Publications:

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The G protein-coupled oestrogen receptor GPER in health and disease: an update.

Nature Reviews. Endocrinology

Prossnitz, Eric R ER; Barton, Matthias M

Publication Date: 2023-05-16

Variant appearance in text: GPER: Pro16Leu; rs11544331

PubMed Link: 37193881

Variant Present in the following documents:

• Main text
• 41574_2023_Article_822.pdf

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A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Jang, H Josh HJ; Hostetter, Galen G; MacFarlane, Alexander W AW; Madaj, Zachary Z; Ross, Eric A EA; Hinoue, Toshinori T; Kulchycki, Justin R JR; Burgos, Ryan S RS; Tafseer, Mahvish M; Alpaugh, R Katherine RK; Schwebel, Candice L CL; Kokate, Rutika R; Geynisman, Daniel M DM; Zibelman, Matthew R MR; Ghatalia, Pooja P; Nichols, Peter W PW; Chung, Woonbok W; Madzo, Jozef J; Hahn, Noah M NM; Quinn, David I DI; Issa, Jean-Pierre J JJ; Topper, Michael J MJ; Baylin, Stephen B SB; Shen, Hui H; Campbell, Kerry S KS; Jones, Peter A PA; Plimack, Elizabeth R ER

Publication Date: 2023-03-16

Variant appearance in text: GPER1: P16L

PubMed Link: 36928921

Variant Present in the following documents:

• ccr-22-3642_supplementary_tables_1_suppts1.xlsx, sheet 3

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Comparative G-Protein-Coupled Estrogen Receptor (GPER) Systems in Diabetic and Cancer Conditions: A Review.

Molecules (Basel, Switzerland)

Muhammad, Aliyu A; Forcados, Gilead Ebiegberi GE; Yusuf, Abdurrahman Pharmacy AP; Abubakar, Murtala Bello MB; Sadiq, Idris Zubairu IZ; Elhussin, Isra I; Siddique, Md Abu Talha MAT; Aminu, Suleiman S; Suleiman, Rabiatu Bako RB; Abubakar, Yakubu Saddeeq YS; Katsayal, Babangida Sanusi BS; Yates, Clayton C CC; Mahavadi, Sunila S

Publication Date: 2022-12-15

Variant appearance in text: GPER: P16L

PubMed Link: 36558071

Variant Present in the following documents:

• Main text
• molecules-27-08943.pdf

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Integrated DNA and RNA Sequencing Reveals Drivers of Endocrine Resistance in Estrogen Receptor-Positive Breast Cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Xia, Youli Y; He, Xiaping X; Renshaw, Lorna L; Martinez-Perez, Carlos C; Kay, Charlene C; Gray, Mark M; Meehan, James J; Parker, Joel S JS; Perou, Charles M CM; Carey, Lisa A LA; Dixon, J Michael JM; Turnbull, Arran A

Publication Date: 2022-08-15

Variant appearance in text: GPER1: P16L; rs11544331

PubMed Link: 35653148

Variant Present in the following documents:

• ccr-21-3189_supplementary_tables_ts1-9_suppts1-9.xlsx, sheet 5

View BVdb publication page

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Targeting the G protein-coupled estrogen receptor (GPER) in obesity and diabetes.

Endocrine And Metabolic Science

Sharma, Geetanjali G; Prossnitz, Eric R ER

Publication Date: 2021-03-31

Variant appearance in text: GPER: P16L

PubMed Link: 35321004

Variant Present in the following documents:

• Main text
• nihms-1739809.pdf

View BVdb publication page

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GPER Agonist G-1 Disrupts Tubulin Dynamics and Potentiates Temozolomide to Impair Glioblastoma Cell Proliferation.

