OPRM1 c.291-2994C>T

Variant ID: 6-154407967-C-T

NM_000914.3(OPRM1):c.291-2994C>T

This variant was identified in 48 publications

View GRCh38 version.




Publications:


Is OPRM1 genotype a valuable predictor of VAS in patients undergoing laparoscopic radical resection of colorectal cancer with fentanyl?

Bmc Anesthesiology
Zhou, Yan Y; Cao, Lei L; Yang, Yihui Y; Gao, Yaoyi Y; Li, Yihao Y; Wang, Beili B; Pan, Baishen B; Huang, Jian J; Guo, Wei W
Publication Date: 2023-05-22

Variant appearance in text: rs563649
PubMed Link: 37217861
Variant Present in the following documents:
  • Main text
  • 12871_2023_Article_2120.pdf
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Pharmacogenomics of Cancer Pain Treatment Outcomes in Asian Populations: A Review.

Journal Of Personalized Medicine
Satkunananthan, Shobha Elizabeth SE; Suppiah, Vijayaprakash V; Toh, Gaik-Theng GT; Yow, Hui-Yin HY
Publication Date: 2022-11-18

Variant appearance in text: rs563649
PubMed Link: 36422103
Variant Present in the following documents:
  • Main text
  • jpm-12-01927.pdf
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Genetic and Clinical Factors Associated with Opioid Response in Chinese Han Patients with Cancer Pain: An Exploratory Cross-Sectional Study.

Pain And Therapy
Shi, Chen C; Liu, Jinmei J; Hu, Jianli J; Chen, Xu X; Xie, Jiyi J; Luo, Juan J; Wang, Cong C; Wang, Hanxiang H; Yuan, Qi Q; Zhu, Haixia H; Gong, Weijing W; Li, Shijun S; Zhou, Hong H; Wang, Leiyun L; Wang, Hui H; Zhang, Yu Y
Publication Date: 2022-03

Variant appearance in text: rs563649
PubMed Link: 35107781
Variant Present in the following documents:
  • Main text
  • 40122_2022_Article_353.pdf
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Disseminated Talaromyces marneffei Infection in a Non-HIV Infant With a Homozygous Private Variant of RELB.

Frontiers In Cellular And Infection Microbiology
Ding, Xiaofang X; Huang, Han H; Zhong, Lili L; Chen, Min M; Peng, Fang F; Zhang, Bing B; Cui, Xinyu X; Yang, Xiu-An XA
Publication Date: 2021

Variant appearance in text: rs563649
PubMed Link: 33791233
Variant Present in the following documents:
  • Table_2.xlsx, sheet 1
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The IMAGEN study: a decade of imaging genetics in adolescents.

Molecular Psychiatry
Mascarell Maričić, Lea L; Walter, Henrik H; Rosenthal, Annika A; Ripke, Stephan S; Quinlan, Erin Burke EB; Banaschewski, Tobias T; Barker, Gareth J GJ; Bokde, Arun L W ALW; Bromberg, Uli U; Büchel, Christian C; Desrivières, Sylvane S; Flor, Herta H; Frouin, Vincent V; Garavan, Hugh H; Itterman, Bernd B; Martinot, Jean-Luc JL; Martinot, Marie-Laure Paillère MP; Nees, Frauke F; Orfanos, Dimitri Papadopoulos DP; Paus, Tomáš T; Poustka, Luise L; Hohmann, Sarah S; Smolka, Michael N MN; Fröhner, Juliane H JH; Whelan, Robert R; Kaminski, Jakob J; Schumann, Gunter G; Heinz, Andreas A; ,
Publication Date: 2020-11

Variant appearance in text: rs563649
PubMed Link: 32601453
Variant Present in the following documents:
  • Main text
  • 41380_2020_Article_822.pdf
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Detecting Weak Signals by Combining Small P-Values in Genetic Association Studies.

