Colocalization of GWAS and eQTL signals at loci with multiple signals identifies additional candidate genes for body fat distribution.
Human Molecular Genetics
Wu, Ying Y; Broadaway, K Alaine KA; Raulerson, Chelsea K CK; Scott, Laura J LJ; Pan, Calvin C; Ko, Arthur A; He, Aiqing A; Tilford, Charles C; Fuchsberger, Christian C; Locke, Adam E AE; Stringham, Heather M HM; Jackson, Anne U AU; Narisu, Narisu N; Kuusisto, Johanna J; Pajukanta, Päivi P; Collins, Francis S FS; Boehnke, Michael M; Laakso, Markku M; Lusis, Aldons J AJ; Civelek, Mete M; Mohlke, Karen L KL
Common Variants in 22 Genes Regulate Response to Metformin Intervention in Children with Obesity: A Pharmacogenetic Study of a Randomized Controlled Trial.
Journal Of Clinical Medicine
Anguita-Ruiz, Augusto A; Pastor-Villaescusa, Belén B; Leis, Rosaura R; Bueno, Gloria G; Hoyos, Raúl R; Vázquez-Cobela, Rocío R; Latorre-Millán, Miriam M; Cañete, M Dolores MD; Caballero-Villarraso, Javier J; Gil, Ángel Á; Cañete, Ramón R; Aguilera, Concepción M CM
Application of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci.
Gut Microbes
Rühlemann, Malte C MC; Degenhardt, Frauke F; Thingholm, Louise B LB; Wang, Jun J; Skiecevičienė, Jurgita J; Rausch, Philipp P; Hov, Johannes R JR; Lieb, Wolfgang W; Karlsen, Tom H TH; Laudes, Matthias M; Baines, John F JF; Heinsen, Femke-Anouska FA; Franke, Andre A
Fine-mapping inflammatory bowel disease loci to single-variant resolution.
Nature
Huang, Hailiang H; Fang, Ming M; Jostins, Luke L; Umićević Mirkov, Maša M; Boucher, Gabrielle G; Anderson, Carl A CA; Andersen, Vibeke V; Cleynen, Isabelle I; Cortes, Adrian A; Crins, François F; D'Amato, Mauro M; Deffontaine, Valérie V; Dmitrieva, Julia J; Docampo, Elisa E; Elansary, Mahmoud M; Farh, Kyle Kai-How KK; Franke, Andre A; Gori, Ann-Stephan AS; Goyette, Philippe P; Halfvarson, Jonas J; Haritunians, Talin T; Knight, Jo J; Lawrance, Ian C IC; Lees, Charlie W CW; Louis, Edouard E; Mariman, Rob R; Meuwissen, Theo T; Mni, Myriam M; Momozawa, Yukihide Y; Parkes, Miles M; Spain, Sarah L SL; Théâtre, Emilie E; Trynka, Gosia G; Satsangi, Jack J; van Sommeren, Suzanne S; Vermeire, Severine S; Xavier, Ramnik J RJ; , ; Weersma, Rinse K RK; Duerr, Richard H RH; Mathew, Christopher G CG; Rioux, John D JD; McGovern, Dermot P B DPB; Cho, Judy H JH; Georges, Michel M; Daly, Mark J MJ; Barrett, Jeffrey C JC
Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity.
Molecular Metabolism
Keller, Maria M; Hopp, Lydia L; Liu, Xuanshi X; Wohland, Tobias T; Rohde, Kerstin K; Cancello, Raffaella R; Klös, Matthias M; Bacos, Karl K; Kern, Matthias M; Eichelmann, Fabian F; Dietrich, Arne A; Schön, Michael R MR; Gärtner, Daniel D; Lohmann, Tobias T; Dreßler, Miriam M; Stumvoll, Michael M; Kovacs, Peter P; DiBlasio, Anna-Maria AM; Ling, Charlotte C; Binder, Hans H; Blüher, Matthias M; Böttcher, Yvonne Y
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.
Nature Communications
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New genetic loci link adipose and insulin biology to body fat distribution.
Nature
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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Nature Genetics
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Fox, Caroline S CS; Mohlke, Karen L KL; Lindgren, Cecilia M CM