Publications:

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Association between ABCB1 rs2235048 Polymorphism and THC Pharmacokinetics and Subjective Effects following Smoked Cannabis in Young Adults.

Brain Sciences

Matheson, Justin J; Zhang, Yollanda J YJ; Brands, Bruna B; Wickens, Christine M CM; Tiwari, Arun K AK; Zai, Clement C CC; Kennedy, James L JL; Le Foll, Bernard B

Publication Date: 2022-09-03

Variant appearance in text: rs510769

PubMed Link: 36138925

Variant Present in the following documents:

• Main text
• brainsci-12-01189.pdf

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Pharmacogenetics of Dolutegravir Plasma Exposure Among Southern Africans With Human Immunodeficiency Virus.

The Journal Of Infectious Diseases

Cindi, Zinhle Z; Kawuma, Aida N AN; Maartens, Gary G; Bradford, Yuki Y; Venter, Francois F; Sokhela, Simiso S; Chandiwana, Nomathemba N; Wasmann, Roeland E RE; Denti, Paolo P; Wiesner, Lubbe L; Ritchie, Marylyn D MD; Haas, David W DW; Sinxadi, Phumla P

Publication Date: 2022-11-01

Variant appearance in text: rs510769

PubMed Link: 35512135

Variant Present in the following documents:

• EMS145648-supplement-Supplementary_file.pdf

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Mu opioid receptor gene variant modulates subjective response to smoked cannabis.

American Journal Of Translational Research

Bourgault, Zoe Z; Matheson, Justin J; Mann, Robert E RE; Brands, Bruna B; Wickens, Christine M CM; Tiwari, Arun K AK; Zai, Clement C CC; Kennedy, James J; Le Foll, Bernard B

Publication Date: 2022

Variant appearance in text: rs510769

PubMed Link: 35173880

Variant Present in the following documents:

• Main text

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Opioid Addiction and Opioid Receptor Dimerization: Structural Modeling of the OPRD1 and OPRM1 Heterodimer and Its Signaling Pathways.

International Journal Of Molecular Sciences

Wu, Bohua B; Hand, William W; Alexov, Emil E

Publication Date: 2021-09-24

Variant appearance in text: rs510769

PubMed Link: 34638633

Variant Present in the following documents:

• Main text
• ijms-22-10290.pdf

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Role of OPRM1, clinical and anthropometric variants in neonatal pain reduction.

Scientific Reports

Erbi, Ilaria I; Ciantelli, Massimiliano M; Farinella, Riccardo R; Tuoni, Cristina C; Gentiluomo, Manuel M; Moscuzza, Francesca F; Rizzato, Cosmeri C; Bedini, Alice A; Faraoni, Maddalena M; Giusfredi, Stefano S; Tavanti, Arianna A; Ghirri, Paolo P; Campa, Daniele D

Publication Date: 2020-04-27

Variant appearance in text: rs510769

PubMed Link: 32341423

Variant Present in the following documents:

• Main text
• 41598_2020_Article_63790.pdf

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Molecular Imaging of Opioid and Dopamine Systems: Insights Into the Pharmacogenetics of Opioid Use Disorders.

Frontiers In Psychiatry

Burns, Jamie A JA; Kroll, Danielle S DS; Feldman, Dana E DE; Kure Liu, Christopher C; Manza, Peter P; Wiers, Corinde E CE; Volkow, Nora D ND; Wang, Gene-Jack GJ

Publication Date: 2019

Variant appearance in text: rs510769

PubMed Link: 31620026

Variant Present in the following documents:

• Main text
• fpsyt-10-00626.pdf

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Introducing Precision Addiction Management of Reward Deficiency Syndrome, the Construct That Underpins All Addictive Behaviors.

