Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis.
Nature Communications
Han, Younghun Y; Byun, Jinyoung J; Zhu, Catherine C; Sun, Ryan R; Roh, Julia Y JY; Cordell, Heather J HJ; Lee, Hyun-Sung HS; Shaw, Vikram R VR; Kang, Sung Wook SW; Razjouyan, Javad J; Cooley, Matthew A MA; Hassan, Manal M MM; Siminovitch, Katherine A KA; Folseraas, Trine T; Ellinghaus, David D; Bergquist, Annika A; Rushbrook, Simon M SM; Franke, Andre A; Karlsen, Tom H TH; Lazaridis, Konstantinos N KN; , ; McGlynn, Katherine A KA; Roberts, Lewis R LR; Amos, Christopher I CI
A genome-wide association study of bronchodilator response in participants of European and African ancestry from six independent cohorts.
Erj Open Research
Gereige, Jessica D JD; Xu, Hanfei H; Ortega, Victor E VE; Cho, Michael H MH; Liu, Ming M; Sakornsakolpat, Phuwanat P; Silverman, Edwin K EK; Beaty, Terri H TH; Miller, Bruce E BE; Bakke, Per P; Gulsvik, Amund A; Hersh, Craig P CP; Morrow, Jarrett D JD; , ; Ampleford, Elizabeth J EJ; Hawkins, Gregory A GA; Bleecker, Eugene R ER; Meyers, Deborah A DA; Peters, Stephen P SP; Celedón, Juan C JC; Tantisira, Kelan K; Li, Jiang J; Dupuis, Josée J; O'Connor, George T GT
A genome-wide association study of serum proteins reveals shared loci with common diseases.
Nature Communications
Gudjonsson, Alexander A; Gudmundsdottir, Valborg V; Axelsson, Gisli T GT; Gudmundsson, Elias F EF; Jonsson, Brynjolfur G BG; Launer, Lenore J LJ; Lamb, John R JR; Jennings, Lori L LL; Aspelund, Thor T; Emilsson, Valur V; Gudnason, Vilmundur V
A genome-wide association study of serum proteins reveals shared loci with common diseases.
Nature Communications
Gudjonsson, Alexander A; Gudmundsdottir, Valborg V; Axelsson, Gisli T GT; Gudmundsson, Elias F EF; Jonsson, Brynjolfur G BG; Launer, Lenore J LJ; Lamb, John R JR; Jennings, Lori L LL; Aspelund, Thor T; Emilsson, Valur V; Gudnason, Vilmundur V
Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.
Nature Communications
Daya, Michelle M; Rafaels, Nicholas N; Brunetti, Tonya M TM; Chavan, Sameer S; Levin, Albert M AM; Shetty, Aniket A; Gignoux, Christopher R CR; Boorgula, Meher Preethi MP; Wojcik, Genevieve G; Campbell, Monica M; Vergara, Candelaria C; Torgerson, Dara G DG; Ortega, Victor E VE; Doumatey, Ayo A; Johnston, Henry Richard HR; Acevedo, Nathalie N; Araujo, Maria Ilma MI; Avila, Pedro C PC; Belbin, Gillian G; Bleecker, Eugene E; Bustamante, Carlos C; Caraballo, Luis L; Cruz, Alvaro A; Dunston, Georgia M GM; Eng, Celeste C; Faruque, Mezbah U MU; Ferguson, Trevor S TS; Figueiredo, Camila C; Ford, Jean G JG; Gan, Weiniu W; Gourraud, Pierre-Antoine PA; Hansel, Nadia N NN; Hernandez, Ryan D RD; Herrera-Paz, Edwin Francisco EF; Jiménez, Silvia S; Kenny, Eimear E EE; Knight-Madden, Jennifer J; Kumar, Rajesh R; Lange, Leslie A LA; Lange, Ethan M EM; Lizee, Antoine A; Maul, Pissamai P; Maul, Trevor T; Mayorga, Alvaro A; Meyers, Deborah D; Nicolae, Dan L DL; O'Connor, Timothy D TD; Oliveira, Ricardo Riccio RR; Olopade, Christopher O CO; Olopade, Olufunmilayo O; Qin, Zhaohui S ZS; Rotimi, Charles C; Vince, Nicolas N; Watson, Harold H; Wilks, Rainford J RJ; Wilson, James G JG; Salzberg, Steven S; Ober, Carole C; Burchard, Esteban G EG; Williams, L Keoki LK; Beaty, Terri H TH; Taub, Margaret A MA; Ruczinski, Ingo I; Mathias, Rasika A RA; Barnes, Kathleen C KC; ,
