Publications:

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Structural mechanisms of CFTR function and dysfunction.

The Journal Of General Physiology

Hwang, Tzyh-Chang TC; Yeh, Jiunn-Tyng JT; Zhang, Jingyao J; Yu, Ying-Chun YC; Yeh, Han-I HI; Destefano, Samantha S

Publication Date: 2018-04-02

Variant appearance in text: CFTR: S341C

PubMed Link: 29581173

Variant Present in the following documents:

• Main text
• JGP_201711946.pdf

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Transmembrane helical interactions in the CFTR channel pore.

Plos Computational Biology

Das, Jhuma J; Aleksandrov, Andrei A AA; Cui, Liying L; He, Lihua L; Riordan, John R JR; Dokholyan, Nikolay V NV

Publication Date: 2017-06

Variant appearance in text: CFTR: S341C

PubMed Link: 28640808

Variant Present in the following documents:

• Main text
• pcbi.1005594.pdf

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Locating a plausible binding site for an open-channel blocker, GlyH-101, in the pore of the cystic fibrosis transmembrane conductance regulator.

Molecular Pharmacology

Norimatsu, Yohei Y; Ivetac, Anthony A; Alexander, Christopher C; O'Donnell, Nicolette N; Frye, Leah L; Sansom, Mark S P MS; Dawson, David C DC

Publication Date: 2012-12

Variant appearance in text: CFTR: S341C

PubMed Link: 22923500

Variant Present in the following documents:

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Cystic fibrosis transmembrane conductance regulator: a molecular model defines the architecture of the anion conduction path and locates a "bottleneck" in the pore.

Biochemistry

Norimatsu, Yohei Y; Ivetac, Anthony A; Alexander, Christopher C; Kirkham, John J; O'Donnell, Nicolette N; Dawson, David C DC; Sansom, Mark S P MS

Publication Date: 2012-03-20

Variant appearance in text: CFTR: S341C

PubMed Link: 22352759

Variant Present in the following documents:

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Alignment of transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore.

The Journal Of General Physiology

Wang, Wuyang W; El Hiani, Yassine Y; Linsdell, Paul P

Publication Date: 2011-08

Variant appearance in text: CFTR: S341C

PubMed Link: 21746847

Variant Present in the following documents:

• Main text
• JGP_201110605.pdf

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Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation.

The Journal Of General Physiology

Bai, Yonghong Y; Li, Min M; Hwang, Tzyh-Chang TC

Publication Date: 2010-09

Variant appearance in text: CFTR: S341C

PubMed Link: 20805575

Variant Present in the following documents:

• Main text
• JGP_201010480.pdf

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Changes in accessibility of cytoplasmic substances to the pore associated with activation of the cystic fibrosis transmembrane conductance regulator chloride channel.

The Journal Of Biological Chemistry

El Hiani, Yassine Y; Linsdell, Paul P

Publication Date: 2010-10-15

Variant appearance in text: CFTR: S341C

PubMed Link: 20675380

Variant Present in the following documents:

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Regulation of conductance by the number of fixed positive charges in the intracellular vestibule of the CFTR chloride channel pore.

The Journal Of General Physiology

Zhou, Jing-Jun JJ; Li, Man-Song MS; Qi, Jiansong J; Linsdell, Paul P

Publication Date: 2010-03

Variant appearance in text: CFTR: S341C

PubMed Link: 20142516

Variant Present in the following documents:

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Cystic fibrosis transmembrane conductance regulator: using differential reactivity toward channel-permeant and channel-impermeant thiol-reactive probes to test a molecular model for the pore.

Biochemistry

Alexander, Christopher C; Ivetac, Anthony A; Liu, Xuehong X; Norimatsu, Yohei Y; Serrano, Jose R JR; Landstrom, Allison A; Sansom, Mark M; Dawson, David C DC

Publication Date: 2009-10-27

Variant appearance in text: CFTR: S341C

PubMed Link: 19754156

Variant Present in the following documents:

• Main text
• bi901314c.pdf
• bi901314c_si_001.pdf

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Locating the anion-selectivity filter of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel.

The Journal Of General Physiology

Cheung, M M; Akabas, M H MH

Publication Date: 1997-03

Variant appearance in text: CFTR: S341C

PubMed Link: 9089437

Variant Present in the following documents:

• Main text
• 7357.pdf

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