Publications:

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Molecular pathology of the R117H cystic fibrosis mutation is explained by loss of a hydrogen bond.

Elife

Simon, Márton A MA; Csanády, László L

Publication Date: 2021-12-06

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PubMed Link: 34870594

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Molecular pathology of the R117H cystic fibrosis mutation is explained by loss of a hydrogen bond.

Elife

Simon, Márton A MA; Csanády, László L

Publication Date: 2021-12-06

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PubMed Link: 34870594

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Potentiation of the cystic fibrosis transmembrane conductance regulator by VX-770 involves stabilization of the pre-hydrolytic, O1 state.

British Journal Of Pharmacology

Langron, Emily E; Prins, Stella S; Vergani, Paola P

Publication Date: 2018-10

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PubMed Link: 30107029

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Structural mechanisms of CFTR function and dysfunction.

The Journal Of General Physiology

Hwang, Tzyh-Chang TC; Yeh, Jiunn-Tyng JT; Zhang, Jingyao J; Yu, Ying-Chun YC; Yeh, Han-I HI; Destefano, Samantha S

Publication Date: 2018-04-02

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PubMed Link: 29581173

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A common mechanism for CFTR potentiators.

The Journal Of General Physiology

Yeh, Han-I HI; Sohma, Yoshiro Y; Conrath, Katja K; Hwang, Tzyh-Chang TC

Publication Date: 2017-12-04

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PubMed Link: 29079713

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Asymmetry of movements in CFTR's two ATP sites during pore opening serves their distinct functions.

Elife

Sorum, Ben B; Töröcsik, Beáta B; Csanády, László L

Publication Date: 2017-09-25

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PubMed Link: 28944753

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Modulation of CFTR gating by permeant ions.

The Journal Of General Physiology

Yeh, Han-I HI; Yeh, Jiunn-Tyng JT; Hwang, Tzyh-Chang TC

Publication Date: 2015-01

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PubMed Link: 25512598

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ATP and AMP mutually influence their interaction with the ATP-binding cassette (ABC) adenylate kinase cystic fibrosis transmembrane conductance regulator (CFTR) at separate binding sites.

The Journal Of Biological Chemistry

Randak, Christoph O CO; Dong, Qian Q; Ver Heul, Amanda R AR; Elcock, Adrian H AH; Welsh, Michael J MJ

Publication Date: 2013-09-20

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PubMed Link: 23921386

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Demonstration of phosphoryl group transfer indicates that the ATP-binding cassette (ABC) transporter cystic fibrosis transmembrane conductance regulator (CFTR) exhibits adenylate kinase activity.

The Journal Of Biological Chemistry

Randak, Christoph O CO; Ver Heul, Amanda R AR; Welsh, Michael J MJ

Publication Date: 2012-10-19

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PubMed Link: 22948143

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On the mechanism of CFTR inhibition by a thiazolidinone derivative.

The Journal Of General Physiology

Kopeikin, Zoia Z; Sohma, Yoshiro Y; Li, Min M; Hwang, Tzyh-Chang TC

Publication Date: 2010-12

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PubMed Link: 21078867

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State-dependent regulation of cystic fibrosis transmembrane conductance regulator (CFTR) gating by a high affinity Fe3+ bridge between the regulatory domain and cytoplasmic loop 3.

The Journal Of Biological Chemistry

Wang, Guangyu G

Publication Date: 2010-12-24

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PubMed Link: 20952391

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Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2.

The Journal Of General Physiology

Szollosi, Andras A; Vergani, Paola P; Csanády, László L

Publication Date: 2010-10

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PubMed Link: 20876359

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Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Csanády, László L; Vergani, Paola P; Gadsby, David C DC

Publication Date: 2010-01-19

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PubMed Link: 19966305

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Direct sensing of intracellular pH by the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel.

The Journal Of Biological Chemistry

Chen, Jeng-Haur JH; Cai, Zhiwei Z; Sheppard, David N DN

Publication Date: 2009-12-18

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PubMed Link: 19837660

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Review. ATP hydrolysis-driven gating in cystic fibrosis transmembrane conductance regulator.

Philosophical Transactions Of The Royal Society Of London. Series B, Biological Sciences

Muallem, Daniella D; Vergani, Paola P

Publication Date: 2009-01-27

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PubMed Link: 18957373

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A mutation in CFTR modifies the effects of the adenylate kinase inhibitor Ap5A on channel gating.

Biophysical Journal

Dong, Qian Q; Randak, Christoph O CO; Welsh, Michael J MJ

Publication Date: 2008-12

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PubMed Link: 18805924

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Control of the CFTR channel's gates.

Biochemical Society Transactions

Vergani, P P; Basso, C C; Mense, M M; Nairn, A C AC; Gadsby, D C DC

Publication Date: 2005-11

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PubMed Link: 16246032

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CFTR gating II: Effects of nucleotide binding on the stability of open states.

The Journal Of General Physiology

Bompadre, Silvia G SG; Cho, Jeong Han JH; Wang, Xiaohui X; Zou, Xiaoqin X; Sohma, Yoshiro Y; Li, Min M; Hwang, Tzyh-Chang TC

Publication Date: 2005-04

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PubMed Link: 15767296

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CFTR gating I: Characterization of the ATP-dependent gating of a phosphorylation-independent CFTR channel (DeltaR-CFTR).

The Journal Of General Physiology

Bompadre, Silvia G SG; Ai, Tomohiko T; Cho, Jeong Han JH; Wang, Xiaohui X; Sohma, Yoshiro Y; Li, Min M; Hwang, Tzyh-Chang TC

Publication Date: 2005-04

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PubMed Link: 15767295

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ADP inhibits function of the ABC transporter cystic fibrosis transmembrane conductance regulator via its adenylate kinase activity.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Randak, Christoph O CO; Welsh, Michael J MJ

Publication Date: 2005-02-08

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PubMed Link: 15684079

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On the mechanism of MgATP-dependent gating of CFTR Cl- channels.

The Journal Of General Physiology

Vergani, Paola P; Nairn, Angus C AC; Gadsby, David C DC

Publication Date: 2003-01

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PubMed Link: 12508051

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Regulation of CFTR Cl- channel gating by ATP binding and hydrolysis.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Ikuma, M M; Welsh, M J MJ

Publication Date: 2000-07-18

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PubMed Link: 10880569

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CFTR: the nucleotide binding folds regulate the accessibility and stability of the activated state.

The Journal Of General Physiology

Wilkinson, D J DJ; Mansoura, M K MK; Watson, P Y PY; Smit, L S LS; Collins, F S FS; Dawson, D C DC

Publication Date: 1996-01

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PubMed Link: 8741733

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• jg1071103.pdf

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