Cells

Hirtz, Alex A; Lebourdais, Nolwenn N; Rech, Fabien F; Bailly, Yann Y; Vaginay, Athénaïs A; Smaïl-Tabbone, Malika M; Dubois-Pot-Schneider, Hélène H; Dumond, Hélène H

Publication Date: 2021-12-07

Variant appearance in text: GPER: P16L

PubMed Link: 34943948

Variant Present in the following documents:

• Main text
• cells-10-03438.pdf

View BVdb publication page

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Multiomics Landscape Uncovers the Molecular Mechanism of the Malignant Evolution of Lung Adenocarcinoma Cells to Chronic Low Dose Cadmium Exposure.

Frontiers In Oncology

Dai, Shun-Dong SD; Wang, Shuang S; Qin, Ya-Nan YN; Zhu, Jin-Chao JC

Publication Date: 2021

Variant appearance in text: GPER: P16L

PubMed Link: 34858801

Variant Present in the following documents:

• Table_1.xls, sheet 1

View BVdb publication page

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Signalling mechanisms in the cardiovascular protective effects of estrogen: With a focus on rapid/membrane signalling.

Current Research In Physiology

Niță, Ana-Roberta AR; Knock, Greg A GA; Heads, Richard J RJ

Publication Date: 2021

Variant appearance in text: GPER: P16L

PubMed Link: 34746830

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genetic analysis of sinonasal undifferentiated carcinoma discovers recurrent SWI/SNF alterations and a novel PGAP3-SRPK1 fusion gene.

Bmc Cancer

Heft Neal, Molly E ME; Birkeland, Andrew C AC; Bhangale, Apurva D AD; Zhai, Jingyi J; Kulkarni, Aditi A; Foltin, Susan K SK; Jewell, Brittany M BM; Ludwig, Megan L ML; Pinatti, Lisa L; Jiang, Hui H; McHugh, Jonathan B JB; Marentette, Lawence L; McKean, Erin L EL; Brenner, J Chad JC

Publication Date: 2021-05-29

Variant appearance in text: GPER1: 47C>T; Pro16Leu; rs11544331

PubMed Link: 34051734

Variant Present in the following documents:

• 12885_2021_8370_MOESM15_ESM.xlsx, sheet 1

View BVdb publication page

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Association between GPER gene polymorphisms and GPER expression levels with cancer predisposition and progression.

Heliyon

Ulhaq, Zulvikar Syambani ZS; Soraya, Gita Vita GV; Milliana, Alvi A; Tse, William Ka Fai WKF

Publication Date: 2021-03

Variant appearance in text: GPER: P16L; rs11544331

PubMed Link: 33748487

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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Clonal evolution in chronic lymphocytic leukemia is scant in relapsed but accelerated in refractory cases after chemo(immune) therapy.

Haematologica

Zapatka, Marc M; Tausch, Eugen E; Öztürk, Selcen S; Yosifov, Deyan Yordanov DY; Seiffert, Martina M; Zenz, Thorsten T; Schneider, Christof C; Blöhdorn, Johannes J; Döhner, Hartmut H; Mertens, Daniel D; Lichter, Peter P; Stilgenbauer, Stephan S

Publication Date: 2022-03-01

Variant appearance in text: GPER: P16L; rs11544331

PubMed Link: 33691380

Variant Present in the following documents:

• 2020_265777_ZAPATKA_TABS4.xlsx, sheet 1

View BVdb publication page

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Estrogen Receptors: Therapeutic Perspectives for the Treatment of Cardiac Dysfunction after Myocardial Infarction.

International Journal Of Molecular Sciences

da Silva, Jaqueline S JS; Montagnoli, Tadeu L TL; Rocha, Bruna S BS; Tacco, Matheus L C A MLCA; Marinho, Sophia C P SCP; Zapata-Sudo, Gisele G

Publication Date: 2021-01-07

Variant appearance in text: GPER: P16L

PubMed Link: 33430254

Variant Present in the following documents:

• Main text
• ijms-22-00525.pdf

View BVdb publication page

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G protein-coupled estrogen receptor 1 as a novel regulator of blood pressure.

