Using Mendelian randomisation to identify opportunities for type 2 diabetes prevention by repurposing medications used for lipid management.
Ebiomedicine
Khankari, Nikhil K NK; Keaton, Jacob M JM; Walker, Venexia M VM; Lee, Kyung Min KM; Shuey, Megan M MM; Clarke, Shoa L SL; Heberer, Kent R KR; Miller, Donald R DR; Reaven, Peter D PD; Lynch, Julie A JA; Vujkovic, Marijana M; Edwards, Todd L TL
Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis.
Nature Communications
Scholz, Markus M; Horn, Katrin K; Pott, Janne J; Gross, Arnd A; Kleber, Marcus E ME; Delgado, Graciela E GE; Mishra, Pashupati Prasad PP; Kirsten, Holger H; Gieger, Christian C; Müller-Nurasyid, Martina M; Tönjes, Anke A; Kovacs, Peter P; Lehtimäki, Terho T; Raitakari, Olli O; Kähönen, Mika M; Gylling, Helena H; Baber, Ronny R; Isermann, Berend B; Stumvoll, Michael M; Loeffler, Markus M; März, Winfried W; Meitinger, Thomas T; Peters, Annette A; Thiery, Joachim J; Teupser, Daniel D; Ceglarek, Uta U
Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis.
Nature Communications
Scholz, Markus M; Horn, Katrin K; Pott, Janne J; Gross, Arnd A; Kleber, Marcus E ME; Delgado, Graciela E GE; Mishra, Pashupati Prasad PP; Kirsten, Holger H; Gieger, Christian C; Müller-Nurasyid, Martina M; Tönjes, Anke A; Kovacs, Peter P; Lehtimäki, Terho T; Raitakari, Olli O; Kähönen, Mika M; Gylling, Helena H; Baber, Ronny R; Isermann, Berend B; Stumvoll, Michael M; Loeffler, Markus M; März, Winfried W; Meitinger, Thomas T; Peters, Annette A; Thiery, Joachim J; Teupser, Daniel D; Ceglarek, Uta U
Crosstalk between Statins and Cancer Prevention and Therapy: An Update.
Pharmaceuticals (Basel, Switzerland)
Grabarek, Beniamin Oskar BO; Boroń, Dariusz D; Morawiec, Emilia E; Michalski, Piotr P; Palazzo-Michalska, Veronica V; Pach, Łukasz Ł; Dziuk, Barbara B; Świder, Magdalena M; Zmarzły, Nikola N
Crosstalk between Statins and Cancer Prevention and Therapy: An Update.
Pharmaceuticals (Basel, Switzerland)
Grabarek, Beniamin Oskar BO; Boroń, Dariusz D; Morawiec, Emilia E; Michalski, Piotr P; Palazzo-Michalska, Veronica V; Pach, Łukasz Ł; Dziuk, Barbara B; Świder, Magdalena M; Zmarzły, Nikola N
Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study.
Plos Genetics
Gormley, Mark M; Yarmolinsky, James J; Dudding, Tom T; Burrows, Kimberley K; Martin, Richard M RM; Thomas, Steven S; Tyrrell, Jessica J; Brennan, Paul P; Pring, Miranda M; Boccia, Stefania S; Olshan, Andrew F AF; Diergaarde, Brenda B; Hung, Rayjean J RJ; Liu, Geoffrey G; Legge, Danny D; Tajara, Eloiza H EH; Severino, Patricia P; Lacko, Martin M; Ness, Andrew R AR; Davey Smith, George G; Vincent, Emma E EE; Richmond, Rebecca C RC
Mendelian randomization for studying the effects of perturbing drug targets.
Wellcome Open Research
Gill, Dipender D; Georgakis, Marios K MK; Walker, Venexia M VM; Schmidt, A Floriaan AF; Gkatzionis, Apostolos A; Freitag, Daniel F DF; Finan, Chris C; Hingorani, Aroon D AD; Howson, Joanna M M JMM; Burgess, Stephen S; Swerdlow, Daniel I DI; Davey Smith, George G; Holmes, Michael V MV; Dichgans, Martin M; Scott, Robert A RA; Zheng, Jie J; Psaty, Bruce M BM; Davies, Neil M NM
Statins as Potential Chemoprevention or Therapeutic Agents in Cancer: a Model for Evaluating Repurposed Drugs.