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Nature Genetics
Demenais, Florence F; Margaritte-Jeannin, Patricia P; Barnes, Kathleen C KC; Cookson, William O C WOC; Altmüller, Janine J; Ang, Wei W; Barr, R Graham RG; Beaty, Terri H TH; Becker, Allan B AB; Beilby, John J; Bisgaard, Hans H; Bjornsdottir, Unnur Steina US; Bleecker, Eugene E; Bønnelykke, Klaus K; Boomsma, Dorret I DI; Bouzigon, Emmanuelle E; Brightling, Christopher E CE; Brossard, Myriam M; Brusselle, Guy G GG; Burchard, Esteban E; Burkart, Kristin M KM; Bush, Andrew A; Chan-Yeung, Moira M; Chung, Kian Fan KF; Couto Alves, Alexessander A; Curtin, John A JA; Custovic, Adnan A; Daley, Denise D; de Jongste, Johan C JC; Del-Rio-Navarro, Blanca E BE; Donohue, Kathleen M KM; Duijts, Liesbeth L; Eng, Celeste C; Eriksson, Johan G JG; Farrall, Martin M; Fedorova, Yuliya Y; Feenstra, Bjarke B; Ferreira, Manuel A MA; , ; Freidin, Maxim B MB; Gajdos, Zofia Z; Gauderman, Jim J; Gehring, Ulrike U; Geller, Frank F; Genuneit, Jon J; Gharib, Sina A SA; Gilliland, Frank F; Granell, Raquel R; Graves, Penelope E PE; Gudbjartsson, Daniel F DF; Haahtela, Tari T; Heckbert, Susan R SR; Heederik, Dick D; Heinrich, Joachim J; Heliövaara, Markku M; Henderson, John J; Himes, Blanca E BE; Hirose, Hiroshi H; Hirschhorn, Joel N JN; Hofman, Albert A; Holt, Patrick P; Hottenga, Jouke J; Hudson, Thomas J TJ; Hui, Jennie J; Imboden, Medea M; Ivanov, Vladimir V; Jaddoe, Vincent W V VWV; James, Alan A; Janson, Christer C; Jarvelin, Marjo-Riitta MR; Jarvis, Deborah D; Jones, Graham G; Jonsdottir, Ingileif I; Jousilahti, Pekka P; Kabesch, Michael M; Kähönen, Mika M; Kantor, David B DB; Karunas, Alexandra S AS; Khusnutdinova, Elza E; Koppelman, Gerard H GH; Kozyrskyj, Anita L AL; Kreiner, Eskil E; Kubo, Michiaki M; Kumar, Rajesh R; Kumar, Ashish A; Kuokkanen, Mikko M; Lahousse, Lies L; Laitinen, Tarja T; Laprise, Catherine C; Lathrop, Mark M; Lau, Susanne S; Lee, Young-Ae YA; Lehtimäki, Terho T; Letort, Sébastien S; Levin, Albert M AM; Li, Guo G; Liang, Liming L; Loehr, Laura R LR; London, Stephanie J SJ; Loth, Daan W DW; Manichaikul, Ani A; Marenholz, Ingo I; Martinez, Fernando J FJ; Matheson, Melanie C MC; Mathias, Rasika A RA; Matsumoto, Kenji K; Mbarek, Hamdi H; McArdle, Wendy L WL; Melbye, Mads M; Melén, Erik E; Meyers, Deborah D; Michel, Sven S; Mohamdi, Hamida H; Musk, Arthur W AW; Myers, Rachel A RA; Nieuwenhuis, Maartje A E MAE; Noguchi, Emiko E; O'Connor, George T GT; Ogorodova, Ludmila M LM; Palmer, Cameron D CD; Palotie, Aarno A; Park, Julie E JE; Pennell, Craig E CE; Pershagen, Göran G; Polonikov, Alexey A; Postma, Dirkje S DS; Probst-Hensch, Nicole N; Puzyrev, Valery P VP; Raby, Benjamin