Variant ID: 6-138196066-T-C

NM_001270507.1(TNFAIP3):c.380T>C;(p.Phe127Ser)

This variant was identified in 79 publications




Publications:


Identifying the culprits in neurological autoimmune diseases.

Journal Of Translational Autoimmunity
Y Acosta-Ampudia, DM Monsalve, C Ramírez-Santana
Publication Date: 2019-12

Variant appearance in text: rs2230926
PMID: 32743503
View BVdb publication page



Genetic Polymorphisms Associated with Rheumatoid Arthritis Development and Antirheumatic Therapy Response.

International Journal Of Molecular Sciences
DS Mikhaylenko, MV Nemtsova, IV Bure, EB Kuznetsova, EA Alekseeva, VV Tarasov, AN Lukashev, MI Beloukhova, AA Deviatkin, AA Zamyatnin
Publication Date: 2020-07-11

Variant appearance in text: N/A
PMID: 32664585
View BVdb publication page



Synergistic activation of NF-κB by TNFAIP3 (A20) reduction and UBE2L3 (UBCH7) augment that synergistically elevate lupus risk.

Arthritis Research & Therapy
T Kim, SC Bae, C Kang
Publication Date: 2020-04-25

Variant appearance in text: rs2230926
PMID: 32334614
View BVdb publication page



TNFAIP3 Gene Polymorphisms in Three Common Autoimmune Diseases: Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Primary Sjogren Syndrome-Association with Disease Susceptibility and Clinical Phenotypes in Italian Patients.

Journal Of Immunology Research
C Ciccacci, A Latini, C Perricone, P Conigliaro, S Colafrancesco, F Ceccarelli, R Priori, F Conti, R Perricone, G Novelli, P Borgiani
Publication Date: 2019

Variant appearance in text: rs2230926
PMID: 31534975
View BVdb publication page



Population pharmacokinetics of cyclosporine in Chinese children receiving hematopoietic stem cell transplantation.

Acta Pharmacologica Sinica
TF Li, L Hu, XL Ma, L Huang, XM Liu, XX Luo, WY Feng, CF Wu
Publication Date: 2019-12

Variant appearance in text: rs2230926
PMID: 31341257
View BVdb publication page



Are Perceived Stress and Cytokine Genotypes Clinically Feasible as Predictors of Psychoneuroimmune Symptoms in Advanced Cancer?

The Permanente Journal
S Gilbertson-White, A Shahnazi, C Cherwin
Publication Date: 2019

Variant appearance in text: rs2230926
PMID: 31314714
View BVdb publication page



TNFAIP3 genetic polymorphisms reduce ankylosing spondylitis risk in Eastern Chinese Han population.

Scientific Reports
J Yang, X Hu, M Wu, Y Ma, X Zhang, M Chen, Y Yuan, R Han, R Liu, S Guan, J Deng, S Xu, X Gao, S Xu, Z Shuai, S Jiang, S Guan, L Chen, F Pan
Publication Date: 2019-07-15

Variant appearance in text: rs2230926
PMID: 31308453
View BVdb publication page



Abstracts from the 51st European Society of Human Genetics Conference: Posters.

European Journal Of Human Genetics : Ejhg
.
Publication Date: 2019-07

Variant appearance in text: rs2230926
PMID: 31270413
View BVdb publication page



Association of Epstein-Barr virus serological reactivation with transitioning to systemic lupus erythematosus in at-risk individuals.

Annals Of The Rheumatic Diseases
NR Jog, KA Young, ME Munroe, MT Harmon, JM Guthridge, JA Kelly, DL Kamen, GS Gilkeson, MH Weisman, DR Karp, PM Gaffney, JB Harley, DJ Wallace, JM Norris, JA James
Publication Date: 2019-09

Variant appearance in text: rs2230926
PMID: 31217170
View BVdb publication page



SNP variations in IL10, TNFα and TNFAIP3 genes in patients with dry eye syndrome and Sjogren's syndrome.

Journal Of Inflammation (London, England)
H Ben-Eli, N Gomel, DJ Aframian, R Abu-Seir, R Perlman, E Ben-Chetrit, D Mevorach, G Kleinstern, O Paltiel, A Solomon
Publication Date: 2019

Variant appearance in text: rs2230926
PMID: 30923465
View BVdb publication page



TNFAIP3, TNIP1, and MyD88 Polymorphisms Predict Septic-Shock-Related Death in Patients Who Underwent Major Surgery.

