Systematic genetic testing for recessively inherited monogenic diabetes: a cross-sectional study in paediatric diabetes clinics.
Diabetologia
Patel, Kashyap A KA; Ozbek, Mehmet N MN; Yildiz, Melek M; Guran, Tulay T; Kocyigit, Cemil C; Acar, Sezer S; Siklar, Zeynep Z; Atar, Muge M; Colclough, Kevin K; Houghton, Jayne J; Johnson, Matthew B MB; Ellard, Sian S; Flanagan, Sarah E SE; Cizmecioglu, Filiz F; Berberoglu, Merih M; Demir, Korcan K; Catli, Gonul G; Bas, Serpil S; Akcay, Teoman T; Demirbilek, Huseyin H; Weedon, Michael N MN; Hattersley, Andrew T AT
Polymorphism in BACH2 gene is a marker of polyglandular autoimmunity.
Endocrine
Fichna, Marta M; Żurawek, Magdalena M; Słomiński, Bartosz B; Sumińska, Marta M; Czarnywojtek, Agata A; Rozwadowska, Natalia N; Fichna, Piotr P; Myśliwiec, Małgorzata M; Ruchała, Marek M
Type 1 diabetes: genes associated with disease development.
Central-European Journal Of Immunology
Klak, Marta M; Gomółka, Magdalena M; Kowalska, Patrycja P; Cichoń, Justyna J; Ambrożkiewicz, Filip F; Serwańska-Świętek, Marta M; Berman, Andrzej A; Wszoła, Michał M
DNA methylation near the INS gene is associated with INS genetic variation (rs689) and type 1 diabetes in the Diabetes Autoimmunity Study in the Young.
Pediatric Diabetes
Carry, Patrick M PM; Vanderlinden, Lauren A LA; Johnson, Randi K RK; Dong, Fran F; Steck, Andrea K AK; Frohnert, Brigitte I BI; Rewers, Marian M; Yang, Ivana V IV; Kechris, Katerina K; Norris, Jill M JM
Genetic Variants in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Bayesian Approach and Systematic Review.
Journal Of Clinical Medicine
Lee, Kwang Seob KS; Kronbichler, Andreas A; Pereira Vasconcelos, Daniel Fernando DF; Pereira da Silva, Felipe Rodolfo FR; Ko, Younhee Y; Oh, Yeon Su YS; Eisenhut, Michael M; Merkel, Peter A PA; Jayne, David D; Amos, Christopher I CI; Siminovitch, Katherine A KA; Rahmattulla, Chinar C; Lee, Keum Hwa KH; Shin, Jae Il JI
First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes.
Diabetes Care
Cousminer, Diana L DL; Ahlqvist, Emma E; Mishra, Rajashree R; Andersen, Mette K MK; Chesi, Alessandra A; Hawa, Mohammad I MI; Davis, Asa A; Hodge, Kenyaita M KM; Bradfield, Jonathan P JP; Zhou, Kaixin K; Guy, Vanessa C VC; Åkerlund, Mikael M; Wod, Mette M; Fritsche, Lars G LG; Vestergaard, Henrik H; Snyder, James J; Højlund, Kurt K; Linneberg, Allan A; Käräjämäki, Annemari A; Brandslund, Ivan I; Kim, Cecilia E CE; Witte, Daniel D; Sørgjerd, Elin Pettersen EP; Brillon, David J DJ; Pedersen, Oluf O; Beck-Nielsen, Henning H; Grarup, Niels N; Pratley, Richard E RE; Rickels, Michael R MR; Vella, Adrian A; Ovalle, Fernando F; Melander, Olle O; Harris, Ronald I RI; Varvel, Stephen S; Grill, Valdemar E R VER; , ; Hakonarson, Hakon H; Froguel, Philippe P; Lonsdale, John T JT; Mauricio, Didac D; Schloot, Nanette C NC; Khunti, Kamlesh K; Greenbaum, Carla J CJ; Åsvold, Bjørn Olav BO; Yderstræde, Knud B KB; Pearson, Ewan R ER; Schwartz, Stanley S; Voight, Benjamin F BF; Hansen, Torben T; Tuomi, Tiinamaija T; Boehm, Bernhard O BO; Groop, Leif L; Leslie, R David RD; Grant, Struan F A SFA
A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk.
