Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease.
Nature Communications
Nielsen, Jonas B JB; Rom, Oren O; Surakka, Ida I; Graham, Sarah E SE; Zhou, Wei W; Roychowdhury, Tanmoy T; Fritsche, Lars G LG; Gagliano Taliun, Sarah A SA; Sidore, Carlo C; Liu, Yuhao Y; Gabrielsen, Maiken E ME; Skogholt, Anne Heidi AH; Wolford, Brooke B; Overton, William W; Zhao, Ying Y; Chen, Jin J; Zhang, He H; Hornsby, Whitney E WE; Acheampong, Akua A; Grooms, Austen A; Schaefer, Amanda A; Zajac, Gregory J M GJM; Villacorta, Luis L; Zhang, Jifeng J; Brumpton, Ben B; Løset, Mari M; Rai, Vivek V; Lundegaard, Pia R PR; Olesen, Morten S MS; Taylor, Kent D KD; Palmer, Nicholette D ND; Chen, Yii-Der YD; Choi, Seung H SH; Lubitz, Steven A SA; Ellinor, Patrick T PT; Barnes, Kathleen C KC; Daya, Michelle M; Rafaels, Nicholas N; Weiss, Scott T ST; Lasky-Su, Jessica J; Tracy, Russell P RP; Vasan, Ramachandran S RS; Cupples, L Adrienne LA; Mathias, Rasika A RA; Yanek, Lisa R LR; Becker, Lewis C LC; Peyser, Patricia A PA; Bielak, Lawrence F LF; Smith, Jennifer A JA; Aslibekyan, Stella S; Hidalgo, Bertha A BA; Arnett, Donna K DK; Irvin, Marguerite R MR; Wilson, James G JG; Musani, Solomon K SK; Correa, Adolfo A; Rich, Stephen S SS; Guo, Xiuqing X; Rotter, Jerome I JI; Konkle, Barbara A BA; Johnsen, Jill M JM; Ashley-Koch, Allison E AE; Telen, Marilyn J MJ; Sheehan, Vivien A VA; Blangero, John J; Curran, Joanne E JE; Peralta, Juan M JM; Montgomery, Courtney C; Sheu, Wayne H-H WH; Chung, Ren-Hua RH; Schwander, Karen K; Nouraie, Seyed M SM; Gordeuk, Victor R VR; Zhang, Yingze Y; Kooperberg, Charles C; Reiner, Alexander P AP; Jackson, Rebecca D RD; Bleecker, Eugene R ER; Meyers, Deborah A DA; Li, Xingnan X; Das, Sayantan S; Yu, Ketian K; LeFaive, Jonathon J; Smith, Albert A; Blackwell, Tom T; Taliun, Daniel D; Zollner, Sebastian S; Forer, Lukas L; Schoenherr, Sebastian S; Fuchsberger, Christian C; Pandit, Anita A; Zawistowski, Matthew M; Kheterpal, Sachin S; Brummett, Chad M CM; Natarajan, Pradeep P; Schlessinger, David D; Lee, Seunggeun S; Kang, Hyun Min HM; Cucca, Francesco F; Holmen, Oddgeir L OL; Åsvold, Bjørn O BO; Boehnke, Michael M; Kathiresan, Sekar S; Abecasis, Goncalo R GR; Chen, Y Eugene YE; Willer, Cristen J CJ; Hveem, Kristian K
Loci identified by a genome-wide association study of carotid artery stenosis in the eMERGE network.
Genetic Epidemiology
Palmer, Melody R MR; Kim, Daniel S DS; Crosslin, David R DR; Stanaway, Ian B IB; Rosenthal, Elisabeth A EA; Carrell, David S DS; Cronkite, David J DJ; Gordon, Adam A; Du, Xiaomeng X; Li, Yatong K YK; Williams, Marc S MS; Weng, Chunhua C; Feng, Qiping Q; Li, Rongling R; Pendergrass, Sarah A SA; Hakonarson, Hakon H; Fasel, David D; Sohn, Sunghwan S; Sleiman, Patrick P; Handelman, Samuel K SK; Speliotes, Elizabeth E; Kullo, Iftikhar J IJ; Larson, Eric B EB; , ; Jarvik, Gail P GP
Genome-wide association study on coronary artery disease in type 1 diabetes suggests beta-defensin 127 as a risk locus.
