AMEERA-1 phase 1/2 study of amcenestrant, SAR439859, in postmenopausal women with ER-positive/HER2-negative advanced breast cancer.
Nature Communications
Bardia, Aditya A; Chandarlapaty, Sarat S; Linden, Hannah M HM; Ulaner, Gary A GA; Gosselin, Alice A; Cartot-Cotton, Sylvaine S; Cohen, Patrick P; Doroumian, Séverine S; Paux, Gautier G; Celanovic, Marina M; Pelekanou, Vasiliki V; Ming, Jeffrey E JE; Ternès, Nils N; Bouaboula, Monsif M; Lee, Joon Sang JS; Bauchet, Anne-Laure AL; Campone, Mario M
Pugh, Trevor J TJ; Bell, Jonathan L JL; Bruce, Jeff P JP; Doherty, Gary J GJ; Galvin, Matthew M; Green, Michelle F MF; Hunter-Zinck, Haley H; Kumari, Priti P; Lenoue-Newton, Michele L ML; Li, Marilyn M MM; Lindsay, James J; Mazor, Tali T; Ovalle, Andrea A; Sammut, Stephen-John SJ; Schultz, Nikolaus N; Yu, Thomas V TV; Sweeney, Shawn M SM; Bernard, Brady B; ,
Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.
Nature Communications
Gounder, Mrinal M MM; Agaram, Narasimhan P NP; Trabucco, Sally E SE; Robinson, Victoria V; Ferraro, Richard A RA; Millis, Sherri Z SZ; Krishnan, Anita A; Lee, Jessica J; Attia, Steven S; Abida, Wassim W; Drilon, Alexander A; Chi, Ping P; Angelo, Sandra P D' SP; Dickson, Mark A MA; Keohan, Mary Lou ML; Kelly, Ciara M CM; Agulnik, Mark M; Chawla, Sant P SP; Choy, Edwin E; Chugh, Rashmi R; Meyer, Christian F CF; Myer, Parvathi A PA; Moore, Jessica L JL; Okimoto, Ross A RA; Pollock, Raphael E RE; Ravi, Vinod V; Singh, Arun S AS; Somaiah, Neeta N; Wagner, Andrew J AJ; Healey, John H JH; Frampton, Garrett M GM; Venstrom, Jeffrey M JM; Ross, Jeffrey S JS; Ladanyi, Marc M; Singer, Samuel S; Brennan, Murray F MF; Schwartz, Gary K GK; Lazar, Alexander J AJ; Thomas, David M DM; Maki, Robert G RG; Tap, William D WD; Ali, Siraj M SM; Jin, Dexter X DX
Molecular landscape of TP53 mutations in breast cancer and their utility for predicting the response to HER-targeted therapy in HER2 amplification-positive and HER2 mutation-positive amplification-negative patients.
A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology.
Nature Cancer
Guillen, Katrin P KP; Fujita, Maihi M; Butterfield, Andrew J AJ; Scherer, Sandra D SD; Bailey, Matthew H MH; Chu, Zhengtao Z; DeRose, Yoko S YS; Zhao, Ling L; Cortes-Sanchez, Emilio E; Yang, Chieh-Hsiang CH; Toner, Jennifer J; Wang, Guoying G; Qiao, Yi Y; Huang, Xiaomeng X; Greenland, Jeffery A JA; Vahrenkamp, Jeffery M JM; Lum, David H DH; Factor, Rachel E RE; Nelson, Edward W EW; Matsen, Cindy B CB; Poretta, Jane M JM; Rosenthal, Regina R; Beck, Anna C AC; Buys, Saundra S SS; Vaklavas, Christos C; Ward, John H JH; Jensen, Randy L RL; Jones, Kevin B KB; Li, Zheqi Z; Oesterreich, Steffi S; Dobrolecki, Lacey E LE; Pathi, Satya S SS; Woo, Xing Yi XY; Berrett, Kristofer C KC; Wadsworth, Mark E ME; Chuang, Jeffrey H JH; Lewis, Michael T MT; Marth, Gabor T GT; Gertz, Jason J; Varley, Katherine E KE; Welm, Bryan E BE; Welm, Alana L AL
Intratumor genetic heterogeneity and clonal evolution to decode endometrial cancer progression.
