Genetic drug target validation using Mendelian randomisation.
Nature Communications
Schmidt, Amand F AF; Finan, Chris C; Gordillo-Marañón, Maria M; Asselbergs, Folkert W FW; Freitag, Daniel F DF; Patel, Riyaz S RS; Tyl, Benoît B; Chopade, Sandesh S; Faraway, Rupert R; Zwierzyna, Magdalena M; Hingorani, Aroon D AD
The Association of Polymorphisms in Circadian Clock and Lipid Metabolism Genes With 2nd Trimester Lipid Levels and Preterm Birth.
Frontiers In Genetics
Kovac, Ursa U; Jasper, Elizabeth A EA; Smith, Caitlin J CJ; Baer, Rebecca J RJ; Bedell, Bruce B; Donovan, Brittney M BM; Weathers, Nancy N; Prosenc Zmrzljak, Ursula U; Jelliffe-Pawlowski, Laura L LL; Rozman, Damjana D; Ryckman, Kelli K KK
Genetic markers of lipid metabolism genes associated with low susceptibility to HCV infection.
Scientific Reports
Real, Luis Miguel LM; Macías, Juan J; Rivero-Juárez, Antonio A; Téllez, Francisco F; Merino, Dolores D; Moreno-Grau, Sonia S; Orellana, Adelina A; Gómez-Salgado, Juan J; Sáez, María E ME; Frías, Mario M; Corma-Gómez, Anaïs A; Merchante, Nicolás N; Ruiz, Agustín A; Caruz, Antonio A; Pineda, Juan A JA; ,
The Korea Biobank Array: Design and Identification of Coding Variants Associated with Blood Biochemical Traits.
Scientific Reports
Moon, Sanghoon S; Kim, Young Jin YJ; Han, Sohee S; Hwang, Mi Yeong MY; Shin, Dong Mun DM; Park, Min Young MY; Lu, Yontao Y; Yoon, Kyungheon K; Jang, Hye-Mi HM; Kim, Yun Kyoung YK; Park, Tae-Joon TJ; Song, Dae Sub DS; Park, Jae Kyung JK; Lee, Jong-Eun JE; Kim, Bong-Jo BJ
Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits.
American Journal Of Human Genetics
Kraja, Aldi T AT; Liu, Chunyu C; Fetterman, Jessica L JL; Graff, Mariaelisa M; Have, Christian Theil CT; Gu, Charles C; Yanek, Lisa R LR; Feitosa, Mary F MF; Arking, Dan E DE; Chasman, Daniel I DI; Young, Kristin K; Ligthart, Symen S; Hill, W David WD; Weiss, Stefan S; Luan, Jian'an J; Giulianini, Franco F; Li-Gao, Ruifang R; Hartwig, Fernando P FP; Lin, Shiow J SJ; Wang, Lihua L; Richardson, Tom G TG; Yao, Jie J; Fernandez, Eliana P EP; Ghanbari, Mohsen M; Wojczynski, Mary K MK; Lee, Wen-Jane WJ; Argos, Maria M; Armasu, Sebastian M SM; Barve, Ruteja A RA; Ryan, Kathleen A KA; An, Ping P; Baranski, Thomas J TJ; Bielinski, Suzette J SJ; Bowden, Donald W DW; Broeckel, Ulrich U; Christensen, Kaare K; Chu, Audrey Y AY; Corley, Janie J; Cox, Simon R SR; Uitterlinden, Andre G AG; Rivadeneira, Fernando F; Cropp, Cheryl D CD; Daw, E Warwick EW; van Heemst, Diana D; de Las Fuentes, Lisa L; Gao, He H; Tzoulaki, Ioanna I; Ahluwalia, Tarunveer S TS; de Mutsert, Renée R; Emery, Leslie S LS; Erzurumluoglu, A Mesut AM; Perry, James A JA; Fu, Mao M; Forouhi, Nita G NG; Gu, Zhenglong Z; Hai, Yang Y; Harris, Sarah E SE; Hemani, Gibran G; Hunt, Steven C SC; Irvin, Marguerite R MR; Jonsson, Anna