Frontiers In Genetics
Vsevolozhskaya, Olga A OA; Hu, Fengjiao F; Zaykin, Dmitri V DV
Publication Date: 2019

Variant appearance in text: rs563649
PubMed Link: 31824555
Variant Present in the following documents:
  • Main text
  • fgene-10-01051.pdf
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Positron emission tomography imaging of endogenous mu-opioid mechanisms during pain and migraine.

Pain Reports
DaSilva, Alexandre F AF; Zubieta, Jon-Kar JK; DosSantos, Marcos F MF
Publication Date: 2019

Variant appearance in text: rs563649
PubMed Link: 31579860
Variant Present in the following documents:
  • Main text
  • painreports-4-e769.pdf
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Systematic Review and Meta-Analysis of Genetic Risk of Developing Chronic Postsurgical Pain.

The Journal Of Pain
Chidambaran, Vidya V; Gang, Yang Y; Pilipenko, Valentina V; Ashton, Maria M; Ding, Lili L
Publication Date: 2020

Variant appearance in text: rs563649
PubMed Link: 31129315
Variant Present in the following documents:
  • Main text
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Candidate gene analyses for acute pain and morphine analgesia after pediatric day surgery: African American versus European Caucasian ancestry and dose prediction limits.

The Pharmacogenomics Journal
Li, Jin J; Wei, Zhi Z; Zhang, Jie J; Hakonarson, Hakon H; Cook-Sather, Scott D SD
Publication Date: 2019-12

Variant appearance in text: rs563649
PubMed Link: 30760877
Variant Present in the following documents:
  • Main text
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Morphine biotransformation genes and neonatal clinical factors predicted behaviour problems in very preterm children at 18 months.

Ebiomedicine
Chau, Cecil M Y CMY; Ross, Colin J D CJD; Chau, Vann V; Synnes, Anne R AR; Miller, Steven P SP; Carleton, Bruce B; Grunau, Ruth E RE
Publication Date: 2019-02

Variant appearance in text: rs563649
PubMed Link: 30709768
Variant Present in the following documents:
  • Main text
  • main.pdf
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Pain polymorphisms and opioids: An evidence based review.

Molecular Medicine Reports
Vieira, Cláudia Margarida Pereira CMP; Fragoso, Rosa Maria RM; Pereira, Deolinda D; Medeiros, Rui R
Publication Date: 2019-03

Variant appearance in text: rs563649
PubMed Link: 30592275
Variant Present in the following documents:
  • Main text
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Introducing Precision Addiction Management of Reward Deficiency Syndrome, the Construct That Underpins All Addictive Behaviors.

Frontiers In Psychiatry
Blum, Kenneth K; Gondré-Lewis, Marjorie C MC; Baron, David D; Thanos, Panayotis K PK; Braverman, Eric R ER; Neary, Jennifer J; Elman, Igor I; Badgaiyan, Rajendra D RD
Publication Date: 2018

Variant appearance in text: rs563649
PubMed Link: 30542299
Variant Present in the following documents:
  • Main text
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Effects of OPRM1 and ABCB1 gene polymorphisms on the analgesic effect and dose of sufentanil after thoracoscopic-assisted radical resection of lung cancer.

Bioscience Reports
Zhao, Zhonghai Z; Lv, Bin B; Zhao, Xiaodong X; Zhang, Yunlong Y
Publication Date: 2019-01-31

Variant appearance in text: rs563649
PubMed Link: 30455395
Variant Present in the following documents:
  • Main text
  • bsr-39-bsr20181211.pdf
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When pain gets stuck: the evolution of pain chronification and treatment resistance.

Pain
Borsook, David D; Youssef, Andrew M AM; Simons, Laura L; Elman, Igor I; Eccleston, Christopher C
Publication Date: 2018-12

Variant appearance in text: rs563649
PubMed Link: 30234696
Variant Present in the following documents:
  • Main text
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PharmGKB summary: oxycodone pathway, pharmacokinetics.