Journal Of Clinical Medicine
MÁ Jiménez-Sousa, A Fadrique, P Liu, A Fernández-Rodríguez, M Lorenzo-López, E Gómez-Sánchez, A Gómez-Sanz, M Heredia-Rodríguez, E Gómez-Pesquera, I Martínez, E Tamayo, S Resino
Publication Date: 2019-02-26

Variant appearance in text: rs2230926
PMID: 30813592
View BVdb publication page



RAEdb: a database of enhancers identified by high-throughput reporter assays.

Database : The Journal Of Biological Databases And Curation
Z Cai, Y Cui, Z Tan, G Zhang, Z Tan, X Zhang, Y Peng
Publication Date: 2019-01-01

Variant appearance in text: rs2230926
PMID: 30624654
View BVdb publication page



Potential Role of Ocular Microbiome, Host Genotype, Tear Cytokines, and Environmental Factors in Corneal Infiltrative Events in Contact Lens Wearers.

Investigative Ophthalmology & Visual Science
C Chao, L Akileswaran, JN Cooke Bailey, M Willcox, R Van Gelder, C Lakkis, F Stapleton, K Richdale
Publication Date: 2018-12-03

Variant appearance in text: rs2230926
PMID: 30516819
View BVdb publication page



Genetic polymorphism in psoriasis and its meaning for the treatment efficacy in the future.

Postepy Dermatologii I Alergologii
A Osmola-Mańkowska, E Teresiak-Mikołajczak, M Skrzypczak-Zielińska, Z Adamski
Publication Date: 2018-08

Variant appearance in text: rs2230926
PMID: 30206443
View BVdb publication page



Lymphoma and Lymphomagenesis in Primary Sjögren's Syndrome.

Frontiers In Medicine
A Alunno, MC Leone, R Giacomelli, R Gerli, F Carubbi
Publication Date: 2018

Variant appearance in text: rs2230926
PMID: 29707540
View BVdb publication page



POLR2C Mutations Are Associated With Primary Ovarian Insufficiency in Women.

Journal Of The Endocrine Society
M Moriwaki, B Moore, T Mosbruger, DW Neklason, M Yandell, LB Jorde, CK Welt
Publication Date: 2017-03-01

Variant appearance in text: rs2230926
PMID: 29367954
View BVdb publication page



Identification of potential genetic causal variants for rheumatoid arthritis by whole-exome sequencing.

Oncotarget
Y Li, E Lai-Han Leung, H Pan, X Yao, Q Huang, M Wu, T Xu, Y Wang, J Cai, R Li, W Liu, L Liu
Publication Date: 2017-12-19

Variant appearance in text: rs2230926
PMID: 29340042
View BVdb publication page



Association of the tandem polymorphisms (rs148314165, rs200820567) in TNFAIP3 with chronic hepatitis B virus infection in Chinese Han population.

Virology Journal
N Li, Y Shi, P Zhang, J Sang, F Li, H Deng, Y Lv, Q Han, Z Liu
Publication Date: 2017-08-07

Variant appearance in text: rs2230926
PMID: 28784141
View BVdb publication page



Transancestral mapping and genetic load in systemic lupus erythematosus.

Nature Communications
CD Langefeld, HC Ainsworth, DS Cunninghame Graham, JA Kelly, ME Comeau, MC Marion, TD Howard, PS Ramos, JA Croker, DL Morris, JK Sandling, JC Almlöf, EM Acevedo-Vásquez, GS Alarcón, AM Babini, V Baca, AA Bengtsson, GA Berbotto, M Bijl, EE Brown, HI Brunner, MH Cardiel, L Catoggio, R Cervera, JM Cucho-Venegas, SR Dahlqvist, S D'Alfonso, BM Da Silva, I de la Rúa Figueroa, A Doria, JC Edberg, E Endreffy, JA Esquivel-Valerio, PR Fortin, BI Freedman, J Frostegård, MA García, IG de la Torre, GS Gilkeson, DD Gladman, I Gunnarsson, JM Guthridge, JL Huggins, JA James, CGM Kallenberg, DL Kamen, DR Karp, KM Kaufman, LC Kottyan, L Kovács, H Laustrup, BR Lauwerys, QZ Li, MA Maradiaga-Ceceña, J Martín, JM McCune, DR McWilliams, JT Merrill, P Miranda, JF Moctezuma, SK Nath, TB Niewold, L Orozco, N Ortego-Centeno, M Petri, CA Pineau, BA Pons-Estel, J Pope, P Raj, R Ramsey-Goldman, JD Reveille, LP Russell, JM Sabio, CA Aguilar-Salinas, HR Scherbarth, R Scorza, MF Seldin, C Sjöwall, E Svenungsson, SD Thompson, SMA Toloza, L Truedsson, T Tusié-Luna, C Vasconcelos, LM Vilá, DJ Wallace, MH Weisman, JE Wither, T Bhangale, JR Oksenberg, JD Rioux, PK Gregersen, AC Syvänen, L Rönnblom, LA Criswell, CO Jacob, KL Sivils, BP Tsao, LE Schanberg, TW Behrens, ED Silverman, ME Alarcón-Riquelme, RP Kimberly, JB Harley, EK Wakeland, RR Graham, PM Gaffney, TJ Vyse
Publication Date: 2017-07-17

