TAS2R16 c.516T>G ;(p.N172K)

Variant ID: 7-122635173-A-C

NM_016945.2(TAS2R16):c.516T>G;(p.N172K)

This variant was identified in 26 publications

View GRCh38 version.




Publications:


Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Publication Date: 2023-02-23

Variant appearance in text: TAS2R16: 516T>G; Asn172Lys
PubMed Link: 36823319
Variant Present in the following documents:
  • 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6
View BVdb publication page



Expanding the prostate cancer cell line repertoire with ACRJ-PC28, an AR-negative neuroendocrine cell line derived from an African-Caribbean patient.

Cancer Research Communications
Valentine, Henkel H; Aiken, William W; Morrison, Belinda B; Zhao, Ziran Z; Fowle, Holly H; Wasserman, Jason S JS; Thompson, Elon E; Chin, Warren W; Young, Mark M; Clarke, Shannique S; Gibbs, Denise D; Harrison, Sharon S; McLaughlin, Wayne W; Kwok, Tim T; Jin, Fang F; Campbell, Kerry S KS; Horvath, Anelia A; Thompson, Rory R; Lee, Norman H NH; Zhou, Yan Y; Graña, Xavier X; Ragin, Camille C; Badal, Simone S
Publication Date: 2022-11

Variant appearance in text: TAS2R16: N172K; rs846664
PubMed Link: 36643868
Variant Present in the following documents:
  • crc-22-0245-s07.xlsx, sheet 1
View BVdb publication page



The Impact of Taste Preference-Related Gene Polymorphisms on Alcohol Consumption Behavior: A Systematic Review.

International Journal Of Molecular Sciences
Kurshed, Ali Abbas Mohammad AAM; Ádány, Róza R; Diószegi, Judit J
Publication Date: 2022-12-15

Variant appearance in text: rs846664
PubMed Link: 36555636
Variant Present in the following documents:
  • Main text
View BVdb publication page



Polymorphisms, diet and nutrigenomics.

Journal Of Preventive Medicine And Hygiene
Kiani, Aysha Karim AK; Bonetti, Gabriele G; Donato, Kevin K; Kaftalli, Jurgen J; Herbst, Karen L KL; Stuppia, Liborio L; Fioretti, Francesco F; Nodari, Savina S; Perrone, Marco M; Chiurazzi, Pietro P; Bellinato, Francesco F; Gisondi, Paolo P; Bertelli, Matteo M
Publication Date: 2022-06

Variant appearance in text: rs846664
PubMed Link: 36479483
Variant Present in the following documents:
  • Main text
  • jpmh-2022-02-e125.pdf
View BVdb publication page



Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines.

Nature Neuroscience
Baxi, Emily G EG; Thompson, Terri T; Li, Jonathan J; Kaye, Julia A JA; Lim, Ryan G RG; Wu, Jie J; Ramamoorthy, Divya D; Lima, Leandro L; Vaibhav, Vineet V; Matlock, Andrea A; Frank, Aaron A; Coyne, Alyssa N AN; Landin, Barry B; Ornelas, Loren L; Mosmiller, Elizabeth E; Thrower, Sara S; Farr, S Michelle SM; Panther, Lindsey L; Gomez, Emilda E; Galvez, Erick E; Perez, Daniel D; Meepe, Imara I; Lei, Susan S; Mandefro, Berhan B; Trost, Hannah H; Pinedo, Louis L; Banuelos, Maria G MG; Liu, Chunyan C; Moran, Ruby R; Garcia, Veronica V; Workman, Michael M; Ho, Richie R; Wyman, Stacia S; Roggenbuck, Jennifer J; Harms, Matthew B MB; Stocksdale, Jennifer J; Miramontes, Ricardo R; Wang, Keona K; Venkatraman, Vidya V; Holewenski, Ronald R; Sundararaman, Niveda N; Pandey, Rakhi R; Manalo, Danica-Mae DM; Donde, Aneesh A; Huynh, Nhan N; Adam, Miriam M; Wassie, Brook T BT; Vertudes, Edward E; Amirani, Naufa N; Raja, Krishna K; Thomas, Reuben R; Hayes, Lindsey L; Lenail, Alex A; Cerezo, Aianna A; Luppino, Sarah S; Farrar, Alanna A; Pothier, Lindsay L; Prina, Carolyn C; Morgan, Todd T; Jamil, Arish A; Heintzman, Sarah S; Jockel-Balsarotti, Jennifer J; Karanja, Elizabeth E; Markway, Jesse J; McCallum, Molly M; Joslin, Ben B; Alibazoglu, Deniz D; Kolb, Stephen S; Ajroud-Driss, Senda S; Baloh, Robert R; Heitzman, Daragh D; Miller, Tim T; Glass, Jonathan D JD; Patel-Murray, Natasha Leanna NL; Yu, Hong H; Sinani, Ervin E; Vigneswaran, Prasha P; Sherman, Alexander V AV; Ahmad, Omar O; Roy, Promit P; Beavers, Jay C JC; Zeiler, Steven S; Krakauer, John W JW; Agurto, Carla C; Cecchi, Guillermo G; Bellard, Mary M; Raghav, Yogindra Y; Sachs, Karen K; Ehrenberger, Tobias T; Bruce, Elizabeth E; Cudkowicz, Merit E ME; Maragakis, Nicholas N; Norel, Raquel R; Van Eyk, Jennifer E JE; Finkbeiner, Steven S; Berry, James J; Sareen, Dhruv D; Thompson, Leslie M LM; Fraenkel, Ernest E; Svendsen, Clive N CN; Rothstein, Jeffrey D JD
Publication Date: 2022-02