E AE; Justice, Anne E AE; Kerrison, Nicola D ND; Larson, Nicholas B NB; Lin, Keng-Hung KH; Love-Gregory, Latisha D LD; Mathias, Rasika A RA; Lee, Joseph H JH; Nauck, Matthias M; Noordam, Raymond R; Ong, Ken K KK; Pankow, James J; Patki, Amit A; Pattie, Alison A; Petersmann, Astrid A; Qi, Qibin Q; Ribel-Madsen, Rasmus R; Rohde, Rebecca R; Sandow, Kevin K; Schnurr, Theresia M TM; Sofer, Tamar T; Starr, John M JM; Taylor, Adele M AM; Teumer, Alexander A; Timpson, Nicholas J NJ; de Haan, Hugoline G HG; Wang, Yujie Y; Weeke, Peter E PE; Williams, Christine C; Wu, Hongsheng H; Yang, Wei W; Zeng, Donglin D; Witte, Daniel R DR; Weir, Bruce S BS; Wareham, Nicholas J NJ; Vestergaard, Henrik H; Turner, Stephen T ST; Torp-Pedersen, Christian C; Stergiakouli, Evie E; Sheu, Wayne Huey-Herng WH; Rosendaal, Frits R FR; Ikram, M Arfan MA; Franco, Oscar H OH; Ridker, Paul M PM; Perls, Thomas T TT; Pedersen, Oluf O; Nohr, Ellen A EA; Newman, Anne B AB; Linneberg, Allan A; Langenberg, Claudia C; Kilpeläinen, Tuomas O TO; Kardia, Sharon L R SLR; Jørgensen, Marit E ME; Jørgensen, Torben T; Sørensen, Thorkild I A TIA; Homuth, Georg G; Hansen, Torben T; Goodarzi, Mark O MO; Deary, Ian J IJ; Christensen, Cramer C; Chen, Yii-Der Ida YI; Chakravarti, Aravinda A; Brandslund, Ivan I; Bonnelykke, Klaus K; Taylor, Kent D KD; Wilson, James G JG; Rodriguez, Santiago S; Davies, Gail G; Horta, Bernardo L BL; Thyagarajan, Bharat B; Rao, D C DC; Grarup, Niels N; Davila-Roman, Victor G VG; Hudson, Gavin G; Guo, Xiuqing X; Arnett, Donna K DK; Hayward, Caroline C; Vaidya, Dhananjay D; Mook-Kanamori, Dennis O DO; Tiwari, Hemant K HK; Levy, Daniel D; Loos, Ruth J F RJF; Dehghan, Abbas A; Elliott, Paul P; Malik, Afshan N AN; Scott, Robert A RA; Becker, Diane M DM; de Andrade, Mariza M; Province, Michael A MA; Meigs, James B JB; Rotter, Jerome I JI; North, Kari E KE
The role of genetic variation of human metabolism for BMI, mental traits and mental disorders.
Molecular Metabolism
Hebebrand, Johannes J; Peters, Triinu T; Schijven, Dick D; Hebebrand, Moritz M; Grasemann, Corinna C; Winkler, Thomas W TW; Heid, Iris M IM; Antel, Jochen J; Föcker, Manuel M; Tegeler, Lisa L; Brauner, Lena L; Adan, Roger A H RAH; Luykx, Jurjen J JJ; Correll, Christoph U CU; König, Inke R IR; Hinney, Anke A; Libuda, Lars L
The effect of genetic variants on the relationship between statins and breast cancer in postmenopausal women in the Women's Health Initiative observational study.
Breast Cancer Research And Treatment
Bock, Cathryn H CH; Jay, Allison M AM; Dyson, Gregory G; Beebe-Dimmer, Jennifer L JL; Cote, Michele L ML; Hou, Lifang L; Howard, Barbara V BV; Desai, Pinkal P; Purrington, Kristen K; Prentice, Ross R; Simon, Michael S MS
Phase I biomarker modulation study of atorvastatin in women at increased risk for breast cancer.