Frontiers In Psychiatry

Blum, Kenneth K; Gondré-Lewis, Marjorie C MC; Baron, David D; Thanos, Panayotis K PK; Braverman, Eric R ER; Neary, Jennifer J; Elman, Igor I; Badgaiyan, Rajendra D RD

Publication Date: 2018

Variant appearance in text: rs510769

PubMed Link: 30542299

Variant Present in the following documents:

• Main text

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The Influence of Genetic Variation on Social Disposition, Romantic Relationships and Social Networks: a Replication Study.

Adaptive Human Behavior And Physiology

Pearce, Eiluned E; Wlodarski, Rafael R; Machin, Anna A; Dunbar, Robin I M RIM

Publication Date: 2018

Variant appearance in text: rs510769

PubMed Link: 30393594

Variant Present in the following documents:

• Main text
• 40750_2018_Article_101.pdf

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Whole genome sequencing identifies high-impact variants in well-known pharmacogenomic genes.

The Pharmacogenomics Journal

Choi, Jihoon J; Tantisira, Kelan G KG; Duan, Qing Ling QL

Publication Date: 2019-04

Variant appearance in text: rs510769

PubMed Link: 30214008

Variant Present in the following documents:

• NIHMS1503453-supplement-3.xlsx, sheet 1

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Pharmacogenetics of Opioid Use Disorder Treatment.

Cns Drugs

Crist, Richard C RC; Clarke, Toni-Kim TK; Berrettini, Wade H WH

Publication Date: 2018-04

Variant appearance in text: rs510769

PubMed Link: 29623639

Variant Present in the following documents:

• Main text

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Previously reported placebo-response-associated variants do not predict patient outcomes in inflammatory disease Phase III trial placebo arms.

Genes And Immunity

Haug-Baltzell, Asher A; Bhangale, Tushar R TR; Chang, Diana D; Dressen, Amy A; Yaspan, Brian L BL; Ortmann, Ward W; Brauer, Matthew J MJ; Hunkapiller, Julie J; Reeder, Jens J; Mukhyala, Kiran K; Cuenco, Karen T KT; Tom, Jennifer A JA; Cowgill, Amy A; Vogel, Jan J; Forrest, William F WF; Behrens, Timothy W TW; Graham, Robert R RR; Wuster, Arthur A

Publication Date: 2019-02

Variant appearance in text: rs510769

PubMed Link: 29550837

Variant Present in the following documents:

• Main text
• 41435_2018_Article_18.pdf

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The μ-opioid receptor nonsynonymous variant 118A>G is associated with prolonged abstinence from heroin without agonist treatment.

Pharmacogenomics

Levran, Orna O; Peles, Einat E; Randesi, Matthew M; da Rosa, Joel Correa JC; Adelson, Miriam M; Kreek, Mary Jeanne MJ

Publication Date: 2017-10

Variant appearance in text: rs510769

PubMed Link: 28976288

Variant Present in the following documents:

• Main text

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Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.

Molecular Psychiatry

Yang, J J; Li, M D MD

Publication Date: 2016-08

Variant appearance in text: rs510769

PubMed Link: 27166759

Variant Present in the following documents:

• Main text
• nihms-767542.pdf

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Parent and peer influences on emerging adult substance use disorder: A genetically informed study.

Development And Psychopathology

Bountress, Kaitlin K; Chassin, Laurie L; Lemery-Chalfant, Kathryn K

Publication Date: 2017-02

Variant appearance in text: rs510769

PubMed Link: 26753847

Variant Present in the following documents:

• Main text

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The Opposing Roles of IVS2+691 CC Genotype and AC/AG Diplotype of 118A>G and IVS2+691G>C of OPRM1 Polymorphisms in Cold Pain Tolerance Among Opioid-Dependent Malay Males on Methadone Therapy.