Pharmacogenetics And Genomics
Huddart, Rachel R; Clarke, Melissa M; Altman, Russ B RB; Klein, Teri E TE
Publication Date: 2018-10

Variant appearance in text: rs563649
PubMed Link: 30222708
Variant Present in the following documents:
  • Main text
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Whole genome sequencing identifies high-impact variants in well-known pharmacogenomic genes.

The Pharmacogenomics Journal
Choi, Jihoon J; Tantisira, Kelan G KG; Duan, Qing Ling QL
Publication Date: 2019-04

Variant appearance in text: rs563649
PubMed Link: 30214008
Variant Present in the following documents:
  • NIHMS1503453-supplement-3.xlsx, sheet 1
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Emotional and Motivational Pain Processing: Current State of Knowledge and Perspectives in Translational Research.

Pain Research & Management
Becker, Susanne S; Navratilova, Edita E; Nees, Frauke F; Van Damme, Stefaan S
Publication Date: 2018

Variant appearance in text: rs563649
PubMed Link: 30123398
Variant Present in the following documents:
  • Main text
  • PRM2018-5457870.pdf
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Novel human genome variants associated with alcohol use disorders identified in a Lithuanian cohort.

Acta Medica Lituanica
Baronas, Karolis K; Rančelis, Tautvydas T; Pranculis, Aidas A; Domarkienė, Ingrida I; Ambrozaitytė, Laima L; Kučinskas, Vaidutis V
Publication Date: 2018

Variant appearance in text: rs563649
PubMed Link: 29928152
Variant Present in the following documents:
  • Main text
  • aml-25-007.pdf
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The Role of Genetic Polymorphisms in Chronic Pain Patients.

International Journal Of Molecular Sciences
Knezevic, Nebojsa Nick NN; Tverdohleb, Tatiana T; Knezevic, Ivana I; Candido, Kenneth D KD
Publication Date: 2018-06-08

Variant appearance in text: rs563649
PubMed Link: 29890676
Variant Present in the following documents:
  • Main text
  • ijms-19-01707.pdf
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Pharmacogenetics of Opioid Use Disorder Treatment.

Cns Drugs
Crist, Richard C RC; Clarke, Toni-Kim TK; Berrettini, Wade H WH
Publication Date: 2018-04

Variant appearance in text: rs563649
PubMed Link: 29623639
Variant Present in the following documents:
  • Main text
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Subliminal (latent) processing of pain and its evolution to conscious awareness.

Neuroscience And Biobehavioral Reviews
Borsook, David D; Youssef, Andrew M AM; Barakat, Nadia N; Sieberg, Christine B CB; Elman, Igor I
Publication Date: 2018-05

Variant appearance in text: rs563649
PubMed Link: 29476771
Variant Present in the following documents:
  • Main text
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Truncated μ-Opioid Receptors With 6 Transmembrane Domains Are Essential for Opioid Analgesia.

Anesthesia And Analgesia
Lu, Zhigang Z; Xu, Jin J; Xu, Mingming M; Rossi, Grace C GC; Majumdar, Susruta S; Pasternak, Gavril W GW; Pan, Ying-Xian YX
Publication Date: 2018-03

Variant appearance in text: rs563649
PubMed Link: 28991118
Variant Present in the following documents:
  • Main text
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Relationship of Genetic Variants With Procedural Pain, Anxiety, and Distress in Children.

Biological Research For Nursing
Ersig, Anne L AL; Schutte, Debra L DL; Standley, Jennifer J; Leslie, Elizabeth E; Zimmerman, Bridget B; Kleiber, Charmaine C; Hanrahan, Kirsten K; Murray, Jeffrey C JC; McCarthy, Ann Marie AM
Publication Date: 2017-05

Variant appearance in text: rs563649
PubMed Link: 28413930
Variant Present in the following documents:
  • Main text
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Opioidergic tone and pain susceptibility: interactions between reward systems and opioid receptors.

