Publications:

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The determination of the effect(s) of solute carrier family 22-member 2 (SLC22A2) haplotype variants on drug binding via molecular dynamic simulation systems.

Scientific Reports

Abrahams-October, Zainonesa Z; Johnson, Rabia R; Benjeddou, Mongi M; Cloete, Ruben R

Publication Date: 2022-10-08

Variant appearance in text: SLC22A2: R400C; rs8177516

PubMed Link: 36209293

Variant Present in the following documents:

• Main text
• 41598_2022_Article_21291.pdf

View BVdb publication page

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Characterization of ADME Gene Variation in Colombian Population by Exome Sequencing.

Frontiers In Pharmacology

Silgado-Guzmán, Daniel Felipe DF; Angulo-Aguado, Mariana M; Morel, Adrien A; Niño-Orrego, María José MJ; Ruiz-Torres, Daniel-Armando DA; Contreras Bravo, Nora Constanza NC; Restrepo, Carlos Martin CM; Ortega-Recalde, Oscar O; Fonseca-Mendoza, Dora Janeth DJ

Publication Date: 2022

Variant appearance in text: N/A

PubMed Link: 35846994

Variant Present in the following documents:

View BVdb publication page

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Determinants in Tailoring Antidiabetic Therapies: A Personalized Approach.

Global Medical Genetics

Rizvi, Aliya A AA; Abbas, Mohammad M; Verma, Sushma S; Verma, Shrikant S; Khan, Almas A; Raza, Syed T ST; Mahdi, Farzana F

Publication Date: 2022-06

Variant appearance in text: rs8177516

PubMed Link: 35707783

Variant Present in the following documents:

• Main text

View BVdb publication page

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Comprehensive analysis of important pharmacogenes in Koreans using the DMET™ platform.

Translational And Clinical Pharmacology

Kim, Byungwook B; Yoon, Deok Yong DY; Lee, SeungHwan S; Jang, In-Jin IJ; Yu, Kyung-Sang KS; Cho, Joo-Youn JY; Oh, Jaeseong J

Publication Date: 2021-09

Variant appearance in text: SLC22A2: 1198C>T; R400C; rs8177516

PubMed Link: 34621706

Variant Present in the following documents:

• tcp-29-135-s001.xls, sheet 1

View BVdb publication page

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The Impact of Genetic Polymorphisms in Organic Cation Transporters on Renal Drug Disposition.

International Journal Of Molecular Sciences

Zazuli, Zulfan Z; Duin, Naut J C B NJCB; Jansen, Katja K; Vijverberg, Susanne J H SJH; Maitland-van der Zee, Anke H AH; Masereeuw, Rosalinde R

Publication Date: 2020-09-10

Variant appearance in text: SLC22A2: R400C; rs8177516

PubMed Link: 32927790

Variant Present in the following documents:

• Main text
• ijms-21-06627.pdf

View BVdb publication page

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Population Pharmacokinetic and Pharmacogenetic Analysis of Mitotane in Patients with Adrenocortical Carcinoma: Towards Individualized Dosing.

Clinical Pharmacokinetics

Yin, Anyue A; Ettaieb, Madeleine H T MHT; Swen, Jesse J JJ; van Deun, Liselotte L; Kerkhofs, Thomas M A TMA; van der Straaten, Robert J H M RJHM; Corssmit, Eleonora P M EPM; Gelderblom, Hans H; Kerstens, Michiel N MN; Feelders, Richard A RA; Eekhoff, Marelise M; Timmers, Henri J L M HJLM; D'Avolio, Antonio A; Cusato, Jessica J; Guchelaar, Henk-Jan HJ; Haak, Harm R HR; Moes, Dirk Jan A R DJAR

Publication Date: 2021-01

Variant appearance in text: SLC22A2: 1198C>T; R400C; rs8177516

PubMed Link: 32607875

Variant Present in the following documents:

• 40262_2020_913_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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Genetic Diversity in Drug Transporters: Impact in African Populations.

Clinical And Translational Science

Rajman, Iris I; Knapp, Laura L; Hanna, Imad I

Publication Date: 2020-09

Variant appearance in text: SLC22A2: R400C; rs8177516

PubMed Link: 32100958

Variant Present in the following documents:

• Main text
• CTS-13-848.pdf

View BVdb publication page

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Histaminergic transmission slows progression of amyotrophic lateral sclerosis.

