BRK phosphorylates SMAD4 for proteasomal degradation and inhibits tumor suppressor FRK to control SNAIL, SLUG, and metastatic potential.
Science Advances
Miah, S S; Banks, C A S CAS; Ogunbolude, Y Y; Bagu, E T ET; Berg, J M JM; Saraf, A A; Tettey, T T TT; Hattem, G G; Dayebgadoh, G G; Kempf, C G CG; Sardiu, M M; Napper, S S; Florens, L L; Lukong, K E KE; Washburn, M P MP
The tyrosine kinase FRK/RAK participates in cytokine-induced islet cell cytotoxicity.
The Biochemical Journal
Welsh, Michael M; Welsh, Charlotte C; Ekman, Maria M; Dixelius, Johan J; Hägerkvist, Robert R; Annerén, Cecilia C; Akerblom, Björn B; Mahboobi, Siavosh S; Chandrasekharan, Subhashini S; Liu, Edison T ET