Publications:

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Recent Strategic Advances in CFTR Drug Discovery: An Overview.

International Journal Of Molecular Sciences

Rusnati, Marco M; D'Ursi, Pasqualina P; Pedemonte, Nicoletta N; Urbinati, Chiara C; Ford, Robert C RC; Cichero, Elena E; Uggeri, Matteo M; Orro, Alessandro A; Fossa, Paola P

Publication Date: 2020-03-31

Variant appearance in text: CFTR: F508R

PubMed Link: 32244346

Variant Present in the following documents:

• Main text
• ijms-21-02407.pdf

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DROIDS 1.20: A GUI-Based Pipeline for GPU-Accelerated Comparative Protein Dynamics.

Biophysical Journal

Babbitt, Gregory A GA; Mortensen, Jamie S JS; Coppola, Erin E EE; Adams, Lily E LE; Liao, Justin K JK

Publication Date: 2018-03-13

Variant appearance in text: CFTR: F508R

PubMed Link: 29539389

Variant Present in the following documents:

• Main text
• main.pdf
• mmc2.pdf

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Requirements for efficient correction of ΔF508 CFTR revealed by analyses of evolved sequences.

Cell

Mendoza, Juan L JL; Schmidt, André A; Li, Qin Q; Nuvaga, Emmanuel E; Barrett, Tyler T; Bridges, Robert J RJ; Feranchak, Andrew P AP; Brautigam, Chad A CA; Thomas, Philip J PJ

Publication Date: 2012-01-20

Variant appearance in text: CFTR: F508R

PubMed Link: 22265409

Variant Present in the following documents:

• Main text

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Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function.

Cell

Rabeh, Wael M WM; Bossard, Florian F; Xu, Haijin H; Okiyoneda, Tsukasa T; Bagdany, Miklos M; Mulvihill, Cory M CM; Du, Kai K; di Bernardo, Salvatore S; Liu, Yuhong Y; Konermann, Lars L; Roldan, Ariel A; Lukacs, Gergely L GL

Publication Date: 2012-01-20

Variant appearance in text: CFTR: F508R

PubMed Link: 22265408

Variant Present in the following documents:

• Main text

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The cystic fibrosis-causing mutation deltaF508 affects multiple steps in cystic fibrosis transmembrane conductance regulator biogenesis.

The Journal Of Biological Chemistry

Thibodeau, Patrick H PH; Richardson, John M JM; Wang, Wei W; Millen, Linda L; Watson, Jarod J; Mendoza, Juan L JL; Du, Kai K; Fischman, Sharon S; Senderowitz, Hanoch H; Lukacs, Gergely L GL; Kirk, Kevin K; Thomas, Philip J PJ

Publication Date: 2010-11-12

Variant appearance in text: CFTR: F508R

PubMed Link: 20667826

Variant Present in the following documents:

• Main text

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A soluble sulfogalactosyl ceramide mimic promotes Delta F508 CFTR escape from endoplasmic reticulum associated degradation.

Chemistry & Biology

Park, Hyun-Joo HJ; Mylvaganum, Murugesapillai M; McPherson, Anne A; Fewell, Sheara W SW; Brodsky, Jeffrey L JL; Lingwood, Clifford A CA

Publication Date: 2009-04-24

Variant appearance in text: CFTR: F508R

PubMed Link: 19389632

Variant Present in the following documents:

• Main text

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Side chain and backbone contributions of Phe508 to CFTR folding.

Nature Structural & Molecular Biology

Thibodeau, Patrick H PH; Brautigam, Chad A CA; Machius, Mischa M; Thomas, Philip J PJ

Publication Date: 2005-01

Variant appearance in text: CFTR: F508R

PubMed Link: 15619636

Variant Present in the following documents:

• Main text

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Comparison of the bacterial HelA protein to the F508 region of the cystic fibrosis transmembrane regulator.

Journal Of Bacteriology

Goldman, B S BS; Sherman, D A DA; Kranz, R G RG

Publication Date: 1997-12

Variant appearance in text: CFTR: F508R

PubMed Link: 9401049

Variant Present in the following documents:

• Main text

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