Ensemble machine learning identifies genetic loci associated with future worsening of disability in people with multiple sclerosis.
Scientific Reports
Fuh-Ngwa, Valery V; Zhou, Yuan Y; Melton, Phillip E PE; van der Mei, Ingrid I; Charlesworth, Jac C JC; Lin, Xin X; Zarghami, Amin A; Broadley, Simon A SA; Ponsonby, Anne-Louise AL; Simpson-Yap, Steve S; Lechner-Scott, Jeannette J; Taylor, Bruce V BV
Identification of Novel Loci Shared by Juvenile Idiopathic Arthritis Subtypes Through Integrative Genetic Analysis.
Arthritis & Rheumatology (Hoboken, N.J.)
Li, Jin J; Li, Yun R YR; Glessner, Joseph T JT; Yang, Jie J; March, Michael E ME; Kao, Charlly C; Vaccaro, Courtney N CN; Bradfield, Jonathan P JP; Li, Junyi J; Mentch, Frank D FD; Qu, Hui-Qi HQ; Qi, Xiaohui X; Chang, Xiao X; Hou, Cuiping C; Abrams, Debra J DJ; Qiu, Haijun H; Wei, Zhi Z; Connolly, John J JJ; Wang, Fengxiang F; Snyder, James J; Flatø, Berit B; Thompson, Susan D SD; Langefeld, Carl D CD; Lie, Benedicte A BA; Munro, Jane E JE; Wise, Carol C; Sleiman, Patrick M A PMA; Hakonarson, Hakon H
Proximal and distal effects of genetic susceptibility to multiple sclerosis on the T cell epigenome.
Nature Communications
Roostaei, Tina T; Klein, Hans-Ulrich HU; Ma, Yiyi Y; Felsky, Daniel D; Kivisäkk, Pia P; Connor, Sarah M SM; Kroshilina, Alexandra A; Yung, Christina C; Kaskow, Belinda J BJ; Shao, Xiaorong X; Rhead, Brooke B; Ordovás, José M JM; Absher, Devin M DM; Arnett, Donna K DK; Liu, Jia J; Patsopoulos, Nikolaos N; Barcellos, Lisa F LF; Weiner, Howard L HL; De Jager, Philip L PL
Proximal and distal effects of genetic susceptibility to multiple sclerosis on the T cell epigenome.
Nature Communications
Roostaei, Tina T; Klein, Hans-Ulrich HU; Ma, Yiyi Y; Felsky, Daniel D; Kivisäkk, Pia P; Connor, Sarah M SM; Kroshilina, Alexandra A; Yung, Christina C; Kaskow, Belinda J BJ; Shao, Xiaorong X; Rhead, Brooke B; Ordovás, José M JM; Absher, Devin M DM; Arnett, Donna K DK; Liu, Jia J; Patsopoulos, Nikolaos N; Barcellos, Lisa F LF; Weiner, Howard L HL; De Jager, Philip L PL
Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability.
Genome Biology
Ge, Xiangyu X; Frank-Bertoncelj, Mojca M; Klein, Kerstin K; McGovern, Amanda A; Kuret, Tadeja T; Houtman, Miranda M; Burja, Blaž B; Micheroli, Raphael R; Shi, Chenfu C; Marks, Miriam M; Filer, Andrew A; Buckley, Christopher D CD; Orozco, Gisela G; Distler, Oliver O; Morris, Andrew P AP; Martin, Paul P; Eyre, Stephen S; Ospelt, Caroline C
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.
Nature Genetics
Robertson, Catherine C CC; Inshaw, Jamie R J JRJ; Onengut-Gumuscu, Suna S; Chen, Wei-Min WM; Santa Cruz, David Flores DF; Yang, Hanzhi H; Cutler, Antony J AJ; Crouch, Daniel J M DJM; Farber, Emily E; Bridges, S Louis SL; Edberg, Jeffrey C JC; Kimberly, Robert P RP; Buckner, Jane H JH; Deloukas, Panos P; Divers, Jasmin J; Dabelea, Dana D; Lawrence, Jean M JM; Marcovina, Santica S; Shah, Amy S AS; Greenbaum, Carla J CJ; Atkinson, Mark A MA; Gregersen, Peter K PK; Oksenberg, Jorge R JR; Pociot, Flemming F; Rewers, Marian J MJ; Steck, Andrea K AK; Dunger, David B DB; , ; Wicker, Linda S LS; Concannon, Patrick P; Todd, John A JA; Rich, Stephen S SS
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.
