FRK c.1490A>T ;(p.Y497F)

Variant ID: 6-116263605-T-A

NM_002031.2(FRK):c.1490A>T;(p.Y497F)

This variant was identified in 3 publications

View GRCh38 version.




Publications:


BRK phosphorylates SMAD4 for proteasomal degradation and inhibits tumor suppressor FRK to control SNAIL, SLUG, and metastatic potential.

Science Advances
Miah, S S; Banks, C A S CAS; Ogunbolude, Y Y; Bagu, E T ET; Berg, J M JM; Saraf, A A; Tettey, T T TT; Hattem, G G; Dayebgadoh, G G; Kempf, C G CG; Sardiu, M M; Napper, S S; Florens, L L; Lukong, K E KE; Washburn, M P MP
Publication Date: 2019-10

Variant appearance in text: FRK: Y497F
PubMed Link: 31681835
Variant Present in the following documents:
  • aaw3113_SM.pdf
View BVdb publication page



FRK inhibits breast cancer cell migration and invasion by suppressing epithelial-mesenchymal transition.

Oncotarget
Ogunbolude, Yetunde Y; Dai, Chenlu C; Bagu, Edward T ET; Goel, Raghuveera Kumar RK; Miah, Sayem S; MacAusland-Berg, Joshua J; Ng, Chi Ying CY; Chibbar, Rajni R; Napper, Scott S; Raptis, Leda L; Vizeacoumar, Frederick F; Vizeacoumar, Franco F; Bonham, Keith K; Lukong, Kiven Erique KE
Publication Date: 2017-12-22

Variant appearance in text: FRK: Y497F
PubMed Link: 29348886
Variant Present in the following documents:
  • Main text
  • oncotarget-08-113034.pdf
  • oncotarget-08-113034-s001.pdf
View BVdb publication page



The tyrosine kinase FRK/RAK participates in cytokine-induced islet cell cytotoxicity.

The Biochemical Journal
Welsh, Michael M; Welsh, Charlotte C; Ekman, Maria M; Dixelius, Johan J; Hägerkvist, Robert R; Annerén, Cecilia C; Akerblom, Björn B; Mahboobi, Siavosh S; Chandrasekharan, Subhashini S; Liu, Edison T ET
Publication Date: 2004-08-15

Variant appearance in text: FRK: Y497F
PubMed Link: 15186217
Variant Present in the following documents:
  • Main text
View BVdb publication page