; Zoete, Vincent V; Berezowska, Sabina S; Brouland, Jean-Philippe JP; Hottinger, Andreas F AF; Daniel, Roy T RT; Hegi, Monika E ME; Joyce, Johanna A JA
Publication Date: 2023-01-17
Variant appearance in text: ADRB2: 491C>T; Thr164Ile
Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity.
Nature Communications
Sandhu, Manbir M; Cho, Aaron A; Ma, Ning N; Mukhaleva, Elizaveta E; Namkung, Yoon Y; Lee, Sangbae S; Ghosh, Soumadwip S; Lee, John H JH; Gloriam, David E DE; Laporte, Stéphane A SA; Babu, M Madan MM; Vaidehi, Nagarajan N
Genome-wide association studies of exacerbations in children using long-acting beta2-agonists.
Pediatric Allergy And Immunology : Official Publication Of The European Society Of Pediatric Allergy And Immunology
Slob, Elise M A EMA; Richards, Levi B LB; Vijverberg, Susanne J H SJH; Longo, Cristina C; Koppelman, Gerard H GH; Pijnenburg, Mariëlle W H MWH; Bel, Elisabeth H D EHD; Neerincx, Anne H AH; Herrera Luis, Esther E; Perez-Garcia, Javier J; Tim Chew, Fook F; Yie Sio, Yang Y; Andiappan, Anand K AK; Turner, Steve W SW; Mukhopadhyay, Somnath S; Palmer, Colin N A CNA; Hawcutt, Daniel D; Jorgensen, Andrea L AL; Burchard, Esteban G EG; Hernandez-Pacheco, Natalia N; Pino-Yanes, Maria M; Maitland-van der Zee, Anke H AH
Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis.
American Journal Of Respiratory And Critical Care Medicine
Allen, Richard J RJ; Guillen-Guio, Beatriz B; Oldham, Justin M JM; Ma, Shwu-Fan SF; Dressen, Amy A; Paynton, Megan L ML; Kraven, Luke M LM; Obeidat, Ma'en M; Li, Xuan X; Ng, Michael M; Braybrooke, Rebecca R; Molina-Molina, Maria M; Hobbs, Brian D BD; Putman, Rachel K RK; Sakornsakolpat, Phuwanat P; Booth, Helen L HL; Fahy, William A WA; Hart, Simon P SP; Hill, Mike R MR; Hirani, Nik N; Hubbard, Richard B RB; McAnulty, Robin J RJ; Millar, Ann B AB; Navaratnam, Vidyia V; Oballa, Eunice E; Parfrey, Helen H; Saini, Gauri G; Whyte, Moira K B MKB; Zhang, Yingze Y; Kaminski, Naftali N; Adegunsoye, Ayodeji A; Strek, Mary E ME; Neighbors, Margaret M; Sheng, Xuting R XR; Gudmundsson, Gunnar G; Gudnason, Vilmundur V; Hatabu, Hiroto H; Lederer, David J DJ; Manichaikul, Ani A; Newell, John D JD; O'Connor, George T GT; Ortega, Victor E VE; Xu, Hanfei H; Fingerlin, Tasha E TE; Bossé, Yohan Y; Hao, Ke K; Joubert, Philippe P; Nickle, David C DC; Sin, Don D DD; Timens, Wim W; Furniss, Dominic D; Morris, Andrew P AP; Zondervan, Krina T KT; Hall, Ian P IP; Sayers, Ian I; Tobin, Martin D MD; Maher, Toby M TM; Cho, Michael H MH; Hunninghake, Gary M GM; Schwartz, David A DA; Yaspan, Brian L BL; Molyneaux, Philip L PL; Flores, Carlos C; Noth, Imre I; Jenkins, R Gisli RG; Wain, Louise V LV
β2-Adrenergic Receptor (ADRB2) Gene Polymorphisms and Risk of COPD Exacerbations: The Rotterdam Study.
Journal Of Clinical Medicine
Karimi, Leila L; Lahousse, Lies L; Ghanbari, Mohsen M; Terzikhan, Natalie N; Uitterlinden, André G AG; van der Lei, Johan J; Brusselle, Guy G GG; Stricker, Bruno H BH; Verhamme, Katia M C KMC
Distinctive mutational spectrum and karyotype disruption in long-term cisplatin-treated urothelial carcinoma cell lines.
