A Review of the Recent Advances in Alzheimer's Disease Research and the Utilization of Network Biology Approaches for Prioritizing Diagnostics and Therapeutics.
Diagnostics (Basel, Switzerland)
Hajjo, Rima R; Sabbah, Dima A DA; Abusara, Osama H OH; Al Bawab, Abdel Qader AQ
Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease.
Nature Genetics
Holstege, Henne H; Hulsman, Marc M; Charbonnier, Camille C; Grenier-Boley, Benjamin B; Quenez, Olivier O; Grozeva, Detelina D; van Rooij, Jeroen G J JGJ; Sims, Rebecca R; Ahmad, Shahzad S; Amin, Najaf N; Norsworthy, Penny J PJ; Dols-Icardo, Oriol O; Hummerich, Holger H; Kawalia, Amit A; Amouyel, Philippe P; Beecham, Gary W GW; Berr, Claudine C; Bis, Joshua C JC; Boland, Anne A; Bossù, Paola P; Bouwman, Femke F; Bras, Jose J; Campion, Dominique D; Cochran, J Nicholas JN; Daniele, Antonio A; Dartigues, Jean-François JF; Debette, Stéphanie S; Deleuze, Jean-François JF; Denning, Nicola N; DeStefano, Anita L AL; Farrer, Lindsay A LA; Fernández, Maria Victoria MV; Fox, Nick C NC; Galimberti, Daniela D; Genin, Emmanuelle E; Gille, Johan J P JJP; Le Guen, Yann Y; Guerreiro, Rita R; Haines, Jonathan L JL; Holmes, Clive C; Ikram, M Arfan MA; Ikram, M Kamran MK; Jansen, Iris E IE; Kraaij, Robert R; Lathrop, Marc M; Lemstra, Afina W AW; Lleó, Alberto A; Luckcuck, Lauren L; Mannens, Marcel M A M MMAM; Marshall, Rachel R; Martin, Eden R ER; Masullo, Carlo C; Mayeux, Richard R; Mecocci, Patrizia P; Meggy, Alun A; Mol, Merel O MO; Morgan, Kevin K; Myers, Richard M RM; Nacmias, Benedetta B; Naj, Adam C AC; Napolioni, Valerio V; Pasquier, Florence F; Pastor, Pau P; Pericak-Vance, Margaret A MA; Raybould, Rachel R; Redon, Richard R; Reinders, Marcel J T MJT; Richard, Anne-Claire AC; Riedel-Heller, Steffi G SG; Rivadeneira, Fernando F; Rousseau, Stéphane S; Ryan, Natalie S NS; Saad, Salha S; Sanchez-Juan, Pascual P; Schellenberg, Gerard D GD; Scheltens, Philip P; Schott, Jonathan M JM; Seripa, Davide D; Seshadri, Sudha S; Sie, Daoud D; Sistermans, Erik A EA; Sorbi, Sandro S; van Spaendonk, Resie R; Spalletta, Gianfranco G; Tesi, Niccolo' N; Tijms, Betty B; Uitterlinden, André G AG; van der Lee, Sven J SJ; Visser, Pieter Jelle PJ; Wagner, Michael M; Wallon, David D; Wang, Li-San LS; Zarea, Aline A; Clarimon, Jordi J; van Swieten, John C JC; Greicius, Michael D MD; Yokoyama, Jennifer S JS; Cruchaga, Carlos C; Hardy, John J; Ramirez, Alfredo A; Mead, Simon S; van der Flier, Wiesje M WM; van Duijn, Cornelia M CM; Williams, Julie J; Nicolas, Gaël G; Bellenguez, Céline C; Lambert, Jean-Charles JC
Publication Date: 2022-12
Variant appearance in text: TREM2: D87N; rs142232675
Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains.
