Publications:

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Structural mechanisms of CFTR function and dysfunction.

The Journal Of General Physiology

Hwang, Tzyh-Chang TC; Yeh, Jiunn-Tyng JT; Zhang, Jingyao J; Yu, Ying-Chun YC; Yeh, Han-I HI; Destefano, Samantha S

Publication Date: 2018-04-02

Variant appearance in text: CFTR: I344C

PubMed Link: 29581173

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• JGP_201711946_TableS1.pdf
• JGP_201711946.pdf

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Localizing a gate in CFTR.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Gao, Xiaolong X; Hwang, Tzyh-Chang TC

Publication Date: 2015-02-24

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PubMed Link: 25675504

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Metal bridges illuminate transmembrane domain movements during gating of the cystic fibrosis transmembrane conductance regulator chloride channel.

The Journal Of Biological Chemistry

El Hiani, Yassine Y; Linsdell, Paul P

Publication Date: 2014-10-10

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PubMed Link: 25143385

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Cystic fibrosis transmembrane conductance regulator chloride channel blockers: Pharmacological, biophysical and physiological relevance.

World Journal Of Biological Chemistry

Linsdell, Paul P

Publication Date: 2014-02-26

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PubMed Link: 24600512

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Cysteine scanning of CFTR's first transmembrane segment reveals its plausible roles in gating and permeation.

Biophysical Journal

Gao, Xiaolong X; Bai, Yonghong Y; Hwang, Tzyh-Chang TC

Publication Date: 2013-02-19

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PubMed Link: 23442957

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Nonequilibrium gating of CFTR on an equilibrium theme.

Physiology (Bethesda, Md.)

Jih, Kang-Yang KY; Hwang, Tzyh-Chang TC

Publication Date: 2012-12

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PubMed Link: 23223629

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Tuning of CFTR chloride channel function by location of positive charges within the pore.

Biophysical Journal

El Hiani, Yassine Y; Linsdell, Paul P

Publication Date: 2012-10-17

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PubMed Link: 23083715

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Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation.

The Journal Of General Physiology

Jih, Kang-Yang KY; Sohma, Yoshiro Y; Hwang, Tzyh-Chang TC

Publication Date: 2012-10

Variant appearance in text: CFTR: I344C

PubMed Link: 22966014

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• Main text
• JGP_201210834.pdf

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Alternating access to the transmembrane domain of the ATP-binding cassette protein cystic fibrosis transmembrane conductance regulator (ABCC7).

The Journal Of Biological Chemistry

Wang, Wuyang W; Linsdell, Paul P

Publication Date: 2012-03-23

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PubMed Link: 22303012

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Structural basis for the channel function of a degraded ABC transporter, CFTR (ABCC7).

The Journal Of General Physiology

Bai, Yonghong Y; Li, Min M; Hwang, Tzyh-Chang TC

Publication Date: 2011-11

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PubMed Link: 22042986

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Alignment of transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore.

The Journal Of General Physiology

Wang, Wuyang W; El Hiani, Yassine Y; Linsdell, Paul P

Publication Date: 2011-08

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PubMed Link: 21746847

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• JGP_201110605.pdf

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Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation.

The Journal Of General Physiology

Bai, Yonghong Y; Li, Min M; Hwang, Tzyh-Chang TC

Publication Date: 2010-09

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PubMed Link: 20805575

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• JGP_201010480.pdf

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Changes in accessibility of cytoplasmic substances to the pore associated with activation of the cystic fibrosis transmembrane conductance regulator chloride channel.

The Journal Of Biological Chemistry

El Hiani, Yassine Y; Linsdell, Paul P

Publication Date: 2010-10-15

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PubMed Link: 20675380

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Cystic fibrosis transmembrane conductance regulator: using differential reactivity toward channel-permeant and channel-impermeant thiol-reactive probes to test a molecular model for the pore.

Biochemistry

Alexander, Christopher C; Ivetac, Anthony A; Liu, Xuehong X; Norimatsu, Yohei Y; Serrano, Jose R JR; Landstrom, Allison A; Sansom, Mark M; Dawson, David C DC

Publication Date: 2009-10-27

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PubMed Link: 19754156

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• bi901314c.pdf
• bi901314c_si_001.pdf

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Locating the anion-selectivity filter of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel.

The Journal Of General Physiology

Cheung, M M; Akabas, M H MH

Publication Date: 1997-03

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PubMed Link: 9089437

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• 7357.pdf

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