Variant appearance in text: TAS2R16: N172K; rs846664
PubMed Link: 35115730
Variant Present in the following documents:
  • 41593_2021_1006_MOESM4_ESM.xlsx, sheet 7
View BVdb publication page



A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution.

Molecular Biology And Evolution
Yang, Hui H; Yang, Songlin S; Fan, Fei F; Li, Yun Y; Dai, Shaoxing S; Zhou, Xin X; Steiner, Cynthia C CC; Coppedge, Bretton B; Roos, Christian C; Cai, Xianghai X; Irwin, David M DM; Shi, Peng P
Publication Date: 2021-12-09

Variant appearance in text: TAS2R16: N172K
PubMed Link: 34469542
Variant Present in the following documents:
  • Main text
  • msab263.pdf
View BVdb publication page



A Bitter Taste in Your Heart.

Frontiers In Physiology
Bloxham, Conor J CJ; Foster, Simon R SR; Thomas, Walter G WG
Publication Date: 2020

Variant appearance in text: T2R16: N172K; rs846664
PubMed Link: 32457649
Variant Present in the following documents:
  • Main text
  • fphys-11-00431.pdf
View BVdb publication page



New insights into the pathogenicity of non-synonymous variants through multi-level analysis.

Scientific Reports
Sun, Hong H; Yu, Guangjun G
Publication Date: 2019-02-07

Variant appearance in text: TAS2R16: 516T>G
PubMed Link: 30733553
Variant Present in the following documents:
  • Main text
  • 41598_2018_Article_38189.pdf
View BVdb publication page



Genes from the TAS1R and TAS2R Families of Taste Receptors: Looking for Signatures of Their Adaptive Role in Human Evolution.

Genome Biology And Evolution
Valente, Cristina C; Alvarez, Luis L; Marques, Patrícia Isabel PI; Gusmão, Leonor L; Amorim, António A; Seixas, Susana S; João Prata, Maria M
Publication Date: 2018-04-01

Variant appearance in text: rs846664
PubMed Link: 29635333
Variant Present in the following documents:
  • Main text
  • evy071.pdf
View BVdb publication page



Development and validation of a targeted next generation DNA sequencing panel outperforming whole exome sequencing for the identification of clinically relevant genetic variants.

Oncotarget
Miller, Eirwen M EM; Patterson, Nicole E NE; Zechmeister, Jenna Marcus JM; Bejerano-Sagie, Michal M; Delio, Maria M; Patel, Kunjan K; Ravi, Nivedita N; Quispe-Tintaya, Wilber W; Maslov, Alexander A; Simmons, Nichelle N; Castaldi, Maria M; Vijg, Jan J; Karabakhtsian, Rouzan G RG; Greally, John M JM; Kuo, Dennis Y S DYS; Montagna, Cristina C
Publication Date: 2017-11-24

Variant appearance in text: TAS2R16: N172K; rs846664
PubMed Link: 29254223
Variant Present in the following documents:
  • oncotarget-08-102033-s003.xlsx, sheet 1
View BVdb publication page



Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer.