Journal Of Cachexia, Sarcopenia And Muscle

Apolloni, Savina S; Amadio, Susanna S; Fabbrizio, Paola P; Morello, Giovanna G; Spampinato, Antonio Gianmaria AG; Latagliata, Emanuele Claudio EC; Salvatori, Illari I; Proietti, Daisy D; Ferri, Alberto A; Madaro, Luca L; Puglisi-Allegra, Stefano S; Cavallaro, Sebastiano S; Volonté, Cinzia C

Publication Date: 2019-08

Variant appearance in text: SLC22A2: R400C

PubMed Link: 31020811

Variant Present in the following documents:

• Main text

View BVdb publication page

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Cisplatin and beyond: molecular mechanisms of action and drug resistance development in cancer chemotherapy.

Radiology And Oncology

Makovec, Tomaz T

Publication Date: 2019-03-28

Variant appearance in text: SLC22A2: 1198C>T

PubMed Link: 30956230

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genotypic and Phenotypic Factors Influencing Drug Response in Mexican Patients With Type 2 Diabetes Mellitus.

Frontiers In Pharmacology

Sanchez-Ibarra, Hector E HE; Reyes-Cortes, Luisa M LM; Jiang, Xian-Li XL; Luna-Aguirre, Claudia M CM; Aguirre-Trevino, Dionicio D; Morales-Alvarado, Ivan A IA; Leon-Cachon, Rafael B RB; Lavalle-Gonzalez, Fernando F; Morcos, Faruck F; Barrera-Saldaña, Hugo A HA

Publication Date: 2018

Variant appearance in text: SLC22A2: R400C; rs8177516

PubMed Link: 29681852

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genetic variation in biotransformation enzymes, air pollution exposures, and risk of spina bifida.

American Journal Of Medical Genetics. Part A

Padula, Amy M AM; Yang, Wei W; Schultz, Kathleen K; Lurmann, Fred F; Hammond, S Katharine SK; Shaw, Gary M GM

Publication Date: 2018-05

Variant appearance in text: rs8177516

PubMed Link: 29681089

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genetic Heterogeneity of SLC22 Family of Transporters in Drug Disposition.

Journal Of Personalized Medicine

Lozano, Elisa E; Briz, Oscar O; Macias, Rocio I R RIR; Serrano, Maria A MA; Marin, Jose J G JJG; Herraez, Elisa E

Publication Date: 2018-04-16

Variant appearance in text: SLC22A2: 1198C>T; R400C

PubMed Link: 29659532

Variant Present in the following documents:

• Main text
• jpm-08-00014.pdf

View BVdb publication page

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Molecular characterization of breast cancer cell response to metabolic drugs.

Oncotarget

Trilla-Fuertes, Lucía L; Gámez-Pozo, Angelo A; Arevalillo, Jorge M JM; Díaz-Almirón, Mariana M; Prado-Vázquez, Guillermo G; Zapater-Moros, Andrea A; Navarro, Hilario H; Aras-López, Rosa R; Dapía, Irene I; López-Vacas, Rocío R; Nanni, Paolo P; Llorente-Armijo, Sara S; Arias, Pedro P; Borobia, Alberto M AM; Maín, Paloma P; Feliú, Jaime J; Espinosa, Enrique E; Fresno Vara, Juan Ángel JÁ

Publication Date: 2018-02-09

Variant appearance in text: SLC22A2: 1198C>T; rs8177516

PubMed Link: 29515760

Variant Present in the following documents:

• Main text
• oncotarget-09-9645.pdf
• oncotarget-09-9645-s002.xlsx, sheet 1

View BVdb publication page

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Genetic variation in human drug-related genes.

Genome Medicine

Schärfe, Charlotta Pauline Irmgard CPI; Tremmel, Roman R; Schwab, Matthias M; Kohlbacher, Oliver O; Marks, Debora Susan DS

Publication Date: 2017-12-22

Variant appearance in text: rs8177516

PubMed Link: 29273096

Variant Present in the following documents:

• 13073_2017_502_MOESM2_ESM.xlsx, sheet 2

View BVdb publication page

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Clinical Implementation of Pharmacogenetic Testing in a Hospital of the Spanish National Health System: Strategy and Experience Over 3 Years.