Nature Genetics
Robertson, Catherine C CC; Inshaw, Jamie R J JRJ; Onengut-Gumuscu, Suna S; Chen, Wei-Min WM; Santa Cruz, David Flores DF; Yang, Hanzhi H; Cutler, Antony J AJ; Crouch, Daniel J M DJM; Farber, Emily E; Bridges, S Louis SL; Edberg, Jeffrey C JC; Kimberly, Robert P RP; Buckner, Jane H JH; Deloukas, Panos P; Divers, Jasmin J; Dabelea, Dana D; Lawrence, Jean M JM; Marcovina, Santica S; Shah, Amy S AS; Greenbaum, Carla J CJ; Atkinson, Mark A MA; Gregersen, Peter K PK; Oksenberg, Jorge R JR; Pociot, Flemming F; Rewers, Marian J MJ; Steck, Andrea K AK; Dunger, David B DB; , ; Wicker, Linda S LS; Concannon, Patrick P; Todd, John A JA; Rich, Stephen S SS
Single Nucleotide Polymorphism in the IL17A Gene Is Associated with Interstitial Lung Disease Positive to Anti-Jo1 Antisynthetase Autoantibodies.
Life (Basel, Switzerland)
Ponce-Gallegos, Marco Antonio MA; González-Pérez, Montserrat I MI; Mejía, Mayra M; Nava-Quiroz, Karol J KJ; Pérez-Rubio, Gloria G; Buendía-Roldán, Ivette I; Ramos-Martínez, Espiridión E; Rojas-Serrano, Jorge J; Falfán-Valencia, Ramcés R
Genetic Susceptibility to Antisynthetase Syndrome Associated With Single-Nucleotide Variants in the IL1B Gene That Lead Variation in IL-1β Serum Levels.
Frontiers In Medicine
Ponce-Gallegos, Marco Antonio MA; Ramos-Martínez, Espiridión E; García-Carmona, Adriana A; Mejía, Mayra M; Nava-Quiroz, Karol J KJ; Pérez-Rubio, Gloria G; Ambrocio-Ortiz, Enrique E; González-Pérez, Montserrat I MI; Buendía-Roldán, Ivette I; Rojas-Serrano, Jorge J; Falfán-Valencia, Ramcés R
Combined genetic analysis of juvenile idiopathic arthritis clinical subtypes identifies novel risk loci, target genes and key regulatory mechanisms.
Annals Of The Rheumatic Diseases
López-Isac, Elena E; Smith, Samantha L SL; Marion, Miranda C MC; Wood, Abigail A; Sudman, Marc M; Yarwood, Annie A; Shi, Chenfu C; Gaddi, Vasanthi Priyadarshini VP; Martin, Paul P; Prahalad, Sampath S; Eyre, Stephen S; Orozco, Gisela G; Morris, Andrew P AP; Langefeld, Carl D CD; Thompson, Susan D SD; Thomson, Wendy W; Bowes, John J
Combined genetic analysis of juvenile idiopathic arthritis clinical subtypes identifies novel risk loci, target genes and key regulatory mechanisms.
Annals Of The Rheumatic Diseases
López-Isac, Elena E; Smith, Samantha L SL; Marion, Miranda C MC; Wood, Abigail A; Sudman, Marc M; Yarwood, Annie A; Shi, Chenfu C; Gaddi, Vasanthi Priyadarshini VP; Martin, Paul P; Prahalad, Sampath S; Eyre, Stephen S; Orozco, Gisela G; Morris, Andrew P AP; Langefeld, Carl D CD; Thompson, Susan D SD; Thomson, Wendy W; Bowes, John J
Association analysis in a Latin American population revealed ethnic differences in rheumatoid arthritis-associated SNPs in Caucasian and Asian populations.
