wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome.
Plos Genetics
Watson, Claire J CJ; Tang, W Joyce WJ; Rojas, Maria F MF; Fiedler, Imke A K IAK; Morfin Montes de Oca, Ernesto E; Cronrath, Andrea R AR; Callies, Lulu K LK; Swearer, Avery Angell AA; Ahmed, Ali R AR; Sethuraman, Visali V; Addish, Sumaya S; Farr, Gist H GH; Gómez, Arianna Ericka AE; Rai, Jyoti J; Monstad-Rios, Adrian T AT; Gardiner, Edith M EM; Karasik, David D; Maves, Lisa L; Busse, Bjorn B; Hsu, Yi-Hsiang YH; Kwon, Ronald Young RY
Level and change in bone microarchitectural parameters and their relationship with previous fracture and established bone mineral density loci.
Bone
Fuggle, Nicholas R NR; Westbury, Leo D LD; Bevilacqua, Gregorio G; Titcombe, Philip P; Ó Breasail, Mícheál M; Harvey, Nicholas C NC; Dennison, Elaine M EM; Cooper, Cyrus C; Ward, Kate A KA
GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures.
Nature Communications
Styrkarsdottir, Unnur U; Stefansson, Olafur A OA; Gunnarsdottir, Kristbjorg K; Thorleifsson, Gudmar G; Lund, Sigrun H SH; Stefansdottir, Lilja L; Juliusson, Kristinn K; Agustsdottir, Arna B AB; Zink, Florian F; Halldorsson, Gisli H GH; Ivarsdottir, Erna V EV; Benonisdottir, Stefania S; Jonsson, Hakon H; Gylfason, Arnaldur A; Norland, Kristjan K; Trajanoska, Katerina K; Boer, Cindy G CG; Southam, Lorraine L; Leung, Jason C S JCS; Tang, Nelson L S NLS; Kwok, Timothy C Y TCY; Lee, Jenny S W JSW; Ho, Suzanne C SC; Byrjalsen, Inger I; Center, Jacqueline R JR; Lee, Seung Hun SH; Koh, Jung-Min JM; Lohmander, L Stefan LS; Ho-Pham, Lan T LT; Nguyen, Tuan V TV; Eisman, John A JA; Woo, Jean J; Leung, Ping-C PC; Loughlin, John J; Zeggini, Eleftheria E; Christiansen, Claus C; Rivadeneira, Fernando F; van Meurs, Joyce J; Uitterlinden, Andre G AG; Mogensen, Brynjolfur B; Jonsson, Helgi H; Ingvarsson, Thorvaldur T; Sigurdsson, Gunnar G; Benediktsson, Rafn R; Sulem, Patrick P; Jonsdottir, Ingileif I; Masson, Gisli G; Holm, Hilma H; Norddahl, Gudmundur L GL; Thorsteinsdottir, Unnur U; Gudbjartsson, Daniel F DF; Stefansson, Kari K
Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density.
Nature Communications
Chesi, Alessandra A; Wagley, Yadav Y; Johnson, Matthew E ME; Manduchi, Elisabetta E; Su, Chun C; Lu, Sumei S; Leonard, Michelle E ME; Hodge, Kenyaita M KM; Pippin, James A JA; Hankenson, Kurt D KD; Wells, Andrew D AD; Grant, Struan F A SFA
The interactions of physical activity, exercise and genetics and their associations with bone mineral density: implications for injury risk in elite athletes.
European Journal Of Applied Physiology
Herbert, Adam J AJ; Williams, Alun G AG; Hennis, Philip J PJ; Erskine, Robert M RM; Sale, Craig C; Day, Stephen H SH; Stebbings, Georgina K GK
A Pilot Genome-Wide Association Study in Postmenopausal Mexican-Mestizo Women Implicates the RMND1/CCDC170 Locus Is Associated with Bone Mineral Density.
International Journal Of Genomics
Villalobos-Comparán, Marisela M; Jiménez-Ortega, Rogelio F RF; Estrada, Karol K; Parra-Torres, Alma Y AY; González-Mercado, Anahí A; Patiño, Nelly N; Castillejos-López, Manuel M; Quiterio, Manuel M; Fernandez-López, Juan Carlos JC; Ibarra, Bertha B; Romero-Hidalgo, Sandra S; Salmerón, Jorge J; Velázquez-Cruz, Rafael R
Gene-Hormone Therapy Interaction and Fracture Risk in Postmenopausal Women.
The Journal Of Clinical Endocrinology And Metabolism
Wang, Youjin Y; Wactawski-Wende, Jean J; Sucheston-Campbell, Lara E LE; Preus, Leah L; Hovey, Kathleen M KM; Nie, Jing J; Jackson, Rebecca D RD; Handelman, Samuel K SK; Nassir, Rami R; Crandall, Carolyn J CJ; Ochs-Balcom, Heather M HM
Identification of IDUA and WNT16 Phosphorylation-Related Non-Synonymous Polymorphisms for Bone Mineral Density in Meta-Analyses of Genome-Wide Association Studies.
Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research
Niu, Tianhua T; Liu, Ning N; Yu, Xun X; Zhao, Ming M; Choi, Hyung Jin HJ; Leo, Paul J PJ; Brown, Matthew A MA; Zhang, Lei L; Pei, Yu-Fang YF; Shen, Hui H; He, Hao H; Fu, Xiaoying X; Lu, Shan S; Chen, Xiang-Ding XD; Tan, Li-Jun LJ; Yang, Tie-Lin TL; Guo, Yan Y; Cho, Nam H NH; Shen, Jie J; Guo, Yan-Fang YF; Nicholson, Geoffrey C GC; Prince, Richard L RL; Eisman, John A JA; Jones, Graeme G; Sambrook, Philip N PN; Tian, Qing Q; Zhu, Xue-Zhen XZ; Papasian, Christopher J CJ; Duncan, Emma L EL; Uitterlinden, André G AG; Shin, Chan Soo CS; Xiang, Shuanglin S; Deng, Hong-Wen HW
Genetic variants in adult bone mineral density and fracture risk genes are associated with the rate of bone mineral density acquisition in adolescence.
Human Molecular Genetics
Warrington, Nicole M NM; Kemp, John P JP; Tilling, Kate K; Tobias, Jonathan H JH; Evans, David M DM
Haplotype association analysis of genes within the WNT signalling pathways in diabetic nephropathy.
Bmc Nephrology
Kavanagh, David H DH; Savage, David A DA; Patterson, Christopher C CC; McKnight, Amy Jayne AJ; Crean, John K JK; Maxwell, Alexander P AP; McKay, Gareth J GJ; ,
Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women.
Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research
Koller, Daniel L DL; Zheng, Hou-Feng HF; Karasik, David D; Yerges-Armstrong, Laura L; Liu, Ching-Ti CT; McGuigan, Fiona F; Kemp, John P JP; Giroux, Sylvie S; Lai, Dongbing D; Edenberg, Howard J HJ; Peacock, Munro M; Czerwinski, Stefan A SA; Choh, Audrey C AC; McMahon, George G; St Pourcain, Beate B; Timpson, Nicholas J NJ; Lawlor, Debbie A DA; Evans, David M DM; Towne, Bradford B; Blangero, John J; Carless, Melanie A MA; Kammerer, Candace C; Goltzman, David D; Kovacs, Christopher S CS; Prior, Jerilynn C JC; Spector, Tim D TD; Rousseau, Francois F; Tobias, Jon H JH; Akesson, Kristina K; Econs, Michael J MJ; Mitchell, Braxton D BD; Richards, J Brent JB; Kiel, Douglas P DP; Foroud, Tatiana T
Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.
Plos Genetics
Medina-Gomez, Carolina C; Kemp, John P JP; Estrada, Karol K; Eriksson, Joel J; Liu, Jeff J; Reppe, Sjur S; Evans, David M DM; Heppe, Denise H M DH; Vandenput, Liesbeth L; Herrera, Lizbeth L; Ring, Susan M SM; Kruithof, Claudia J CJ; Timpson, Nicholas J NJ; Zillikens, M Carola MC; Olstad, Ole K OK; Zheng, Hou-Feng HF; Richards, J Brent JB; St Pourcain, Beate B; Hofman, Albert A; Jaddoe, Vincent W V VW; Smith, George Davey GD; Lorentzon, Mattias M; Gautvik, Kaare M KM; Uitterlinden, André G AG; Brommage, Robert R; Ohlsson, Claes C; Tobias, Jonathan H JH; Rivadeneira, Fernando F
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
Nature Genetics
Estrada, Karol K; Styrkarsdottir, Unnur U; Evangelou, Evangelos E; Hsu, Yi-Hsiang YH; Duncan, Emma L EL; Ntzani, Evangelia E EE; Oei, Ling L; Albagha, Omar M E OM; Amin, Najaf N; Kemp, John P JP; Koller, Daniel L DL; Li, Guo G; Liu, Ching-Ti CT; Minster, Ryan L RL; Moayyeri, Alireza A; Vandenput, Liesbeth L; Willner, Dana D; Xiao, Su-Mei SM; Yerges-Armstrong, Laura M LM; Zheng, Hou-Feng HF; Alonso, Nerea N; Eriksson, Joel J; Kammerer, Candace M CM; Kaptoge, Stephen K SK; Leo, Paul