Clinical And Translational Science

Borobia, Alberto M AM; Dapia, Irene I; Tong, Hoi Y HY; Arias, Pedro P; Muñoz, Mario M; Tenorio, Jair J; Hernández, Rafael R; García García, Irene I; Gordo, Gema G; Ramírez, Elena E; Frías, Jesús J; Lapunzina, Pablo P; Carcas, Antonio J AJ

Publication Date: 2018-03

Variant appearance in text: rs8177516

PubMed Link: 29193749

Variant Present in the following documents:

• Main text
• CTS-11-189.pdf

View BVdb publication page

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Organic Cation Transporter 2 (OCT2/SLC22A2) Gene Variation in the South African Bantu-Speaking Population and Functional Promoter Variants.

Omics : A Journal Of Integrative Biology

Wilson, Nina C NC; Choudhury, Ananyo A; Carstens, Nadia N; Mavri-Damelin, Demetra D

Publication Date: 2017-03

Variant appearance in text: SLC22A2: Arg400Cys; rs8177516

PubMed Link: 28253084

Variant Present in the following documents:

• Main text

View BVdb publication page

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Characterization of ADME gene variation in 21 populations by exome sequencing.

Pharmacogenetics And Genomics

Hovelson, Daniel H DH; Xue, Zhengyu Z; Zawistowski, Matthew M; Ehm, Margaret G MG; Harris, Elizabeth C EC; Stocker, Sophie L SL; Gross, Annette S AS; Jang, In-Jin IJ; Ieiri, Ichiro I; Lee, Jong-Eun JE; Cardon, Lon R LR; Chissoe, Stephanie L SL; Abecasis, Gonçalo G; Nelson, Matthew R MR

Publication Date: 2017-03

Variant appearance in text: SLC22A2: R400C; rs8177516

PubMed Link: 27984508

Variant Present in the following documents:

• fpc-27-089-s005.xlsx, sheet 2
• fpc-27-089-s004.xlsx, sheet 2

View BVdb publication page

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Polymorphisms in genes involved in the absorption, distribution, metabolism, and excretion of drugs in the Kazakhs of Kazakhstan.

Bmc Genetics

Iskakova, Aisha N AN; Romanova, Aliya A AA; Aitkulova, Akbota M AM; Sikhayeva, Nurgul S NS; Zholdybayeva, Elena V EV; Ramanculov, Erlan M EM

Publication Date: 2016-01-19

Variant appearance in text: rs8177516

PubMed Link: 26785747

Variant Present in the following documents:

View BVdb publication page

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Reproducible Analysis of Post-Translational Modifications in Proteomes--Application to Human Mutations.

Plos One

Holehouse, Alex S AS; Naegle, Kristen M KM

Publication Date: 2015

Variant appearance in text: rs8177516

PubMed Link: 26659599

Variant Present in the following documents:

• pone.0144692.s002.xlsx, sheet 1

View BVdb publication page

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Characterization of 137 Genomic DNA Reference Materials for 28 Pharmacogenetic Genes: A GeT-RM Collaborative Project.

The Journal Of Molecular Diagnostics : Jmd

Pratt, Victoria M VM; Everts, Robin E RE; Aggarwal, Praful P; Beyer, Brittany N BN; Broeckel, Ulrich U; Epstein-Baak, Ruth R; Hujsak, Paul P; Kornreich, Ruth R; Liao, Jun J; Lorier, Rachel R; Scott, Stuart A SA; Smith, Chingying Huang CH; Toji, Lorraine H LH; Turner, Amy A; Kalman, Lisa V LV

Publication Date: 2016-01

Variant appearance in text: SLC22A2: R400C

PubMed Link: 26621101

Variant Present in the following documents:

• Main text

View BVdb publication page

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GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics

Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J

Publication Date: 2015-07-25

Variant appearance in text: SLC22A2: R400C

PubMed Link: 26206375

Variant Present in the following documents:

• 12859_2015_673_MOESM1_ESM.xls, sheet 2

View BVdb publication page

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The Affymetrix DMET Plus platform reveals unique distribution of ADME-related variants in ethnic Arabs.

Disease Markers

Wakil, Salma M SM; Nguyen, Cao C; Muiya, Nzioka P NP; Andres, Editha E; Lykowska-Tarnowska, Agnieszka A; Baz, Batoul B; Tahir, Asma I AI; Meyer, Brian F BF; Morahan, Grant G; Dzimiri, Nduna N

Publication Date: 2015

Variant appearance in text: rs8177516

PubMed Link: 25802476

Variant Present in the following documents:

• 542543.f1.xlsx, sheet 1

View BVdb publication page

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The RPTEC/TERT1 cell line models key renal cell responses to the environmental toxicants, benzo[a]pyrene and cadmium.