Bmc Gastroenterology
Barontini, Jonathan J; Antinucci, Marco M; Tofanelli, Sergio S; Cammalleri, Maurizio M; Dal Monte, Massimo M; Gemignani, Federica F; Vodicka, Pavel P; Marangoni, Roberto R; Vodickova, Ludmila L; Kupcinskas, Juozas J; Vymetalkova, Veronika V; Forsti, Asta A; Canzian, Federico F; Stein, Angelika A; Moreno, Victor V; Mastrodonato, Nicola N; Tavano, Francesca F; Panza, Anna A; Barale, Roberto R; Landi, Stefano S; Campa, Daniele D
Publication Date: 2017-09-15

Variant appearance in text: rs846664
PubMed Link: 28915899
Variant Present in the following documents:
  • Main text
  • 12876_2017_Article_659.pdf
View BVdb publication page



Association between taste receptor (TAS) genes and the perception of wine characteristics.

Scientific Reports
Carrai, Maura M; Campa, Daniele D; Vodicka, Pavel P; Flamini, Riccardo R; Martelli, Irene I; Slyskova, Jana J; Jiraskova, Katerina K; Rejhova, Alexandra A; Vodenkova, Sona S; Canzian, Federico F; Bertelli, Alberto A; Dalla Vedova, Antonio A; Bavaresco, Luigi L; Vodickova, Ludmila L; Barale, Roberto R
Publication Date: 2017-08-23

Variant appearance in text: rs846664
PubMed Link: 28835712
Variant Present in the following documents:
  • Main text
View BVdb publication page



The Bitter Taste Receptor TAS2R16 Achieves High Specificity and Accommodates Diverse Glycoside Ligands by using a Two-faced Binding Pocket.

Scientific Reports
Thomas, Anu A; Sulli, Chidananda C; Davidson, Edgar E; Berdougo, Eli E; Phillips, Morganne M; Puffer, Bridget A BA; Paes, Cheryl C; Doranz, Benjamin J BJ; Rucker, Joseph B JB
Publication Date: 2017-08-10

Variant appearance in text: N/A
PubMed Link: 28798468
Variant Present in the following documents:
View BVdb publication page



Reproducible Analysis of Post-Translational Modifications in Proteomes--Application to Human Mutations.

Plos One
Holehouse, Alex S AS; Naegle, Kristen M KM
Publication Date: 2015

Variant appearance in text: rs846664
PubMed Link: 26659599
Variant Present in the following documents:
  • pone.0144692.s002.xlsx, sheet 1
View BVdb publication page



GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics
Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J
Publication Date: 2015-07-25

Variant appearance in text: TAS2R16: N172K
PubMed Link: 26206375
Variant Present in the following documents:
  • 12859_2015_673_MOESM1_ESM.xls, sheet 1
View BVdb publication page



Whole-genome sequencing of the world's oldest people.

Plos One
Gierman, Hinco J HJ; Fortney, Kristen K; Roach, Jared C JC; Coles, Natalie S NS; Li, Hong H; Glusman, Gustavo G; Markov, Glenn J GJ; Smith, Justin D JD; Hood, Leroy L; Coles, L Stephen LS; Kim, Stuart K SK
Publication Date: 2014

Variant appearance in text: TAS2R16: N172K; rs846664
PubMed Link: 25390934
Variant Present in the following documents:
  • pone.0112430.s004.xlsx, sheet 1
View BVdb publication page



NCI-60 whole exome sequencing and pharmacological CellMiner analyses.

Plos One
Reinhold, William C WC; Varma, Sudhir S; Sousa, Fabricio F; Sunshine, Margot M; Abaan, Ogan D OD; Davis, Sean R SR; Reinhold, Spencer W SW; Kohn, Kurt W KW; Morris, Joel J; Meltzer, Paul S PS; Doroshow, James H JH; Pommier, Yves Y
Publication Date: 2014

Variant appearance in text: TAS2R16: N172K; rs846664
PubMed Link: 25032700
Variant Present in the following documents:
  • pone.0101670.s004.xlsx, sheet 1
View BVdb publication page



Variations in bitter-taste receptor genes, dietary intake, and colorectal adenoma risk.