Oncogene
Mota, Alba A; Oltra, Sara S SS; Selenica, Pier P; Moiola, Cristian P CP; Casas-Arozamena, Carlos C; López-Gil, Carlos C; Diaz, Eva E; Gatius, Sonia S; Ruiz-Miro, María M; Calvo, Ana A; Rojo-Sebastián, Alejandro A; Hurtado, Pablo P; Piñeiro, Roberto R; Colas, Eva E; Gil-Moreno, Antonio A; Reis-Filho, Jorge S JS; Muinelo-Romay, Laura L; Abal, Miguel M; Matias-Guiu, Xavier X; Weigelt, Britta B; Moreno-Bueno, Gema G
Transcriptional Reprogramming Differentiates Active from Inactive ESR1 Fusions in Endocrine Therapy-Refractory Metastatic Breast Cancer.
Cancer Research
Gou, Xuxu X; Anurag, Meenakshi M; Lei, Jonathan T JT; Kim, Beom-Jun BJ; Singh, Purba P; Seker, Sinem S; Fandino, Diana D; Han, Airi A; Rehman, Saif S; Hu, Jianhong J; Korchina, Viktoriya V; Doddapaneni, Harshavardhan H; Dobrolecki, Lacey E LE; Mitsiades, Nicholas N; Lewis, Michael T MT; Welm, Alana L AL; Li, Shunqiang S; Lee, Adrian V AV; Robinson, Dan R DR; Foulds, Charles E CE; Ellis, Matthew J MJ
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Complementary Sequential Circulating Tumor Cell (CTC) and Cell-Free Tumor DNA (ctDNA) Profiling Reveals Metastatic Heterogeneity and Genomic Changes in Lung Cancer and Breast Cancer.
Frontiers In Oncology
Kong, Say Li SL; Liu, Xingliang X; Tan, Swee Jin SJ; Tai, Joyce A JA; Phua, Ler Yee LY; Poh, Huay Mei HM; Yeo, Trifanny T; Chua, Yong Wei YW; Haw, Yu Xuan YX; Ling, Wen Huan WH; Ng, Raymond Chee Hui RCH; Tan, Tira J TJ; Loh, Kiley Wei Jen KWJ; Tan, Daniel Shao-Weng DS; Ng, Quan Sing QS; Ang, Mei Kim MK; Toh, Chee Keong CK; Lee, Yi Fang YF; Lim, Chwee Teck CT; Lim, Tony Kiat Hon TKH; Hillmer, Axel M AM; Yap, Yoon Sim YS; Lim, Wan-Teck WT
Longitudinal Dynamics of Circulating Tumor Cells and Circulating Tumor DNA for Treatment Monitoring in Metastatic Breast Cancer.
Jco Precision Oncology
Gerratana, Lorenzo L; Davis, Andrew A AA; Zhang, Qiang Q; Basile, Debora D; Rossi, Giovanna G; Strickland, Kimberly K; Franzoni, Alessandra A; Allegri, Lorenzo L; Mu, Zhaomei Z; Zhang, Youbin Y; Flaum, Lisa E LE; Damante, Giuseppe G; Gradishar, William John WJ; Platanias, Leonidas C LC; Behdad, Amir A; Yang, Hushan H; Puglisi, Fabio F; Cristofanilli, Massimo M
Tumor fraction-guided cell-free DNA profiling in metastatic solid tumor patients.
Genome Medicine
Tsui, Dana W Y DWY; Cheng, Michael L ML; Shady, Maha M; Yang, Julie L JL; Stephens, Dennis D; Won, Helen H; Srinivasan, Preethi P; Huberman, Kety K; Meng, Fanli F; Jing, Xiaohong X; Patel, Juber J; Hasan, Maysun M; Johnson, Ian I; Gedvilaite, Erika E; Houck-Loomis, Brian B; Socci, Nicholas D ND; Selcuklu, S Duygu SD; Seshan, Venkatraman E VE; Zhang, Hongxin H; Chakravarty, Debyani D; Zehir, Ahmet A; Benayed, Ryma R; Arcila, Maria M; Ladanyi, Marc M; Funt, Samuel A SA; Feldman, Darren R DR; Li, Bob T BT; Razavi, Pedram P; Rosenberg, Jonathan J; Bajorin, Dean D; Iyer, Gopa G; Abida, Wassim W; Scher, Howard I HI; Rathkopf, Dana D; Viale, Agnes A; Berger, Michael F MF; Solit, David B DB
Preexisting Somatic Mutations of Estrogen Receptor Alpha (ESR1) in Early-Stage Primary Breast Cancer.