Breast Cancer Research And Treatment
Arun, Banu K BK; Gong, Yun Y; Liu, Diane D; Litton, Jennifer K JK; Gutierrez-Barrera, Angelica M AM; Jack Lee, J J; Vornik, Lana L; Ibrahim, Nuhad K NK; Cornelison, Terri T; Hortobagyi, Gabriel N GN; Heckman-Stoddard, Brandy M BM; Koenig, Kimberly B KB; Alvarez, Ricardo R RR; Murray, James L JL; Valero, Vicente V; Lippman, Scott M SM; Brown, Powel P; Sneige, Nour N
Harnessing publicly available genetic data to prioritize lipid modifying therapeutic targets for prevention of coronary heart disease based on dysglycemic risk.
Human Genetics
Tragante, Vinicius V; Asselbergs, Folkert W FW; Swerdlow, Daniel I DI; Palmer, Tom M TM; Moore, Jason H JH; de Bakker, Paul I W PIW; Keating, Brendan J BJ; Holmes, Michael V MV
Screening for 392 polymorphisms in 141 pharmacogenes.
Biomedical Reports
Kim, Jason Yongha JY; Cheong, Hyun Sub HS; Park, Tae-Joon TJ; Shin, Hee Jung HJ; Seo, Doo Won DW; Na, Han Sung HS; Chung, Myeon Woo MW; Shin, Hyoung Doo HD
A clinical trial of lovastatin for modification of biomarkers associated with breast cancer risk.
Breast Cancer Research And Treatment
Vinayak, Shaveta S; Schwartz, Erich J EJ; Jensen, Kristin K; Lipson, Jafi J; Alli, Elizabeth E; McPherson, Lisa L; Fernandez, Adrian M AM; Sharma, Vandana B VB; Staton, Ashley A; Mills, Meredith A MA; Schackmann, Elizabeth A EA; Telli, Melinda L ML; Kardashian, Ani A; Ford, James M JM; Kurian, Allison W AW
No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population.
Human Genetics
Dumitrescu, Logan L; Carty, Cara L CL; Franceschini, Nora N; Hindorff, Lucia A LA; Cole, Shelley A SA; Bůžková, Petra P; Schumacher, Fredrick R FR; Eaton, Charles B CB; Goodloe, Robert J RJ; Duggan, David J DJ; Haessler, Jeff J; Cochran, Barbara B; Henderson, Brian E BE; Cheng, Iona I; Johnson, Karen C KC; Carlson, Chris S CS; Love, Shelly-Anne SA; Brown-Gentry, Kristin K; Nato, Alejandro Q AQ; Quibrera, Miguel M; Shohet, Ralph V RV; Ambite, José Luis JL; Wilkens, Lynne R LR; Le Marchand, Loïc L; Haiman, Christopher A CA; Buyske, Steven S; Kooperberg, Charles C; North, Kari E KE; Fornage, Myriam M; Crawford, Dana C DC
Investigation of gene-by-sex interactions for lipid traits in diverse populations from the population architecture using genomics and epidemiology study.
Bmc Genetics
Taylor, Kira C KC; Carty, Cara L CL; Dumitrescu, Logan L; Bůžková, Petra P; Cole, Shelley A SA; Hindorff, Lucia L; Schumacher, Fred R FR; Wilkens, Lynne R LR; Shohet, Ralph V RV; Quibrera, P Miguel PM; Johnson, Karen C KC; Henderson, Brian E BE; Haessler, Jeff J; Franceschini, Nora N; Eaton, Charles B CB; Duggan, David J DJ; Cochran, Barbara B; Cheng, Iona I; Carlson, Chris S CS; Brown-Gentry, Kristin K; Anderson, Garnet G; Ambite, Jose Luis JL; Haiman, Christopher C; Le Marchand, Loïc L; Kooperberg, Charles C; Crawford, Dana C DC; Buyske, Steven S; North, Kari E KE; Fornage, Myriam M; ,
Polymorphisms in the fetal progesterone receptor and a calcium-activated potassium channel isoform are associated with preterm birth in an Argentinian population.