Toxicology Reports

Simon, B R BR; Wilson, M J MJ; Wickliffe, J K JK

Publication Date: 2014

Variant appearance in text: rs8177516

PubMed Link: 25126521

Variant Present in the following documents:

• mmc1.xls, sheet 1

View BVdb publication page

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Screening for 392 polymorphisms in 141 pharmacogenes.

Biomedical Reports

Kim, Jason Yongha JY; Cheong, Hyun Sub HS; Park, Tae-Joon TJ; Shin, Hee Jung HJ; Seo, Doo Won DW; Na, Han Sung HS; Chung, Myeon Woo MW; Shin, Hyoung Doo HD

Publication Date: 2014-07

Variant appearance in text: SLC22A2: R400C; rs8177516

PubMed Link: 24944790

Variant Present in the following documents:

• Main text

View BVdb publication page

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An update on the pharmacogenomics of metformin: progress, problems and potential.

Pharmacogenomics

Todd, Jennifer N JN; Florez, Jose C JC

Publication Date: 2014-03

Variant appearance in text: SLC22A2: R400C

PubMed Link: 24624919

Variant Present in the following documents:

• Main text

View BVdb publication page

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Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity.

Nature Genetics

Dulak, Austin M AM; Stojanov, Petar P; Peng, Shouyong S; Lawrence, Michael S MS; Fox, Cameron C; Stewart, Chip C; Bandla, Santhoshi S; Imamura, Yu Y; Schumacher, Steven E SE; Shefler, Erica E; McKenna, Aaron A; Carter, Scott L SL; Cibulskis, Kristian K; Sivachenko, Andrey A; Saksena, Gordon G; Voet, Douglas D; Ramos, Alex H AH; Auclair, Daniel D; Thompson, Kristin K; Sougnez, Carrie C; Onofrio, Robert C RC; Guiducci, Candace C; Beroukhim, Rameen R; Zhou, Zhongren Z; Lin, Lin L; Lin, Jules J; Reddy, Rishindra R; Chang, Andrew A; Landrenau, Rodney R; Pennathur, Arjun A; Ogino, Shuji S; Luketich, James D JD; Golub, Todd R TR; Gabriel, Stacey B SB; Lander, Eric S ES; Beer, David G DG; Godfrey, Tony E TE; Getz, Gad G; Bass, Adam J AJ

Publication Date: 2013-05

Variant appearance in text: SLC22A2: R400C

PubMed Link: 23525077

Variant Present in the following documents:

• NIHMS474888-supplement-6.xlsx, sheet 1

View BVdb publication page

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Pharmacogenomics of drug metabolizing enzymes and transporters: implications for cancer therapy.

Pharmacogenomics And Personalized Medicine

Li, Jing J; Bluth, Martin H MH

Publication Date: 2011

Variant appearance in text: SLC22A2: R400C

PubMed Link: 23226051

Variant Present in the following documents:

• Main text
• pgpm-4-011.pdf

View BVdb publication page

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The pharmacogenomics of membrane transporters project: research at the interface of genomics and transporter pharmacology.

Clinical Pharmacology And Therapeutics

Kroetz, D L DL; Yee, S W SW; Giacomini, K M KM

Publication Date: 2010-01

Variant appearance in text: SLC22A2: R400C; rs8177516

PubMed Link: 19940846

Variant Present in the following documents:

• Main text

View BVdb publication page

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Identification of the endogenous key substrates of the human organic cation transporter OCT2 and their implication in function of dopaminergic neurons.

Plos One

Taubert, Dirk D; Grimberg, Gundula G; Stenzel, Werner W; Schömig, Edgar E

Publication Date: 2007-04-25

Variant appearance in text: SLC22A2: R400C

PubMed Link: 17460754

Variant Present in the following documents:

• Main text
• pone.0000385.pdf

View BVdb publication page

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Human pharmacogenomic variations and their implications for antifungal efficacy.

Clinical Microbiology Reviews

Meletiadis, Joseph J; Chanock, Stephen S; Walsh, Thomas J TJ

Publication Date: 2006-10

Variant appearance in text: SLC22A2: R400C

PubMed Link: 17041143

Variant Present in the following documents:

• Main text

View BVdb publication page

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