Jnci Cancer Spectrum
Dahlgren, Malin M; George, Anthony M AM; Brueffer, Christian C; Gladchuk, Sergii S; Chen, Yilun Y; Vallon-Christersson, Johan J; Hegardt, Cecilia C; Häkkinen, Jari J; Rydén, Lisa L; Malmberg, Martin M; Larsson, Christer C; Gruvberger-Saal, Sofia K SK; Ehinger, Anna A; Loman, Niklas N; Borg, Åke Å; Saal, Lao H LH
Predictive Biomarkers for Immune Checkpoint Inhibitors in Metastatic Breast Cancer.
Cancer Medicine
Sivapiragasam, Abirami A; Ashok Kumar, Prashanth P; Sokol, Ethan S ES; Albacker, Lee A LA; Killian, Jonathan K JK; Ramkissoon, Shakti H SH; Huang, Richard S P RSP; Severson, Eric A EA; Brown, Charlotte A CA; Danziger, Natalie N; McGregor, Kimberly K; Ross, Jeffrey S JS
HIF1A signaling selectively supports proliferation of breast cancer in the brain.
Nature Communications
Ebright, Richard Y RY; Zachariah, Marcus A MA; Micalizzi, Douglas S DS; Wittner, Ben S BS; Niederhoffer, Kira L KL; Nieman, Linda T LT; Chirn, Brian B; Wiley, Devon F DF; Wesley, Benjamin B; Shaw, Brian B; Nieblas-Bedolla, Edwin E; Atlas, Lian L; Szabolcs, Annamaria A; Iafrate, Anthony J AJ; Toner, Mehmet M; Ting, David T DT; Brastianos, Priscilla K PK; Haber, Daniel A DA; Maheswaran, Shyamala S
RON signalling promotes therapeutic resistance in ESR1 mutant breast cancer.
British Journal Of Cancer
Dustin, Derek D; Gu, Guowei G; Beyer, Amanda R AR; Herzog, Sarah K SK; Edwards, David G DG; Lin, Hangqing H; Gonzalez, Thomas L TL; Grimm, Sandra L SL; Coarfa, Cristian C; Chan, Doug W DW; Kim, Beom-Jun BJ; De La O, Jean-Paul JP; Ellis, Matthew J MJ; Liu, Dan D; Li, Shunqiang S; Welm, Alana L AL; Fuqua, Suzanne A W SAW
A phase 1b study evaluating the effect of elacestrant treatment on estrogen receptor availability and estradiol binding to the estrogen receptor in metastatic breast cancer lesions using 18F-FES PET/CT imaging.
Breast Cancer Research : Bcr
Jager, Agnes A; de Vries, Elisabeth G E EGE; der Houven van Oordt, C Willemien Menke-van CWM; Neven, Patrick P; Venema, Clasina M CM; Glaudemans, Andor W J M AWJM; Wang, Yamei Y; Bagley, Rebecca G RG; Conlan, Maureen G MG; Aftimos, Philippe P
Phase and context shape the function of composite oncogenic mutations.
Nature
Gorelick, Alexander N AN; Sánchez-Rivera, Francisco J FJ; Cai, Yanyan Y; Bielski, Craig M CM; Biederstedt, Evan E; Jonsson, Philip P; Richards, Allison L AL; Vasan, Neil N; Penson, Alexander V AV; Friedman, Noah D ND; Ho, Yu-Jui YJ; Baslan, Timour T; Bandlamudi, Chaitanya C; Scaltriti, Maurizio M; Schultz, Nikolaus N; Lowe, Scott W SW; Reznik, Ed E; Taylor, Barry S BS
Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.
Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Pan-cancer whole-genome analyses of metastatic solid tumours.
Nature
Priestley, Peter P; Baber, Jonathan J; Lolkema, Martijn P MP; Steeghs, Neeltje N; de Bruijn, Ewart E; Shale, Charles C; Duyvesteyn, Korneel K; Haidari, Susan S; van Hoeck, Arne A; Onstenk, Wendy W; Roepman, Paul P; Voda, Mircea M; Bloemendal, Haiko J HJ; Tjan-Heijnen, Vivianne C G VCG; van Herpen, Carla M L CML; Labots, Mariette M; Witteveen, Petronella O PO; Smit, Egbert F EF; Sleijfer, Stefan S; Voest, Emile E EE; Cuppen, Edwin E
Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study.
