LPA c.4632-6923C>T

Variant ID: 6-160985526-G-A

NM_005577.2(LPA):c.4632-6923C>T

This variant was identified in 17 publications

View GRCh38 version.




Publications:


Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells.

Plos Genetics
Wünnemann, Florian F; Fotsing Tadjo, Thierry T; Beaudoin, Mélissa M; Lalonde, Simon S; Lo, Ken Sin KS; Kleinstiver, Benjamin P BP; Lettre, Guillaume G
Publication Date: 2023-03-16

Variant appearance in text: rs118039278
PubMed Link: 36928188
Variant Present in the following documents:
  • Main text
  • pgen.1010680.pdf
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Are Alzheimer's and coronary artery diseases genetically related to longevity?

Frontiers In Psychiatry
Bellou, Eftychia E; Escott-Price, Valentina V
Publication Date: 2022

Variant appearance in text: rs118039278
PubMed Link: 36684006
Variant Present in the following documents:
  • fpsyt-13-1102347.pdf
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Identification of a miRSNP Regulatory Axis in Abdominal Aortic Aneurysm by a Network and Pathway-Based Integrative Analysis.

Oxidative Medicine And Cellular Longevity
Liu, Shenrong S; Liao, Yanfen Y; Liu, Changsong C; Zhou, Haobin H; Chen, Gui G; Lu, Weiling W; Huang, Zheng Z
Publication Date: 2022

Variant appearance in text: rs118039278
PubMed Link: 36275900
Variant Present in the following documents:
  • OMCL2022-8776566.pdf
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Inflammatory and Prothrombotic Biomarkers, DNA Polymorphisms, MicroRNAs and Personalized Medicine for Patients with Peripheral Arterial Disease.

International Journal Of Molecular Sciences
Poredoš, Pavel P; Šabovič, Mišo M; Božič Mijovski, Mojca M; Nikolajević, Jovana J; Antignani, Pier Luigi PL; Paraskevas, Kosmas I KI; Mikhailidis, Dimitri P DP; Blinc, Aleš A
Publication Date: 2022-10-10

Variant appearance in text: rs118039278
PubMed Link: 36233355
Variant Present in the following documents:
  • Main text
  • ijms-23-12054.pdf
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Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study.

Human Molecular Genetics
Portilla-Fernandez, Eliana E; Klarin, Derek D; Hwang, Shih-Jen SJ; Biggs, Mary L ML; Bis, Joshua C JC; Weiss, Stefan S; Rospleszcz, Susanne S; Natarajan, Pradeep P; Hoffmann, Udo U; Rogers, Ian S IS; Truong, Quynh A QA; Völker, Uwe U; Dörr, Marcus M; Bülow, Robin R; Criqui, Michael H MH; Allison, Matthew M; Ganesh, Santhi K SK; Yao, Jie J; Waldenberger, Melanie M; Bamberg, Fabian F; Rice, Kenneth M KM; Essers, Jeroen J; Kapteijn, Daniek M C DMC; van der Laan, Sander W SW; de Knegt, Rob J RJ; Ghanbari, Mohsen M; Felix, Janine F JF; Ikram, M Arfan MA; Kavousi, Maryam M; Uitterlinden, Andre G AG; Roks, Anton J M AJM; Danser, A H Jan AHJ; Tsao, Philip S PS; Damrauer, Scott M SM; Guo, Xiuqing X; Rotter, Jerome I JI; Psaty, Bruce M BM; Kathiresan, Sekar S; Völzke, Henry H; Peters, Annette A; Johnson, Craig C; Strauch, Konstantin K; Meitinger, Thomas T; O'Donnell, Christopher J CJ; Dehghan, Abbas A; ,
Publication Date: 2022-10-10

Variant appearance in text: rs118039278
PubMed Link: 35234888
Variant Present in the following documents:
  • Main text
  • ddac051.pdf
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A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts.

Nature Genetics
Veturi, Yogasudha Y; Lucas, Anastasia A; Bradford, Yuki Y; Hui, Daniel D; Dudek, Scott S; Theusch, Elizabeth E; Verma, Anurag A; Miller, Jason E JE; Kullo, Iftikhar I; Hakonarson, Hakon H; Sleiman, Patrick P; Schaid, Daniel D; Stein, Charles M CM; Edwards, Digna R Velez DRV; Feng, QiPing Q; Wei, Wei-Qi WQ; Medina, Marisa W MW; Krauss, Ronald M RM; Hoffmann, Thomas J TJ; Risch, Neil N; Voight, Benjamin F BF; Rader, Daniel J DJ; Ritchie, Marylyn D MD
Publication Date: 2021-07

Variant appearance in text: rs118039278
PubMed Link: 34140684
Variant Present in the following documents:
  • Main text
  • nihms-1701163.pdf
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A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts.

