Publications:

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ERpS294 is a biomarker of ligand or mutational ERα activation and a breast cancer target for CDK2 inhibition.

Oncotarget

Scott, Gary K GK; Chu, David D; Kaur, Ravneet R; Malato, Julia J; Rothschild, Daniel E DE; Frazier, Katya K; Eppenberger-Castori, Serenella S; Hann, Byron B; Park, Ben Ho BH; Benz, Christopher C CC

Publication Date: 2017-10-13

Variant appearance in text: ESR1: S294A

PubMed Link: 29137354

Variant Present in the following documents:

• Main text
• oncotarget-08-83432.pdf

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Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs.

Journal Of Hematology & Oncology

Knutson, Todd P TP; Truong, Thu H TH; Ma, Shihong S; Brady, Nicholas J NJ; Sullivan, Megan E ME; Raj, Ganesh G; Schwertfeger, Kathryn L KL; Lange, Carol A CA

Publication Date: 2017-04-17

Variant appearance in text: ER-alpha: S294A

PubMed Link: 28412963

Variant Present in the following documents:

• 13045_2017_Article_462.pdf

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p21-activated kinase group II small compound inhibitor GNE-2861 perturbs estrogen receptor alpha signaling and restores tamoxifen-sensitivity in breast cancer cells.

Oncotarget

Zhuang, Ting T; Zhu, Jian J; Li, Zhilun Z; Lorent, Julie J; Zhao, Chunyan C; Dahlman-Wright, Karin K; Strömblad, Staffan S

Publication Date: 2015-12-22

Variant appearance in text: ESR1: S294A

PubMed Link: 26554417

Variant Present in the following documents:

• Main text
• oncotarget-06-43853.pdf

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Ligand binding promotes CDK-dependent phosphorylation of ER-alpha on hinge serine 294 but inhibits ligand-independent phosphorylation of serine 305.

Molecular Cancer Research : Mcr

Held, Jason M JM; Britton, David J DJ; Scott, Gary K GK; Lee, Elbert L EL; Schilling, Birgit B; Baldwin, Michael A MA; Gibson, Bradford W BW; Benz, Christopher C CC

Publication Date: 2012-08

Variant appearance in text: ER-alpha: Ser294Ala

PubMed Link: 22669764

Variant Present in the following documents:

• Main text

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Integration of progesterone receptor action with rapid signaling events in breast cancer models.

The Journal Of Steroid Biochemistry And Molecular Biology

Lange, Carol A CA

Publication Date: 2008-02

Variant appearance in text: ER-alpha: S294A

PubMed Link: 17964138

Variant Present in the following documents:

• Main text

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CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome.

The Embo Journal

Zhang, Pei-Jing PJ; Zhao, Jie J; Li, Hui-Yan HY; Man, Jiang-Hong JH; He, Kun K; Zhou, Tao T; Pan, Xin X; Li, Ai-Ling AL; Gong, Wei-Li WL; Jin, Bao-Feng BF; Xia, Qing Q; Yu, Ming M; Shen, Bei-Fen BF; Zhang, Xue-Min XM

Publication Date: 2007-04-04

Variant appearance in text: ER-alpha: S294A

PubMed Link: 17347654

Variant Present in the following documents:

• Main text

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