Publications:

Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator.

The Journal Of Biological Chemistry

Wang, Chi C; Aleksandrov, Andrei A AA; Yang, Zhengrong Z; Forouhar, Farhad F; Proctor, Elizabeth A EA; Kota, Pradeep P; An, Jianli J; Kaplan, Anna A; Khazanov, Netaly N; Boël, Grégory G; Stockwell, Brent R BR; Senderowitz, Hanoch H; Dokholyan, Nikolay V NV; Riordan, John R JR; Brouillette, Christie G CG; Hunt, John F JF

Publication Date: 2018-11-16

Variant appearance in text: CFTR: C592L

PubMed Link: 29903914

Variant Present in the following documents:

• Main text

View BVdb publication page

Two salt bridges differentially contribute to the maintenance of cystic fibrosis transmembrane conductance regulator (CFTR) channel function.

The Journal Of Biological Chemistry

Cui, Guiying G; Freeman, Cody S CS; Knotts, Taylor T; Prince, Chengyu Z CZ; Kuang, Christopher C; McCarty, Nael A NA

Publication Date: 2013-07-12

Variant appearance in text: CFTR: C592L

PubMed Link: 23709221

Variant Present in the following documents:

• Main text

View BVdb publication page

Cystic fibrosis transmembrane conductance regulator: using differential reactivity toward channel-permeant and channel-impermeant thiol-reactive probes to test a molecular model for the pore.

Biochemistry

Alexander, Christopher C; Ivetac, Anthony A; Liu, Xuehong X; Norimatsu, Yohei Y; Serrano, Jose R JR; Landstrom, Allison A; Sansom, Mark M; Dawson, David C DC

Publication Date: 2009-10-27

Variant appearance in text: CFTR: C592L

PubMed Link: 19754156

Variant Present in the following documents:

• Main text
• bi901314c.pdf

View BVdb publication page

CFTR: Ligand exchange between a permeant anion ([Au(CN)2]-) and an engineered cysteine (T338C) blocks the pore.

Biophysical Journal

Serrano, José R JR; Liu, Xuehong X; Borg, Erik R ER; Alexander, Christopher S CS; Shaw, C Frank CF; Dawson, David C DC

Publication Date: 2006-09-01

Variant appearance in text: CFTR: C592L

PubMed Link: 16766608

Variant Present in the following documents:

• Main text

View BVdb publication page