MET c.967A>G ;(p.S323G)

Variant ID: 7-116340105-A-G

NM_000245.2(MET):c.967A>G;(p.S323G)

This variant was identified in 24 publications

View GRCh38 version.




Publications:


Assessing variants of uncertain significance implicated in hearing loss using a comprehensive deafness proteome.

Human Genetics
Tollefson, Mallory R MR; Gogal, Rose A RA; Weaver, A Monique AM; Schaefer, Amanda M AM; Marini, Robert J RJ; Azaiez, Hela H; Kolbe, Diana L DL; Wang, Donghong D; Weaver, Amy E AE; Casavant, Thomas L TL; Braun, Terry A TA; Smith, Richard J H RJH; Schnieders, Michael J MJ
Publication Date: 2023-04-22

Variant appearance in text: MET: 967A>G; Ser323Gly
PubMed Link: 37086329
Variant Present in the following documents:
  • 439_2023_2559_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Calibration of computational tools for missense variant pathogenicity classification and ClinGen recommendations for PP3/BP4 criteria.

American Journal Of Human Genetics
Pejaver, Vikas V; Byrne, Alicia B AB; Feng, Bing-Jian BJ; Pagel, Kymberleigh A KA; Mooney, Sean D SD; Karchin, Rachel R; O'Donnell-Luria, Anne A; Harrison, Steven M SM; Tavtigian, Sean V SV; Greenblatt, Marc S MS; Biesecker, Leslie G LG; Radivojac, Predrag P; Brenner, Steven E SE; ,
Publication Date: 2022-12-01

Variant appearance in text: MET: S323G; rs201467281
PubMed Link: 36413997
Variant Present in the following documents:
  • mmc3.xlsx, sheet 1
View BVdb publication page



The Emerging Role of c-Met in Carcinogenesis and Clinical Implications as a Possible Therapeutic Target.

Journal Of Oncology
Faiella, Antonio A; Riccardi, Ferdinando F; Cartenì, Giacomo G; Chiurazzi, Martina M; Onofrio, Livia L
Publication Date: 2022

Variant appearance in text: MET: S323G
PubMed Link: 35069735
Variant Present in the following documents:
  • Main text
  • JO2022-5179182.pdf
View BVdb publication page



Oncogenic mechanism-based pharmaceutical validation of therapeutics targeting MET receptor tyrosine kinase.

Therapeutic Advances In Medical Oncology
Yao, Hang-Ping HP; Tong, Xiang-Min XM; Wang, Ming-Hai MH
Publication Date: 2021

Variant appearance in text: MET: S323G
PubMed Link: 33868463
Variant Present in the following documents:
  • 10.1177_17588359211006957.pdf
View BVdb publication page



Usefulness of a novel device to divide core needle biopsy specimens in a spatially matched fashion.

Scientific Reports
Shiraishi, Takumi T; Inui, Shogo S; Inoue, Yuta Y; Saito, Yumiko Y; Taga, Hideto H; Kaneko, Masatomo M; Tsuji, Keisuke K; Ueda, Saya S; Ueda, Takashi T; Matsugasumi, Toru T; Taniguchi, Hidefumi H; Ueno, Akihisa A; Yamada, Takeshi T; Yamada, Yasuhiro Y; Iwata, Tsuyoshi T; Fujihara, Atsuko A; Hongo, Fumiya F; Ukimura, Osamu O
Publication Date: 2020-10-13

Variant appearance in text: rs201467281
PubMed Link: 33051506
Variant Present in the following documents:
  • 41598_2020_74136_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



MET-dependent solid tumours - molecular diagnosis and targeted therapy.

Nature Reviews. Clinical Oncology
Guo, Robin R; Luo, Jia J; Chang, Jason J; Rekhtman, Natasha N; Arcila, Maria M; Drilon, Alexander A
Publication Date: 2020-09

Variant appearance in text: MET: S323G
PubMed Link: 32514147
Variant Present in the following documents:
  • Main text
View BVdb publication page



A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma.

Nature Communications
Kong, Li Ren LR; Mohamed Salleh, Nur Afiqah Binte NAB; Ong, Richard Weijie RW; Tan, Tuan Zea TZ; Syn, Nicholas L NL; Goh, Robby Miguel RM; Fhu, Chee Wai CW; Tan, Daniel S W DSW; Iyer, N Gopalakrishna NG; Kannan, Srinivasaraghavan S; Verma, Chandra S CS; Lim, Yaw Chyn YC; Soo, Ross R; Ho, Jingshan J; Huang, Yiqing Y; Lim, Joline S J JSJ; Yan, Benedict Junrong BJ; Nga, Min En ME; Lim, Seng Gee SG; Koeffler, H Phillip HP; Lee, Soo Chin SC; Kappei, Dennis D; Hung, Huynh The HT; Goh, Boon Cher BC
Publication Date: 2020-03-25

Variant appearance in text: MET: S323G
PubMed Link: 32214092
Variant Present in the following documents:
  • Main text
  • 41467_2020_15318_MOESM1_ESM.pdf
  • 41467_2020_Article_15318.pdf
View BVdb publication page



Status of Agents Targeting the HGF/c-Met Axis in Lung Cancer.