Pain
Borsook, David D
Publication Date: 2017-02

Variant appearance in text: rs563649
PubMed Link: 28092322
Variant Present in the following documents:
  • Main text
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Next-generation sequencing of human opioid receptor genes based on a custom AmpliSeq™ library and ion torrent personal genome machine.

Clinica Chimica Acta; International Journal Of Clinical Chemistry
Kringel, Dario D; Lötsch, Jörn J
Publication Date: 2016-12-01

Variant appearance in text: rs563649
PubMed Link: 27725223
Variant Present in the following documents:
  • Main text
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The Opposing Roles of IVS2+691 CC Genotype and AC/AG Diplotype of 118A>G and IVS2+691G>C of OPRM1 Polymorphisms in Cold Pain Tolerance Among Opioid-Dependent Malay Males on Methadone Therapy.

Pain And Therapy
Zahari, Zalina Z; Lee, Chee Siong CS; Ibrahim, Muslih Abdulkarim MA; Musa, Nurfadhlina N; Yasin, Mohd Azhar Mohd MA; Lee, Yeong Yeh YY; Tan, Soo Choon SC; Mohamad, Nasir N; Ismail, Rusli R
Publication Date: 2015-12

Variant appearance in text: rs563649
PubMed Link: 26581429
Variant Present in the following documents:
  • Main text
  • 40122_2015_Article_41.pdf
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Mu Opioid Splice Variant MOR-1K Contributes to the Development of Opioid-Induced Hyperalgesia.

Plos One
Oladosu, Folabomi A FA; Conrad, Matthew S MS; O'Buckley, Sandra C SC; Rashid, Naim U NU; Slade, Gary D GD; Nackley, Andrea G AG
Publication Date: 2015

Variant appearance in text: rs563649
PubMed Link: 26270813
Variant Present in the following documents:
  • Main text
  • pone.0135711.pdf
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Cis-Expression Quantitative Trait Loci Mapping Reveals Replicable Associations with Heroin Addiction in OPRM1.

Biological Psychiatry
Hancock, Dana B DB; Levy, Joshua L JL; Gaddis, Nathan C NC; Glasheen, Cristie C; Saccone, Nancy L NL; Page, Grier P GP; Hulse, Gary K GK; Wildenauer, Dieter D; Kelty, Erin A EA; Schwab, Sibylle G SG; Degenhardt, Louisa L; Martin, Nicholas G NG; Montgomery, Grant W GW; Attia, John J; Holliday, Elizabeth G EG; McEvoy, Mark M; Scott, Rodney J RJ; Bierut, Laura J LJ; Nelson, Elliot C EC; Kral, Alex H AH; Johnson, Eric O EO
Publication Date: 2015-10-01

Variant appearance in text: rs563649
PubMed Link: 25744370
Variant Present in the following documents:
  • Main text
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μ-Opioid receptor 6-transmembrane isoform: A potential therapeutic target for new effective opioids.

Progress In Neuro-Psychopharmacology & Biological Psychiatry
Convertino, Marino M; Samoshkin, Alexander A; Gauthier, Josee J; Gold, Michael S MS; Maixner, William W; Dokholyan, Nikolay V NV; Diatchenko, Luda L
Publication Date: 2015-10-01

Variant appearance in text: rs563649
PubMed Link: 25485963
Variant Present in the following documents:
  • Main text
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The design and methods of genetic studies on acute and chronic postoperative pain in patients after total knee replacement.

Pain Medicine (Malden, Mass.)
Belfer, Inna I; Greco, Carol M CM; Lokshin, Anna A; Vulakovich, Katie K; Landsittel, Douglas D; Dai, Feng F; Crossett, Lawrence L; Chelly, Jacques E JE
Publication Date: 2014-09

Variant appearance in text: rs563649
PubMed Link: 25040948
Variant Present in the following documents:
  • Main text
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Review of preclinical studies on treatment of mucositis and associated pain.