Current Oncology Reports
Joharatnam-Hogan, Nalinie N; Alexandre, Leo L; Yarmolinsky, James J; Lake, Blossom B; Capps, Nigel N; Martin, Richard M RM; Ring, Alistair A; Cafferty, Fay F; Langley, Ruth E RE
Lower plasma PCSK9 in normocholesterolemic subjects is associated with upregulated adipose tissue surface-expression of LDLR and CD36 and NLRP3 inflammasome.
Physiological Reports
Cyr, Yannick Y; Lamantia, Valérie V; Bissonnette, Simon S; Burnette, Melanie M; Besse-Patin, Aurèle A; Demers, Annie A; Wabitsch, Martin M; Chrétien, Michel M; Mayer, Gaétan G; Estall, Jennifer L JL; Saleh, Maya M; Faraj, May M
Metabolic profiling of angiopoietin-like protein 3 and 4 inhibition: a drug-target Mendelian randomization analysis.
European Heart Journal
Wang, Qin Q; Oliver-Williams, Clare C; Raitakari, Olli T OT; Viikari, Jorma J; Lehtimäki, Terho T; Kähönen, Mika M; Järvelin, Marjo-Riitta MR; Salomaa, Veikko V; Perola, Markus M; Danesh, John J; Kettunen, Johannes J; Butterworth, Adam S AS; Holmes, Michael V MV; Ala-Korpela, Mika M
Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease.
Nature Communications
Nielsen, Jonas B JB; Rom, Oren O; Surakka, Ida I; Graham, Sarah E SE; Zhou, Wei W; Roychowdhury, Tanmoy T; Fritsche, Lars G LG; Gagliano Taliun, Sarah A SA; Sidore, Carlo C; Liu, Yuhao Y; Gabrielsen, Maiken E ME; Skogholt, Anne Heidi AH; Wolford, Brooke B; Overton, William W; Zhao, Ying Y; Chen, Jin J; Zhang, He H; Hornsby, Whitney E WE; Acheampong, Akua A; Grooms, Austen A; Schaefer, Amanda A; Zajac, Gregory J M GJM; Villacorta, Luis L; Zhang, Jifeng J; Brumpton, Ben B; Løset, Mari M; Rai, Vivek V; Lundegaard, Pia R PR; Olesen, Morten S MS; Taylor, Kent D KD; Palmer, Nicholette D ND; Chen, Yii-Der YD; Choi, Seung H SH; Lubitz, Steven A SA; Ellinor, Patrick T PT; Barnes, Kathleen C KC; Daya, Michelle M; Rafaels, Nicholas N; Weiss, Scott T ST; Lasky-Su, Jessica J; Tracy, Russell P RP; Vasan, Ramachandran S RS; Cupples, L Adrienne LA; Mathias, Rasika A RA; Yanek, Lisa R LR; Becker, Lewis C LC; Peyser, Patricia A PA; Bielak, Lawrence F LF; Smith, Jennifer A JA; Aslibekyan, Stella S; Hidalgo, Bertha A BA; Arnett, Donna K DK; Irvin, Marguerite R MR; Wilson, James G JG; Musani, Solomon K SK; Correa, Adolfo A; Rich, Stephen S SS; Guo, Xiuqing X; Rotter, Jerome I JI; Konkle, Barbara A BA; Johnsen, Jill M JM; Ashley-Koch, Allison E AE; Telen, Marilyn J MJ; Sheehan, Vivien A VA; Blangero, John J; Curran, Joanne E JE; Peralta, Juan M JM; Montgomery, Courtney C; Sheu, Wayne H-H WH; Chung, Ren-Hua RH; Schwander, Karen K; Nouraie, Seyed M SM; Gordeuk, Victor R VR; Zhang, Yingze Y; Kooperberg, Charles C; Reiner, Alexander P AP; Jackson, Rebecca D RD; Bleecker, Eugene R ER; Meyers, Deborah A DA; Li, Xingnan X; Das, Sayantan S; Yu, Ketian K; LeFaive, Jonathon J; Smith, Albert A; Blackwell, Tom T; Taliun, Daniel D; Zollner, Sebastian S; Forer, Lukas L; Schoenherr, Sebastian S; Fuchsberger, Christian C; Pandit, Anita A; Zawistowski, Matthew M; Kheterpal, Sachin S; Brummett, Chad M CM; Natarajan, Pradeep P; Schlessinger, David D; Lee, Seunggeun S; Kang, Hyun Min HM; Cucca, Francesco F; Holmen, Oddgeir L OL; Åsvold, Bjørn O BO; Boehnke, Michael M; Kathiresan, Sekar S; Abecasis, Goncalo R GR; Chen, Y Eugene YE; Willer, Cristen J CJ; Hveem, Kristian K
Genetic drug target validation using Mendelian randomisation.