Nature Genetics
Veturi, Yogasudha Y; Lucas, Anastasia A; Bradford, Yuki Y; Hui, Daniel D; Dudek, Scott S; Theusch, Elizabeth E; Verma, Anurag A; Miller, Jason E JE; Kullo, Iftikhar I; Hakonarson, Hakon H; Sleiman, Patrick P; Schaid, Daniel D; Stein, Charles M CM; Edwards, Digna R Velez DRV; Feng, QiPing Q; Wei, Wei-Qi WQ; Medina, Marisa W MW; Krauss, Ronald M RM; Hoffmann, Thomas J TJ; Risch, Neil N; Voight, Benjamin F BF; Rader, Daniel J DJ; Ritchie, Marylyn D MD
Publication Date: 2021-07

Variant appearance in text: rs118039278
PubMed Link: 34140684
Variant Present in the following documents:
  • Main text
  • nihms-1701163.pdf
View BVdb publication page



Genetics of 35 blood and urine biomarkers in the UK Biobank.

Nature Genetics
Sinnott-Armstrong, Nasa N; Tanigawa, Yosuke Y; Amar, David D; Mars, Nina N; Benner, Christian C; Aguirre, Matthew M; Venkataraman, Guhan Ram GR; Wainberg, Michael M; Ollila, Hanna M HM; Kiiskinen, Tuomo T; Havulinna, Aki S AS; Pirruccello, James P JP; Qian, Junyang J; Shcherbina, Anna A; , ; Rodriguez, Fatima F; Assimes, Themistocles L TL; Agarwala, Vineeta V; Tibshirani, Robert R; Hastie, Trevor T; Ripatti, Samuli S; Pritchard, Jonathan K JK; Daly, Mark J MJ; Rivas, Manuel A MA
Publication Date: 2021-02

Variant appearance in text: LPA: 4632-6923C>T; rs118039278
PubMed Link: 33462484
Variant Present in the following documents:
  • NIHMS1651539-supplement-2.xlsx, sheet 21
View BVdb publication page



Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program.

Circulation
Klarin, Derek D; Verma, Shefali Setia SS; Judy, Renae R; Dikilitas, Ozan O; Wolford, Brooke N BN; Paranjpe, Ishan I; Levin, Michael G MG; Pan, Cuiping C; Tcheandjieu, Catherine C; Spin, Joshua M JM; Lynch, Julie J; Assimes, Themistocles L TL; Åldstedt Nyrønning, Linn L; Mattsson, Erney E; Edwards, Todd L TL; Denny, Josh J; Larson, Eric E; Lee, Ming Ta Michael MTM; Carrell, David D; Zhang, Yanfei Y; Jarvik, Gail P GP; Gharavi, Ali G AG; Harley, John J; Mentch, Frank F; Pacheco, Jennifer A JA; Hakonarson, Hakon H; Skogholt, Anne Heidi AH; Thomas, Laurent L; Gabrielsen, Maiken Elvestad ME; Hveem, Kristian K; Nielsen, Jonas Bille JB; Zhou, Wei W; Fritsche, Lars L; Huang, Jie J; Natarajan, Pradeep P; Sun, Yan V YV; DuVall, Scott L SL; Rader, Daniel J DJ; Cho, Kelly K; Chang, Kyong-Mi KM; Wilson, Peter W F PWF; O'Donnell, Christopher J CJ; Kathiresan, Sekar S; Scali, Salvatore T ST; Berceli, Scott A SA; Willer, Cristen C; Jones, Gregory T GT; Bown, Matthew J MJ; Nadkarni, Girish G; Kullo, Iftikhar J IJ; Ritchie, Marylyn M; Damrauer, Scott M SM; Tsao, Philip S PS; ,
Publication Date: 2020-10-27

Variant appearance in text: rs118039278
PubMed Link: 32981348
Variant Present in the following documents:
  • cir-142-1633.pdf
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Loci identified by a genome-wide association study of carotid artery stenosis in the eMERGE network.

