Brief Communication on Pathologic Assessment of Persistent Stable Metastatic Lesions in Patients Treated With Anti-CTLA-4 or Anti-CTLA-4 + Anti-PD-1 Therapy.
Journal Of Immunotherapy (Hagerstown, Md. : 1997)
Buchbinder, Elizabeth I EI; Pfaff, Kathleen L KL; Turner, Madison M MM; Manos, Michael M; Ouyang, Olivia O; Ott, Patrick A PA; Giobbie-Hurder, Anita A; Rodig, Scott J SJ; Hodi, F Stephen FS
The molecular and functional landscape of resistance to immune checkpoint blockade in melanoma.
Nature Communications
Lim, Su Yin SY; Shklovskaya, Elena E; Lee, Jenny H JH; Pedersen, Bernadette B; Stewart, Ashleigh A; Ming, Zizhen Z; Irvine, Mal M; Shivalingam, Brindha B; Saw, Robyn P M RPM; Menzies, Alexander M AM; Carlino, Matteo S MS; Scolyer, Richard A RA; Long, Georgina V GV; Rizos, Helen H
Network expansion of genetic associations defines a pleiotropy map of human cell biology.
Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Publication Date: 2023-02-23
Variant appearance in text: BRAF: 1789_1790delinsTC
Implementation of an NGS panel for clinical practice in paraffin-embedded tissue samples from locally advanced and metastatic melanoma patients.
Exploration Of Targeted Anti-Tumor Therapy
Castillo, Paola P; Marginet, Marta M; Jares, Pedro P; García, Mireia M; Gonzalvo, Elena E; Arance, Ana A; García, Adriana A; Alos, Llucia L; Teixido, Cristina C
Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.
Nature Genetics
Kar, Siddhartha P SP; Quiros, Pedro M PM; Gu, Muxin M; Jiang, Tao T; Mitchell, Jonathan J; Langdon, Ryan R; Iyer, Vivek V; Barcena, Clea C; Vijayabaskar, M S MS; Fabre, Margarete A MA; Carter, Paul P; Petrovski, Slavé S; Burgess, Stephen S; Vassiliou, George S GS
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
High sensitivity sanger sequencing detection of BRAF mutations in metastatic melanoma FFPE tissue specimens.
Scientific Reports
Cheng, Lauren Y LY; Haydu, Lauren E LE; Song, Ping P; Nie, Jianyi J; Tetzlaff, Michael T MT; Kwong, Lawrence N LN; Gershenwald, Jeffrey E JE; Davies, Michael A MA; Zhang, David Yu DY
Assessment of RAS Dependency for BRAF Alterations Using Cancer Genomic Databases.
Jama Network Open
Zhao, Yiqing Y; Yu, Hanzhong H; Ida, Cris M CM; Halling, Kevin C KC; Kipp, Benjamin R BR; Geiersbach, Katherine K; Rumilla, Kandelaria M KM; Gupta, Sounak S; Lin, Ming-Tseh MT; Zheng, Gang G
Integrated molecular drivers coordinate biological and clinical states in melanoma.
Nature Genetics
Conway, Jake R JR; Dietlein, Felix F; Taylor-Weiner, Amaro A; AlDubayan, Saud S; Vokes, Natalie N; Keenan, Tanya T; Reardon, Brendan B; He, Meng Xiao MX; Margolis, Claire A CA; Weirather, Jason L JL; Haq, Rizwan R; Schilling, Bastian B; Stephen Hodi, F F; Schadendorf, Dirk D; Liu, David D; Van Allen, Eliezer M EM
Publication Date: 2020-12
Variant appearance in text: BRAF: L597S; rs121913368
Atypical UV Photoproducts Induce Non-canonical Mutation Classes Associated with Driver Mutations in Melanoma.
Cell Reports
Laughery, Marian F MF; Brown, Alexander J AJ; Bohm, Kaitlynne A KA; Sivapragasam, Smitha S; Morris, Haley S HS; Tchmola, Mila M; Washington, Angelica D AD; Mitchell, Debra D; Mather, Stephen S; Malc, Ewa P EP; Mieczkowski, Piotr A PA; Roberts, Steven A SA; Wyrick, John J JJ
BRAF in Lung Cancers: Analysis of Patient Cases Reveals Recurrent BRAF Mutations, Fusions, Kinase Duplications, and Concurrent Alterations.
Jco Precision Oncology
Sheikine, Yuri Y; Pavlick, Dean D; Klempner, Samuel J SJ; Trabucco, Sally E SE; Chung, Jon H JH; Rosenzweig, Mark M; Wang, Kai K; Velcheti, Vamsidhar V; Frampton, Garrett M GM; Peled, Nir N; Murray, Molly M; Chae, Young Kwang YK; Albacker, Lee A LA; Gay, Laurie L; Husain, Hatim H; Suh, James H JH; Millis, Sherri Z SZ; Reddy, Venkataprasanth P VP; Elvin, Julia A JA; Hartmaier, Ryan J RJ; Dowlati, Afshin A; Stephens, Phil P; Ross, Jeffrey S JS; Bivona, Trever G TG; Miller, Vincent A VA; Ganesan, Shridar S; Schrock, Alexa B AB; Ou, Sai-Hong Ignatius SI; Ali, Siraj M SM
Phase and context shape the function of composite oncogenic mutations.