Variant appearance in text: rs2230926
PMID: 28714469
View BVdb publication page



Inflammation-Related Gene Polymorphisms Associated With Primary Immune Thrombocytopenia.

Frontiers In Immunology
J Li, S Ma, L Shao, C Ma, C Gao, XH Zhang, M Hou, J Peng
Publication Date: 2017

Variant appearance in text: rs2230926
PMID: 28702029
View BVdb publication page



Unfolding the pathogenesis of scleroderma through genomics and epigenomics.

Journal Of Autoimmunity
PS Tsou, AH Sawalha
Publication Date: 2017-09

Variant appearance in text: rs2230926
PMID: 28526340
View BVdb publication page



Positive Association between ANKRD55 Polymorphism 7731626 and Dermatomyositis/Polymyositis with Interstitial Lung Disease in Chinese Han Population.

Biomed Research International
L Li, S Chen, X Wen, Q Wang, G Lv, J Li, F Yang, F Zhang, Y Li
Publication Date: 2017

Variant appearance in text: rs2230926
PMID: 28470010
View BVdb publication page



rs10499194 polymorphism in the tumor necrosis factor-α inducible protein 3 (TNFAIP3) gene is associated with type-1 autoimmune hepatitis risk in Chinese Han population.

Plos One
E Xu, H Cao, L Lin, H Liu
Publication Date: 2017

Variant appearance in text: N/A
PMID: 28448618
View BVdb publication page



Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis.

Annals Of The Rheumatic Diseases
C Terao, T Kawaguchi, P Dieude, J Varga, M Kuwana, M Hudson, Y Kawaguchi, M Matucci-Cerinic, K Ohmura, G Riemekasten, A Kawasaki, P Airo, T Horita, A Oka, E Hachulla, H Yoshifuji, P Caramaschi, N Hunzelmann, M Baron, T Atsumi, P Hassoun, T Torii, M Takahashi, Y Tabara, M Shimizu, A Tochimoto, N Ayuzawa, H Yanagida, H Furukawa, S Tohma, M Hasegawa, M Fujimoto, O Ishikawa, T Yamamoto, D Goto, Y Asano, M Jinnin, H Endo, H Takahashi, K Takehara, S Sato, H Ihn, S Raychaudhuri, K Liao, P Gregersen, N Tsuchiya, V Riccieri, I Melchers, G Valentini, A Cauvet, M Martinez, T Mimori, F Matsuda, Y Allanore
Publication Date: 2017-06

Variant appearance in text: rs2230926
PMID: 28314753
View BVdb publication page



Three single nucleotide polymorphisms of TNFAIP3 gene increase the risk of rheumatoid arthritis.

Oncotarget
N Shen, Y Ruan, Y Lu, X Jiang, H Sun, G Gao, L Nong, K Ren
Publication Date: 2017-03-28

Variant appearance in text: rs2230926
PMID: 28199970
View BVdb publication page



Association between NF-κB Pathway Gene Variants and sICAM1 Levels in Taiwanese.

Plos One
S Wu, MS Teng, LK Er, WY Hsiao, LA Hsu, CH Yeh, JF Lin, YY Lin, CW Su, YL Ko
Publication Date: 2017

Variant appearance in text: rs2230926
PMID: 28095483
View BVdb publication page



A20 suppresses canonical Smad-dependent fibroblast activation: novel function for an endogenous inflammatory modulator.