American Journal Of Physiology. Renal Physiology

Gohar, Eman Y EY

Publication Date: 2020-10-01

Variant appearance in text: GPER: P16L

PubMed Link: 32893662

Variant Present in the following documents:

• Main text

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A hypertension patient-derived iPSC model demonstrates a role for G protein-coupled estrogen receptor in hypertension risk and development.

American Journal Of Physiology. Cell Physiology

Fredette, Natalie C NC; Malik, Eliyah E; Mukhtar, Marah L ML; Prossnitz, Eric R ER; Terada, Naohiro N

Publication Date: 2020-11-01

Variant appearance in text: GPER1: P16L; rs11544331

PubMed Link: 32783656

Variant Present in the following documents:

• Main text

View BVdb publication page

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An exome-wide rare variant analysis of Korean men identifies three novel genes predisposing to prostate cancer.

Scientific Reports

Oh, Jong Jin JJ; Shivakumar, Manu M; Miller, Jason J; Verma, Shefali S; Lee, Hakmin H; Hong, Sung Kyu SK; Lee, Sang Eun SE; Lee, Younghee Y; Lee, Soo Ji SJ; Sung, Joohon J; Kim, Dokyoon D; Byun, Seok-Soo SS

Publication Date: 2019-11-20

Variant appearance in text: GPER1: P16L; rs11544331

PubMed Link: 31748686

Variant Present in the following documents:

• Main text
• 41598_2019_Article_53445.pdf

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Distinctive mutational spectrum and karyotype disruption in long-term cisplatin-treated urothelial carcinoma cell lines.

Scientific Reports

Skowron, Margaretha A MA; Petzsch, Patrick P; Hardt, Karin K; Wagner, Nicholas N; Beier, Manfred M; Stepanow, Stefanie S; Drechsler, Matthias M; Rieder, Harald H; Köhrer, Karl K; Niegisch, Günter G; Hoffmann, Michèle J MJ; Schulz, Wolfgang A WA

Publication Date: 2019-10-09

Variant appearance in text: GPER1: P16L; rs11544331

PubMed Link: 31597922

Variant Present in the following documents:

• 41598_2019_50891_MOESM6_ESM.xlsx, sheet 1
• 41598_2019_50891_MOESM9_ESM.xlsx, sheet 1
• 41598_2019_50891_MOESM8_ESM.xlsx, sheet 1

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Role of G Protein-Coupled Estrogen Receptor in Cancer Progression.

Toxicological Research

Jung, Joohee J

Publication Date: 2019-07

Variant appearance in text: GPER: p16L

PubMed Link: 31341549

Variant Present in the following documents:

• Main text
• tr-35-209.pdf

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A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma.

Scientific Reports

Stringer, Brett W BW; Day, Bryan W BW; D'Souza, Rochelle C J RCJ; Jamieson, Paul R PR; Ensbey, Kathleen S KS; Bruce, Zara C ZC; Lim, Yi Chieh YC; Goasdoué, Kate K; Offenhäuser, Carolin C; Akgül, Seçkin S; Allan, Suzanne S; Robertson, Thomas T; Lucas, Peter P; Tollesson, Gert G; Campbell, Scott S; Winter, Craig C; Do, Hongdo H; Dobrovic, Alexander A; Inglis, Po-Ling PL; Jeffree, Rosalind L RL; Johns, Terrance G TG; Boyd, Andrew W AW

Publication Date: 2019-03-20

Variant appearance in text: GPER: P16L; rs11544331

PubMed Link: 30894629

Variant Present in the following documents:

• 41598_2019_41277_MOESM4_ESM.xlsx, sheet 6
• 41598_2019_41277_MOESM4_ESM.xlsx, sheet 13
• 41598_2019_41277_MOESM4_ESM.xlsx, sheet 3
• 41598_2019_41277_MOESM4_ESM.xlsx, sheet 11
• 41598_2019_41277_MOESM4_ESM.xlsx, sheet 5

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Organoids as a new model for improving regenerative medicine and cancer personalized therapy in renal diseases.