Nutrition And Cancer
Schembre, Susan M SM; Cheng, Iona I; Wilkens, Lynne R LR; Albright, Cheryl L CL; Marchand, Le Loïc le L
Publication Date: 2013

Variant appearance in text: rs846664
PubMed Link: 24083639
Variant Present in the following documents:
  • Main text
View BVdb publication page



Do polymorphisms in chemosensory genes matter for human ingestive behavior?

Food Quality And Preference
Hayes, John E JE; Feeney, Emma L EL; Allen, Alissa L AL
Publication Date: 2013-12

Variant appearance in text: TAS2R16: Asn172Lys; rs846664
PubMed Link: 23878414
Variant Present in the following documents:
  • Main text
View BVdb publication page



Exome-wide association study of replicable nonsynonymous variants conferring risk for alcohol dependence.

Journal Of Studies On Alcohol And Drugs
Zuo, Lingjun L; Saba, Laura L; Wang, Kesheng K; Zhang, Xiangyang X; Krystal, John H JH; Tabakoff, Boris B; Luo, Xingguang X
Publication Date: 2013-07

Variant appearance in text: rs846664
PubMed Link: 23739027
Variant Present in the following documents:
  • Main text
View BVdb publication page



Bitter taste receptor polymorphisms and human aging.

Plos One
Campa, Daniele D; De Rango, Francesco F; Carrai, Maura M; Crocco, Paolina P; Montesanto, Alberto A; Canzian, Federico F; Rose, Giuseppina G; Rizzato, Cosmeri C; Passarino, Giuseppe G; Barale, Roberto R
Publication Date: 2012

Variant appearance in text: rs846664
PubMed Link: 23133589
Variant Present in the following documents:
  • Main text
  • pone.0045232.pdf
View BVdb publication page



Functional diversity of bitter taste receptor TAS2R16 in primates.

Biology Letters
Imai, Hiroo H; Suzuki, Nami N; Ishimaru, Yoshiro Y; Sakurai, Takanobu T; Yin, Lijie L; Pan, Wenshi W; Abe, Keiko K; Misaka, Takumi T; Hirai, Hirohisa H
Publication Date: 2012-08-23

Variant appearance in text: N/A
PubMed Link: 22399783
Variant Present in the following documents:
View BVdb publication page



A faster pedigree-based generalized multifactor dimensionality reduction method for detecting gene-gene interactions.

Statistics And Its Interface
Chen, Guo-Bo GB; Zhu, Jun J; Lou, Xiang-Yang XY
Publication Date: 2011-01-01

Variant appearance in text: rs846664
PubMed Link: 21927640
Variant Present in the following documents:
  • Main text
View BVdb publication page



A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies.

American Journal Of Human Genetics
Lou, Xiang-Yang XY; Chen, Guo-Bo GB; Yan, Lei L; Ma, Jennie Z JZ; Mangold, Jamie E JE; Zhu, Jun J; Elston, Robert C RC; Li, Ming D MD
Publication Date: 2008-10

Variant appearance in text: rs846664
PubMed Link: 18834969
Variant Present in the following documents:
  • Main text
View BVdb publication page



Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence.

American Journal Of Human Genetics
Hinrichs, Anthony L AL; Wang, Jen C JC; Bufe, Bernd B; Kwon, Jennifer M JM; Budde, John J; Allen, Rebecca R; Bertelsen, Sarah S; Evans, Whitney W; Dick, Danielle D; Rice, John J; Foroud, Tatiana T; Nurnberger, John J; Tischfield, Jay A JA; Kuperman, Samuel S; Crowe, Raymond R; Hesselbrock, Victor V; Schuckit, Marc M; Almasy, Laura L; Porjesz, Bernice B; Edenberg, Howard J HJ; Begleiter, Henri H; Meyerhof, Wolfgang W; Bierut, Laura J LJ; Goate, Alison M AM
Publication Date: 2006-01

Variant appearance in text: rs846664
PubMed Link: 16385453
Variant Present in the following documents:
  • Main text
View BVdb publication page