Arthritis Research & Therapy
S Bhattacharyya, W Wang, LV Graham, J Varga
Publication Date: 2016-10-03

Variant appearance in text: rs2230926
PMID: 27716397
View BVdb publication page



Negative regulation of TLR signaling in myeloid cells--implications for autoimmune diseases.

Immunological Reviews
JA Hamerman, J Pottle, M Ni, Y He, ZY Zhang, JH Buckner
Publication Date: 2016-01

Variant appearance in text: N/A
PMID: 26683155
View BVdb publication page



Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.

Arthritis & Rheumatology (Hoboken, N.J.)
CJ Lessard, S Sajuthi, J Zhao, K Kim, JA Ice, H Li, H Ainsworth, A Rasmussen, JA Kelly, M Marion, SY Bang, YB Joo, J Choi, HS Lee, YM Kang, CH Suh, WT Chung, SK Lee, JY Choe, SC Shim, JH Oh, YJ Kim, BG Han, N Shen, HS Howe, EK Wakeland, QZ Li, YW Song, PM Gaffney, ME Alarcón-Riquelme, LA Criswell, CO Jacob, RP Kimberly, TJ Vyse, JB Harley, KL Sivils, SC Bae, CD Langefeld, BP Tsao
Publication Date: 2016-05

Variant appearance in text: N/A
PMID: 26663301
View BVdb publication page



Contribution of Genetic Factors to Sjögren's Syndrome and Sjögren's Syndrome Related Lymphomagenesis.

Journal Of Immunology Research
A Nezos, CP Mavragani
Publication Date: 2015

Variant appearance in text: rs2230926
PMID: 26550578
View BVdb publication page



An in silico Approach Reveals Associations between Genetic and Epigenetic Factors within Regulatory Elements in B Cells from Primary Sjögren's Syndrome Patients.

Frontiers In Immunology
OD Konsta, C Le Dantec, A Charras, WH Brooks, MI Arleevskaya, A Bordron, Y Renaudineau
Publication Date: 2015

Variant appearance in text: N/A
PMID: 26379672
View BVdb publication page



Immunogenetics of systemic lupus erythematosus: A comprehensive review.

Journal Of Autoimmunity
Y Ghodke-Puranik, TB Niewold
Publication Date: 2015-11

Variant appearance in text: rs2230926
PMID: 26324017
View BVdb publication page



Genetics, Epigenetics, and Genomics of Systemic Sclerosis.

Rheumatic Diseases Clinics Of North America
G Salazar, MD Mayes
Publication Date: 2015-08

Variant appearance in text: rs2230926
PMID: 26210123
View BVdb publication page



Characteristics of A20 gene polymorphisms and clinical significance in patients with rheumatoid arthritis.

Journal Of Translational Medicine
L Zhu, L Wang, X Wang, L Zhou, Z Liao, L Xu, H Wu, J Ren, Z Li, L Yang, S Chen, B Li, X Wu, Y Zhou, Y Li
Publication Date: 2015-07-05

Variant appearance in text: rs2230926
PMID: 26143186
View BVdb publication page



Pharmacogenetics of treatment response in psoriatic arthritis.

Current Rheumatology Reports
M Jani, A Barton, P Ho
Publication Date: 2015-07

Variant appearance in text: rs2230926
PMID: 25980667
View BVdb publication page



Association between TNFAIP3 nonsynonymous single-nucleotide polymorphism rs2230926 and chronic hepatitis B virus infection in a Chinese Han population.

Virology Journal
P Zhang, N Li, Q Zhu, F Li, C Yang, X Zeng, Y Lv, Z Zhou, Q Han, Z Liu
Publication Date: 2015-02-28

Variant appearance in text: rs2230926
PMID: 25890346
View BVdb publication page



TNFAIP3 rs2230926 polymorphisms in rheumatoid arthritis of southern Chinese Han population: a case-control study.

International Journal Of Clinical And Experimental Pathology
G Hao, Y Li, J Liu, M Wo
Publication Date: 2014

Variant appearance in text: rs2230926
PMID: 25674272
View BVdb publication page



Meta-analysis of the TNFAIP3 region in psoriasis reveals a risk haplotype that is distinct from other autoimmune diseases.