Cell Death & Disease

Grassi, Ludovica L; Alfonsi, Romina R; Francescangeli, Federica F; Signore, Michele M; De Angelis, Maria Laura ML; Addario, Antonio A; Costantini, Manuela M; Flex, Elisabetta E; Ciolfi, Andrea A; Pizzi, Simone S; Bruselles, Alessandro A; Pallocca, Matteo M; Simone, Giuseppe G; Haoui, Mustapha M; Falchi, Mario M; Milella, Michele M; Sentinelli, Steno S; Di Matteo, Paola P; Stellacci, Emilia E; Gallucci, Michele M; Muto, Giovanni G; Tartaglia, Marco M; De Maria, Ruggero R; Bonci, Désirée D

Publication Date: 2019-02-27

Variant appearance in text: GPER: 47C>T; rs11544331

PubMed Link: 30814510

Variant Present in the following documents:

• 41419_2019_1453_MOESM27_ESM.xlsx, sheet 2
• 41419_2019_1453_MOESM27_ESM.xlsx, sheet 3
• 41419_2019_1453_MOESM27_ESM.xlsx, sheet 1

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Multiple genetic mutations caused by NKX6.3 depletion contribute to gastric tumorigenesis.

Scientific Reports

Yoon, Jung Hwan JH; Kim, Olga O; Eun, Jung Woo JW; Choi, Sung Sook SS; Ashktorab, Hassan H; Smoot, Duane T DT; Nam, Suk Woo SW; Park, Won Sang WS

Publication Date: 2018-12-04

Variant appearance in text: rs11544331

PubMed Link: 30514953

Variant Present in the following documents:

• 41598_2018_35733_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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X-linked ADGRG2 mutation and obstructive azoospermia in a large Pakistani family.

Scientific Reports

Khan, Muhammad Jaseem MJ; Pollock, Nijole N; Jiang, Huaiyang H; Castro, Carlos C; Nazli, Rubina R; Ahmed, Jawad J; Basit, Sulman S; Rajkovic, Aleksandar A; Yatsenko, Alexander N AN

Publication Date: 2018-11-02

Variant appearance in text: GPER: P16L; rs11544331

PubMed Link: 30389958

Variant Present in the following documents:

• 41598_2018_34262_MOESM2_ESM.xlsx, sheet 2

View BVdb publication page

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GPCRs in context: sexual dimorphism in the cardiovascular system.

British Journal Of Pharmacology

Mouat, Margaret A MA; Coleman, James L J JLJ; Smith, Nicola J NJ

Publication Date: 2018-11

Variant appearance in text: rs11544331

PubMed Link: 29451687

Variant Present in the following documents:

• Main text

View BVdb publication page

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G-Protein-Coupled Estrogen Receptor (GPER) and Sex-Specific Metabolic Homeostasis.

Advances In Experimental Medicine And Biology

Sharma, Geetanjali G; Prossnitz, Eric R ER

Publication Date: 2017

Variant appearance in text: GPER: P16L

PubMed Link: 29224106

Variant Present in the following documents:

• Main text

View BVdb publication page

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A genetic polymorphism repurposes the G-protein coupled and membrane-associated estrogen receptor GPER to a transcription factor-like molecule promoting paracrine signaling between stroma and breast carcinoma cells.

Oncotarget

Pupo, Marco M; Bodmer, Alexandre A; Berto, Melissa M; Maggiolini, Marcello M; Dietrich, Pierre-Yves PY; Picard, Didier D

Publication Date: 2017-07-18

Variant appearance in text: GPER: P16L; rs11544331

PubMed Link: 28596490

Variant Present in the following documents:

• Main text
• oncotarget-08-46728.pdf

View BVdb publication page

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Translational and Therapeutic Approaches to the Understanding and Treatment of Dyslipidemia.