Alzheimer'S & Dementia : The Journal Of The Alzheimer'S Association
Novotny, Brenna C BC; Fernandez, Maria Victoria MV; Wang, Ciyang C; Budde, John P JP; Bergmann, Kristy K; Eteleeb, Abdallah M AM; Bradley, Joseph J; Webster, Carol C; Ebl, Curtis C; Norton, Joanne J; Gentsch, Jen J; Dube, Umber U; Wang, Fengxian F; Morris, John C JC; Bateman, Randall J RJ; Perrin, Richard J RJ; McDade, Eric E; Xiong, Chengjie C; Chhatwal, Jasmeer J; , ; , ; , ; Goate, Alison A; Farlow, Martin M; Schofield, Peter P; Chui, Helena H; Karch, Celeste M CM; Cruchaga, Carlos C; Benitez, Bruno A BA; Harari, Oscar O
Transgenic Mouse Models of Alzheimer's Disease: An Integrative Analysis.
International Journal Of Molecular Sciences
Sanchez-Varo, Raquel R; Mejias-Ortega, Marina M; Fernandez-Valenzuela, Juan Jose JJ; Nuñez-Diaz, Cristina C; Caceres-Palomo, Laura L; Vegas-Gomez, Laura L; Sanchez-Mejias, Elisabeth E; Trujillo-Estrada, Laura L; Garcia-Leon, Juan Antonio JA; Moreno-Gonzalez, Ines I; Vizuete, Marisa M; Vitorica, Javier J; Baglietto-Vargas, David D; Gutierrez, Antonia A
Publication Date: 2022-05-12
Variant appearance in text: TREM2: D87N; rs142232675
Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Belsare, Ketaki D KD; Wu, Haifan H; Mondal, Dibyendu D; Bond, Annalise A; Castillo, Erika E; Jin, Jia J; Jo, Hyunil H; Roush, Addison E AE; Pilla, Kala Bharath KB; Sali, Andrej A; Condello, Carlo C; DeGrado, William F WF
Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Belsare, Ketaki D KD; Wu, Haifan H; Mondal, Dibyendu D; Bond, Annalise A; Castillo, Erika E; Jin, Jia J; Jo, Hyunil H; Roush, Addison E AE; Pilla, Kala Bharath KB; Sali, Andrej A; Condello, Carlo C; DeGrado, William F WF
Systematic Review: Genetic, Neuroimaging, and Fluids Biomarkers for Frontotemporal Dementia Across Latin America Countries.
Frontiers In Neurology
Duran-Aniotz, Claudia C; Orellana, Paulina P; Leon Rodriguez, Tomas T; Henriquez, Fernando F; Cabello, Victoria V; Aguirre-Pinto, María F MF; Escobedo, Tamara T; Takada, Leonel T LT; Pina-Escudero, Stefanie D SD; Lopez, Oscar O; Yokoyama, Jennifer S JS; Ibanez, Agustin A; Parra, Mario A MA; Slachevsky, Andrea A
Integrated molecular drivers coordinate biological and clinical states in melanoma.
Nature Genetics
Conway, Jake R JR; Dietlein, Felix F; Taylor-Weiner, Amaro A; AlDubayan, Saud S; Vokes, Natalie N; Keenan, Tanya T; Reardon, Brendan B; He, Meng Xiao MX; Margolis, Claire A CA; Weirather, Jason L JL; Haq, Rizwan R; Schilling, Bastian B; Stephen Hodi, F F; Schadendorf, Dirk D; Liu, David D; Van Allen, Eliezer M EM
Examination of the Effect of Rare Variants in TREM2, ABI3, and PLCG2 in LOAD Through Multiple Phenotypes.
Journal Of Alzheimer'S Disease : Jad
Olive, Claudia C; Ibanez, Laura L; Farias, Fabiana H Geraldo FHG; Wang, Fengxian F; Budde, John P JP; Norton, Joanne B JB; Gentsch, Jen J; Morris, John C JC; Li, Zeran Z; Dube, Umber U; Del-Aguila, Jorge J; Bergmann, Kristy K; Bradley, Joseph J; Benitez, Bruno A BA; Harari, Oscar O; Fagan, Anne A; Ances, Beau B; Cruchaga, Carlos C; Fernandez, Maria Victoria MV
Publication Date: 2020
Variant appearance in text: TREM2: D87N; rs142232675
Association of APOE With Primary Open-Angle Glaucoma Suggests a Protective Effect for APOE ε4.