Diabetes Care
Redondo, Maria J MJ; Geyer, Susan S; Steck, Andrea K AK; Sharp, Seth S; Wentworth, John M JM; Weedon, Michael N MN; Antinozzi, Peter P; Sosenko, Jay J; Atkinson, Mark M; Pugliese, Alberto A; Oram, Richard A RA; ,
Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children.
Plos Medicine
Bonifacio, Ezio E; Beyerlein, Andreas A; Hippich, Markus M; Winkler, Christiane C; Vehik, Kendra K; Weedon, Michael N MN; Laimighofer, Michael M; Hattersley, Andrew T AT; Krumsiek, Jan J; Frohnert, Brigitte I BI; Steck, Andrea K AK; Hagopian, William A WA; Krischer, Jeffrey P JP; Lernmark, Åke Å; Rewers, Marian J MJ; She, Jin-Xiong JX; Toppari, Jorma J; Akolkar, Beena B; Oram, Richard A RA; Rich, Stephen S SS; Ziegler, Anette-G AG; ,
Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.
Scientific Reports
Perry, Daniel J DJ; Wasserfall, Clive H CH; Oram, Richard A RA; Williams, MacKenzie D MD; Posgai, Amanda A; Muir, Andrew B AB; Haller, Michael J MJ; Schatz, Desmond A DA; Wallet, Mark A MA; Mathews, Clayton E CE; Atkinson, Mark A MA; Brusko, Todd M TM
Prediction of type 1 diabetes using a genetic risk model in the Diabetes Autoimmunity Study in the Young.
Pediatric Diabetes
Frohnert, Brigitte I BI; Laimighofer, Michael M; Krumsiek, Jan J; Theis, Fabian J FJ; Winkler, Christiane C; Norris, Jill M JM; Ziegler, Anette-Gabriele AG; Rewers, Marian J MJ; Steck, Andrea K AK
Genetic and Environmental Interactions Modify the Risk of Diabetes-Related Autoimmunity by 6 Years of Age: The TEDDY Study.
Diabetes Care
Krischer, Jeffrey P JP; Lynch, Kristian F KF; Lernmark, Åke Å; Hagopian, William A WA; Rewers, Marian J MJ; She, Jin-Xiong JX; Toppari, Jorma J; Ziegler, Anette-G AG; Akolkar, Beena B; ,
A Variant in the BACH2 Gene Is Associated With Susceptibility to Autoimmune Addison's Disease in Humans.
The Journal Of Clinical Endocrinology And Metabolism
Pazderska, Agnieszka A; Oftedal, Bergithe E BE; Napier, Catherine M CM; Ainsworth, Holly F HF; Husebye, Eystein S ES; Cordell, Heather J HJ; Pearce, Simon H S SH; Mitchell, Anna L AL
Distinct Gene Regulatory Pathways for Human Innate versus Adaptive Lymphoid Cells.
Cell
Koues, Olivia I OI; Collins, Patrick L PL; Cella, Marina M; Robinette, Michelle L ML; Porter, Sofia I SI; Pyfrom, Sarah C SC; Payton, Jacqueline E JE; Colonna, Marco M; Oltz, Eugene M EM
Genetic Risk Score Modelling for Disease Progression in New-Onset Type 1 Diabetes Patients: Increased Genetic Load of Islet-Expressed and Cytokine-Regulated Candidate Genes Predicts Poorer Glycemic Control.
Journal Of Diabetes Research
Brorsson, Caroline A CA; Nielsen, Lotte B LB; Andersen, Marie Louise ML; Kaur, Simranjeet S; Bergholdt, Regine R; Hansen, Lars L; Mortensen, Henrik B HB; Pociot, Flemming F; Størling, Joachim J; ,
Shared Genetic Basis for Type 1 Diabetes, Islet Autoantibodies, and Autoantibodies Associated With Other Immune-Mediated Diseases in Families With Type 1 Diabetes.