Scientific Reports
Skowron, Margaretha A MA; Petzsch, Patrick P; Hardt, Karin K; Wagner, Nicholas N; Beier, Manfred M; Stepanow, Stefanie S; Drechsler, Matthias M; Rieder, Harald H; Köhrer, Karl K; Niegisch, Günter G; Hoffmann, Michèle J MJ; Schulz, Wolfgang A WA
Publication Date: 2019-10-09
Variant appearance in text: ADRB2: T164I; rs1800888
Targeted next generation sequencing as a tool for precision medicine.
Bmc Medical Genomics
Gulilat, Markus M; Lamb, Tyler T; Teft, Wendy A WA; Wang, Jian J; Dron, Jacqueline S JS; Robinson, John F JF; Tirona, Rommel G RG; Hegele, Robert A RA; Kim, Richard B RB; Schwarz, Ute I UI
Publication Date: 2019-06-03
Variant appearance in text: ADRB2: T164I; rs1800888
β2 -Adrenergic Receptor Gene Affects the Heart Rate Response of β-Blockers: Evidence From 3 Clinical Studies.
Journal Of Clinical Pharmacology
Shahin, Mohamed H MH; Rouby, Nihal El NE; Conrado, Daniela J DJ; Gonzalez, Daniel D; Gong, Yan Y; Lobmeyer, Maximilian T MT; Beitelshees, Amber L AL; Boerwinkle, Eric E; Gums, John G JG; Chapman, Arlene A; Turner, Stephen T ST; Pepine, Carl J CJ; Cooper-DeHoff, Rhonda M RM; Johnson, Julie A JA
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
Nature Genetics
Shrine, Nick N; Guyatt, Anna L AL; Erzurumluoglu, A Mesut AM; Jackson, Victoria E VE; Hobbs, Brian D BD; Melbourne, Carl A CA; Batini, Chiara C; Fawcett, Katherine A KA; Song, Kijoung K; Sakornsakolpat, Phuwanat P; Li, Xingnan X; Boxall, Ruth R; Reeve, Nicola F NF; Obeidat, Ma'en M; Zhao, Jing Hua JH; Wielscher, Matthias M; Weiss, Stefan S; Kentistou, Katherine A KA; Cook, James P JP; Sun, Benjamin B BB; Zhou, Jian J; Hui, Jennie J; Karrasch, Stefan S; Imboden, Medea M; Harris, Sarah E SE; Marten, Jonathan J; Enroth, Stefan S; Kerr, Shona M SM; Surakka, Ida I; Vitart, Veronique V; Lehtimäki, Terho T; Allen, Richard J RJ; Bakke, Per S PS; Beaty, Terri H TH; Bleecker, Eugene R ER; Bossé, Yohan Y; Brandsma, Corry-Anke CA; Chen, Zhengming Z; Crapo, James D JD; Danesh, John J; DeMeo, Dawn L DL; Dudbridge, Frank F; Ewert, Ralf R; Gieger, Christian C; Gulsvik, Amund A; Hansell, Anna L AL; Hao, Ke K; Hoffman, Joshua D JD; Hokanson, John E JE; Homuth, Georg G; Joshi, Peter K PK; Joubert, Philippe P; Langenberg, Claudia C; Li, Xuan X; Li, Liming L; Lin, Kuang K; Lind, Lars L; Locantore, Nicholas N; Luan, Jian'an J; Mahajan, Anubha A; Maranville, Joseph C JC; Murray, Alison A; Nickle, David C DC; Packer, Richard R; Parker, Margaret M MM; Paynton, Megan L ML; Porteous, David J DJ; Prokopenko, Dmitry D; Qiao, Dandi D; Rawal, Rajesh R; Runz, Heiko H; Sayers, Ian I; Sin, Don D DD; Smith, Blair H BH; Soler Artigas, María M; Sparrow, David D; Tal-Singer, Ruth R; Timmers, Paul R H J PRHJ; Van den Berge, Maarten M; Whittaker, John C JC; Woodruff, Prescott G PG; Yerges-Armstrong, Laura M LM; Troyanskaya, Olga G OG; Raitakari, Olli T OT; Kähönen, Mika M; Polašek, Ozren O; Gyllensten, Ulf U; Rudan, Igor I; Deary, Ian J IJ; Probst-Hensch, Nicole M NM; Schulz, Holger H; James, Alan L AL; Wilson, James F JF; Stubbe, Beate B; Zeggini, Eleftheria E; Jarvelin, Marjo-Riitta MR; Wareham, Nick N; Silverman, Edwin K EK; Hayward, Caroline C; Morris, Andrew P AP; Butterworth, Adam S AS; Scott, Robert A RA; Walters, Robin G RG; Meyers, Deborah A DA; Cho, Michael H MH; Strachan, David P DP; Hall, Ian P IP; Tobin, Martin D MD; Wain, Louise V LV; ,
β2-Adrenergic Receptor Gene Polymorphisms Are Associated with Cardiovascular Events But not All-Cause Mortality in Coronary Artery Disease Patients: A Meta-Analysis of Prospective Studies.