Investigative Ophthalmology & Visual Science
Margeta, Milica A MA; Letcher, Sophia M SM; Igo, Robert P RP; Cooke Bailey, Jessica N JN; Pasquale, Louis R LR; Haines, Jonathan L JL; Butovsky, Oleg O; Wiggs, Janey L JL; ,
Publication Date: 2020-07-01
Variant appearance in text: TREM2: D87N; rs142232675
Differential role of triggering receptors expressed on myeloid cells 2 R47H in 3 neurodegenerative diseases based on a systematic review and meta-analysis.
Medicine
Zhang, Bin B; Li, Rui R; Zhang, Yufan Y; Gao, Xia X
Genome sequencing for early-onset or atypical dementia: high diagnostic yield and frequent observation of multiple contributory alleles.
Cold Spring Harbor Molecular Case Studies
Cochran, J Nicholas JN; McKinley, Emily C EC; Cochran, Meagan M; Amaral, Michelle D MD; Moyers, Bryan A BA; Lasseigne, Brittany N BN; Gray, David E DE; Lawlor, James M J JMJ; Prokop, Jeremy W JW; Geier, Ethan G EG; Holt, James M JM; Thompson, Michelle L ML; Newberry, J Scott JS; Yokoyama, Jennifer S JS; Worthey, Elizabeth A EA; Geldmacher, David S DS; Love, Marissa Natelson MN; Cooper, Gregory M GM; Myers, Richard M RM; Roberson, Erik D ED
Publication Date: 2019-12
Variant appearance in text: TREM2: 259G>A; Asp87Asn; rs142232675
Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers.
Alzheimer'S Research & Therapy
Ashton, Nicholas J NJ; Suárez-Calvet, Marc M; Heslegrave, Amanda A; Hye, Abdul A; Razquin, Cristina C; Pastor, Pau P; Sanchez-Valle, Raquel R; Molinuevo, José L JL; Visser, Pieter Jelle PJ; Blennow, Kaj K; Hodges, Angela K AK; Zetterberg, Henrik H
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk.
Science Translational Medicine
Deming, Yuetiva Y; Filipello, Fabia F; Cignarella, Francesca F; Cantoni, Claudia C; Hsu, Simon S; Mikesell, Robert R; Li, Zeran Z; Del-Aguila, Jorge L JL; Dube, Umber U; Farias, Fabiana Geraldo FG; Bradley, Joseph J; Budde, John J; Ibanez, Laura L; Fernandez, Maria Victoria MV; Blennow, Kaj K; Zetterberg, Henrik H; Heslegrave, Amanda A; Johansson, Per M PM; Svensson, Johan J; Nellgård, Bengt B; Lleo, Alberto A; Alcolea, Daniel D; Clarimon, Jordi J; Rami, Lorena L; Molinuevo, José Luis JL; Suárez-Calvet, Marc M; Morenas-Rodríguez, Estrella E; Kleinberger, Gernot G; Ewers, Michael M; Harari, Oscar O; Haass, Christian C; Brett, Thomas J TJ; Benitez, Bruno A BA; Karch, Celeste M CM; Piccio, Laura L; Cruchaga, Carlos C
Brain somatic mutations observed in Alzheimer's disease associated with aging and dysregulation of tau phosphorylation.
Nature Communications
Park, Jun Sung JS; Lee, Junehawk J; Jung, Eun Sun ES; Kim, Myeong-Heui MH; Kim, Il Bin IB; Son, Hyeonju H; Kim, Sangwoo S; Kim, Sanghyeon S; Park, Young Mok YM; Mook-Jung, Inhee I; Yu, Seok Jong SJ; Lee, Jeong Ho JH
TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers.
Molecular Neurodegeneration
Del-Aguila, Jorge L JL; Benitez, Bruno A BA; Li, Zeran Z; Dube, Umber U; Mihindukulasuriya, Kathie A KA; Budde, John P JP; Farias, Fabiana H G FHG; Fernández, Maria Victoria MV; Ibanez, Laura L; Jiang, Shan S; Perrin, Richard J RJ; Cairns, Nigel J NJ; Morris, John C JC; Harari, Oscar O; Cruchaga, Carlos C