Scientific Reports
Castro-Santos, P P; Verdugo, R A RA; Alonso-Arias, R R; Gutiérrez, M A MA; Suazo, J J; Aguillón, J C JC; Olloquequi, J J; Pinochet, C C; Lucia, A A; Quiñones, L A LA; Díaz-Peña, R R
Genetic influences on susceptibility to rheumatoid arthritis in African-Americans.
Human Molecular Genetics
Laufer, Vincent A VA; Tiwari, Hemant K HK; Reynolds, Richard J RJ; Danila, Maria I MI; Wang, Jelai J; Edberg, Jeffrey C JC; Kimberly, Robert P RP; Kottyan, Leah C LC; Harley, John B JB; Mikuls, Ted R TR; Gregersen, Peter K PK; Absher, Devin M DM; Langefeld, Carl D CD; Arnett, Donna K DK; Bridges, S Louis SL
Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes.
Nature Genetics
Westra, Harm-Jan HJ; Martínez-Bonet, Marta M; Onengut-Gumuscu, Suna S; Lee, Annette A; Luo, Yang Y; Teslovich, Nikola N; Worthington, Jane J; Martin, Javier J; Huizinga, Tom T; Klareskog, Lars L; Rantapaa-Dahlqvist, Solbritt S; Chen, Wei-Min WM; Quinlan, Aaron A; Todd, John A JA; Eyre, Steve S; Nigrovic, Peter A PA; Gregersen, Peter K PK; Rich, Stephen S SS; Raychaudhuri, Soumya S
Fine-mapping inflammatory bowel disease loci to single-variant resolution.
Nature
Huang, Hailiang H; Fang, Ming M; Jostins, Luke L; Umićević Mirkov, Maša M; Boucher, Gabrielle G; Anderson, Carl A CA; Andersen, Vibeke V; Cleynen, Isabelle I; Cortes, Adrian A; Crins, François F; D'Amato, Mauro M; Deffontaine, Valérie V; Dmitrieva, Julia J; Docampo, Elisa E; Elansary, Mahmoud M; Farh, Kyle Kai-How KK; Franke, Andre A; Gori, Ann-Stephan AS; Goyette, Philippe P; Halfvarson, Jonas J; Haritunians, Talin T; Knight, Jo J; Lawrance, Ian C IC; Lees, Charlie W CW; Louis, Edouard E; Mariman, Rob R; Meuwissen, Theo T; Mni, Myriam M; Momozawa, Yukihide Y; Parkes, Miles M; Spain, Sarah L SL; Théâtre, Emilie E; Trynka, Gosia G; Satsangi, Jack J; van Sommeren, Suzanne S; Vermeire, Severine S; Xavier, Ramnik J RJ; , ; Weersma, Rinse K RK; Duerr, Richard H RH; Mathew, Christopher G CG; Rioux, John D JD; McGovern, Dermot P B DPB; Cho, Judy H JH; Georges, Michel M; Daly, Mark J MJ; Barrett, Jeffrey C JC
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
Nature Medicine
Li, Yun R YR; Li, Jin J; Zhao, Sihai D SD; Bradfield, Jonathan P JP; Mentch, Frank D FD; Maggadottir, S Melkorka SM; Hou, Cuiping C; Abrams, Debra J DJ; Chang, Diana D; Gao, Feng F; Guo, Yiran Y; Wei, Zhi Z; Connolly, John J JJ; Cardinale, Christopher J CJ; Bakay, Marina M; Glessner, Joseph T JT; Li, Dong D; Kao, Charlly C; Thomas, Kelly A KA; Qiu, Haijun H; Chiavacci, Rosetta M RM; Kim, Cecilia E CE; Wang, Fengxiang F; Snyder, James J; Richie, Marylyn D MD; Flatø, Berit B; Førre, Øystein Ø; Denson, Lee A LA; Thompson, Susan D SD; Becker, Mara L