A BA; Raitakari, Olli T OT; Ramasamy, Adaikalavan A; Rich, Stephen S SS; Robertson, Colin F CF; Romieu, Isabelle I; Salam, Muhammad T MT; Salomaa, Veikko V; Schlünssen, Vivi V; Scott, Robert R; Selivanova, Polina A PA; Sigsgaard, Torben T; Simpson, Angela A; Siroux, Valérie V; Smith, Lewis J LJ; Solodilova, Maria M; Standl, Marie M; Stefansson, Kari K; Strachan, David P DP; Stricker, Bruno H BH; Takahashi, Atsushi A; Thompson, Philip J PJ; Thorleifsson, Gudmar G; Thorsteinsdottir, Unnur U; Tiesler, Carla M T CMT; Torgerson, Dara G DG; Tsunoda, Tatsuhiko T; Uitterlinden, André G AG; van der Valk, Ralf J P RJP; Vaysse, Amaury A; Vedantam, Sailaja S; von Berg, Andrea A; von Mutius, Erika E; Vonk, Judith M JM; Waage, Johannes J; Wareham, Nick J NJ; Weiss, Scott T ST; White, Wendy B WB; Wickman, Magnus M; Widén, Elisabeth E; Willemsen, Gonneke G; Williams, L Keoki LK; Wouters, Inge M IM; Yang, James J JJ; Zhao, Jing Hua JH; Moffatt, Miriam F MF; Ober, Carole C; Nicolae, Dan L DL
Generating testable hypotheses for schizophrenia and rheumatoid arthritis pathogenesis by integrating epidemiological, genomic, and protein interaction data.
Npj Schizophrenia
Malavia, Tulsi A TA; Chaparala, Srilakshmi S; Wood, Joel J; Chowdari, Kodavali K; Prasad, Konasale M KM; McClain, Lora L; Jegga, Anil G AG; Ganapathiraju, Madhavi K MK; Nimgaonkar, Vishwajit L VL
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
Genes And Immunity
Armstrong, D L DL; Zidovetzki, R R; Alarcón-Riquelme, M E ME; Tsao, B P BP; Criswell, L A LA; Kimberly, R P RP; Harley, J B JB; Sivils, K L KL; Vyse, T J TJ; Gaffney, P M PM; Langefeld, C D CD; Jacob, C O CO
Pedigree and genotyping quality analyses of over 10,000 DNA samples from the Generation Scotland: Scottish Family Health Study.
Bmc Medical Genetics
Kerr, Shona M SM; Campbell, Archie A; Murphy, Lee L; Hayward, Caroline C; Jackson, Cathy C; Wain, Louise V LV; Tobin, Martin D MD; Dominiczak, Anna A; Morris, Andrew A; Smith, Blair H BH; Porteous, David J DJ
Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases.
Diabetologia
Howson, J M M JM; Krause, S S; Stevens, H H; Smyth, D J DJ; Wenzlau, J M JM; Bonifacio, E E; Hutton, J J; Ziegler, A G AG; Todd, J A JA; Achenbach, P P
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
Nature Genetics
Soler Artigas, María M; Loth, Daan W DW; Wain, Louise V LV; Gharib, Sina A SA; Obeidat, Ma'en M; Tang, Wenbo W; Zhai, Guangju G; Zhao, Jing Hua JH; Smith, Albert Vernon AV; Huffman, Jennifer E JE; Albrecht, Eva E; Jackson, Catherine M CM; Evans, David M DM; Cadby, Gemma G; Fornage, Myriam M; Manichaikul, Ani A; Lopez, Lorna M LM; Johnson, Toby T; Aldrich, Melinda C MC; Aspelund, Thor T; Barroso, Inês I; Campbell, Harry H; Cassano, Patricia A PA; Couper, David J DJ; Eiriksdottir, Gudny G; Franceschini, Nora N; Garcia, Melissa M; Gieger, Christian C; Gislason, Gauti Kjartan GK; Grkovic, Ivica I; Hammond, Christopher J CJ; Hancock, Dana B DB; Harris, Tamara B TB; Ramasamy, Adaikalavan A; Heckbert, Susan