Nature Communications
Schmidt, Amand F AF; Finan, Chris C; Gordillo-Marañón, Maria M; Asselbergs, Folkert W FW; Freitag, Daniel F DF; Patel, Riyaz S RS; Tyl, Benoît B; Chopade, Sandesh S; Faraway, Rupert R; Zwierzyna, Magdalena M; Hingorani, Aroon D AD
Association Between Genetically Proxied Inhibition of HMG-CoA Reductase and Epithelial Ovarian Cancer.
Jama
Yarmolinsky, James J; Bull, Caroline J CJ; Vincent, Emma E EE; Robinson, Jamie J; Walther, Axel A; Smith, George Davey GD; Lewis, Sarah J SJ; Relton, Caroline L CL; Martin, Richard M RM
Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition.
Plos Biology
Kettunen, Johannes J; Holmes, Michael V MV; Allara, Elias E; Anufrieva, Olga O; Ohukainen, Pauli P; Oliver-Williams, Clare C; Wang, Qin Q; Tillin, Therese T; Hughes, Alun D AD; Kähönen, Mika M; Lehtimäki, Terho T; Viikari, Jorma J; Raitakari, Olli T OT; Salomaa, Veikko V; Järvelin, Marjo-Riitta MR; Perola, Markus M; Davey Smith, George G; Chaturvedi, Nish N; Danesh, John J; Di Angelantonio, Emanuele E; Butterworth, Adam S AS; Ala-Korpela, Mika M
Genetic Determinants of Lipids and Cardiovascular Disease Outcomes: A Wide-Angled Mendelian Randomization Investigation.
Circulation. Genomic And Precision Medicine
Allara, Elias E; Morani, Gabriele G; Carter, Paul P; Gkatzionis, Apostolos A; Zuber, Verena V; Foley, Christopher N CN; Rees, Jessica M B JMB; Mason, Amy M AM; Bell, Steven S; Gill, Dipender D; Lindström, Sara S; Butterworth, Adam S AS; Di Angelantonio, Emanuele E; Peters, James J; Burgess, Stephen S; ,
Mendelian randomization analysis rules out disylipidaemia as colorectal cancer cause.
Scientific Reports
Ibáñez-Sanz, Gemma G; Díez-Villanueva, Anna A; Riera-Ponsati, Marina M; Fernández-Villa, Tania T; Fernández Navarro, Pablo P; Bustamante, Mariona M; Llorca, Javier J; Amiano, Pilar P; Ascunce, Nieves N; Fernández-Tardón, Guillermo G; Salcedo Bellido, Inmaculada I; Salas, Dolores D; Capelo Álvarez, Rocío R; Crous-Bou, Marta M; Ortega-Valín, Luis L; Pérez-Gómez, Beatriz B; Castaño-Vinyals, Gemma G; Palazuelos, Camilo C; Altzibar, Jone M JM; Ardanaz, Eva E; Tardón, Adonina A; Jiménez Moleón, José Juan JJ; Olmos Juste, Valle V; Aragonés, Nuria N; Pollán, Marina M; Kogevinas, Manolis M; Moreno, Victor V