Pain And Therapy

Zahari, Zalina Z; Lee, Chee Siong CS; Ibrahim, Muslih Abdulkarim MA; Musa, Nurfadhlina N; Yasin, Mohd Azhar Mohd MA; Lee, Yeong Yeh YY; Tan, Soo Choon SC; Mohamad, Nasir N; Ismail, Rusli R

Publication Date: 2015-12

Variant appearance in text: rs510769

PubMed Link: 26581429

Variant Present in the following documents:

• Main text
• 40122_2015_Article_41.pdf

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Association between Opioid Receptor mu 1 (OPRM1) Gene Polymorphisms and Tobacco and Alcohol Consumption in a Spanish Population.

Bosnian Journal Of Basic Medical Sciences

Francès, Francesc F; Portolés, Olga O; Castelló, Ana A; Costa, Jose Antonio JA; Verdú, Fernando F

Publication Date: 2015-04-25

Variant appearance in text: rs510769

PubMed Link: 26042510

Variant Present in the following documents:

• Main text

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Genetics and the placebo effect: the placebome.

Trends In Molecular Medicine

Hall, Kathryn T KT; Loscalzo, Joseph J; Kaptchuk, Ted J TJ

Publication Date: 2015-05

Variant appearance in text: rs510769

PubMed Link: 25883069

Variant Present in the following documents:

• Main text

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A review of pharmacogenetic studies of substance-related disorders.

Drug And Alcohol Dependence

Jones, Jermaine D JD; Comer, Sandra D SD

Publication Date: 2015-07-01

Variant appearance in text: rs510769

PubMed Link: 25819021

Variant Present in the following documents:

• Main text

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Cis-Expression Quantitative Trait Loci Mapping Reveals Replicable Associations with Heroin Addiction in OPRM1.

Biological Psychiatry

Hancock, Dana B DB; Levy, Joshua L JL; Gaddis, Nathan C NC; Glasheen, Cristie C; Saccone, Nancy L NL; Page, Grier P GP; Hulse, Gary K GK; Wildenauer, Dieter D; Kelty, Erin A EA; Schwab, Sibylle G SG; Degenhardt, Louisa L; Martin, Nicholas G NG; Montgomery, Grant W GW; Attia, John J; Holliday, Elizabeth G EG; McEvoy, Mark M; Scott, Rodney J RJ; Bierut, Laura J LJ; Nelson, Elliot C EC; Kral, Alex H AH; Johnson, Eric O EO

Publication Date: 2015-10-01

Variant appearance in text: rs510769

PubMed Link: 25744370

Variant Present in the following documents:

• Main text

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Genetic variants and early cigarette smoking and nicotine dependence phenotypes in adolescents.

Plos One

O'Loughlin, Jennifer J; Sylvestre, Marie-Pierre MP; Labbe, Aurélie A; Low, Nancy C NC; Roy-Gagnon, Marie-Hélène MH; Dugas, Erika N EN; Karp, Igor I; Engert, James C JC

Publication Date: 2014

Variant appearance in text: rs510769

PubMed Link: 25545355

Variant Present in the following documents:

• Main text
• pone.0115716.pdf

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Pharmacogenetics of OPRM1.

Pharmacology, Biochemistry, And Behavior

Crist, Richard C RC; Berrettini, Wade H WH

Publication Date: 2014-08

Variant appearance in text: rs510769

PubMed Link: 24201053

Variant Present in the following documents:

• Main text

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Association of polymorphisms in pharmacogenetic candidate genes (OPRD1, GAL, ABCB1, OPRM1) with opioid dependence in European population: a case-control study.

Plos One

Beer, Beate B; Erb, Robert R; Pavlic, Marion M; Ulmer, Hanno H; Giacomuzzi, Salvatore S; Riemer, Yvonne Y; Oberacher, Herbert H

Publication Date: 2013

Variant appearance in text: rs510769

PubMed Link: 24086514

Variant Present in the following documents:

• Main text

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Introduction to deep sequencing and its application to drug addiction research with a focus on rare variants.