Genetic Testing And Molecular Biomarkers
Li, Yanrong Y; Yuan, Huiping H; Sun, Liang L; Zhou, Qi Q; Yang, Fan F; Yang, Ze Z; Liu, Deping D
Publication Date: 2019-02
Variant appearance in text: ADRB2: Thr164Ile; rs1800888
TRPV4 and KRAS and FGFR1 gain-of-function mutations drive giant cell lesions of the jaw.
Nature Communications
Gomes, Carolina Cavalieri CC; Gayden, Tenzin T; Bajic, Andrea A; Harraz, Osama F OF; Pratt, Jonathan J; Nikbakht, Hamid H; Bareke, Eric E; Diniz, Marina Gonçalves MG; Castro, Wagner Henriques WH; St-Onge, Pascal P; Sinnett, Daniel D; Han, HyeRim H; Rivera, Barbara B; Mikael, Leonie G LG; De Jay, Nicolas N; Kleinman, Claudia L CL; Valera, Elvis Terci ET; Bassenden, Angelia V AV; Berghuis, Albert M AM; Majewski, Jacek J; Nelson, Mark T MT; Gomez, Ricardo Santiago RS; Jabado, Nada N
Publication Date: 2018-11-01
Variant appearance in text: ADRB2: T164I; rs1800888
ADRB2 polymorphism Arg16Gly modifies the natural outcome of heart failure and dictates therapeutic response to β-blockers in patients with heart failure.
Genetic polymorphisms in very important pharmacogenomic variants in the Zhuang ethnic group of Southwestern China: A cohort study in the Zhuang population.
Medicine
Li, Jing J; Guo, Chenghao C; Yan, Mengdan M; Niu, Fanglin F; Chen, Peng P; Li, Bin B; Jin, Tianbo T
Publication Date: 2018-04
Variant appearance in text: ADRB2: Thr164Ile; rs1800888
Association between ß2-adrenergic receptor gene polymorphisms and adverse events of ritodrine in the treatment of preterm labor: a prospective observational study.
Bmc Genetics
Chung, Jee Eun JE; Choi, Soo An SA; Hwang, Han Sung HS; Park, Jin Young JY; Lee, Kyung Eun KE; Yee, Jeong J; Kim, Young Ju YJ; Gwak, Hye Sun HS
Publication Date: 2017-11-13
Variant appearance in text: ADRB2: Thr164Ile; rs1800888
Continuity and Admixture in the Last Five Millennia of Levantine History from Ancient Canaanite and Present-Day Lebanese Genome Sequences.
American Journal Of Human Genetics
Haber, Marc M; Doumet-Serhal, Claude C; Scheib, Christiana C; Xue, Yali Y; Danecek, Petr P; Mezzavilla, Massimo M; Youhanna, Sonia S; Martiniano, Rui R; Prado-Martinez, Javier J; Szpak, Michał M; Matisoo-Smith, Elizabeth E; Schutkowski, Holger H; Mikulski, Richard R; Zalloua, Pierre P; Kivisild, Toomas T; Tyler-Smith, Chris C
Benchmarking of Whole Exome Sequencing and Ad Hoc Designed Panels for Genetic Testing of Hereditary Cancer.
Scientific Reports
Feliubadaló, Lídia L; Tonda, Raúl R; Gausachs, Mireia M; Trotta, Jean-Rémi JR; Castellanos, Elisabeth E; López-Doriga, Adriana A; Teulé, Àlex À; Tornero, Eva E; Del Valle, Jesús J; Gel, Bernat B; Gut, Marta M; Pineda, Marta M; González, Sara S; Menéndez, Mireia M; Navarro, Matilde M; Capellá, Gabriel G; Gut, Ivo I; Serra, Eduard E; Brunet, Joan J; Beltran, Sergi S; Lázaro, Conxi C
Publication Date: 2017-01-04
Variant appearance in text: ADRB2: 491C>T; Thr164Ile