Genes And Immunity
J Nititham, KE Taylor, R Gupta, H Chen, R Ahn, J Liu, M Seielstad, A Ma, AM Bowcock, LA Criswell, M Stahle, W Liao
Publication Date: 2015-03

Variant appearance in text: rs2230926
PMID: 25521225
View BVdb publication page



Enhancer variants: evaluating functions in common disease.

Genome Medicine
O Corradin, PC Scacheri
Publication Date: 2014

Variant appearance in text: rs2230926
PMID: 25473424
View BVdb publication page



Genetic association study of TNFAIP3, IFIH1, IRF5 polymorphisms with polymyositis/dermatomyositis in Chinese Han population.

Plos One
S Chen, Q Wang, Z Wu, Y Li, P Li, F Sun, W Zheng, Q Wu, C Wu, C Deng, F Zhang, Y Li
Publication Date: 2014

Variant appearance in text: rs2230926
PMID: 25337792
View BVdb publication page



Clinical perspectives on lupus genetics: advances and opportunities.

Rheumatic Diseases Clinics Of North America
JA James
Publication Date: 2014-08

Variant appearance in text: rs2230926
PMID: 25034154
View BVdb publication page



Alternative expression pattern of MALT1-A20-NF-κB in patients with rheumatoid arthritis.

Journal Of Immunology Research
X Wang, L Zhu, Z Liao, F Zhang, L Xu, Y Xu, S Chen, L Yang, Y Zhou, Y Li
Publication Date: 2014

Variant appearance in text: rs2230926
PMID: 24971370
View BVdb publication page



Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus.

Arthritis Research & Therapy
E Alonso-Perez, M Suarez-Gestal, M Calaza, FJ Blanco, A Suarez, MJ Santos, C Papasteriades, P Carreira, R Pullmann, J Ordi-Ros, M Marchini, FN Skopouli, M Bijl, N Barrizone, GD Sebastiani, S Migliaresi, T Witte, BR Lauwerys, A Kovacs, S Ruzickova, JJ Gomez-Reino, A Gonzalez,
Publication Date: 2014-06-19

Variant appearance in text: rs2230926
PMID: 24946689
View BVdb publication page



RAvariome: a genetic risk variants database for rheumatoid arthritis based on assessment of reproducibility between or within human populations.

Database : The Journal Of Biological Databases And Curation
Y Nagai, T Imanishi
Publication Date: 2013

Variant appearance in text: rs2230926
PMID: 24158836
View BVdb publication page



Genetics of psoriasis and pharmacogenetics of biological drugs.

Autoimmune Diseases
R Prieto-Pérez, T Cabaleiro, E Daudén, D Ochoa, M Roman, F Abad-Santos
Publication Date: 2013

Variant appearance in text: N/A
PMID: 24069534
View BVdb publication page



An enhancer element harboring variants associated with systemic lupus erythematosus engages the TNFAIP3 promoter to influence A20 expression.

Plos Genetics
S Wang, F Wen, GB Wiley, MT Kinter, PM Gaffney
Publication Date: 2013

Variant appearance in text: rs2230926
PMID: 24039598
View BVdb publication page



Analysis of gender differences in genetic risk: association of TNFAIP3 polymorphism with male childhood-onset systemic lupus erythematosus in the Japanese population.

Plos One
K Kadota, M Mori, M Yanagimachi, T Miyamae, T Hara, T Kanetaka, T Nozawa, M Kikuchi, R Hara, T Imagawa, T Kaneko, S Yokota
Publication Date: 2013

Variant appearance in text: rs2230926
PMID: 24023622
View BVdb publication page



PADI4 and HLA-DRB1 are genetic risks for radiographic progression in RA patients, independent of ACPA status: results from the IORRA cohort study.

Plos One
T Suzuki, K Ikari, K Yano, E Inoue, Y Toyama, A Taniguchi, H Yamanaka, S Momohara
Publication Date: 2013

Variant appearance in text: rs2230926
PMID: 23577190
View BVdb publication page



Genome-wide analysis of LXRα activation reveals new transcriptional networks in human atherosclerotic foam cells.

Nucleic Acids Research
R Feldmann, C Fischer, V Kodelja, S Behrens, S Haas, M Vingron, B Timmermann, A Geikowski, S Sauer
Publication Date: 2013-04-01

Variant appearance in text: N/A
PMID: 23393188
View BVdb publication page



A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1).