Nature Medicine
Sicklick, Jason K JK; Kato, Shumei S; Okamura, Ryosuke R; Schwaederle, Maria M; Hahn, Michael E ME; Williams, Casey B CB; De, Pradip P; Krie, Amy A; Piccioni, David E DE; Miller, Vincent A VA; Ross, Jeffrey S JS; Benson, Adam A; Webster, Jennifer J; Stephens, Philip J PJ; Lee, J Jack JJ; Fanta, Paul T PT; Lippman, Scott M SM; Leyland-Jones, Brian B; Kurzrock, Razelle R
Targeted mutation detection in breast cancer using MammaSeq™.
Breast Cancer Research : Bcr
Smith, Nicholas G NG; Gyanchandani, Rekha R; Shah, Osama S OS; Gurda, Grzegorz T GT; Lucas, Peter C PC; Hartmaier, Ryan J RJ; Brufsky, Adam M AM; Puhalla, Shannon S; Bahreini, Amir A; Kota, Karthik K; Wald, Abigail I AI; Nikiforov, Yuri E YE; Nikiforova, Marina N MN; Oesterreich, Steffi S; Lee, Adrian V AV
Analytical Validation of a Hybrid Capture-Based Next-Generation Sequencing Clinical Assay for Genomic Profiling of Cell-Free Circulating Tumor DNA.
The Journal Of Molecular Diagnostics : Jmd
Clark, Travis A TA; Chung, Jon H JH; Kennedy, Mark M; Hughes, Jason D JD; Chennagiri, Niru N; Lieber, Daniel S DS; Fendler, Bernard B; Young, Lauren L; Zhao, Mandy M; Coyne, Michael M; Breese, Virginia V; Young, Geneva G; Donahue, Amy A; Pavlick, Dean D; Tsiros, Alyssa A; Brennan, Timothy T; Zhong, Shan S; Mughal, Tariq T; Bailey, Mark M; He, Jie J; Roels, Steven S; Frampton, Garrett M GM; Spoerke, Jill M JM; Gendreau, Steven S; Lackner, Mark M; Schleifman, Erica E; Peters, Eric E; Ross, Jeffrey S JS; Ali, Siraj M SM; Miller, Vincent A VA; Gregg, Jeffrey P JP; Stephens, Philip J PJ; Welsh, Allison A; Otto, Geoff A GA; Lipson, Doron D
Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.
Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Phase Ib study evaluating safety and clinical activity of the anti-HER3 antibody lumretuzumab combined with the anti-HER2 antibody pertuzumab and paclitaxel in HER3-positive, HER2-low metastatic breast cancer.
Investigational New Drugs
Schneeweiss, Andreas A; Park-Simon, Tjoung-Won TW; Albanell, Joan J; Lassen, Ulrik U; Cortés, Javier J; Dieras, Veronique V; May, Marcus M; Schindler, Christoph C; Marmé, Frederik F; Cejalvo, Juan Miguel JM; Martinez-Garcia, Maria M; Gonzalez, Iria I; Lopez-Martin, Jose J; Welt, Anja A; Levy, Christelle C; Joly, Florence F; Michielin, Francesca F; Jacob, Wolfgang W; Adessi, Céline C; Moisan, Annie A; Meneses-Lorente, Georgina G; Racek, Tomas T; James, Ian I; Ceppi, Maurizio M; Hasmann, Max M; Weisser, Martin M; Cervantes, Andrés A
Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors.