Journal Of Dental Research
Viet, C T CT; Corby, P M PM; Akinwande, A A; Schmidt, B L BL
Publication Date: 2014-09

Variant appearance in text: rs563649
PubMed Link: 24943201
Variant Present in the following documents:
  • Main text
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Therapygenetics in mindfulness-based cognitive therapy: do genes have an impact on therapy-induced change in real-life positive affective experiences?

Translational Psychiatry
Bakker, J M JM; Lieverse, R R; Menne-Lothmann, C C; Viechtbauer, W W; Pishva, E E; Kenis, G G; Geschwind, N N; Peeters, F F; van Os, J J; Wichers, M M
Publication Date: 2014-04-22

Variant appearance in text: rs563649
PubMed Link: 24755993
Variant Present in the following documents:
  • Main text
  • tp201423a.pdf
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Pharmacogenetics of OPRM1.

Pharmacology, Biochemistry, And Behavior
Crist, Richard C RC; Berrettini, Wade H WH
Publication Date: 2014-08

Variant appearance in text: rs563649
PubMed Link: 24201053
Variant Present in the following documents:
  • Main text
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Gender, variation in opioid receptor genes and sensitivity to experimental pain.

Molecular Pain
Sato, Hiroe H; Droney, Joanne J; Ross, Joy J; Olesen, Anne Estrup AE; Staahl, Camilla C; Andresen, Trine T; Branford, Ruth R; Riley, Julia J; Arendt-Nielsen, Lars L; Drewes, Asbjørn Mohr AM
Publication Date: 2013-04-09

Variant appearance in text: rs563649
PubMed Link: 23570317
Variant Present in the following documents:
  • Main text
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Mu opioid receptor (OPRM1) as a predictor of treatment outcome in opiate-dependent individuals of Arab descent.

Pharmacogenomics And Personalized Medicine
Al-Eitan, Laith N LN; Jaradat, Saied A SA; Su, Steve Ys SY; Tay, Guan K GK; Hulse, Gary K GK
Publication Date: 2012

Variant appearance in text: rs563649
PubMed Link: 23226066
Variant Present in the following documents:
  • Main text
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A non-synonymous single nucleotide polymorphism in an OPRM1 splice variant is associated with fentanyl-induced emesis in women undergoing minor gynaecological surgery.

Plos One
Pang, Grace Su Yin GS; Ithnin, Farida F; Wong, Yin Yee YY; Wang, Jing Bo JB; Lim, Yvonne Y; Sia, Alex Tiong Heng AT; Lee, Caroline Guat Lay CG
Publication Date: 2012

Variant appearance in text: rs563649
PubMed Link: 23144877
Variant Present in the following documents:
  • Main text
  • pone.0048416.pdf
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Analgesia and central side-effects: two separate dimensions of morphine response.

British Journal Of Clinical Pharmacology
Droney, Joanne M JM; Gretton, Sophy K SK; Sato, Hiroe H; Ross, Joy R JR; Branford, Ruth R; Welsh, Kenneth I KI; Cookson, William W; Riley, Julia J
Publication Date: 2013-05

Variant appearance in text: rs563649
PubMed Link: 23072578
Variant Present in the following documents:
  • Main text
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The genetics of the opioid system and specific drug addictions.

Human Genetics
Levran, Orna O; Yuferov, Vadim V; Kreek, Mary Jeanne MJ
Publication Date: 2012-06

Variant appearance in text: rs563649
PubMed Link: 22547174
Variant Present in the following documents:
  • Main text
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μ-Opioid receptor gene A118G polymorphism predicts survival in patients with breast cancer.

Anesthesiology
Bortsov, Andrey V AV; Millikan, Robert C RC; Belfer, Inna I; Boortz-Marx, Richard L RL; Arora, Harendra H; McLean, Samuel A SA
Publication Date: 2012-04

Variant appearance in text: rs563649
PubMed Link: 22433205
Variant Present in the following documents:
  • Main text
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Pharmacogenetic approaches to the treatment of alcohol addiction.

