Publications:

Unconventional isoquinoline-based SERMs elicit fulvestrant-like transcriptional programs in ER+ breast cancer cells.

Npj Breast Cancer

Hancock, G R GR; Young, K S KS; Hosfield, D J DJ; Joiner, C C; Sullivan, E A EA; Yildiz, Y Y; Lainé, M M; Greene, G L GL; Fanning, S W SW

Publication Date: 2022-12-14

Variant appearance in text: ESR1: C417S

PubMed Link: 36517522

Variant Present in the following documents:

• Main text
• 41523_2022_Article_497.pdf

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Covalent ERα Antagonist H3B-6545 Demonstrates Encouraging Preclinical Activity in Therapy-Resistant Breast Cancer.

Molecular Cancer Therapeutics

Furman, Craig C; Puyang, Xiaoling X; Zhang, Zhaojie Z; Wu, Zhenhua J ZJ; Banka, Deepti D; Aithal, Kiran B KB; Albacker, Lee A LA; Hao, Ming-Hong MH; Irwin, Sean S; Kim, Amy A; Montesion, Meagan M; Moriarty, Alyssa D AD; Murugesan, Karthikeyan K; Nguyen, Tuong-Vi TV; Rimkunas, Victoria V; Sahmoud, Tarek T; Wick, Michael J MJ; Yao, Shihua S; Zhang, Xun X; Zeng, Hao H; Vaillancourt, Frédéric H FH; Bolduc, David M DM; Larsen, Nicholas N; Zheng, Guo Zhu GZ; Prajapati, Sudeep S; Zhu, Ping P; Korpal, Manav M

Publication Date: 2022-06-01

Variant appearance in text: ESR1: C417S

PubMed Link: 35642432

Variant Present in the following documents:

• Main text
• 890.pdf

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Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.

Elife

Hosfield, David J DJ; Weber, Sandra S; Li, Nan-Sheng NS; Sauvage, Madline M; Joiner, Carstyn F CF; Hancock, Govinda R GR; Sullivan, Emily A EA; Ndukwe, Estelle E; Han, Ross R; Cush, Sydney S; Lainé, Muriel M; Mader, Sylvie C SC; Greene, Geoffrey L GL; Fanning, Sean W SW

Publication Date: 2022-05-16

Variant appearance in text: ESR1: C417S

PubMed Link: 35575456

Variant Present in the following documents:

• Main text
• elife-72512.pdf

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Computer-Aided Ligand Discovery for Estrogen Receptor Alpha.

International Journal Of Molecular Sciences

Bafna, Divya D; Ban, Fuqiang F; Rennie, Paul S PS; Singh, Kriti K; Cherkasov, Artem A

Publication Date: 2020-06-12

Variant appearance in text: ESR1: C417S

PubMed Link: 32545494

Variant Present in the following documents:

• Main text
• ijms-21-04193.pdf

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Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity.

Nature Communications

Fanning, S W SW; Hodges-Gallagher, L L; Myles, D C DC; Sun, R R; Fowler, C E CE; Plant, I N IN; Green, B D BD; Harmon, C L CL; Greene, G L GL; Kushner, P J PJ

Publication Date: 2018-06-18

Variant appearance in text: ESR1: C417S

PubMed Link: 29915250

Variant Present in the following documents:

• 41467_2018_Article_4413.pdf

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