Arteriosclerosis, Thrombosis, And Vascular Biology

Zhang, Hanrui H; de Aguiar Vallim, Thomas Q TQ; Martel, Catherine C; ,

Publication Date: 2016-07

Variant appearance in text: GPER: P16L

PubMed Link: 27335468

Variant Present in the following documents:

• Main text

View BVdb publication page

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GPER-novel membrane oestrogen receptor.

Clinical Science (London, England : 1979)

Zimmerman, Margaret A MA; Budish, Rebecca A RA; Kashyap, Shreya S; Lindsey, Sarah H SH

Publication Date: 2016-06-01

Variant appearance in text: GPER: P16L

PubMed Link: 27154744

Variant Present in the following documents:

• Main text

View BVdb publication page

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G-protein-coupled estrogen receptor-30 gene polymorphisms are associated with uterine leiomyoma risk.

Bosnian Journal Of Basic Medical Sciences

Kasap, Burcu B; Öztürk Turhan, Nilgün N; Edgünlü, Tuba T; Duran, Müzeyyen M; Akbaba, Eren E; Öner, Gökalp G

Publication Date: 2016-01-06

Variant appearance in text: GPR30: Pro16Leu; rs11544331

PubMed Link: 26773178

Variant Present in the following documents:

• Main text

View BVdb publication page

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Reproducible Analysis of Post-Translational Modifications in Proteomes--Application to Human Mutations.

Plos One

Holehouse, Alex S AS; Naegle, Kristen M KM

Publication Date: 2015

Variant appearance in text: rs11544331

PubMed Link: 26659599

Variant Present in the following documents:

• pone.0144692.s002.xlsx, sheet 1

View BVdb publication page

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Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.

Stem Cell Reports

Garate, Zita Z; Quintana-Bustamante, Oscar O; Crane, Ana M AM; Olivier, Emmanuel E; Poirot, Laurent L; Galetto, Roman R; Kosinski, Penelope P; Hill, Collin C; Kung, Charles C; Agirre, Xabi X; Orman, Israel I; Cerrato, Laura L; Alberquilla, Omaira O; Rodriguez-Fornes, Fatima F; Fusaki, Noemi N; Garcia-Sanchez, Felix F; Maia, Tabita M TM; Ribeiro, Maria L ML; Sevilla, Julian J; Prosper, Felipe F; Jin, Shengfang S; Mountford, Joanne J; Guenechea, Guillermo G; Gouble, Agnes A; Bueren, Juan A JA; Davis, Brian R BR; Segovia, Jose C JC

Publication Date: 2015-12-08

Variant appearance in text: GPER: P16L; rs11544331

PubMed Link: 26549847

Variant Present in the following documents:

• mmc3.xlsx, sheet 1
• mmc3.xlsx, sheet 3
• mmc3.xlsx, sheet 2

View BVdb publication page

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Sex Hormones and Their Receptors Regulate Liver Energy Homeostasis.

International Journal Of Endocrinology

Shen, Minqian M; Shi, Haifei H

Publication Date: 2015

Variant appearance in text: GPER: P16L

PubMed Link: 26491440

Variant Present in the following documents:

• Main text
• IJE2015-294278.pdf

View BVdb publication page

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Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes.

Oncotarget

Keerthikumar, Shivakumar S; Gangoda, Lahiru L; Liem, Michael M; Fonseka, Pamali P; Atukorala, Ishara I; Ozcitti, Cemil C; Mechler, Adam A; Adda, Christopher G CG; Ang, Ching-Seng CS; Mathivanan, Suresh S

Publication Date: 2015-06-20

Variant appearance in text: GPER: P16L; rs11544331

PubMed Link: 25944692

Variant Present in the following documents:

• oncotarget-06-15375-s005.xlsx, sheet 2

View BVdb publication page

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Exome sequencing of case-unaffected-parents trios reveals recessive and de novo genetic variants in sporadic ALS.