Molecular Neurobiology

Wang, Shaolin S; Yang, Zhongli Z; Ma, Jennie Z JZ; Payne, Thomas J TJ; Li, Ming D MD

Publication Date: 2014-02

Variant appearance in text: rs510769

PubMed Link: 23990377

Variant Present in the following documents:

• Main text

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Candidate gene studies of a promising intermediate phenotype: failure to replicate.

Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology

Hart, Amy B AB; de Wit, Harriet H; Palmer, Abraham A AA

Publication Date: 2013-04

Variant appearance in text: rs510769

PubMed Link: 23303064

Variant Present in the following documents:

• Main text

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Mu opioid receptor (OPRM1) as a predictor of treatment outcome in opiate-dependent individuals of Arab descent.

Pharmacogenomics And Personalized Medicine

Al-Eitan, Laith N LN; Jaradat, Saied A SA; Su, Steve Ys SY; Tay, Guan K GK; Hulse, Gary K GK

Publication Date: 2012

Variant appearance in text: rs510769

PubMed Link: 23226066

Variant Present in the following documents:

• Main text
• pgpm-5-099.pdf

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κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction.

Trends In Neurosciences

Butelman, Eduardo R ER; Yuferov, Vadim V; Kreek, Mary Jeanne MJ

Publication Date: 2012-10

Variant appearance in text: rs510769

PubMed Link: 22709632

Variant Present in the following documents:

• Main text

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The genetics of the opioid system and specific drug addictions.

Human Genetics

Levran, Orna O; Yuferov, Vadim V; Kreek, Mary Jeanne MJ

Publication Date: 2012-06

Variant appearance in text: rs510769

PubMed Link: 22547174

Variant Present in the following documents:

• Main text

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Common and specific liability to addiction: approaches to association studies of opioid addiction.

Drug And Alcohol Dependence

Nielsen, David A DA; Kreek, Mary Jeanne MJ

Publication Date: 2012-06

Variant appearance in text: rs510769

PubMed Link: 22542464

Variant Present in the following documents:

• Main text

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Association of polymorphisms of the mu opioid receptor gene with the severity of HIV infection and response to HIV treatment.

The Journal Of Infectious Diseases

Proudnikov, Dmitri D; Randesi, Matthew M; Levran, Orna O; Crystal, Howard H; Dorn, Magdalena M; Ott, Jurg J; Ho, Ann A; Kreek, Mary Jeanne MJ

Publication Date: 2012-06

Variant appearance in text: rs510769

PubMed Link: 22457278

Variant Present in the following documents:

• Main text

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Genetic factors modulating the response to stimulant drugs in humans.

Current Topics In Behavioral Neurosciences

Hart, Amy B AB; de Wit, Harriet H; Palmer, Abraham A AA

Publication Date: 2012

Variant appearance in text: rs510769

PubMed Link: 22261702

Variant Present in the following documents:

• Main text

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Molecular mechanisms of opioid receptor-dependent signaling and behavior.

Anesthesiology

Al-Hasani, Ream R; Bruchas, Michael R MR

Publication Date: 2011-12

Variant appearance in text: rs510769

PubMed Link: 22020140

Variant Present in the following documents:

• Main text

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Different phenotypic and genotypic presentations in alcohol dependence: age at onset matters.

Journal Of Studies On Alcohol And Drugs

Chen, Yu-Chu YC; Prescott, Carol A CA; Walsh, Dermot D; Patterson, Diana G DG; Riley, Brien P BP; Kendler, Kenneth S KS; Kuo, Po-Hsiu PH

Publication Date: 2011-09

Variant appearance in text: rs510769

PubMed Link: 21906503

Variant Present in the following documents:

• Main text

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Gender-stratified gene and gene-treatment interactions in smoking cessation.