Plos Genetics
R Rubicz, R Yolken, E Drigalenko, MA Carless, TD Dyer, L Bauman, PE Melton, JW Kent, JB Harley, JE Curran, MP Johnson, SA Cole, L Almasy, EK Moses, NV Dhurandhar, E Kraig, J Blangero, CT Leach, HH Göring
Publication Date: 2013

Variant appearance in text: N/A
PMID: 23326239
View BVdb publication page



Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid arthritis.

American Journal Of Human Genetics
D Diogo, F Kurreeman, EA Stahl, KP Liao, N Gupta, JD Greenberg, MA Rivas, B Hickey, J Flannick, B Thomson, C Guiducci, S Ripke, I Adzhubey, A Barton, JM Kremer, L Alfredsson, , , S Sunyaev, J Martin, A Zhernakova, J Bowes, S Eyre, KA Siminovitch, PK Gregersen, J Worthington, L Klareskog, L Padyukov, S Raychaudhuri, RM Plenge
Publication Date: 2013-01-10

Variant appearance in text: rs2230926
PMID: 23261300
View BVdb publication page



Genetics of SLE: functional relevance for monocytes/macrophages in disease.

Clinical & Developmental Immunology
JC Byrne, J Ní Gabhann, E Lazzari, R Mahony, S Smith, K Stacey, C Wynne, CA Jefferies
Publication Date: 2012

Variant appearance in text: rs2230926
PMID: 23227085
View BVdb publication page



Further evidence of subphenotype association with systemic lupus erythematosus susceptibility loci: a European cases only study.

Plos One
E Alonso-Perez, M Suarez-Gestal, M Calaza, J Ordi-Ros, E Balada, M Bijl, C Papasteriades, P Carreira, FN Skopouli, T Witte, E Endreffy, M Marchini, S Migliaresi, GD Sebastiani, MJ Santos, A Suarez, FJ Blanco, N Barizzone, R Pullmann, S Ruzickova, BR Lauwerys, JJ Gomez-Reino, A Gonzalez,
Publication Date: 2012

Variant appearance in text: rs2230926
PMID: 23049788
View BVdb publication page



Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways.

Journal Of Leukocyte Biology
SE Vaughn, LC Kottyan, ME Munroe, JB Harley
Publication Date: 2012-09

Variant appearance in text: rs2230926
PMID: 22753952
View BVdb publication page



The genetics of lupus: a functional perspective.

Arthritis Research & Therapy
SG Guerra, TJ Vyse, DS Cunninghame Graham
Publication Date: 2012-05-29

Variant appearance in text: N/A
PMID: 22640752
View BVdb publication page



Bias in effect size of systemic lupus erythematosus susceptibility loci across Europe: a case-control study.

Arthritis Research & Therapy
E Alonso-Perez, M Suarez-Gestal, M Calaza, GD Sebastiani, R Pullmann, C Papasteriades, A Kovacs, FN Skopouli, M Bijl, A Suarez, M Marchini, S Migliaresi, P Carreira, J Ordi-Ros, T Witte, S Ruzickova, MJ Santos, N Barizzone, FJ Blanco, BR Lauwerys, JJ Gomez-Reino, A Gonzalez,
Publication Date: 2012-04-27

Variant appearance in text: rs2230926
PMID: 22541939
View BVdb publication page



Identification of CSK as a systemic sclerosis genetic risk factor through Genome Wide Association Study follow-up.

Human Molecular Genetics
JE Martin, JC Broen, FD Carmona, M Teruel, CP Simeon, MC Vonk, R van 't Slot, L Rodriguez-Rodriguez, E Vicente, V Fonollosa, N Ortego-Centeno, MA González-Gay, FJ García-Hernández, PG de la Peña, P Carreira, , AE Voskuyl, AJ Schuerwegh, PL van Riel, A Kreuter, T Witte, G Riemekasten, P Airo, R Scorza, C Lunardi, N Hunzelmann, JH Distler, L Beretta, J van Laar, MM Chee, J Worthington, A Herrick, C Denton, FK Tan, FC Arnett, S Assassi, C Fonseca, MD Mayes, TR Radstake, BP Koeleman, J Martin
Publication Date: 2012-06-15

Variant appearance in text: rs2230926
PMID: 22407130
View BVdb publication page



A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese.