ML; Guthery, Stephen L SL; Latiano, Anna A; Perez, Elena E; Resnick, Elena E; Russell, Richard K RK; Wilson, David C DC; Silverberg, Mark S MS; Annese, Vito V; Lie, Benedicte A BA; Punaro, Marilynn M; Dubinsky, Marla C MC; Monos, Dimitri S DS; Strisciuglio, Caterina C; Staiano, Annamaria A; Miele, Erasmo E; Kugathasan, Subra S; Ellis, Justine A JA; Munro, Jane E JE; Sullivan, Kathleen E KE; Wise, Carol A CA; Chapel, Helen H; Cunningham-Rundles, Charlotte C; Grant, Struan F A SF; Orange, Jordan S JS; Sleiman, Patrick M A PM; Behrens, Edward M EM; Griffiths, Anne M AM; Satsangi, Jack J; Finkel, Terri H TH; Keinan, Alon A; Prak, Eline T Luning ET; Polychronakos, Constantin C; Baldassano, Robert N RN; Li, Hongzhe H; Keating, Brendan J BJ; Hakonarson, Hakon H
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
Nature
Okada, Yukinori Y; Wu, Di D; Trynka, Gosia G; Raj, Towfique T; Terao, Chikashi C; Ikari, Katsunori K; Kochi, Yuta Y; Ohmura, Koichiro K; Suzuki, Akari A; Yoshida, Shinji S; Graham, Robert R RR; Manoharan, Arun A; Ortmann, Ward W; Bhangale, Tushar T; Denny, Joshua C JC; Carroll, Robert J RJ; Eyler, Anne E AE; Greenberg, Jeffrey D JD; Kremer, Joel M JM; Pappas, Dimitrios A DA; Jiang, Lei L; Yin, Jian J; Ye, Lingying L; Su, Ding-Feng DF; Yang, Jian J; Xie, Gang G; Keystone, Ed E; Westra, Harm-Jan HJ; Esko, Tõnu T; Metspalu, Andres A; Zhou, Xuezhong X; Gupta, Namrata N; Mirel, Daniel D; Stahl, Eli A EA; Diogo, Dorothée D; Cui, Jing J; Liao, Katherine K; Guo, Michael H MH; Myouzen, Keiko K; Kawaguchi, Takahisa T; Coenen, Marieke J H MJ; van Riel, Piet L C M PL; van de Laar, Mart A F J MA; Guchelaar, Henk-Jan HJ; Huizinga, Tom W J TW; Dieudé, Philippe P; Mariette, Xavier X; Bridges, S Louis SL; Zhernakova, Alexandra A; Toes, Rene E M RE; Tak, Paul P PP; Miceli-Richard, Corinne C; Bang, So-Young SY; Lee, Hye-Soon HS; Martin, Javier J; Gonzalez-Gay, Miguel A MA; Rodriguez-Rodriguez, Luis L; Rantapää-Dahlqvist, Solbritt S; Arlestig, Lisbeth L; Choi, Hyon K HK; Kamatani, Yoichiro Y; Galan, Pilar P; Lathrop, Mark M; , ; , ; Eyre, Steve S; Bowes, John J; Barton, Anne A; de Vries, Niek N; Moreland, Larry W LW; Criswell, Lindsey A LA; Karlson, Elizabeth W EW; Taniguchi, Atsuo A; Yamada, Ryo R; Kubo, Michiaki M; Liu, Jun S JS; Bae, Sang-Cheol SC; Worthington, Jane J; Padyukov, Leonid L; Klareskog, Lars L; Gregersen, Peter K PK; Raychaudhuri, Soumya S; Stranger, Barbara E BE; De Jager, Philip L PL; Franke, Lude L; Visscher, Peter M PM; Brown, Matthew A MA; Yamanaka, Hisashi H; Mimori, Tsuneyo T; Takahashi, Atsushi A; Xu, Huji H; Behrens, Timothy W TW; Siminovitch, Katherine A KA; Momohara, Shigeki S; Matsuda, Fumihiko F; Yamamoto, Kazuhiko K; Plenge, Robert M RM