The Pharmacogenomics Journal

Lee, W W; Bergen, A W AW; Swan, G E GE; Li, D D; Liu, J J; Thomas, P P; Tyndale, R F RF; Benowitz, N L NL; Lerman, C C; Conti, D V DV

Publication Date: 2012-12

Variant appearance in text: rs510769

PubMed Link: 21808284

Variant Present in the following documents:

• NIHMS305090-supplement-3.pdf

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No evidence of association between 118A>G OPRM1 polymorphism and heroin dependence in a large Bulgarian case-control sample.

Drug And Alcohol Dependence

Nikolov, Momchil A MA; Beltcheva, Olga O; Galabova, Antoaneta A; Ljubenova, Anna A; Jankova, Elena E; Gergov, Galin G; Russev, Atanas A AA; Lynskey, Michael T MT; Nelson, Elliot C EC; Nesheva, Eleonora E; Krasteva, Dorita D; Lazarov, Philip P; Mitev, Vanio I VI; Kremensky, Ivo M IM; Kaneva, Radka P RP; Todorov, Alexandre A AA

Publication Date: 2011-08-01

Variant appearance in text: rs510769

PubMed Link: 21277709

Variant Present in the following documents:

• Main text

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Haplotype block structure of the genomic region of the mu opioid receptor gene.

Journal Of Human Genetics

Levran, Orna O; Awolesi, Olaoluwakitan O; Linzy, Shirley S; Adelson, Miriam M; Kreek, Mary Jeanne MJ

Publication Date: 2011-02

Variant appearance in text: rs510769

PubMed Link: 21160491

Variant Present in the following documents:

• Main text
• nihms-252057.pdf

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OPRM1 gene variants modulate amphetamine-induced euphoria in humans.

Genes, Brain, And Behavior

Dlugos, A M AM; Hamidovic, A A; Hodgkinson, C C; Shen, P H PH; Goldman, D D; Palmer, A A AA; de Wit, H H

Publication Date: 2011-03

Variant appearance in text: rs510769

PubMed Link: 21029375

Variant Present in the following documents:

• Main text

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Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment.

Annals Of The New York Academy Of Sciences

Yuferov, Vadim V; Levran, Orna O; Proudnikov, Dmitri D; Nielsen, David A DA; Kreek, Mary Jeanne MJ

Publication Date: 2010-02

Variant appearance in text: rs510769

PubMed Link: 20201854

Variant Present in the following documents:

• Main text

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PCA-based bootstrap confidence interval tests for gene-disease association involving multiple SNPs.

Bmc Genetics

Peng, Qianqian Q; Zhao, Jinghua J; Xue, Fuzhong F

Publication Date: 2010-01-26

Variant appearance in text: rs510769

PubMed Link: 20100356

Variant Present in the following documents:

• Main text

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A gene-based method for detecting gene-gene co-association in a case-control association study.

European Journal Of Human Genetics : Ejhg

Peng, Qianqian Q; Zhao, Jinghua J; Xue, Fuzhong F

Publication Date: 2010-05

Variant appearance in text: rs510769

PubMed Link: 20029457

Variant Present in the following documents:

• Main text

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Nicotine withdrawal sensitivity, linkage to chr6q26, and association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) sample.

Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology

Hardin, Jill J; He, Yungang Y; Javitz, Harold S HS; Wessel, Jennifer J; Krasnow, Ruth E RE; Tildesley, Elizabeth E; Hops, Hyman H; Swan, Gary E GE; Bergen, Andrew W AW

Publication Date: 2009-12

Variant appearance in text: rs510769

PubMed Link: 19959688

Variant Present in the following documents:

• Main text

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The interpersonal dimension of borderline personality disorder: toward a neuropeptide model.

The American Journal Of Psychiatry

Stanley, Barbara B; Siever, Larry J LJ

Publication Date: 2010-01

Variant appearance in text: rs510769

PubMed Link: 19952075

Variant Present in the following documents:

• Main text

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Heroin addiction in African Americans: a hypothesis-driven association study.