Plos Genetics
Y Okada, K Shimane, Y Kochi, T Tahira, A Suzuki, K Higasa, A Takahashi, T Horita, T Atsumi, T Ishii, A Okamoto, K Fujio, M Hirakata, H Amano, Y Kondo, S Ito, K Takada, A Mimori, K Saito, M Kamachi, Y Kawaguchi, K Ikari, OW Mohammed, K Matsuda, C Terao, K Ohmura, K Myouzen, N Hosono, T Tsunoda, N Nishimoto, T Mimori, F Matsuda, Y Tanaka, T Sumida, H Yamanaka, Y Takasaki, T Koike, T Horiuchi, K Hayashi, M Kubo, N Kamatani, R Yamada, Y Nakamura, K Yamamoto
Publication Date: 2012-01

Variant appearance in text: rs2230926
PMID: 22291604
View BVdb publication page



Association of single-nucleotide polymorphisms in CCR6, TAGAP, and TNFAIP3 with rheumatoid arthritis in African Americans.

Arthritis And Rheumatism
EA Perkins, D Landis, ZL Causey, Y Edberg, RJ Reynolds, LB Hughes, PK Gregersen, RP Kimberly, JC Edberg, SL Bridges,
Publication Date: 2012-05

Variant appearance in text: rs2230926
PMID: 22127930
View BVdb publication page



TNFAIP3 gene polymorphisms are associated with response to TNF blockade in psoriasis.

The Journal Of Investigative Dermatology
T Tejasvi, PE Stuart, V Chandran, JJ Voorhees, DD Gladman, P Rahman, JT Elder, RP Nair
Publication Date: 2012-03

Variant appearance in text: rs2230926
PMID: 22113471
View BVdb publication page



Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population.

Arthritis Research & Therapy
H Zhong, XL Li, M Li, LX Hao, RW Chen, K Xiang, XB Qi, RZ Ma, B Su
Publication Date: 2011

Variant appearance in text: rs2230926
PMID: 22087647
View BVdb publication page



A systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis.

Plos One
H Nakaoka, T Cui, A Tajima, A Oka, S Mitsunaga, K Kashiwase, Y Homma, S Sato, Y Suzuki, H Inoko, I Inoue
Publication Date: 2011

Variant appearance in text: N/A
PMID: 21980439
View BVdb publication page



Neurodegenerative and inflammatory pathway components linked to TNF-α/TNFR1 signaling in the glaucomatous human retina.

Investigative Ophthalmology & Visual Science
X Yang, C Luo, J Cai, DW Powell, D Yu, MH Kuehn, G Tezel
Publication Date: 2011-10-31

Variant appearance in text: rs2230926
PMID: 21917936
View BVdb publication page



Genetic susceptibility to systemic lupus erythematosus in the genomic era.

Nature Reviews. Rheumatology
Y Deng, BP Tsao
Publication Date: 2010-12

Variant appearance in text: rs2230926
PMID: 21060334
View BVdb publication page



Accelerated atherosclerosis in systemic lupus erythematosus: role of proinflammatory cytokines and therapeutic approaches.

Journal Of Biomedicine & Biotechnology
C López-Pedrera, MÁ Aguirre, N Barbarroja, MJ Cuadrado
Publication Date: 2010

Variant appearance in text: rs2230926
PMID: 20936125
View BVdb publication page



Recent findings on genetics of systemic autoimmune diseases.

Current Opinion In Immunology
A Delgado-Vega, E Sánchez, S Löfgren, C Castillejo-López, ME Alarcón-Riquelme
Publication Date: 2010-12

Variant appearance in text: N/A
PMID: 20933377
View BVdb publication page



Genome-wide significant associations for variants with minor allele frequency of 5% or less--an overview: A HuGE review.

American Journal Of Epidemiology
OA Panagiotou, E Evangelou, JP Ioannidis
Publication Date: 2010-10-15

Variant appearance in text: rs2230926
PMID: 20876667
View BVdb publication page



Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study.

Arthritis Research & Therapy
A Kawasaki, S Ito, H Furukawa, T Hayashi, D Goto, I Matsumoto, M Kusaoi, J Ohashi, RR Graham, K Matsuta, TW Behrens, S Tohma, Y Takasaki, H Hashimoto, T Sumida, N Tsuchiya
Publication Date: 2010

Variant appearance in text: rs2230926
PMID: 20849588
View BVdb publication page



Functional evaluation of TNFAIP3 (A20) in rheumatoid arthritis.