Contrasting the Genetic Background of Type 1 Diabetes and Celiac Disease Autoimmunity.
Diabetes Care
Gutierrez-Achury, Javier J; Romanos, Jihane J; Bakker, Sjoerd F SF; Kumar, Vinod V; de Haas, Esther C EC; Trynka, Gosia G; Ricaño-Ponce, Isis I; Steck, Andrea A; , ; Chen, Wei-Min WM; Onengut-Gumuscu, Suna S; Simsek, Suat S; , ; Rewers, Marian M; Mulder, Chris J CJ; Liu, Ed E; Rich, Stephen S SS; Wijmenga, Cisca C
Role of Type 1 Diabetes-Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study.
Diabetes
Törn, Carina C; Hadley, David D; Lee, Hye-Seung HS; Hagopian, William W; Lernmark, Åke Å; Simell, Olli O; Rewers, Marian M; Ziegler, Anette A; Schatz, Desmond D; Akolkar, Beena B; Onengut-Gumuscu, Suna S; Chen, Wei-Min WM; Toppari, Jorma J; Mykkänen, Juha J; Ilonen, Jorma J; Rich, Stephen S SS; She, Jin-Xiong JX; Steck, Andrea K AK; Krischer, Jeffrey J; ,
Improving prediction of type 1 diabetes by testing non-HLA genetic variants in addition to HLA markers.
Pediatric Diabetes
Steck, Andrea K AK; Dong, Fran F; Wong, Randall R; Fouts, Alexandra A; Liu, Edwin E; Romanos, Jihane J; Wijmenga, Cisca C; Norris, Jill M JM; Rewers, Marian J MJ
Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes.
Clinical And Experimental Immunology
Thompson, W S WS; Pekalski, M L ML; Simons, H Z HZ; Smyth, D J DJ; Castro-Dopico, X X; Guo, H H; Guy, C C; Dunger, D B DB; Arif, S S; Peakman, M M; Wallace, C C; Wicker, L S LS; Todd, J A JA; Ferreira, R C RC
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Plos Genetics
Lauc, Gordan G; Huffman, Jennifer E JE; Pučić, Maja M; Zgaga, Lina L; Adamczyk, Barbara B; Mužinić, Ana A; Novokmet, Mislav M; Polašek, Ozren O; Gornik, Olga O; Krištić, Jasminka J; Keser, Toma T; Vitart, Veronique V; Scheijen, Blanca B; Uh, Hae-Won HW; Molokhia, Mariam M; Patrick, Alan Leslie AL; McKeigue, Paul P; Kolčić, Ivana I; Lukić, Ivan Krešimir IK; Swann, Olivia O; van Leeuwen, Frank N FN; Ruhaak, L Renee LR; Houwing-Duistermaat, Jeanine J JJ; Slagboom, P Eline PE; Beekman, Marian M; de Craen, Anton J M AJ; Deelder, André M AM; Zeng, Qiang Q; Wang, Wei W; Hastie, Nicholas D ND; Gyllensten, Ulf U; Wilson, James F JF; Wuhrer, Manfred M; Wright, Alan F AF; Rudd, Pauline M PM; Hayward, Caroline C; Aulchenko, Yurii Y; Campbell, Harry H; Rudan, Igor I
Seven newly identified loci for autoimmune thyroid disease.
Human Molecular Genetics
Cooper, Jason D JD; Simmonds, Matthew J MJ; Walker, Neil M NM; Burren, Oliver O; Brand, Oliver J OJ; Guo, Hui H; Wallace, Chris C; Stevens, Helen H; Coleman, Gillian G; , ; Franklyn, Jayne A JA; Todd, John A JA; Gough, Stephen C L SC
Meta-analysis of genetic polymorphisms in granulomatosis with polyangiitis (Wegener's) reveals shared susceptibility loci with rheumatoid arthritis.
