Novel insights in the pathomechanism of Brugada syndrome and fever-related type 1 ECG changes in a preclinical study using human-induced pluripotent stem cell-derived cardiomyocytes.
Clinical And Translational Medicine
Li, Yingrui Y; Dinkel, Hendrik H; Pakalniskyte, Dalia D; Busley, Alexandra Viktoria AV; Cyganek, Lukas L; Zhong, Rujia R; Zhang, Feng F; Xu, Qiang Q; Maywald, Lasse L; Aweimer, Assem A; Huang, Mengying M; Liao, Zhenxing Z; Meng, Zenghui Z; Yan, Chen C; Prädel, Timo T; Rose, Lena L; Moscu-Gregor, Alexander A; Hohn, Alyssa A; Yang, Zhen Z; Qiao, Lin L; Mügge, Andreas A; Zhou, Xiaobo X; Akin, Ibrahim I; El-Battrawy, Ibrahim I
Recruited monocytes/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosis.
Cell Reports
Öz, Hasan H HH; Cheng, Ee-Chun EC; Di Pietro, Caterina C; Tebaldi, Toma T; Biancon, Giulia G; Zeiss, Caroline C; Zhang, Ping-Xia PX; Huang, Pamela H PH; Esquibies, Sofia S SS; Britto, Clemente J CJ; Schupp, Jonas C JC; Murray, Thomas S TS; Halene, Stephanie S; Krause, Diane S DS; Egan, Marie E ME; Bruscia, Emanuela M EM
Park, Hak H; Seo, Soo Kyung SK; Sim, Ju-Ri JR; Hwang, Su Jin SJ; Kim, Ye Jin YJ; Shin, Dong Hoon DH; Jang, Dong Geon DG; Noh, Shin Hye SH; Park, Pil-Gu PG; Ko, Si Hwan SH; Shin, Mi Hwa MH; Choi, Jae Young JY; Ito, Yukishige Y; Kang, Chung-Min CM; Lee, Jae Myun JM; Lee, Min Goo MG
Quantitative cross-species translators of cardiac myocyte electrophysiology: Model training, experimental validation, and applications.
Science Advances
Morotti, Stefano S; Liu, Caroline C; Hegyi, Bence B; Ni, Haibo H; Fogli Iseppe, Alex A; Wang, Lianguo L; Pritoni, Marco M; Ripplinger, Crystal M CM; Bers, Donald M DM; Edwards, Andrew G AG; Grandi, Eleonora E
Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia.
Nature Communications
Alfano, Massimo M; Tascini, Anna Sofia AS; Pederzoli, Filippo F; Locatelli, Irene I; Nebuloni, Manuela M; Giannese, Francesca F; Garcia-Manteiga, Jose Manuel JM; Tonon, Giovanni G; Amodio, Giada G; Gregori, Silvia S; Agresti, Alessandra A; Montorsi, Francesco F; Salonia, Andrea A
Inhibition of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae with aromatic sulphonamides and clinically licenced drugs - a joint docking/molecular dynamics study.
Journal Of Enzyme Inhibition And Medicinal Chemistry
Airway Mucin Concentration as a Marker of Chronic Bronchitis.
The New England Journal Of Medicine
Kesimer, Mehmet M; Ford, Amina A AA; Ceppe, Agathe A; Radicioni, Giorgia G; Cao, Rui R; Davis, C William CW; Doerschuk, Claire M CM; Alexis, Neil E NE; Anderson, Wayne H WH; Henderson, Ashley G AG; Barr, R Graham RG; Bleecker, Eugene R ER; Christenson, Stephanie A SA; Cooper, Christopher B CB; Han, MeiLan K MK; Hansel, Nadia N NN; Hastie, Annette T AT; Hoffman, Eric A EA; Kanner, Richard E RE; Martinez, Fernando F; Paine, Robert R; Woodruff, Prescott G PG; O'Neal, Wanda K WK; Boucher, Richard C RC
Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling.
Gut
Hohwieler, Meike M; Illing, Anett A; Hermann, Patrick C PC; Mayer, Tobias T; Stockmann, Marianne M; Perkhofer, Lukas L; Eiseler, Tim T; Antony, Justin S JS; Müller, Martin M; Renz, Susanne S; Kuo, Chao-Chung CC; Lin, Qiong Q; Sendler, Matthias M; Breunig, Markus M; Kleiderman, Susanne M SM; Lechel, André A; Zenker, Martin M; Leichsenring, Michael M; Rosendahl, Jonas J; Zenke, Martin M; Sainz, Bruno B; Mayerle, Julia J; Costa, Ivan G IG; Seufferlein, Thomas T; Kormann, Michael M; Wagner, Martin M; Liebau, Stefan S; Kleger, Alexander A
ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43.
COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.
Molecular Biology Of The Cell
Phillips-Krawczak, Christine A CA; Singla, Amika A; Starokadomskyy, Petro P; Deng, Zhihui Z; Osborne, Douglas G DG; Li, Haiying H; Dick, Christopher J CJ; Gomez, Timothy S TS; Koenecke, Megan M; Zhang, Jin-San JS; Dai, Haiming H; Sifuentes-Dominguez, Luis F LF; Geng, Linda N LN; Kaufmann, Scott H SH; Hein, Marco Y MY; Wallis, Mathew M; McGaughran, Julie J; Gecz, Jozef J; Sluis, Bart van de Bv; Billadeau, Daniel D DD; Burstein, Ezra E
Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression.
Human Molecular Genetics
Baradaran-Heravi, Alireza A; Cho, Kyoung Sang KS; Tolhuis, Bas B; Sanyal, Mrinmoy M; Morozova, Olena O; Morimoto, Marie M; Elizondo, Leah I LI; Bridgewater, Darren D; Lubieniecka, Joanna J; Beirnes, Kimberly K; Myung, Clara C; Leung, Danny D; Fam, Hok Khim HK; Choi, Kunho K; Huang, Yan Y; Dionis, Kira Y KY; Zonana, Jonathan J; Keller, Kory K; Stenzel, Peter P; Mayfield, Christy C; Lücke, Thomas T; Bokenkamp, Arend A; Marra, Marco A MA; van Lohuizen, Maarten M; Lewis, David B DB; Shaw, Chad C; Boerkoel, Cornelius F CF