Coding and regulatory variants are associated with serum protein levels and disease.
Nature Communications
Emilsson, Valur V; Gudmundsdottir, Valborg V; Gudjonsson, Alexander A; Jonmundsson, Thorarinn T; Jonsson, Brynjolfur G BG; Karim, Mohd A MA; Ilkov, Marjan M; Staley, James R JR; Gudmundsson, Elias F EF; Launer, Lenore J LJ; Lindeman, Jan H JH; Morton, Nicholas M NM; Aspelund, Thor T; Lamb, John R JR; Jennings, Lori L LL; Gudnason, Vilmundur V
Coding and regulatory variants are associated with serum protein levels and disease.
Nature Communications
Emilsson, Valur V; Gudmundsdottir, Valborg V; Gudjonsson, Alexander A; Jonmundsson, Thorarinn T; Jonsson, Brynjolfur G BG; Karim, Mohd A MA; Ilkov, Marjan M; Staley, James R JR; Gudmundsson, Elias F EF; Launer, Lenore J LJ; Lindeman, Jan H JH; Morton, Nicholas M NM; Aspelund, Thor T; Lamb, John R JR; Jennings, Lori L LL; Gudnason, Vilmundur V
Polygenic risk scores predict diabetes complications and their response to intensive blood pressure and glucose control.
Diabetologia
Tremblay, Johanne J; Haloui, Mounsif M; Attaoua, Redha R; Tahir, Ramzan R; Hishmih, Camil C; Harvey, François F; Marois-Blanchet, François-Christophe FC; Long, Carole C; Simon, Paul P; Santucci, Lara L; Hizel, Candan C; Chalmers, John J; Marre, Michel M; Harrap, Stephen S; Cífková, Renata R; Krajčoviechová, Alena A; Matthews, David R DR; Williams, Bryan B; Poulter, Neil N; Zoungas, Sophia S; Colagiuri, Stephen S; Mancia, Giuseppe G; Grobbee, Diederick E DE; Rodgers, Anthony A; Liu, Liusheng L; Agbessi, Mawussé M; Bruat, Vanessa V; Favé, Marie-Julie MJ; Harwood, Michelle P MP; Awadalla, Philip P; Woodward, Mark M; Hussin, Julie G JG; Hamet, Pavel P
RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro.
Nature Communications
Loh, Nellie Y NY; Minchin, James E N JEN; Pinnick, Katherine E KE; Verma, Manu M; Todorčević, Marijana M; Denton, Nathan N; Moustafa, Julia El-Sayed JE; Kemp, John P JP; Gregson, Celia L CL; Evans, David M DM; Neville, Matt J MJ; Small, Kerrin S KS; McCarthy, Mark I MI; Mahajan, Anubha A; Rawls, John F JF; Karpe, Fredrik F; Christodoulides, Constantinos C
Genetic predictors of weight loss in overweight and obese subjects.
Scientific Reports
Lamiquiz-Moneo, Itziar I; Mateo-Gallego, Rocío R; Bea, Ana M AM; Dehesa-García, Blanca B; Pérez-Calahorra, Sofía S; Marco-Benedí, Victoria V; Baila-Rueda, Lucía L; Laclaustra, Martín M; Civeira, Fernando F; Cenarro, Ana A
Functional DNA variations associated with Saudi female with low VO2max: a pilot microarray study.
American Journal Of Translational Research
Al Asoom, Lubna Ibrahim LI; Alsuwat, Hind Saleh HS; Rafique, Nazish N; Al Makhaita, Marwah M; Alamoudi, Widyan W; AbdulAzeez, Sayed S; Borgio, Jesu Francis JF
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.
Nature Genetics
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Fine-mapping inflammatory bowel disease loci to single-variant resolution.
Nature
Huang, Hailiang H; Fang, Ming M; Jostins, Luke L; Umićević Mirkov, Maša M; Boucher, Gabrielle G; Anderson, Carl A CA; Andersen, Vibeke V; Cleynen, Isabelle I; Cortes, Adrian A; Crins, François F; D'Amato, Mauro M; Deffontaine, Valérie V; Dmitrieva, Julia J; Docampo, Elisa E; Elansary, Mahmoud M; Farh, Kyle Kai-How KK; Franke, Andre A; Gori, Ann-Stephan AS; Goyette, Philippe P; Halfvarson, Jonas J; Haritunians, Talin T; Knight, Jo J; Lawrance, Ian C IC; Lees, Charlie W CW; Louis, Edouard E; Mariman, Rob R; Meuwissen, Theo T; Mni, Myriam M; Momozawa, Yukihide Y; Parkes, Miles M; Spain, Sarah L SL; Théâtre, Emilie E; Trynka, Gosia G; Satsangi, Jack J; van Sommeren, Suzanne S; Vermeire, Severine S; Xavier, Ramnik J RJ; , ; Weersma, Rinse K RK; Duerr, Richard H RH; Mathew, Christopher G CG; Rioux, John D JD; McGovern, Dermot P B DPB; Cho, Judy H JH; Georges, Michel M; Daly, Mark J MJ; Barrett, Jeffrey C JC
Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations.
International Journal Of Obesity (2005)
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Investigation of Genetic Variation Underlying Central Obesity amongst South Asians.
Plos One
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rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery.