Arthritis And Rheumatism
Chung, Sharon A SA; Xie, Gang G; Roshandel, Delnaz D; Sherva, Richard R; Edberg, Jeffrey C JC; Kravitz, Megan M; Dellaripa, Paul F PF; Hoffman, Gary S GS; Mahr, Alfred D AD; Seo, Philip P; Specks, Ulrich U; Spiera, Robert F RF; St Clair, E William EW; Stone, John H JH; Plenge, Robert M RM; Siminovitch, Katherine A KA; Merkel, Peter A PA; Monach, Paul A PA
Effects of non-HLA gene polymorphisms on development of islet autoimmunity and type 1 diabetes in a population with high-risk HLA-DR,DQ genotypes.
Diabetes
Steck, Andrea K AK; Wong, Randall R; Wagner, Brandie B; Johnson, Kelly K; Liu, Edwin E; Romanos, Jihane J; Wijmenga, Cisca C; Norris, Jill M JM; Eisenbarth, George S GS; Rewers, Marian J MJ
Pervasive sharing of genetic effects in autoimmune disease.
Plos Genetics
Cotsapas, Chris C; Voight, Benjamin F BF; Rossin, Elizabeth E; Lage, Kasper K; Neale, Benjamin M BM; Wallace, Chris C; Abecasis, Gonçalo R GR; Barrett, Jeffrey C JC; Behrens, Timothy T; Cho, Judy J; De Jager, Philip L PL; Elder, James T JT; Graham, Robert R RR; Gregersen, Peter P; Klareskog, Lars L; Siminovitch, Katherine A KA; van Heel, David A DA; Wijmenga, Cisca C; Worthington, Jane J; Todd, John A JA; Hafler, David A DA; Rich, Stephen S SS; Daly, Mark J MJ; ,
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
Plos Genetics
Plagnol, Vincent V; Howson, Joanna M M JM; Smyth, Deborah J DJ; Walker, Neil N; Hafler, Jason P JP; Wallace, Chris C; Stevens, Helen H; Jackson, Laura L; Simmonds, Matthew J MJ; , ; Bingley, Polly J PJ; Gough, Stephen C SC; Todd, John A JA
Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease.
Arthritis Research & Therapy
Eyre, Stephen S; Hinks, Anne A; Bowes, John J; Flynn, Edward E; Martin, Paul P; Wilson, Anthony G AG; Morgan, Ann W AW; Emery, Paul P; Steer, Sophia S; Hocking, Lynne J LJ; Reid, David M DM; Harrison, Pille P; Wordsworth, Paul P; , ; , ; Thomson, Wendy W; Worthington, Jane J; Barton, Anne A
Pociot, Flemming F; Akolkar, Beena B; Concannon, Patrick P; Erlich, Henry A HA; Julier, Cécile C; Morahan, Grant G; Nierras, Concepcion R CR; Todd, John A JA; Rich, Stephen S SS; Nerup, Jørn J
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
Nature Genetics
Barrett, Jeffrey C JC; Clayton, David G DG; Concannon, Patrick P; Akolkar, Beena B; Cooper, Jason D JD; Erlich, Henry A HA; Julier, Cécile C; Morahan, Grant G; Nerup, Jørn J; Nierras, Concepcion C; Plagnol, Vincent V; Pociot, Flemming F; Schuilenburg, Helen H; Smyth, Deborah J DJ; Stevens, Helen H; Todd, John A JA; Walker, Neil M NM; Rich, Stephen S SS; ,
Shared and distinct genetic variants in type 1 diabetes and celiac disease.
The New England Journal Of Medicine
Smyth, Deborah J DJ; Plagnol, Vincent V; Walker, Neil M NM; Cooper, Jason D JD; Downes, Kate K; Yang, Jennie H M JH; Howson, Joanna M M JM; Stevens, Helen H; McManus, Ross R; Wijmenga, Cisca C; Heap, Graham A GA; Dubois, Patrick C PC; Clayton, David G DG; Hunt, Karen A KA; van Heel, David A DA; Todd, John A JA
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
Nature Genetics
Cooper, Jason D JD; Smyth, Deborah J DJ; Smiles, Adam M AM; Plagnol, Vincent V; Walker, Neil M NM; Allen, James E JE; Downes, Kate K; Barrett, Jeffrey C JC; Healy, Barry C BC; Mychaleckyj, Josyf C JC; Warram, James H JH; Todd, John A JA