Multi-level evidence of an allelic hierarchy of USH2A variants in hearing, auditory processing and speech/language outcomes.
Communications Biology
Perrino, Peter A PA; Talbot, Lidiya L; Kirkland, Rose R; Hill, Amanda A; Rendall, Amanda R AR; Mountford, Hayley S HS; Taylor, Jenny J; , ; Buscarello, Alexzandrea N AN; Lahiri, Nayana N; Saggar, Anand A; Fitch, R Holly RH; Newbury, Dianne F DF
A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma.
Scientific Reports
Stringer, Brett W BW; Day, Bryan W BW; D'Souza, Rochelle C J RCJ; Jamieson, Paul R PR; Ensbey, Kathleen S KS; Bruce, Zara C ZC; Lim, Yi Chieh YC; Goasdoué, Kate K; Offenhäuser, Carolin C; Akgül, Seçkin S; Allan, Suzanne S; Robertson, Thomas T; Lucas, Peter P; Tollesson, Gert G; Campbell, Scott S; Winter, Craig C; Do, Hongdo H; Dobrovic, Alexander A; Inglis, Po-Ling PL; Jeffree, Rosalind L RL; Johns, Terrance G TG; Boyd, Andrew W AW
Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density.
Nature Communications
Chesi, Alessandra A; Wagley, Yadav Y; Johnson, Matthew E ME; Manduchi, Elisabetta E; Su, Chun C; Lu, Sumei S; Leonard, Michelle E ME; Hodge, Kenyaita M KM; Pippin, James A JA; Hankenson, Kurt D KD; Wells, Andrew D AD; Grant, Struan F A SFA
Genome-wide association studies of brain imaging phenotypes in UK Biobank.
Nature
Elliott, Lloyd T LT; Sharp, Kevin K; Alfaro-Almagro, Fidel F; Shi, Sinan S; Miller, Karla L KL; Douaud, Gwenaëlle G; Marchini, Jonathan J; Smith, Stephen M SM
A mutation in FRIZZLED2 impairs Wnt signaling and causes autosomal dominant omodysplasia.
Human Molecular Genetics
Saal, Howard M HM; Prows, Cynthia A CA; Guerreiro, Iris I; Donlin, Milene M; Knudson, Luke L; Sund, Kristen L KL; Chang, Ching-Fang CF; Brugmann, Samantha A SA; Stottmann, Rolf W RW
Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
Plos Genetics
Kemp, John P JP; Medina-Gomez, Carolina C; Estrada, Karol K; St Pourcain, Beate B; Heppe, Denise H M DH; Warrington, Nicole M NM; Oei, Ling L; Ring, Susan M SM; Kruithof, Claudia J CJ; Timpson, Nicholas J NJ; Wolber, Lisa E LE; Reppe, Sjur S; Gautvik, Kaare K; Grundberg, Elin E; Ge, Bing B; van der Eerden, Bram B; van de Peppel, Jeroen J; Hibbs, Matthew A MA; Ackert-Bicknell, Cheryl L CL; Choi, Kwangbom K; Koller, Daniel L DL; Econs, Michael J MJ; Williams, Frances M K FM; Foroud, Tatiana T; Zillikens, M Carola MC; Ohlsson, Claes C; Hofman, Albert A; Uitterlinden, André G AG; Davey Smith, George G; Jaddoe, Vincent W V VW; Tobias, Jonathan H JH; Rivadeneira, Fernando F; Evans, David M DM
Meta-analysis of genome-wide studies identifies MEF2C SNPs associated with bone mineral density at forearm.
Journal Of Medical Genetics
Zheng, Hou-Feng HF; Duncan, Emma L EL; Yerges-Armstrong, Laura M LM; Eriksson, Joel J; Bergström, Ulrica U; Leo, Paul J PJ; Leslie, William D WD; Goltzman, David D; Blangero, John J; Hanley, David A DA; Carless, Melanie A MA; Streeten, Elizabeth A EA; Lorentzon, Mattias M; Brown, Matthew A MA; Spector, Tim D TD; Pettersson-Kymmer, Ulrika U; Ohlsson, Claes C; Mitchell, Braxton D BD; Richards, J Brent JB
Duplication of C7orf58, WNT16 and FAM3C in an obese female with a t(7;22)(q32.1;q11.2) chromosomal translocation and clinical features resembling Coffin-Siris Syndrome.
Plos One
Zhu, Jun J; Qiu, Jun J; Magrane, Gregg G; Abedalthagafi, Malak M; Zanko, Andrea A; Golabi, Mahin M; Chehab, Farid F FF
WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk.
Plos Genetics
Zheng, Hou-Feng HF; Tobias, Jon H JH; Duncan, Emma E; Evans, David M DM; Eriksson, Joel J; Paternoster, Lavinia L; Yerges-Armstrong, Laura M LM; Lehtimäki, Terho T; Bergström, Ulrica U; Kähönen, Mika M; Leo, Paul J PJ; Raitakari, Olli O; Laaksonen, Marika M; Nicholson, Geoffrey C GC; Viikari, Jorma J; Ladouceur, Martin M; Lyytikäinen, Leo-Pekka LP; Medina-Gomez, Carolina C; Rivadeneira, Fernando F; Prince, Richard L RL; Sievanen, Harri H; Leslie, William D WD; Mellström, Dan D; Eisman, John A JA; Movérare-Skrtic, Sofia S; Goltzman, David D; Hanley, David A DA; Jones, Graeme G; St Pourcain, Beate B; Xiao, Yongjun Y; Timpson, Nicholas J NJ; Smith, George Davey GD; Reid, Ian R IR; Ring, Susan M SM; Sambrook, Philip N PN; Karlsson, Magnus M; Dennison, Elaine M EM; Kemp, John P JP; Danoy, Patrick P; Sayers, Adrian A; Wilson, Scott G SG; Nethander, Maria M; McCloskey, Eugene E; Vandenput, Liesbeth L; Eastell, Richard R; Liu, Jeff J; Spector, Tim T; Mitchell, Braxton D BD; Streeten, Elizabeth A EA; Brommage, Robert R; Pettersson-Kymmer, Ulrika U; Brown, Matthew A MA; Ohlsson, Claes C; Richards, J Brent JB; Lorentzon, Mattias M
Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.
Plos Genetics
Medina-Gomez, Carolina C; Kemp, John P JP; Estrada, Karol K; Eriksson, Joel J; Liu, Jeff J; Reppe, Sjur S; Evans, David M DM; Heppe, Denise H M DH; Vandenput, Liesbeth L; Herrera, Lizbeth L; Ring, Susan M SM; Kruithof, Claudia J CJ; Timpson, Nicholas J NJ; Zillikens, M Carola MC; Olstad, Ole K OK; Zheng, Hou-Feng HF; Richards, J Brent JB; St Pourcain, Beate B; Hofman, Albert A; Jaddoe, Vincent W V VW; Smith, George Davey GD; Lorentzon, Mattias M; Gautvik, Kaare M KM; Uitterlinden, André G AG; Brommage, Robert R; Ohlsson, Claes C; Tobias, Jonathan H JH; Rivadeneira, Fernando F