Genes, Brain, And Behavior

Levran, O O; Londono, D D; O'Hara, K K; Randesi, M M; Rotrosen, J J; Casadonte, P P; Linzy, S S; Ott, J J; Adelson, M M; Kreek, M J MJ

Publication Date: 2009-07

Variant appearance in text: rs510769

PubMed Link: 19500151

Variant Present in the following documents:

• Main text

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OPRM1 Asn40Asp predicts response to naltrexone treatment: a haplotype-based approach.

Alcoholism, Clinical And Experimental Research

Oroszi, Gabor G; Anton, Raymond F RF; O'Malley, Stephanie S; Swift, Robert R; Pettinati, Helen H; Couper, David D; Yuan, Qiaoping Q; Goldman, David D

Publication Date: 2009-03

Variant appearance in text: rs510769

PubMed Link: 19053977

Variant Present in the following documents:

• Main text

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Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking.

Addiction (Abingdon, England)

Sherva, Richard R; Wilhelmsen, Kirk K; Pomerleau, Cynthia S CS; Chasse, Scott A SA; Rice, John P JP; Snedecor, Sandy M SM; Bierut, Laura J LJ; Neuman, Rosalind J RJ; Pomerleau, Ovide F OF

Publication Date: 2008-09

Variant appearance in text: rs510769

PubMed Link: 18783506

Variant Present in the following documents:

• Main text

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Genetic susceptibility to heroin addiction: a candidate gene association study.

Genes, Brain, And Behavior

Levran, O O; Londono, D D; O'Hara, K K; Nielsen, D A DA; Peles, E E; Rotrosen, J J; Casadonte, P P; Linzy, S S; Randesi, M M; Ott, J J; Adelson, M M; Kreek, M J MJ

Publication Date: 2008-10

Variant appearance in text: rs510769

PubMed Link: 18518925

Variant Present in the following documents:

• Main text

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Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs.

Human Molecular Genetics

Saccone, Scott F SF; Hinrichs, Anthony L AL; Saccone, Nancy L NL; Chase, Gary A GA; Konvicka, Karel K; Madden, Pamela A F PA; Breslau, Naomi N; Johnson, Eric O EO; Hatsukami, Dorothy D; Pomerleau, Ovide O; Swan, Gary E GE; Goate, Alison M AM; Rutter, Joni J; Bertelsen, Sarah S; Fox, Louis L; Fugman, Douglas D; Martin, Nicholas G NG; Montgomery, Grant W GW; Wang, Jen C JC; Ballinger, Dennis G DG; Rice, John P JP; Bierut, Laura Jean LJ

Publication Date: 2007-01-01

Variant appearance in text: rs510769

PubMed Link: 17135278

Variant Present in the following documents:

• Main text

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The mu-opioid receptor gene and smoking initiation and nicotine dependence.

Behavioral And Brain Functions : Bbf

Zhang, Lan L; Kendler, Kenneth S KS; Chen, Xiangning X

Publication Date: 2006-08-04

Variant appearance in text: rs510769

PubMed Link: 16887046

Variant Present in the following documents:

• Main text
• 1744-9081-2-28.pdf

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Clone-based systematic haplotyping (CSH): a procedure for physical haplotyping of whole genomes.

Genome Research

Burgtorf, Carola C; Kepper, Pamela P; Hoehe, Margret M; Schmitt, Carsten C; Reinhardt, Richard R; Lehrach, Hans H; Sauer, Sascha S

Publication Date: 2003-12

Variant appearance in text: rs510769

PubMed Link: 14656974

Variant Present in the following documents:

• Main text

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MALDI mass spectrometry analysis of single nucleotide polymorphisms by photocleavage and charge-tagging.

Nucleic Acids Research

Sauer, Sascha S; Lehrach, Hans H; Reinhardt, Richard R

Publication Date: 2003-06-01

Variant appearance in text: rs510769

PubMed Link: 12771227

Variant Present in the following documents:

• Main text

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