Genetic Epidemiology
Palmer, Melody R MR; Kim, Daniel S DS; Crosslin, David R DR; Stanaway, Ian B IB; Rosenthal, Elisabeth A EA; Carrell, David S DS; Cronkite, David J DJ; Gordon, Adam A; Du, Xiaomeng X; Li, Yatong K YK; Williams, Marc S MS; Weng, Chunhua C; Feng, Qiping Q; Li, Rongling R; Pendergrass, Sarah A SA; Hakonarson, Hakon H; Fasel, David D; Sohn, Sunghwan S; Sleiman, Patrick P; Handelman, Samuel K SK; Speliotes, Elizabeth E; Kullo, Iftikhar J IJ; Larson, Eric B EB; , ; Jarvik, Gail P GP
Publication Date: 2021-02

Variant appearance in text: rs118039278
PubMed Link: 32964493
Variant Present in the following documents:
  • Main text
View BVdb publication page



A genome-wide analysis of DNA methylation identifies a novel association signal for Lp(a) concentrations in the LPA promoter.

Plos One
Coassin, Stefan S; Hermann-Kleiter, Natascha N; Haun, Margot M; Wahl, Simone S; Wilson, Rory R; Paulweber, Bernhard B; Kunze, Sonja S; Meitinger, Thomas T; Strauch, Konstantin K; Peters, Annette A; Waldenberger, Melanie M; Kronenberg, Florian F; Lamina, Claudia C
Publication Date: 2020

Variant appearance in text: rs118039278
PubMed Link: 32343731
Variant Present in the following documents:
  • Main text
  • pone.0232073.pdf
View BVdb publication page



DNA methylation profiling identifies a high effect genetic variant for lipoprotein(a) levels.

Epigenetics
Jones, Gregory T GT; Marsman, Judith J; Bhat, Basharat B; Phillips, Victoria L VL; Chatterjee, Aniruddha A; Rodger, Euan J EJ; Williams, Michael J A MJA; van Rij, André M AM; McCormick, Sally P A SPA
Publication Date: 2020-09

Variant appearance in text: rs118039278
PubMed Link: 32237968
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk: A Mendelian Randomization Analysis.

Jama Network Open
Arsenault, Benoit J BJ; Pelletier, William W; Kaiser, Yannick Y; Perrot, Nicolas N; Couture, Christian C; Khaw, Kay-Tee KT; Wareham, Nicholas J NJ; Bossé, Yohan Y; Pibarot, Philippe P; Stroes, Erik S G ESG; Mathieu, Patrick P; Thériault, Sébastien S; Boekholdt, S Matthijs SM
Publication Date: 2020-02-05

Variant appearance in text: rs118039278
PubMed Link: 32108890
Variant Present in the following documents:
  • jamanetwopen-3-e200129-s001.pdf
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Genome-wide association study of peripheral artery disease in the Million Veteran Program.

Nature Medicine
Klarin, Derek D; Lynch, Julie J; Aragam, Krishna K; Chaffin, Mark M; Assimes, Themistocles L TL; Huang, Jie J; Lee, Kyung Min KM; Shao, Qing Q; Huffman, Jennifer E JE; Natarajan, Pradeep P; Arya, Shipra S; Small, Aeron A; Sun, Yan V YV; Vujkovic, Marijana M; Freiberg, Matthew S MS; Wang, Lu L; Chen, Jinbo J; Saleheen, Danish D; Lee, Jennifer S JS; Miller, Donald R DR; Reaven, Peter P; Alba, Patrick R PR; Patterson, Olga V OV; DuVall, Scott L SL; Boden, William E WE; Beckman, Joshua A JA; Gaziano, J Michael JM; Concato, John J; Rader, Daniel J DJ; Cho, Kelly K; Chang, Kyong-Mi KM; Wilson, Peter W F PWF; O'Donnell, Christopher J CJ; Kathiresan, Sekar S; , ; Tsao, Philip S PS; Damrauer, Scott M SM
Publication Date: 2019-08

Variant appearance in text: rs118039278
PubMed Link: 31285632
Variant Present in the following documents:
  • Main text
  • nihms-1529756.pdf
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Meta-analysis of genome-wide association studies of aggressive and chronic periodontitis identifies two novel risk loci.