Cancers
Miranda, Oshin O; Farooqui, Mariya M; Siegfried, Jill M JM
Publication Date: 2018-08-21

Variant appearance in text: MET: S323G
PubMed Link: 30134579
Variant Present in the following documents:
  • Main text
  • cancers-10-00280.pdf
View BVdb publication page



Unexpected cancer-predisposition gene variants in Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome patients without underlying germline PTEN mutations.

Plos Genetics
Yehia, Lamis L; Ni, Ying Y; Sesock, Kaitlin K; Niazi, Farshad F; Fletcher, Benjamin B; Chen, Hannah Jin Lian HJL; LaFramboise, Thomas T; Eng, Charis C
Publication Date: 2018-04

Variant appearance in text: MET: S323G
PubMed Link: 29684080
Variant Present in the following documents:
  • pgen.1007352.s010.xlsx, sheet 1
View BVdb publication page



MET in human cancer: germline and somatic mutations.

Annals Of Translational Medicine
Tovar, Elizabeth A EA; Graveel, Carrie R CR
Publication Date: 2017-05

Variant appearance in text: MET: S323G
PubMed Link: 28603720
Variant Present in the following documents:
  • Main text
View BVdb publication page



Sources of discordance among germ-line variant classifications in ClinVar.

Genetics In Medicine : Official Journal Of The American College Of Medical Genetics
Yang, Shan S; Lincoln, Stephen E SE; Kobayashi, Yuya Y; Nykamp, Keith K; Nussbaum, Robert L RL; Topper, Scott S
Publication Date: 2017-10

Variant appearance in text: MET: 967A>G; Ser323Gly
PubMed Link: 28569743
Variant Present in the following documents:
  • gim201760x7.xlsx, sheet 2
View BVdb publication page



Enrichment of Targetable Mutations in the Relapsed Neuroblastoma Genome.

Plos Genetics
Padovan-Merhar, Olivia M OM; Raman, Pichai P; Ostrovnaya, Irina I; Kalletla, Karthik K; Rubnitz, Kaitlyn R KR; Sanford, Eric M EM; Ali, Siraj M SM; Miller, Vincent A VA; Mossé, Yael P YP; Granger, Meaghan P MP; Weiss, Brian B; Maris, John M JM; Modak, Shakeel S
Publication Date: 2016-12

Variant appearance in text: MET: 967A>G; S323G
PubMed Link: 27997549
Variant Present in the following documents:
  • pgen.1006501.s002.xlsx, sheet 1
View BVdb publication page



VarDict: a novel and versatile variant caller for next-generation sequencing in cancer research.

Nucleic Acids Research
Lai, Zhongwu Z; Markovets, Aleksandra A; Ahdesmaki, Miika M; Chapman, Brad B; Hofmann, Oliver O; McEwen, Robert R; Johnson, Justin J; Dougherty, Brian B; Barrett, J Carl JC; Dry, Jonathan R JR
Publication Date: 2016-06-20

Variant appearance in text: MET: 967A>G; S323G; rs201467281
PubMed Link: 27060149
Variant Present in the following documents:
  • supp_gkw227_nar-03544-met-k-2015-File003.xls, sheet 2
View BVdb publication page



Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Toledo, Rodrigo A RA; Qin, Yuejuan Y; Cheng, Zi-Ming ZM; Gao, Qing Q; Iwata, Shintaro S; Silva, Gustavo M GM; Prasad, Manju L ML; Ocal, I Tolgay IT; Rao, Sarika S; Aronin, Neil N; Barontini, Marta M; Bruder, Jan J; Reddick, Robert L RL; Chen, Yidong Y; Aguiar, Ricardo C T RC; Dahia, Patricia L M PL
Publication Date: 2016-05-01

Variant appearance in text: MET: 967A>G; S323G
PubMed Link: 26700204
Variant Present in the following documents:
  • Main text
View BVdb publication page



Biology of MET: a double life between normal tissue repair and tumor progression.

Annals Of Translational Medicine
Petrini, Iacopo I
Publication Date: 2015-04

Variant appearance in text: MET: S323G
PubMed Link: 25992381
Variant Present in the following documents:
  • Main text
View BVdb publication page



MET genetic lesions in non-small-cell lung cancer: pharmacological and clinical implications.

