Stabilization of a nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator yields insight into disease-causing mutations.
The Journal Of Biological Chemistry
Vernon, Robert M RM; Chong, P Andrew PA; Lin, Hong H; Yang, Zhengrong Z; Zhou, Qingxian Q; Aleksandrov, Andrei A AA; Dawson, Jennifer E JE; Riordan, John R JR; Brouillette, Christie G CG; Thibodeau, Patrick H PH; Forman-Kay, Julie D JD
A sequence upstream of canonical PDZ-binding motif within CFTR COOH-terminus enhances NHERF1 interaction.
American Journal Of Physiology. Lung Cellular And Molecular Physiology
Sharma, Neeraj N; LaRusch, Jessica J; Sosnay, Patrick R PR; Gottschalk, Laura B LB; Lopez, Andrea P AP; Pellicore, Matthew J MJ; Evans, Taylor T; Davis, Emily E; Atalar, Melis M; Na, Chan-Hyun CH; Rosson, Gedge D GD; Belchis, Deborah D; Milewski, Michal M; Pandey, Akhilesh A; Cutting, Garry R GR
Development and characterization of synthetic antibodies binding to the cystic fibrosis conductance regulator.
Mabs
Gakhal, Amandeep K AK; Jensen, Timothy J TJ; Bozoky, Zoltan Z; Roldan, Ariel A; Lukacs, Gergely L GL; Forman-Kay, Julie J; Riordan, John R JR; Sidhu, Sachdev S SS
Regulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra- and intermolecular interactions.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Bozoky, Zoltan Z; Krzeminski, Mickael M; Muhandiram, Ranjith R; Birtley, James R JR; Al-Zahrani, Ateeq A; Thomas, Philip J PJ; Frizzell, Raymond A RA; Ford, Robert C RC; Forman-Kay, Julie D JD
The H-loop in the second nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator is required for efficient chloride channel closing.
Cellular Physiology And Biochemistry : International Journal Of Experimental Cellular Physiology, Biochemistry, And Pharmacology
Kloch, Monika M; Milewski, Michał M; Nurowska, Ewa E; Dworakowska, Beata B; Cutting, Garry R GR; Dołowy, Krzysztof K