Obesity Surgery
Rasmussen-Torvik, Laura J LJ; Baldridge, Abigail S AS; Pacheco, Jennifer A JA; Aufox, Sharon A SA; Kim, Kwang-Youn A KY; Silverstein, Jonathan C JC; Denham, Erwin W EW; Hungness, Eric E; Smith, Maureen E ME; Greenland, Philip P
Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci.
Human Molecular Genetics
Rahmioglu, Nilufer N; Macgregor, Stuart S; Drong, Alexander W AW; Hedman, Åsa K ÅK; Harris, Holly R HR; Randall, Joshua C JC; Prokopenko, Inga I; , ; Nyholt, Dale R DR; Morris, Andrew P AP; Montgomery, Grant W GW; Missmer, Stacey A SA; Lindgren, Cecilia M CM; Zondervan, Krina T KT
Multi-ethnic fine-mapping of 14 central adiposity loci.
Human Molecular Genetics
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Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations.
Human Molecular Genetics
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Generalization of adiposity genetic loci to US Hispanic women.
Nutrition & Diabetes
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Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
Plos Genetics
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Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
Plos Genetics
Fox, Caroline S CS; Liu, Yongmei Y; White, Charles C CC; Feitosa, Mary M; Smith, Albert V AV; Heard-Costa, Nancy N; Lohman, Kurt K; , ; , ; , ; Johnson, Andrew D AD; Foster, Meredith C MC; Greenawalt, Danielle M DM; Griffin, Paula P; Ding, Jinghong J; Newman, Anne B AB; Tylavsky, Fran F; Miljkovic, Iva I; Kritchevsky, Stephen B SB; Launer, Lenore L; Garcia, Melissa M; Eiriksdottir, Gudny G; Carr, J Jeffrey JJ; Gudnason, Vilmunder V; Harris, Tamara B TB; Cupples, L Adrienne LA; Borecki, Ingrid B IB
An integrative genomics approach identifies activation of thioredoxin/thioredoxin reductase-1-mediated oxidative stress defense pathway and inhibition of angiogenesis in obese nondiabetic human subjects.
The Journal Of Clinical Endocrinology And Metabolism
Das, Swapan K SK; Sharma, Neeraj K NK; Hasstedt, Sandra J SJ; Mondal, Ashis K AK; Ma, Lijun L; Langberg, Kurt A KA; Elbein, Steven C SC
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Nature Genetics
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Ohlsson, Claes C; Palmer, Lyle J LJ; Raitakari, Olli O; Ridker, Paul M PM; Stumvoll, Michael M; Tönjes, Anke A; Viikari, Jorma J; Balkau, Beverley B; Ben-Shlomo, Yoav Y; Bergman, Richard N RN; Boeing, Heiner H; Smith, George Davey GD; Ebrahim, Shah S; Froguel, Philippe P; Hansen, Torben T; Hengstenberg, Christian C; Hveem, Kristian K; Isomaa, Bo B; Jørgensen, Torben T; Karpe, Fredrik F; Khaw, Kay-Tee KT; Laakso, Markku M; Lawlor, Debbie A DA; Marre, Michel M; Meitinger, Thomas T; Metspalu, Andres A; Midthjell, Kristian K; Pedersen, Oluf O; Salomaa, Veikko V; Schwarz, Peter E H PE; Tuomi, Tiinamaija T; Tuomilehto, Jaakko J; Valle, Timo T TT; Wareham, Nicholas J NJ; Arnold, Alice M AM; Beckmann, Jacques S JS; Bergmann, Sven S; Boerwinkle, Eric E; Boomsma, Dorret I DI; Caulfield, Mark J MJ; Collins, Francis S FS; Eiriksdottir, Gudny G; Gudnason, Vilmundur V; Gyllensten, Ulf U; Hamsten, Anders A; Hattersley, Andrew T AT; Hofman, Albert A; Hu, Frank B FB; Illig, Thomas T; Iribarren, Carlos C; Jarvelin, Marjo-Riitta MR; Kao, W H Linda WH; Kaprio, Jaakko J; Launer, Lenore J LJ; Munroe, Patricia B PB; Oostra, Ben B; Penninx, Brenda W BW; Pramstaller, Peter P PP; Psaty, Bruce M BM; Quertermous, Thomas T; Rissanen, Aila A; Rudan, Igor I; Shuldiner, Alan R AR; Soranzo, Nicole N; Spector, Timothy D TD; Syvanen, Ann-Christine AC; Uda, Manuela M; Uitterlinden, André A; Völzke, Henry H; Vollenweider, Peter P; Wilson, James F JF; Witteman, Jacqueline C JC; Wright, Alan F AF; Abecasis, Gonçalo R GR; Boehnke, Michael M; Borecki, Ingrid B IB; Deloukas, Panos P; Frayling, Timothy M TM; Groop, Leif C LC; Haritunians, Talin T; Hunter, David J DJ; Kaplan, Robert C RC; North, Kari E KE; O'Connell, Jeffrey R JR; Peltonen, Leena L; Schlessinger, David D; Strachan, David P DP; Hirschhorn, Joel N JN; Assimes, Themistocles L TL; Wichmann, H-Erich HE; Thorsteinsdottir, Unnur U; van Duijn, Cornelia M CM; Stefansson, Kari K; Cupples, L Adrienne LA; Loos, Ruth J F RJ; Barroso, Inês I; McCarthy, Mark I MI; Fox, Caroline S CS; Mohlke, Karen L KL; Lindgren, Cecilia M CM