Translational Lung Cancer Research
Zorzetto, Michele M; Ferrari, Simona S; Saracino, Laura L; Inghilleri, Simona S; Stella, Giulia M GM
Publication Date: 2012-09

Variant appearance in text: MET: S323G
PubMed Link: 25806181
Variant Present in the following documents:
  • Main text
View BVdb publication page



Functional consequence of the MET-T1010I polymorphism in breast cancer.

Oncotarget
Liu, Shuying S; Meric-Bernstam, Funda F; Parinyanitikul, Napa N; Wang, Bailiang B; Eterovic, Agda K AK; Zheng, Xiaofeng X; Gagea, Mihai M; Chavez-MacGregor, Mariana M; Ueno, Naoto T NT; Lei, Xiudong X; Zhou, Wanding W; Nair, Lakshmy L; Tripathy, Debu D; Brown, Powel H PH; Hortobagyi, Gabriel N GN; Chen, Ken K; Mendelsohn, John J; Mills, Gordon B GB; Gonzalez-Angulo, Ana M AM
Publication Date: 2015-02-20

Variant appearance in text: MET: S323G
PubMed Link: 25605252
Variant Present in the following documents:
  • Main text
  • oncotarget-06-2604.pdf
View BVdb publication page



Sporadic hemangioblastomas are characterized by cryptic VHL inactivation.

Acta Neuropathologica Communications
Shankar, Ganesh M GM; Taylor-Weiner, Amaro A; Lelic, Nina N; Jones, Robert T RT; Kim, James C JC; Francis, Joshua M JM; Abedalthagafi, Malak M; Borges, Lawrence F LF; Coumans, Jean-Valery JV; Curry, William T WT; Nahed, Brian V BV; Shin, John H JH; Paek, Sun Ha SH; Park, Sung-Hye SH; Stewart, Chip C; Lawrence, Michael S MS; Cibulskis, Kristian K; Thorner, Aaron R AR; Van Hummelen, Paul P; Stemmer-Rachamimov, Anat O AO; Batchelor, Tracy T TT; Carter, Scott L SL; Hoang, Mai P MP; Santagata, Sandro S; Louis, David N DN; Barker, Fred G FG; Meyerson, Matthew M; Getz, Gad G; Brastianos, Priscilla K PK; Cahill, Daniel P DP
Publication Date: 2014-12-24

Variant appearance in text: MET: 967A>G; S323G
PubMed Link: 25589003
Variant Present in the following documents:
  • 40478_2014_167_MOESM1_ESM.xlsx, sheet 6
View BVdb publication page



The Hepatocyte Growth Factor Receptor: Structure, Function and Pharmacological Targeting in Cancer.

Current Signal Transduction Therapy
Cecchi, Fabiola F; Rabe, Daniel C DC; Bottaro, Donald P DP
Publication Date: 2011

Variant appearance in text: MET: S323G
PubMed Link: 25197268
Variant Present in the following documents:
  • Main text
View BVdb publication page



Targeting the hepatocyte growth factor-cMET axis in cancer therapy.

Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology
Blumenschein, George R GR; Mills, Gordon B GB; Gonzalez-Angulo, Ana M AM
Publication Date: 2012-09-10

Variant appearance in text: MET: S323G
PubMed Link: 22869872
Variant Present in the following documents:
  • Main text
View BVdb publication page



A novel classification of lung cancer into molecular subtypes.

Plos One
West, Lisandra L; Vidwans, Smruti J SJ; Campbell, Nicholas P NP; Shrager, Jeff J; Simon, George R GR; Bueno, Raphael R; Dennis, Phillip A PA; Otterson, Gregory A GA; Salgia, Ravi R
Publication Date: 2012

Variant appearance in text: MET: S323G
PubMed Link: 22363766
Variant Present in the following documents:
  • Main text
  • pone.0031906.pdf
View BVdb publication page



Targeting the HGF/Met signalling pathway in cancer.

European Journal Of Cancer (Oxford, England : 1990)
Cecchi, Fabiola F; Rabe, Daniel C DC; Bottaro, Donald P DP
Publication Date: 2010-05

Variant appearance in text: MET: S323G
PubMed Link: 20303741
Variant Present in the following documents:
  • Main text
View BVdb publication page



MET molecular mechanisms and therapies in lung cancer.

Cell Adhesion & Migration
Lawrence, Ryan E RE; Salgia, Ravi R
Publication Date: 2010

Variant appearance in text: MET: S323G
PubMed Link: 20139696
Variant Present in the following documents:
  • Main text
View BVdb publication page



MET as a target for treatment of chest tumors.

Lung Cancer (Amsterdam, Netherlands)
Cipriani, Nicole A NA; Abidoye, Oyewale O OO; Vokes, Everett E; Salgia, Ravi R
Publication Date: 2009-02

Variant appearance in text: MET: S323G
PubMed Link: 18672314
Variant Present in the following documents:
  • Main text
View BVdb publication page