Inhibition of tumor-associated αvβ3 integrin regulates the angiogenic switch by enhancing expression of IGFBP-4 leading to reduced melanoma growth and angiogenesis in vivo.
Angiogenesis
Contois, Liangru W LW; Akalu, Abebe A; Caron, Jennifer M JM; Tweedie, Eric E; Cretu, Alexandra A; Henderson, Terry T; Liaw, Lucy L; Friesel, Robert R; Vary, Calvin C; Brooks, Peter C PC