Nature Reviews. Neuroscience
Heilig, Markus M; Goldman, David D; Berrettini, Wade W; O'Brien, Charles P CP
Publication Date: 2011-10-20

Variant appearance in text: rs563649
PubMed Link: 22011682
Variant Present in the following documents:
  • Main text
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Gender-stratified gene and gene-treatment interactions in smoking cessation.

The Pharmacogenomics Journal
Lee, W W; Bergen, A W AW; Swan, G E GE; Li, D D; Liu, J J; Thomas, P P; Tyndale, R F RF; Benowitz, N L NL; Lerman, C C; Conti, D V DV
Publication Date: 2012-12

Variant appearance in text: rs563649
PubMed Link: 21808284
Variant Present in the following documents:
  • NIHMS305090-supplement-3.pdf
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Pharmacogenomics of the RNA world: structural RNA polymorphisms in drug therapy.

Clinical Pharmacology And Therapeutics
Sadee, W W; Wang, D D; Papp, A C AC; Pinsonneault, J K JK; Smith, R M RM; Moyer, R A RA; Johnson, A D AD
Publication Date: 2011-03

Variant appearance in text: rs563649
PubMed Link: 21289622
Variant Present in the following documents:
  • Main text
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Recent advances in the use of opioids for cancer pain.

Journal Of Pain Research
Droney, Joanne J; Riley, Julia J
Publication Date: 2009-09-23

Variant appearance in text: rs563649
PubMed Link: 21197301
Variant Present in the following documents:
  • Main text
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Haplotype block structure of the genomic region of the mu opioid receptor gene.

Journal Of Human Genetics
Levran, Orna O; Awolesi, Olaoluwakitan O; Linzy, Shirley S; Adelson, Miriam M; Kreek, Mary Jeanne MJ
Publication Date: 2011-02

Variant appearance in text: rs563649
PubMed Link: 21160491
Variant Present in the following documents:
  • Main text
  • nihms-252057.pdf
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Nicotine withdrawal sensitivity, linkage to chr6q26, and association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) sample.

Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology
Hardin, Jill J; He, Yungang Y; Javitz, Harold S HS; Wessel, Jennifer J; Krasnow, Ruth E RE; Tildesley, Elizabeth E; Hops, Hyman H; Swan, Gary E GE; Bergen, Andrew W AW
Publication Date: 2009-12

Variant appearance in text: rs563649
PubMed Link: 19959688
Variant Present in the following documents:
  • Main text
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Do genetic predictors of pain sensitivity associate with persistent widespread pain?

Molecular Pain
Holliday, Kate L KL; Nicholl, Barbara I BI; Macfarlane, Gary J GJ; Thomson, Wendy W; Davies, Kelly A KA; McBeth, John J
Publication Date: 2009-09-23

Variant appearance in text: rs563649
PubMed Link: 19775452
Variant Present in the following documents:
  • Main text
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Expansion of the human mu-opioid receptor gene architecture: novel functional variants.

Human Molecular Genetics
Shabalina, Svetlana A SA; Zaykin, Dmitri V DV; Gris, Pavel P; Ogurtsov, Aleksey Y AY; Gauthier, Josee J; Shibata, Kyoko K; Tchivileva, Inna E IE; Belfer, Inna I; Mishra, Bikashkumar B; Kiselycznyk, Carly C; Wallace, Margaret R MR; Staud, Roland R; Spiridonov, Nikolay A NA; Max, Mitchell B MB; Goldman, David D; Fillingim, Roger B RB; Maixner, William W; Diatchenko, Luda L
Publication Date: 2009-03-15

Variant appearance in text: rs563649
PubMed Link: 19103668
Variant Present in the following documents:
  • Main text
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Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians.

Bmc Medical Genetics
Ehlers, Cindy L CL; Lind, Penelope A PA; Wilhelmsen, Kirk C KC
Publication Date: 2008-04-23

Variant appearance in text: rs563649
PubMed Link: 18433502
Variant Present in the following documents:
  • Main text
  • 1471-2350-9-35.pdf
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