Nature Communications
Adalsteinsson, Viktor A VA; Ha, Gavin G; Freeman, Samuel S SS; Choudhury, Atish D AD; Stover, Daniel G DG; Parsons, Heather A HA; Gydush, Gregory G; Reed, Sarah C SC; Rotem, Denisse D; Rhoades, Justin J; Loginov, Denis D; Livitz, Dimitri D; Rosebrock, Daniel D; Leshchiner, Ignaty I; Kim, Jaegil J; Stewart, Chip C; Rosenberg, Mara M; Francis, Joshua M JM; Zhang, Cheng-Zhong CZ; Cohen, Ofir O; Oh, Coyin C; Ding, Huiming H; Polak, Paz P; Lloyd, Max M; Mahmud, Sairah S; Helvie, Karla K; Merrill, Margaret S MS; Santiago, Rebecca A RA; O'Connor, Edward P EP; Jeong, Seong H SH; Leeson, Rachel R; Barry, Rachel M RM; Kramkowski, Joseph F JF; Zhang, Zhenwei Z; Polacek, Laura L; Lohr, Jens G JG; Schleicher, Molly M; Lipscomb, Emily E; Saltzman, Andrea A; Oliver, Nelly M NM; Marini, Lori L; Waks, Adrienne G AG; Harshman, Lauren C LC; Tolaney, Sara M SM; Van Allen, Eliezer M EM; Winer, Eric P EP; Lin, Nancy U NU; Nakabayashi, Mari M; Taplin, Mary-Ellen ME; Johannessen, Cory M CM; Garraway, Levi A LA; Golub, Todd R TR; Boehm, Jesse S JS; Wagle, Nikhil N; Getz, Gad G; Love, J Christopher JC; Meyerson, Matthew M
Hybrid capture-based genomic profiling of circulating tumor DNA from patients with estrogen receptor-positive metastatic breast cancer.
Annals Of Oncology : Official Journal Of The European Society For Medical Oncology
Chung, J H JH; Pavlick, D D; Hartmaier, R R; Schrock, A B AB; Young, L L; Forcier, B B; Ye, P P; Levin, M K MK; Goldberg, M M; Burris, H H; Gay, L M LM; Hoffman, A D AD; Stephens, P J PJ; Frampton, G M GM; Lipson, D M DM; Nguyen, D M DM; Ganesan, S S; Park, B H BH; Vahdat, L T LT; Leyland-Jones, B B; Mughal, T I TI; Pusztai, L L; O'Shaughnessy, J J; Miller, V A VA; Ross, J S JS; Ali, S M SM
Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination.
Nature Communications
Zheng, Yu Y; Miyamoto, David T DT; Wittner, Ben S BS; Sullivan, James P JP; Aceto, Nicola N; Jordan, Nicole Vincent NV; Yu, Min M; Karabacak, Nezihi Murat NM; Comaills, Valentine V; Morris, Robert R; Desai, Rushil R; Desai, Niyati N; Emmons, Erin E; Milner, John D JD; Lee, Richard J RJ; Wu, Chin-Lee CL; Sequist, Lecia V LV; Haas, Wilhelm W; Ting, David T DT; Toner, Mehmet M; Ramaswamy, Sridhar S; Maheswaran, Shyamala S; Haber, Daniel A DA
Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant.
Nature Communications
Spoerke, Jill M JM; Gendreau, Steven S; Walter, Kimberly K; Qiu, Jiaheng J; Wilson, Timothy R TR; Savage, Heidi H; Aimi, Junko J; Derynck, Mika K MK; Chen, Meng M; Chan, Iris T IT; Amler, Lukas C LC; Hampton, Garret M GM; Johnston, Stephen S; Krop, Ian I; Schmid, Peter P; Lackner, Mark R MR
Estrogen receptor-alpha as a predictive biomarker in endometrioid endometrial cancer.
Gynecologic Oncology
Backes, Floor J FJ; Walker, Christopher J CJ; Goodfellow, Paul J PJ; Hade, Erinn M EM; Agarwal, Garima G; Mutch, David D; Cohn, David E DE; Suarez, Adrian A AA
Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility.
Science (New York, N.Y.)
Yu, Min M; Bardia, Aditya A; Aceto, Nicola N; Bersani, Francesca F; Madden, Marissa W MW; Donaldson, Maria C MC; Desai, Rushil R; Zhu, Huili H; Comaills, Valentine V; Zheng, Zongli Z; Wittner, Ben S BS; Stojanov, Petar P; Brachtel, Elena E; Sgroi, Dennis D; Kapur, Ravi R; Shioda, Toshihiro T; Ting, David T DT; Ramaswamy, Sridhar S; Getz, Gad G; Iafrate, A John AJ; Benes, Cyril C; Toner, Mehmet M; Maheswaran, Shyamala S; Haber, Daniel A DA