J PJ; Thorleifsson, Gudmar G; Wilson, Scott G SG; Wilson, James F JF; Aalto, Ville V; Alen, Markku M; Aragaki, Aaron K AK; Aspelund, Thor T; Center, Jacqueline R JR; Dailiana, Zoe Z; Duggan, David J DJ; Garcia, Melissa M; Garcia-Giralt, Natàlia N; Giroux, Sylvie S; Hallmans, Göran G; Hocking, Lynne J LJ; Husted, Lise Bjerre LB; Jameson, Karen A KA; Khusainova, Rita R; Kim, Ghi Su GS; Kooperberg, Charles C; Koromila, Theodora T; Kruk, Marcin M; Laaksonen, Marika M; Lacroix, Andrea Z AZ; Lee, Seung Hun SH; Leung, Ping C PC; Lewis, Joshua R JR; Masi, Laura L; Mencej-Bedrac, Simona S; Nguyen, Tuan V TV; Nogues, Xavier X; Patel, Millan S MS; Prezelj, Janez J; Rose, Lynda M LM; Scollen, Serena S; Siggeirsdottir, Kristin K; Smith, Albert V AV; Svensson, Olle O; Trompet, Stella S; Trummer, Olivia O; van Schoor, Natasja M NM; Woo, Jean J; Zhu, Kun K; Balcells, Susana S; Brandi, Maria Luisa ML; Buckley, Brendan M BM; Cheng, Sulin S; Christiansen, Claus C; Cooper, Cyrus C; Dedoussis, George G; Ford, Ian I; Frost, Morten M; Goltzman, David D; González-Macías, Jesús J; Kähönen, Mika M; Karlsson, Magnus M; Khusnutdinova, Elza E; Koh, Jung-Min JM; Kollia, Panagoula P; Langdahl, Bente Lomholt BL; Leslie, William D WD; Lips, Paul P; Ljunggren, Östen Ö; Lorenc, Roman S RS; Marc, Janja J; Mellström, Dan D; Obermayer-Pietsch, Barbara B; Olmos, José M JM; Pettersson-Kymmer, Ulrika U; Reid, David M DM; Riancho, José A JA; Ridker, Paul M PM; Rousseau, François F; Slagboom, P Eline PE; Tang, Nelson L S NL; Urreizti, Roser R; Van Hul, Wim W; Viikari, Jorma J; Zarrabeitia, María T MT; Aulchenko, Yurii S YS; Castano-Betancourt, Martha M; Grundberg, Elin E; Herrera, Lizbeth L; Ingvarsson, Thorvaldur T; Johannsdottir, Hrefna H; Kwan, Tony T; Li, Rui R; Luben, Robert R; Medina-Gómez, Carolina C; Palsson, Stefan Th ST; Reppe, Sjur S; Rotter, Jerome I JI; Sigurdsson, Gunnar G; van Meurs, Joyce B J JB; Verlaan, Dominique D; Williams, Frances M K FM; Wood, Andrew R AR; Zhou, Yanhua Y; Gautvik, Kaare M KM; Pastinen, Tomi T; Raychaudhuri, Soumya S; Cauley, Jane A JA; Chasman, Daniel I DI; Clark, Graeme R GR; Cummings, Steven R SR; Danoy, Patrick P; Dennison, Elaine M EM; Eastell, Richard R; Eisman, John A JA; Gudnason, Vilmundur V; Hofman, Albert A; Jackson, Rebecca D RD; Jones, Graeme G; Jukema, J Wouter JW; Khaw, Kay-Tee KT; Lehtimäki, Terho T; Liu, Yongmei Y; Lorentzon, Mattias M; McCloskey, Eugene E; Mitchell, Braxton D BD; Nandakumar, Kannabiran K; Nicholson, Geoffrey C GC; Oostra, Ben A BA; Peacock, Munro M; Pols, Huibert A P HA; Prince, Richard L RL; Raitakari, Olli O; Reid, Ian R IR; Robbins, John J; Sambrook, Philip N PN; Sham, Pak Chung PC; Shuldiner, Alan R AR; Tylavsky, Frances A FA; van Duijn, Cornelia M CM; Wareham, Nick J NJ; Cupples, L Adrienne LA; Econs, Michael J MJ; Evans, David M DM; Harris, Tamara B TB; Kung, Annie Wai Chee AW; Psaty, Bruce M BM; Reeve, Jonathan J; Spector, Timothy D TD; Streeten, Elizabeth A EA; Zillikens, M Carola MC; Thorsteinsdottir, Unnur U; Ohlsson, Claes C; Karasik, David D; Richards, J Brent JB; Brown, Matthew A MA; Stefansson, Kari K; Uitterlinden, André G AG; Ralston, Stuart H SH; Ioannidis, John P A JP; Kiel, Douglas P DP; Rivadeneira, Fernando F