Nature
Gorelick, Alexander N AN; Sánchez-Rivera, Francisco J FJ; Cai, Yanyan Y; Bielski, Craig M CM; Biederstedt, Evan E; Jonsson, Philip P; Richards, Allison L AL; Vasan, Neil N; Penson, Alexander V AV; Friedman, Noah D ND; Ho, Yu-Jui YJ; Baslan, Timour T; Bandlamudi, Chaitanya C; Scaltriti, Maurizio M; Schultz, Nikolaus N; Lowe, Scott W SW; Reznik, Ed E; Taylor, Barry S BS
Tumor Location Is Associated With the Prevalence of Braf And Pik3ca Mutations in Patients with Wild-Type Ras Colorectal Cancer: A Prospective Multi-Center Cohort Study in Japan.
Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.
Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
A comprehensive evaluation of pathogenic mutations in primary cutaneous melanomas, including the identification of novel loss-of-function variants.
Scientific Reports
Ticha, Ivana I; Hojny, Jan J; Michalkova, Romana R; Kodet, Ondrej O; Krkavcova, Eva E; Hajkova, Nikola N; Nemejcova, Kristyna K; Bartu, Michaela M; Jaksa, Radek R; Dura, Miroslav M; Kanwal, Madiha M; Martinikova, Andra S AS; Macurek, Libor L; Zemankova, Petra P; Kleibl, Zdenek Z; Dundr, Pavel P
Pan-cancer whole-genome analyses of metastatic solid tumours.
Nature
Priestley, Peter P; Baber, Jonathan J; Lolkema, Martijn P MP; Steeghs, Neeltje N; de Bruijn, Ewart E; Shale, Charles C; Duyvesteyn, Korneel K; Haidari, Susan S; van Hoeck, Arne A; Onstenk, Wendy W; Roepman, Paul P; Voda, Mircea M; Bloemendal, Haiko J HJ; Tjan-Heijnen, Vivianne C G VCG; van Herpen, Carla M L CML; Labots, Mariette M; Witteveen, Petronella O PO; Smit, Egbert F EF; Sleijfer, Stefan S; Voest, Emile E EE; Cuppen, Edwin E
Durable Clinical Benefit in Patients with Advanced Cutaneous Melanoma after Discontinuation of Anti-PD-1 Therapies Due to Immune-Related Adverse Events.
Journal Of Oncology
Swami, Umang U; Monga, Varun V; Bossler, Aaron D AD; Zakharia, Yousef Y; Milhem, Mohammed M
Clinical mutational profiling and categorization of BRAF mutations in melanomas using next generation sequencing.
Bmc Cancer
Lokhandwala, Parvez M PM; Tseng, Li-Hui LH; Rodriguez, Erika E; Zheng, Gang G; Pallavajjalla, Aparna A; Gocke, Christopher D CD; Eshleman, James R JR; Lin, Ming-Tseh MT
Publication Date: 2019-07-05
Variant appearance in text: BRAF: 1789_1790delinsTC
Lack of Response to Vemurafenib in Melanoma Carrying BRAF K601E Mutation.
Case Reports In Oncology
Moiseyenko, Fedor V FV; Egorenkov, Vitaliy V VV; Kramchaninov, Mikhail M MM; Artemieva, Elizaveta V EV; Aleksakhina, Svetlana N SN; Holmatov, Maxim M MM; Moiseyenko, Vladimir M VM; Imyanitov, Evgeny N EN
Pre-operative ctDNA predicts survival in high-risk stage III cutaneous melanoma patients.
Annals Of Oncology : Official Journal Of The European Society For Medical Oncology
Lee, J H JH; Saw, R P RP; Thompson, J F JF; Lo, S S; Spillane, A J AJ; Shannon, K F KF; Stretch, J R JR; Howle, J J; Menzies, A M AM; Carlino, M S MS; Kefford, R F RF; Long, G V GV; Scolyer, R A RA; Rizos, H H
An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures.
Scientific Reports
Collord, Grace G; Tarpey, Patrick P; Kurbatova, Natalja N; Martincorena, Inigo I; Moran, Sebastian S; Castro, Manuel M; Nagy, Tibor T; Bignell, Graham G; Maura, Francesco F; Young, Matthew D MD; Berna, Jorge J; Tubio, Jose M C JMC; McMurran, Chris E CE; Young, Adam M H AMH; Sanders, Mathijs M; Noorani, Imran I; Price, Stephen J SJ; Watts, Colin C; Leipnitz, Elke E; Kirsch, Matthias M; Schackert, Gabriele G; Pearson, Danita D; Devadass, Abel A; Ram, Zvi Z; Collins, V Peter VP; Allinson, Kieren K; Jenkinson, Michael D MD; Zakaria, Rasheed R; Syed, Khaja K; Hanemann, C Oliver CO; Dunn, Jemma J; McDermott, Michael W MW; Kirollos, Ramez W RW; Vassiliou, George S GS; Esteller, Manel M; Behjati, Sam S; Brazma, Alvis A; Santarius, Thomas T; McDermott, Ultan U
Inherited Genetic Variants Associated with Melanoma BRAF/NRAS Subtypes.