Cardiovascular Research
Antikainen, Anni A V AAV; Sandholm, Niina N; Trégouët, David-Alexandre DA; Charmet, Romain R; McKnight, Amy Jayne AJ; Ahluwalia, Tarunveer S TS; Syreeni, Anna A; Valo, Erkka E; Forsblom, Carol C; Gordin, Daniel D; Harjutsalo, Valma V; Hadjadj, Samy S; Maxwell, Alexander P AP; Rossing, Peter P; Groop, Per-Henrik PH
Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.
Nature Communications
Zekavat, Seyedeh M SM; Ruotsalainen, Sanni S; Handsaker, Robert E RE; Alver, Maris M; Bloom, Jonathan J; Poterba, Timothy T; Seed, Cotton C; Ernst, Jason J; Chaffin, Mark M; Engreitz, Jesse J; Peloso, Gina M GM; Manichaikul, Ani A; Yang, Chaojie C; Ryan, Kathleen A KA; Fu, Mao M; Johnson, W Craig WC; Tsai, Michael M; Budoff, Matthew M; Vasan, Ramachandran S RS; Cupples, L Adrienne LA; Rotter, Jerome I JI; Rich, Stephen S SS; Post, Wendy W; Mitchell, Braxton D BD; Correa, Adolfo A; Metspalu, Andres A; Wilson, James G JG; Salomaa, Veikko V; Kellis, Manolis M; Daly, Mark J MJ; Neale, Benjamin M BM; McCarroll, Steven S; Surakka, Ida I; Esko, Tonu T; Ganna, Andrea A; Ripatti, Samuli S; Kathiresan, Sekar S; Natarajan, Pradeep P; ,
LPA Variants Are Associated With Residual Cardiovascular Risk in Patients Receiving Statins.
Circulation
Wei, Wei-Qi WQ; Li, Xiaohui X; Feng, Qiping Q; Kubo, Michiaki M; Kullo, Iftikhar J IJ; Peissig, Peggy L PL; Karlson, Elizabeth W EW; Jarvik, Gail P GP; Lee, Ming Ta Michael MTM; Shang, Ning N; Larson, Eric A EA; Edwards, Todd T; Shaffer, Christian M CM; Mosley, Jonathan D JD; Maeda, Shiro S; Horikoshi, Momoko M; Ritchie, Marylyn M; Williams, Marc S MS; Larson, Eric B EB; Crosslin, David R DR; Bland, Sarah T ST; Pacheco, Jennifer A JA; Rasmussen-Torvik, Laura J LJ; Cronkite, David D; Hripcsak, George G; Cox, Nancy J NJ; Wilke, Russell A RA; Stein, C Michael CM; Rotter, Jerome I JI; Momozawa, Yukihide Y; Roden, Dan M DM; Krauss, Ronald M RM; Denny, Joshua C JC
A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis.
Nature Communications
Thériault, Sébastien S; Gaudreault, Nathalie N; Lamontagne, Maxime M; Rosa, Mickael M; Boulanger, Marie-Chloé MC; Messika-Zeitoun, David D; Clavel, Marie-Annick MA; Capoulade, Romain R; Dagenais, François F; Pibarot, Philippe P; Mathieu, Patrick P; Bossé, Yohan Y
Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants.
Genome Medicine
Nagy, Reka R; Boutin, Thibaud S TS; Marten, Jonathan J; Huffman, Jennifer E JE; Kerr, Shona M SM; Campbell, Archie A; Evenden, Louise L; Gibson, Jude J; Amador, Carmen C; Howard, David M DM; Navarro, Pau P; Morris, Andrew A; Deary, Ian J IJ; Hocking, Lynne J LJ; Padmanabhan, Sandosh S; Smith, Blair H BH; Joshi, Peter P; Wilson, James F JF; Hastie, Nicholas D ND; Wright, Alan F AF; McIntosh, Andrew M AM; Porteous, David J DJ; Haley, Chris S CS; Vitart, Veronique V; Hayward, Caroline C