Publications:

Synergistic Potentiation of Cystic Fibrosis Transmembrane Conductance Regulator Gating by Two Chemically Distinct Potentiators, Ivacaftor (VX-770) and 5-Nitro-2-(3-Phenylpropylamino) Benzoate.

Molecular Pharmacology

Lin, Wen-Ying WY; Sohma, Yoshiro Y; Hwang, Tzyh-Chang TC

Publication Date: 2016-09

Variant appearance in text: CFTR: Y1219F

PubMed Link: 27413118

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A single amino acid substitution in CFTR converts ATP to an inhibitory ligand.

The Journal Of General Physiology

Lin, Wen-Ying WY; Jih, Kang-Yang KY; Hwang, Tzyh-Chang TC

Publication Date: 2014-10

Variant appearance in text: CFTR: Y1219F

PubMed Link: 25225552

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• JGP_201411247.pdf

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A stable ATP binding to the nucleotide binding domain is important for reliable gating cycle in an ABC transporter CFTR.

The Journal Of Physiological Sciences : Jps

Shimizu, Hiroyasu H; Yu, Ying-Chun YC; Kono, Koichi K; Kubota, Takahiro T; Yasui, Masato M; Li, Min M; Hwang, Tzyh-Chang TC; Sohma, Yoshiro Y

Publication Date: 2010-09

Variant appearance in text: CFTR: Y1219F

PubMed Link: 20628841

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The two ATP binding sites of cystic fibrosis transmembrane conductance regulator (CFTR) play distinct roles in gating kinetics and energetics.

The Journal Of General Physiology

Zhou, Zhen Z; Wang, Xiaohui X; Liu, Hao-Yang HY; Zou, Xiaoqin X; Li, Min M; Hwang, Tzyh-Chang TC

Publication Date: 2006-10

Variant appearance in text: CFTR: Y1219F

PubMed Link: 16966475

Variant Present in the following documents:

• Main text
• jgp1280413.pdf

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