Clinical And Experimental Rheumatology
LM Elsby, G Orozco, J Denton, J Worthington, DW Ray, RP Donn
Publication Date: 2010

Variant appearance in text: rs2230926
PMID: 20822710
View BVdb publication page



Association of TNFAIP3 polymorphism with susceptibility to systemic lupus erythematosus in a Japanese population.

Journal Of Biomedicine & Biotechnology
A Kawasaki, I Ito, S Ito, T Hayashi, D Goto, I Matsumoto, Y Takasaki, H Hashimoto, T Sumida, N Tsuchiya
Publication Date: 2010

Variant appearance in text: rs2230926
PMID: 20617138
View BVdb publication page



Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus.

Plos Genetics
W Yang, N Shen, DQ Ye, Q Liu, Y Zhang, XX Qian, N Hirankarn, D Ying, HF Pan, CC Mok, TM Chan, RW Wong, KW Lee, MY Mok, SN Wong, AM Leung, XP Li, Y Avihingsanon, CM Wong, TL Lee, MH Ho, PP Lee, YK Chang, PH Li, RJ Li, L Zhang, WH Wong, IO Ng, CS Lau, PC Sham, YL Lau,
Publication Date: 2010-02-12

Variant appearance in text: rs2230926
PMID: 20169177
View BVdb publication page



Complex genetic association of 6q23 with autoimmune rheumatic conditions.

Arthritis Research & Therapy
JR Maxwell, IR Gowers, AG Wilson
Publication Date: 2009

Variant appearance in text: rs2230926
PMID: 19439038
View BVdb publication page



Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23.

Human Molecular Genetics
G Orozco, A Hinks, S Eyre, X Ke, LJ Gibbons, J Bowes, E Flynn, P Martin, , , AG Wilson, DE Bax, AW Morgan, P Emery, S Steer, L Hocking, DM Reid, P Wordsworth, P Harrison, W Thomson, A Barton, J Worthington
Publication Date: 2009-07-15

Variant appearance in text: rs2230926
PMID: 19417005
View BVdb publication page



Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations.

Genes And Immunity
JS Bates, CJ Lessard, JM Leon, T Nguyen, LJ Battiest, J Rodgers, KM Kaufman, JA James, GS Gilkeson, JA Kelly, MB Humphrey, JB Harley, C Gray-McGuire, KL Moser, PM Gaffney
Publication Date: 2009-07

Variant appearance in text: rs2230926
PMID: 19387456
View BVdb publication page



Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.

Nature Genetics
RP Nair, KC Duffin, C Helms, J Ding, PE Stuart, D Goldgar, JE Gudjonsson, Y Li, T Tejasvi, BJ Feng, A Ruether, S Schreiber, M Weichenthal, D Gladman, P Rahman, SJ Schrodi, S Prahalad, SL Guthery, J Fischer, W Liao, PY Kwok, A Menter, GM Lathrop, CA Wise, AB Begovich, JJ Voorhees, JT Elder, GG Krueger, AM Bowcock, GR Abecasis,
Publication Date: 2009-02

Variant appearance in text: rs2230926
PMID: 19169254
View BVdb publication page



Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus.

Nature Genetics
SL Musone, KE Taylor, TT Lu, J Nititham, RC Ferreira, W Ortmann, N Shifrin, MA Petri, MI Kamboh, S Manzi, MF Seldin, PK Gregersen, TW Behrens, A Ma, PY Kwok, LA Criswell
Publication Date: 2008-09

Variant appearance in text: rs2230926
PMID: 19165919
View BVdb publication page



Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.

Nature Genetics
RR Graham, C Cotsapas, L Davies, R Hackett, CJ Lessard, JM Leon, NP Burtt, C Guiducci, M Parkin, C Gates, RM Plenge, TW Behrens, JE Wither, JD Rioux, PR Fortin, DC Graham, AK Wong, TJ Vyse, MJ Daly, D Altshuler, KL Moser, PM Gaffney
Publication Date: 2008-09

Variant appearance in text: rs2230926
PMID: 19165918
View BVdb publication page



Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000237289.4 c.380T>C p.Phe127Ser missense_variant 3/9 -
ENST00000420009.1 c.380T>C p.Phe127Ser missense_variant 3/3 -
NM_001270507.2 c.380T>C p.Phe127Ser missense_variant 3/9 -
NM_001270508.2 c.380T>C p.Phe127Ser missense_variant 3/9 -
NM_006290.4 c.380T>C p.Phe127Ser missense_variant 3/9 -