Publications:

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Potentiation of the cystic fibrosis transmembrane conductance regulator by VX-770 involves stabilization of the pre-hydrolytic, O1 state.

British Journal Of Pharmacology

Langron, Emily E; Prins, Stella S; Vergani, Paola P

Publication Date: 2018-10

Variant appearance in text: CFTR: K1250R

PubMed Link: 30107029

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Asymmetry of movements in CFTR's two ATP sites during pore opening serves their distinct functions.

Elife

Sorum, Ben B; Töröcsik, Beáta B; Csanády, László L

Publication Date: 2017-09-25

Variant appearance in text: CFTR: K1250R

PubMed Link: 28944753

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• Main text
• elife-29013.pdf

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Obligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerization.

Elife

Mihályi, Csaba C; Töröcsik, Beáta B; Csanády, László L

Publication Date: 2016-06-21

Variant appearance in text: CFTR: K1250R

PubMed Link: 27328319

Variant Present in the following documents:

• Main text
• elife-18164.pdf

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New structural insights into the gating movements of CFTR.

The Journal Of General Physiology

Puljung, Michael C MC

Publication Date: 2015-05

Variant appearance in text: CFTR: K1250R

PubMed Link: 25918357

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Cysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels.

The Journal Of General Physiology

Chaves, Luiz A Poletto LA; Gadsby, David C DC

Publication Date: 2015-04

Variant appearance in text: CFTR: K1250R

PubMed Link: 25825169

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• Main text
• JGP_201411347.pdf

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Mutant cycles at CFTR's non-canonical ATP-binding site support little interface separation during gating.

The Journal Of General Physiology

Szollosi, Andras A; Muallem, Daniella R DR; Csanády, László L; Vergani, Paola P

Publication Date: 2011-06

Variant appearance in text: CFTR: K1250R

PubMed Link: 21576373

Variant Present in the following documents:

• Main text
• JGP_201110608.pdf

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Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2.

The Journal Of General Physiology

Szollosi, Andras A; Vergani, Paola P; Csanády, László L

Publication Date: 2010-10

Variant appearance in text: CFTR: K1250R

PubMed Link: 20876359

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• JGP_201010434.pdf

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Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Csanády, László L; Vergani, Paola P; Gadsby, David C DC

Publication Date: 2010-01-19

Variant appearance in text: CFTR: K1250R

PubMed Link: 19966305

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Review. ATP hydrolysis-driven gating in cystic fibrosis transmembrane conductance regulator.

Philosophical Transactions Of The Royal Society Of London. Series B, Biological Sciences

Muallem, Daniella D; Vergani, Paola P

Publication Date: 2009-01-27

Variant appearance in text: CFTR: K1250R

PubMed Link: 18957373

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Thermodynamics of CFTR channel gating: a spreading conformational change initiates an irreversible gating cycle.

The Journal Of General Physiology

Csanády, László L; Nairn, Angus C AC; Gadsby, David C DC

Publication Date: 2006-11

Variant appearance in text: CFTR: K1250R

PubMed Link: 17043148

Variant Present in the following documents:

• Main text
• jgenphysiol_jgp.200609558_1.pdf
• jgp1280523.pdf

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Control of the CFTR channel's gates.

Biochemical Society Transactions

Vergani, P P; Basso, C C; Mense, M M; Nairn, A C AC; Gadsby, D C DC

Publication Date: 2005-11

Variant appearance in text: CFTR: K1250R

PubMed Link: 16246032

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CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains.

Nature

Vergani, Paola P; Lockless, Steve W SW; Nairn, Angus C AC; Gadsby, David C DC

Publication Date: 2005-02-24

Variant appearance in text: CFTR: K1250R

PubMed Link: 15729345

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CFTR: the nucleotide binding folds regulate the accessibility and stability of the activated state.

The Journal Of General Physiology

Wilkinson, D J DJ; Mansoura, M K MK; Watson, P Y PY; Smit, L S LS; Collins, F S FS; Dawson, D C DC

Publication Date: 1996-01

Variant appearance in text: CFTR: K1250R

PubMed Link: 8741733

Variant Present in the following documents:

• jg1071103.pdf

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