R SR; Heliövaara, Markku M; Homuth, Georg G; Hysi, Pirro G PG; James, Alan L AL; Jankovic, Stipan S; Joubert, Bonnie R BR; Karrasch, Stefan S; Klopp, Norman N; Koch, Beate B; Kritchevsky, Stephen B SB; Launer, Lenore J LJ; Liu, Yongmei Y; Loehr, Laura R LR; Lohman, Kurt K; Loos, Ruth J F RJ; Lumley, Thomas T; Al Balushi, Khalid A KA; Ang, Wei Q WQ; Barr, R Graham RG; Beilby, John J; Blakey, John D JD; Boban, Mladen M; Boraska, Vesna V; Brisman, Jonas J; Britton, John R JR; Brusselle, Guy G GG; Cooper, Cyrus C; Curjuric, Ivan I; Dahgam, Santosh S; Deary, Ian J IJ; Ebrahim, Shah S; Eijgelsheim, Mark M; Francks, Clyde C; Gaysina, Darya D; Granell, Raquel R; Gu, Xiangjun X; Hankinson, John L JL; Hardy, Rebecca R; Harris, Sarah E SE; Henderson, John J; Henry, Amanda A; Hingorani, Aroon D AD; Hofman, Albert A; Holt, Patrick G PG; Hui, Jennie J; Hunter, Michael L ML; Imboden, Medea M; Jameson, Karen A KA; Kerr, Shona M SM; Kolcic, Ivana I; Kronenberg, Florian F; Liu, Jason Z JZ; Marchini, Jonathan J; McKeever, Tricia T; Morris, Andrew D AD; Olin, Anna-Carin AC; Porteous, David J DJ; Postma, Dirkje S DS; Rich, Stephen S SS; Ring, Susan M SM; Rivadeneira, Fernando F; Rochat, Thierry T; Sayer, Avan Aihie AA; Sayers, Ian I; Sly, Peter D PD; Smith, George Davey GD; Sood, Akshay A; Starr, John M JM; Uitterlinden, André G AG; Vonk, Judith M JM; Wannamethee, S Goya SG; Whincup, Peter H PH; Wijmenga, Cisca C; Williams, O Dale OD; Wong, Andrew A; Mangino, Massimo M; Marciante, Kristin D KD; McArdle, Wendy L WL; Meibohm, Bernd B; Morrison, Alanna C AC; North, Kari E KE; Omenaas, Ernst E; Palmer, Lyle J LJ; Pietiläinen, Kirsi H KH; Pin, Isabelle I; Pola Sbreve Ek, Ozren O; Pouta, Anneli A; Psaty, Bruce M BM; Hartikainen, Anna-Liisa AL; Rantanen, Taina T; Ripatti, Samuli S; Rotter, Jerome I JI; Rudan, Igor I; Rudnicka, Alicja R AR; Schulz, Holger H; Shin, So-Youn SY; Spector, Tim D TD; Surakka, Ida I; Vitart, Veronique V; Völzke, Henry H; Wareham, Nicholas J NJ; Warrington, Nicole M NM; Wichmann, H-Erich HE; Wild, Sarah H SH; Wilk, Jemma B JB; Wjst, Matthias M; Wright, Alan F AF; Zgaga, Lina L; Zemunik, Tatijana T; Pennell, Craig E CE; Nyberg, Fredrik F; Kuh, Diana D; Holloway, John W JW; Boezen, H Marike HM; Lawlor, Debbie A DA; Morris, Richard W RW; Probst-Hensch, Nicole N; , ; , ; Kaprio, Jaakko J; Wilson, James F JF; Hayward, Caroline C; Kähönen, Mika M; Heinrich, Joachim J; Musk, Arthur W AW; Jarvis, Deborah L DL; Gläser, Sven S; Järvelin, Marjo-Riitta MR; Ch Stricker, Bruno H BH; Elliott, Paul P; O'Connor, George T GT; Strachan, David P DP; London, Stephanie J SJ; Hall, Ian P IP; Gudnason, Vilmundur V; Tobin, Martin D MD
Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus.
Molecular Medicine (Cambridge, Mass.)
Lee, Hye-Soon HS; Lee, Annette T AT; Criswell, Lindsey A LA; Seldin, Michael F MF; Amos, Christopher I CI; Carulli, John P JP; Navarrete, Cristina C; Remmers, Elaine F EF; Kastner, Daniel L DL; Plenge, Robert M RM; Li, Wentian W; Gregersen, Peter K PK