Publications:

Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.

Elife

Hosfield, David J DJ; Weber, Sandra S; Li, Nan-Sheng NS; Sauvage, Madline M; Joiner, Carstyn F CF; Hancock, Govinda R GR; Sullivan, Emily A EA; Ndukwe, Estelle E; Han, Ross R; Cush, Sydney S; Lainé, Muriel M; Mader, Sylvie C SC; Greene, Geoffrey L GL; Fanning, Sean W SW

Publication Date: 2022-05-16

Variant appearance in text: ESR1: L536S

PubMed Link: 35575456

Variant Present in the following documents:

• Main text
• elife-72512.pdf

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Computer-Aided Ligand Discovery for Estrogen Receptor Alpha.

International Journal Of Molecular Sciences

Bafna, Divya D; Ban, Fuqiang F; Rennie, Paul S PS; Singh, Kriti K; Cherkasov, Artem A

Publication Date: 2020-06-12

Variant appearance in text: ESR1: L536S

PubMed Link: 32545494

Variant Present in the following documents:

• Main text
• ijms-21-04193.pdf

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Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity.

Nature Communications

Fanning, S W SW; Hodges-Gallagher, L L; Myles, D C DC; Sun, R R; Fowler, C E CE; Plant, I N IN; Green, B D BD; Harmon, C L CL; Greene, G L GL; Kushner, P J PJ

Publication Date: 2018-06-18

Variant appearance in text: ESR1: L536S

PubMed Link: 29915250

Variant Present in the following documents:

• 41467_2018_Article_4413.pdf

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Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells.

Molecular Cell

Stender, Joshua D JD; Nwachukwu, Jerome C JC; Kastrati, Irida I; Kim, Yohan Y; Strid, Tobias T; Yakir, Maayan M; Srinivasan, Sathish S; Nowak, Jason J; Izard, Tina T; Rangarajan, Erumbi S ES; Carlson, Kathryn E KE; Katzenellenbogen, John A JA; Yao, Xin-Qiu XQ; Grant, Barry J BJ; Leong, Hon S HS; Lin, Chin-Yo CY; Frasor, Jonna J; Nettles, Kendall W KW; Glass, Christopher K CK

Publication Date: 2017-03-16

Variant appearance in text: ESR1: L536S

PubMed Link: 28306507

Variant Present in the following documents:

• Main text

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