Scientific Reports

Steinberg, Karyn Meltz KM; Yu, Bing B; Koboldt, Daniel C DC; Mardis, Elaine R ER; Pamphlett, Roger R

Publication Date: 2015-03-16

Variant appearance in text: GPER: P16L; rs11544331

PubMed Link: 25773295

Variant Present in the following documents:

• srep09124-s3.xls, sheet 1

View BVdb publication page

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Whole-genome sequencing of the world's oldest people.

Plos One

Gierman, Hinco J HJ; Fortney, Kristen K; Roach, Jared C JC; Coles, Natalie S NS; Li, Hong H; Glusman, Gustavo G; Markov, Glenn J GJ; Smith, Justin D JD; Hood, Leroy L; Coles, L Stephen LS; Kim, Stuart K SK

Publication Date: 2014

Variant appearance in text: GPER: P16L; rs11544331

PubMed Link: 25390934

Variant Present in the following documents:

• pone.0112430.s004.xlsx, sheet 1

View BVdb publication page

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The eSNV-detect: a computational system to identify expressed single nucleotide variants from transcriptome sequencing data.

Nucleic Acids Research

Tang, Xiaojia X; Baheti, Saurabh S; Shameer, Khader K; Thompson, Kevin J KJ; Wills, Quin Q; Niu, Nifang N; Holcomb, Ilona N IN; Boutet, Stephane C SC; Ramakrishnan, Ramesh R; Kachergus, Jennifer M JM; Kocher, Jean-Pierre A JP; Weinshilboum, Richard M RM; Wang, Liewei L; Thompson, E Aubrey EA; Kalari, Krishna R KR

Publication Date: 2014-12-16

Variant appearance in text: GPER: P16L; rs11544331

PubMed Link: 25352556

Variant Present in the following documents:

• supp_gku1005_nar-01266-met-n-2014-File012.xlsx, sheet 23

View BVdb publication page

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A common hypofunctional genetic variant of GPER is associated with increased blood pressure in women.

British Journal Of Clinical Pharmacology

Feldman, Ross D RD; Gros, Robert R; Ding, Qingming Q; Hussain, Yasin Y; Ban, Matthew R MR; McIntyre, Adam D AD; Hegele, Robert A RA

Publication Date: 2014-12

Variant appearance in text: GPER: P16L; rs11544331

PubMed Link: 25039431

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genetic variants of GPER/GPR30, a novel estrogen-related G protein receptor, are associated with human seminoma.

International Journal Of Molecular Sciences

Chevalier, Nicolas N; Paul-Bellon, Rachel R; Camparo, Philippe P; Michiels, Jean-François JF; Chevallier, Daniel D; Fénichel, Patrick P

Publication Date: 2014-01-21

Variant appearance in text: GPER: 47C>T; rs11544331

PubMed Link: 24451139

Variant Present in the following documents:

• Main text
• ijms-15-01574.pdf

View BVdb publication page

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Enhanced expression of G-protein coupled estrogen receptor (GPER/GPR30) in lung cancer.

Bmc Cancer

Jala, Venkatakrishna Rao VR; Radde, Brandie N BN; Haribabu, Bodduluri B; Klinge, Carolyn M CM

Publication Date: 2012-12-28

Variant appearance in text: GPER: Pro16Leu

PubMed Link: 23273253

Variant Present in the following documents:

• Main text
• 1471-2407-12-624.pdf

View BVdb publication page

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Genomic polymorphisms of G-protein estrogen receptor 1 are associated with severity of adolescent idiopathic scoliosis.

International Orthopaedics

Peng, Yan Y; Liang, Guoyan G; Pei, Yuanyuan Y; Ye, Wei W; Liang, Anjing A; Su, Peiqiang P

Publication Date: 2012-03

Variant appearance in text: GPER: Pro16Leu; rs11544331

PubMed Link: 22002330

Variant Present in the following documents:

• Main text

View BVdb publication page

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