Journal Of Perinatology : Official Journal Of The California Perinatal Association
Mann, P C PC; Cooper, M E ME; Ryckman, K K KK; Comas, B B; Gili, J J; Crumley, S S; Bream, E N A EN; Byers, H M HM; Piester, T T; Schaefer, A A; Christine, P J PJ; Lawrence, A A; Schaa, K L KL; Kelsey, K J P KJ; Berends, S K SK; Momany, A M AM; Gadow, E E; Cosentino, V V; Castilla, E E EE; López Camelo, J J; Saleme, C C; Day, L J LJ; England, S K SK; Marazita, M L ML; Dagle, J M JM; Murray, J C JC
A short-term biomarker modulation study of simvastatin in women at increased risk of a new breast cancer.
Breast Cancer Research And Treatment
Higgins, Michaela J MJ; Prowell, Tatiana M TM; Blackford, Amanda L AL; Byrne, Celia C; Khouri, Nagi F NF; Slater, Shannon A SA; Jeter, Stacie C SC; Armstrong, Deborah K DK; Davidson, Nancy E NE; Emens, Leisha A LA; Fetting, John H JH; Powers, Pendleton P PP; Wolff, Antonio C AC; Green, Hannah H; Thibert, Jacklyn N JN; Rae, James M JM; Folkerd, Elizabeth E; Dowsett, Mitchell M; Blumenthal, Roger S RS; Garber, Judy E JE; Stearns, Vered V
The Next PAGE in understanding complex traits: design for the analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study.
American Journal Of Epidemiology
Matise, Tara C TC; Ambite, Jose Luis JL; Buyske, Steven S; Carlson, Christopher S CS; Cole, Shelley A SA; Crawford, Dana C DC; Haiman, Christopher A CA; Heiss, Gerardo G; Kooperberg, Charles C; Marchand, Loic Le LL; Manolio, Teri A TA; North, Kari E KE; Peters, Ulrike U; Ritchie, Marylyn D MD; Hindorff, Lucia A LA; Haines, Jonathan L JL; ,
Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study.
Plos Genetics
Dumitrescu, Logan L; Carty, Cara L CL; Taylor, Kira K; Schumacher, Fredrick R FR; Hindorff, Lucia A LA; Ambite, José L JL; Anderson, Garnet G; Best, Lyle G LG; Brown-Gentry, Kristin K; Bůžková, Petra P; Carlson, Christopher S CS; Cochran, Barbara B; Cole, Shelley A SA; Devereux, Richard B RB; Duggan, Dave D; Eaton, Charles B CB; Fornage, Myriam M; Franceschini, Nora N; Haessler, Jeff J; Howard, Barbara V BV; Johnson, Karen C KC; Laston, Sandra S; Kolonel, Laurence N LN; Lee, Elisa T ET; MacCluer, Jean W JW; Manolio, Teri A TA; Pendergrass, Sarah A SA; Quibrera, Miguel M; Shohet, Ralph V RV; Wilkens, Lynne R LR; Haiman, Christopher A CA; Le Marchand, Loïc L; Buyske, Steven S; Kooperberg, Charles C; North, Kari E KE; Crawford, Dana C DC
Dysregulation of the mevalonate pathway promotes transformation.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Clendening, James W JW; Pandyra, Aleks A; Boutros, Paul C PC; El Ghamrasni, Samah S; Khosravi, Fereshteh F; Trentin, Grace A GA; Martirosyan, Anna A; Hakem, Anne A; Hakem, Razqallah R; Jurisica, Igor I; Penn, Linda Z LZ
Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.
Plos One
Zeller, Tanja T; Wild, Philipp P; Szymczak, Silke S; Rotival, Maxime M; Schillert, Arne A; Castagne, Raphaele R; Maouche, Seraya S; Germain, Marine M; Lackner, Karl K; Rossmann, Heidi H; Eleftheriadis, Medea M; Sinning, Christoph R CR; Schnabel, Renate B RB; Lubos, Edith E; Mennerich, Detlev D; Rust, Werner W; Perret, Claire C; Proust, Carole C; Nicaud, Viviane V; Loscalzo, Joseph J; Hübner, Norbert N; Tregouet, David D; Münzel, Thomas T; Ziegler, Andreas A; Tiret, Laurence L; Blankenberg, Stefan S; Cambien, François F
Association of blood lipids with common DNA sequence variants at 19 genetic loci in the multiethnic United States National Health and Nutrition Examination Survey III.
