LEP c.-29+492G>A

Variant ID: 7-127881851-G-A

NM_000230.3(LEP):c.-29+492G>A

This variant was identified in 9 publications

View GRCh38 version.




Publications:


A GWAS top hit for circulating leptin is associated with weight gain but not with leptin protein levels in lithium-augmented patients with major depression.

European Neuropsychopharmacology : The Journal Of The European College Of Neuropsychopharmacology
Bopp, Sandra K SK; Heilbronner, Urs U; Schlattmann, Peter P; Buspavanich, Pichit J PJ; Lang, Undine E UE; Heinz, Andreas A; Schulze, Thomas G TG; Adli, Mazda M; Mühleisen, Thomas W TW; Ricken, Roland R
Publication Date: 2021-12

Variant appearance in text: rs2278815
PubMed Link: 34653833
Variant Present in the following documents:
  • Main text
View BVdb publication page



A GWAS top hit for circulating leptin is associated with weight gain but not with leptin protein levels in lithium-augmented patients with major depression.

European Neuropsychopharmacology : The Journal Of The European College Of Neuropsychopharmacology
Bopp, Sandra K SK; Heilbronner, Urs U; Schlattmann, Peter P; Buspavanich, Pichit J PJ; Lang, Undine E UE; Heinz, Andreas A; Schulze, Thomas G TG; Adli, Mazda M; Mühleisen, Thomas W TW; Ricken, Roland R
Publication Date: 2021-12

Variant appearance in text: rs2278815
PubMed Link: 34653833
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus.

Clinical Immunology (Orlando, Fla.)
Zhao, Jian J; Wu, Hui H; Langefeld, Carl D CD; Kaufman, Kenneth M KM; Kelly, Jennifer A JA; Bae, Sang-Cheol SC; , ; Alarcón, Graciela S GS; Anaya, Juan-Manuel JM; Criswell, Lindsey A LA; Freedman, Barry I BI; Kamen, Diane L DL; Gilkeson, Gary S GS; Jacob, Chaim O CO; James, Judith A JA; Merrill, Joan T JT; Gaffney, Patrick M PM; Sivils, Kathy Moser KM; Niewold, Timothy B TB; Petri, Michelle A MA; Song, Seung Taek ST; Jeong, Hye-Jin HJ; Ramsey-Goldman, Rosalind R; Reveille, John D JD; Scofield, R Hal RH; Stevens, Anne M AM; Boackle, Susan A SA; Vilá, Luis M LM; Chang, Deh-Ming DM; Song, Yeong Wook YW; Vyse, Timothy J TJ; Harley, John B JB; Brown, Elizabeth E EE; Edberg, Jeffrey C JC; Kimberly, Robert P RP; Hahn, Bevra H BH; Grossman, Jennifer M JM; Tsao, Betty P BP; La Cava, Antonio A
Publication Date: 2015-12

Variant appearance in text: rs2278815
PubMed Link: 26385092
Variant Present in the following documents:
  • Main text
View BVdb publication page



Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene, decreased leptin mRNA expression, and decreased leptin serum levels.

European Neuropsychopharmacology : The Journal Of The European College Of Neuropsychopharmacology
Kloiber, Stefan S; Ripke, Stephan S; Kohli, Martin A MA; Reppermund, Simone S; Salyakina, Daria D; Uher, Rudolf R; McGuffin, Peter P; Perlis, Roy H RH; Hamilton, Steven P SP; Pütz, Benno B; Hennings, Johannes J; Brückl, Tanja T; Klengel, Torsten T; Bettecken, Thomas T; Ising, Marcus M; Uhr, Manfred M; Dose, Tatjana T; Unschuld, Paul G PG; Zihl, Josef J; Binder, Elisabeth E; Müller-Myhsok, Bertram B; Holsboer, Florian F; Lucae, Susanne S
Publication Date: 2013-07

Variant appearance in text: rs2278815
PubMed Link: 23026132
Variant Present in the following documents:
  • Main text
View BVdb publication page



Appetite regulation genes are associated with body mass index in black South African adolescents: a genetic association study.

Bmj Open
Lombard, Zané Z; Crowther, Nigel J NJ; van der Merwe, Lize L; Pitamber, Punita P; Norris, Shane A SA; Ramsay, Michèle M
Publication Date: 2012

Variant appearance in text: rs2278815
PubMed Link: 22614171
Variant Present in the following documents:
  • Main text
  • bmjopen-2012-000873.pdf
  • bmjopen-2012-000873.draft_revisions.pdf
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HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes.

American Journal Of Epidemiology
Edwards, Todd L TL; Velez Edwards, Digna R DR; Villegas, Raquel R; Cohen, Sarah S SS; Buchowski, Maciej S MS; Fowke, Jay H JH; Schlundt, David D; Long, Jirong J; Long, Ji Rong JR; Cai, Qiuyin Q; Zheng, Wei W; Shu, Xiao-Ou XO; Hargreaves, Margaret K MK; Smith, Jeffrey J; Jeffrey, Smith S; Williams, Scott M SM; Signorello, Lisa B LB; Blot, William J WJ; Matthews, Charles E CE
Publication Date: 2012-01-01

Variant appearance in text: rs2278815
PubMed Link: 22106445
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic polymorphisms in the hypothalamic pathway in relation to subsequent weight change--the DiOGenes study.

Plos One
Du, Huaidong H; Vimaleswaran, Karani S KS; Angquist, Lars L; Hansen, Rikke D RD; van der A, Daphne L DL; Holst, Claus C; Tjønneland, Anne A; Overvad, Kim K; Jakobsen, Marianne Uhre MU; Boeing, Heiner H; Meidtner, Karina K; Palli, Domenico D; Masala, Giovanna G; Bouatia-Naji, Nabila N; Saris, Wim H M WH; Feskens, Edith J M EJ; Wareham, Nicolas J NJ; Sørensen, Thorkild I A TI; Loos, Ruth J F RJ
Publication Date: 2011-02-24

Variant appearance in text: rs2278815
PubMed Link: 21390334
Variant Present in the following documents:
  • Main text
  • pone.0017436.pdf
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A Bayesian hierarchical model for analysis of SNP diversity in multilocus, multipopulation samples.

Journal Of The American Statistical Association
Guo, Feng F; Dey, Dipak K DK; Holsinger, Kent E KE
Publication Date: 2009-03-01

Variant appearance in text: rs2278815
PubMed Link: 19623271
Variant Present in the following documents:
  • Main text
View BVdb publication page



Leptin is associated with blood pressure and hypertension in women from the National Heart, Lung, and Blood Institute Family Heart Study.

Hypertension (Dallas, Tex. : 1979)
Ma, Duanduan D; Feitosa, Mary F MF; Wilk, Jemma B JB; Laramie, Jason M JM; Yu, Kai K; Leiendecker-Foster, Catherine C; Myers, Richard H RH; Province, Michael A MA; Borecki, Ingrid B IB
Publication Date: 2009-03

Variant appearance in text: rs2278815
PubMed Link: 19204185
Variant Present in the following documents:
  • Main text
View BVdb publication page



Common variants in the 5' region of the leptin gene are associated with body mass index in men from the National Heart, Lung, and Blood Institute Family Heart Study.

American Journal Of Human Genetics
Jiang, Y Y; Wilk, J B JB; Borecki, I I; Williamson, S S; DeStefano, A L AL; Xu, G G; Liu, J J; Ellison, R C RC; Province, M M; Myers, R H RH
Publication Date: 2004-08

Variant appearance in text: rs2278815
PubMed Link: 15197684
Variant Present in the following documents:
  • Main text
View BVdb publication page