European Journal Of Human Genetics : Ejhg
Munz, Matthias M; Richter, Gesa M GM; Loos, Bruno G BG; Jepsen, Søren S; Divaris, Kimon K; Offenbacher, Steven S; Teumer, Alexander A; Holtfreter, Birte B; Kocher, Thomas T; Bruckmann, Corinna C; Jockel-Schneider, Yvonne Y; Graetz, Christian C; Ahmad, Ilyas I; Staufenbiel, Ingmar I; van der Velde, Nathalie N; Uitterlinden, André G AG; de Groot, Lisette C P G M LCPGM; Wellmann, Jürgen J; Berger, Klaus K; Krone, Bastian B; Hoffmann, Per P; Laudes, Matthias M; Lieb, Wolfgang W; Franke, Andre A; Erdmann, Jeanette J; Dommisch, Henrik H; Schaefer, Arne S AS
Publication Date: 2019-01

Variant appearance in text: rs118039278
PubMed Link: 30218097
Variant Present in the following documents:
  • Main text
View BVdb publication page



Whole genome sequencing identifies high-impact variants in well-known pharmacogenomic genes.

The Pharmacogenomics Journal
Choi, Jihoon J; Tantisira, Kelan G KG; Duan, Qing Ling QL
Publication Date: 2019-04

Variant appearance in text: rs118039278
PubMed Link: 30214008
Variant Present in the following documents:
  • NIHMS1503453-supplement-3.xlsx, sheet 1
View BVdb publication page



LPA Variants Are Associated With Residual Cardiovascular Risk in Patients Receiving Statins.

Circulation
Wei, Wei-Qi WQ; Li, Xiaohui X; Feng, Qiping Q; Kubo, Michiaki M; Kullo, Iftikhar J IJ; Peissig, Peggy L PL; Karlson, Elizabeth W EW; Jarvik, Gail P GP; Lee, Ming Ta Michael MTM; Shang, Ning N; Larson, Eric A EA; Edwards, Todd T; Shaffer, Christian M CM; Mosley, Jonathan D JD; Maeda, Shiro S; Horikoshi, Momoko M; Ritchie, Marylyn M; Williams, Marc S MS; Larson, Eric B EB; Crosslin, David R DR; Bland, Sarah T ST; Pacheco, Jennifer A JA; Rasmussen-Torvik, Laura J LJ; Cronkite, David D; Hripcsak, George G; Cox, Nancy J NJ; Wilke, Russell A RA; Stein, C Michael CM; Rotter, Jerome I JI; Momozawa, Yukihide Y; Roden, Dan M DM; Krauss, Ronald M RM; Denny, Joshua C JC
Publication Date: 2018-10-23

Variant appearance in text: rs118039278
PubMed Link: 29703846
Variant Present in the following documents:
  • Main text
View BVdb publication page



A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms.

Journal Of Lipid Research
Mack, Salome S; Coassin, Stefan S; Rueedi, Rico R; Yousri, Noha A NA; Seppälä, Ilkka I; Gieger, Christian C; Schönherr, Sebastian S; Forer, Lukas L; Erhart, Gertraud G; Marques-Vidal, Pedro P; Ried, Janina S JS; Waeber, Gerard G; Bergmann, Sven S; Dähnhardt, Doreen D; Stöckl, Andrea A; Raitakari, Olli T OT; Kähönen, Mika M; Peters, Annette A; Meitinger, Thomas T; Strauch, Konstantin K; Kedenko, Ludmilla L; Paulweber, Bernhard B; Lehtimäki, Terho T; Hunt, Steven C SC; Vollenweider, Peter P; Lamina, Claudia C; Kronenberg, Florian F
Publication Date: 2017-09

Variant appearance in text: rs118039278
PubMed Link: 28512139
Variant Present in the following documents:
  • Main text
  • 10.1194_M076232_jlr.M076232-1.pdf
  • jlrM076232.pdf
View BVdb publication page



A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms.

Journal Of Lipid Research
Mack, Salome S; Coassin, Stefan S; Rueedi, Rico R; Yousri, Noha A NA; Seppälä, Ilkka I; Gieger, Christian C; Schönherr, Sebastian S; Forer, Lukas L; Erhart, Gertraud G; Marques-Vidal, Pedro P; Ried, Janina S JS; Waeber, Gerard G; Bergmann, Sven S; Dähnhardt, Doreen D; Stöckl, Andrea A; Raitakari, Olli T OT; Kähönen, Mika M; Peters, Annette A; Meitinger, Thomas T; Strauch, Konstantin K; , ; Kedenko, Ludmilla L; Paulweber, Bernhard B; Lehtimäki, Terho T; Hunt, Steven C SC; Vollenweider, Peter P; Lamina, Claudia C; Kronenberg, Florian F
Publication Date: 2017-09

Variant appearance in text: rs118039278
PubMed Link: 28512139
Variant Present in the following documents:
  • Main text
  • 10.1194_M076232_jlr.M076232-1.pdf
  • jlrM076232.pdf
View BVdb publication page