The Journal Of Investigative Dermatology
Thomas, Nancy E NE; Edmiston, Sharon N SN; Orlow, Irene I; Kanetsky, Peter A PA; Luo, Li L; Gibbs, David C DC; Parrish, Eloise A EA; Hao, Honglin H; Busam, Klaus J KJ; Armstrong, Bruce K BK; Kricker, Anne A; Cust, Anne E AE; Anton-Culver, Hoda H; Gruber, Stephen B SB; Gallagher, Richard P RP; Zanetti, Roberto R; Rosso, Stefano S; Sacchetto, Lidia L; Dwyer, Terence T; Ollila, David W DW; Begg, Colin B CB; Berwick, Marianne M; Conway, Kathleen K; ,
BRAF internal deletions and resistance to BRAF/MEK inhibitor therapy.
Pigment Cell & Melanoma Research
Johnson, Douglas B DB; Childress, Merrida A MA; Chalmers, Zachary R ZR; Frampton, Garrett M GM; Ali, Siraj M SM; Rubinstein, Samuel M SM; Fabrizio, David D; Ross, Jeffrey S JS; Balasubramanian, Sohail S; Miller, Vincent A VA; Stephens, Philip J PJ; Sosman, Jeffrey A JA; Lovly, Christine M CM
Associations of MC1R Genotype and Patient Phenotypes with BRAF and NRAS Mutations in Melanoma.
The Journal Of Investigative Dermatology
Thomas, Nancy E NE; Edmiston, Sharon N SN; Kanetsky, Peter A PA; Busam, Klaus J KJ; Kricker, Anne A; Armstrong, Bruce K BK; Cust, Anne E AE; Anton-Culver, Hoda H; Gruber, Stephen B SB; Luo, Li L; Orlow, Irene I; Reiner, Anne S AS; Gallagher, Richard P RP; Zanetti, Roberto R; Rosso, Stefano S; Sacchetto, Lidia L; Dwyer, Terence T; Parrish, Eloise A EA; Hao, Honglin H; Gibbs, David C DC; Frank, Jill S JS; Ollila, David W DW; Begg, Colin B CB; Berwick, Marianne M; Conway, Kathleen K; ,
Prognostic significance of BRAF and NRAS mutations in melanoma: a German study from routine care.
Bmc Cancer
Heppt, Markus V MV; Siepmann, Timo T; Engel, Jutta J; Schubert-Fritschle, Gabriele G; Eckel, Renate R; Mirlach, Laura L; Kirchner, Thomas T; Jung, Andreas A; Gesierich, Anja A; Ruzicka, Thomas T; Flaig, Michael J MJ; Berking, Carola C
Pan-urologic cancer genomic subtypes that transcend tissue of origin.
Nature Communications
Chen, Fengju F; Zhang, Yiqun Y; Bossé, Dominick D; Lalani, Aly-Khan A AA; Hakimi, A Ari AA; Hsieh, James J JJ; Choueiri, Toni K TK; Gibbons, Don L DL; Ittmann, Michael M; Creighton, Chad J CJ
Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.
Genome Research
Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U
Clinicopathological features and clinical outcomes associated with TP53 and BRAFNon-V600 mutations in cutaneous melanoma patients.
Cancer
Kim, Dae Won DW; Haydu, Lauren E LE; Joon, Aron Y AY; Bassett, Roland L RL; Siroy, Alan E AE; Tetzlaff, Michael T MT; Routbort, Mark J MJ; Amaria, Rodabe N RN; Wargo, Jennifer A JA; McQuade, Jennifer L JL; Kemnade, Jan J; Hwu, Patrick P; Woodman, Scott E SE; Roszik, Jason J; Kim, Kevin B KB; Gershenwald, Jeffrey E JE; Lazar, Alexander J AJ; Davies, Michael A MA
NRAS and EPHB6 mutation rates differ in metastatic melanomas of patients in the North Island versus South Island of New Zealand.
Oncotarget
Jones, Angela M AM; Ferguson, Peter P; Gardner, Jacqui J; Rooker, Serena S; Sutton, Tim T; Ahn, Antonio A; Chatterjee, Aniruddha A; Bickley, Vivienne M VM; Sarwar, Makhdoom M; Emanuel, Patrick P; Kenwright, Diane D; Shepherd, Peter R PR; Eccles, Michael R MR
Detection of BRAF Mutations Using a Fully Automated Platform and Comparison with High Resolution Melting, Real-Time Allele Specific Amplification, Immunohistochemistry and Next Generation Sequencing Assays, for Patients with Metastatic Melanoma.