Circulation. Cardiovascular Genetics
Keebler, Mary E ME; Sanders, Christopher L CL; Surti, Aarti A; Guiducci, Candace C; Burtt, Noel P NP; Kathiresan, Sekar S
Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
Lipids In Health And Disease
Ronald, James J; Rajagopalan, Ramakrishnan R; Ranchalis, Jane E JE; Marshall, Julieann K JK; Hatsukami, Thomas S TS; Heagerty, Patrick J PJ; Jarvik, Gail P GP
Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.
European Heart Journal
Murray, Anna A; Cluett, Christie C; Bandinelli, Stefania S; Corsi, Anna Maria AM; Ferrucci, Luigi L; Guralnik, Jack J; Singleton, Andrew A; Frayling, Timothy T; Melzer, David D
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
Plos Genetics
Lowe, Jennifer K JK; Maller, Julian B JB; Pe'er, Itsik I; Neale, Benjamin M BM; Salit, Jacqueline J; Kenny, Eimear E EE; Shea, Jessica L JL; Burkhardt, Ralph R; Smith, J Gustav JG; Ji, Weizhen W; Noel, Martha M; Foo, Jia Nee JN; Blundell, Maude L ML; Skilling, Vita V; Garcia, Laura L; Sullivan, Marcia L ML; Lee, Heather E HE; Labek, Anna A; Ferdowsian, Hope H; Auerbach, Steven B SB; Lifton, Richard P RP; Newton-Cheh, Christopher C; Breslow, Jan L JL; Stoffel, Markus M; Daly, Mark J MJ; Altshuler, David M DM; Friedman, Jeffrey M JM
Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.
American Journal Of Human Genetics
Ferrucci, Luigi L; Perry, John R B JR; Matteini, Amy A; Perola, Markus M; Tanaka, Toshiko T; Silander, Kaisa K; Rice, Neil N; Melzer, David D; Murray, Anna A; Cluett, Christie C; Fried, Linda P LP; Albanes, Demetrius D; Corsi, Anna-Maria AM; Cherubini, Antonio A; Guralnik, Jack J; Bandinelli, Stefania S; Singleton, Andrew A; Virtamo, Jarmo J; Walston, Jeremy J; Semba, Richard D RD; Frayling, Timothy M TM
Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.
Plos Genetics
Deo, Rahul C RC; Reich, David D; Tandon, Arti A; Akylbekova, Ermeg E; Patterson, Nick N; Waliszewska, Alicja A; Kathiresan, Sekar S; Sarpong, Daniel D; Taylor, Herman A HA; Wilson, James G JG
Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13.
Arteriosclerosis, Thrombosis, And Vascular Biology
Burkhardt, Ralph R; Kenny, Eimear E EE; Lowe, Jennifer K JK; Birkeland, Andrew A; Josowitz, Rebecca R; Noel, Martha M; Salit, Jacqueline J; Maller, Julian B JB; Pe'er, Itsik I; Daly, Mark J MJ; Altshuler, David D; Stoffel, Markus M; Friedman, Jeffrey M JM; Breslow, Jan L JL
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
Nature Genetics
Kathiresan, Sekar S; Melander, Olle O; Guiducci, Candace C; Surti, Aarti A; Burtt, Noël P NP; Rieder, Mark J MJ; Cooper, Gregory M GM; Roos, Charlotta C; Voight, Benjamin F BF; Havulinna, Aki S AS; Wahlstrand, Björn B; Hedner, Thomas T; Corella, Dolores D; Tai, E Shyong ES; Ordovas, Jose M JM; Berglund, Göran G; Vartiainen, Erkki E; Jousilahti, Pekka P; Hedblad, Bo B; Taskinen, Marja-Riitta MR; Newton-Cheh, Christopher C; Salomaa, Veikko V; Peltonen, Leena L; Groop, Leif L; Altshuler, David M DM; Orho-Melander, Marju M