Publications:

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Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics

Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P

Publication Date: 2023-02-23

Variant appearance in text: BRAF: 1722C>G; His574Gln

PubMed Link: 36823319

Variant Present in the following documents:

• 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6

View BVdb publication page

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Molecular underpinnings of exceptional response in primary malignant melanoma of the esophagus to anti-PD-1 monotherapy.

Journal For Immunotherapy Of Cancer

Dai, Jie J; Bai, Xue X; Gao, Xuan X; Tang, Lirui L; Chen, Yu Y; Sun, Linzi L; Wei, Xiaoting X; Li, Caili C; Qi, Zhonghui Z; Kong, Yan Y; Cui, Chuanliang C; Chi, Zhihong Z; Sheng, Xinan X; Xu, Zelong Z; Lian, Bin B; Li, Siming S; Yan, Xieqiao X; Tang, Bixia B; Zhou, Li L; Wang, Xuan X; Xia, Xuefeng X; Guo, Jun J; Mao, Lili L; Si, Lu L

Publication Date: 2023-01

Variant appearance in text: BRAF: His574Gln

PubMed Link: 36593066

Variant Present in the following documents:

• jitc-2022-005937supp007.xls, sheet 1

View BVdb publication page

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The mutational landscape of cancer's vulnerability to ionizing radiation.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Gopal, Priyanka P; Yard, Brian D BD; Petty, Aaron A; Lal, Jessica C JC; Bera, Titas K TK; Hoang, Trung Q TQ; Buhimschi, Alexandru B AB; Abazeed, Mohamed E ME

Publication Date: 2022-10-12

Variant appearance in text: BRAF: H574Q

PubMed Link: 36222846

Variant Present in the following documents:

• ccr-22-1914_supplementary_data_2_suppds2.xlsx, sheet 1
• ccr-22-1914_supplementary_data_3_suppds3.xlsx, sheet 1

View BVdb publication page

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Are transient protein-protein interactions more dispensable?

Plos Computational Biology

Ghadie, Mohamed Ali MA; Xia, Yu Y

Publication Date: 2022-04

Variant appearance in text: BRAF: 1722C>G; His574Gln

PubMed Link: 35404956

Variant Present in the following documents:

• pcbi.1010013.s002.xlsx, sheet 4

View BVdb publication page

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Cell Painting predicts impact of lung cancer variants.

Molecular Biology Of The Cell

Caicedo, Juan C JC; Arevalo, John J; Piccioni, Federica F; Bray, Mark-Anthony MA; Hartland, Cathy L CL; Wu, Xiaoyun X; Brooks, Angela N AN; Berger, Alice H AH; Boehm, Jesse S JS; Carpenter, Anne E AE; Singh, Shantanu S

Publication Date: 2022-05-15

Variant appearance in text: BRAF: H574Q

PubMed Link: 35353015

Variant Present in the following documents:

• Main text
• mbc-33-ar49.pdf

View BVdb publication page

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: BRAF: H574Q

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

View BVdb publication page

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BRAF mutations may identify a clinically distinct subset of glioblastoma.

Scientific Reports

McNulty, Samantha N SN; Schwetye, Katherine E KE; Ferguson, Cole C; Storer, Chad E CE; Ansstas, George G; Kim, Albert H AH; Gutmann, David H DH; Rubin, Joshua B JB; Head, Richard D RD; Dahiya, Sonika S

Publication Date: 2021-10-08

Variant appearance in text: BRAF: H574Q

PubMed Link: 34625582

Variant Present in the following documents:

• Main text
• 41598_2021_Article_99278.pdf

View BVdb publication page

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A next-generation sequencing-based strategy combining microsatellite instability and tumor mutation burden for comprehensive molecular diagnosis of advanced colorectal cancer.

Bmc Cancer

Xiao, Jian J; Li, Wenyun W; Huang, Yan Y; Huang, Mengli M; Li, Shanshan S; Zhai, Xiaohui X; Zhao, Jing J; Gao, Chan C; Xie, Wenzhuan W; Qin, Hao H; Cai, Shangli S; Bai, Yuezong Y; Lan, Ping P; Zou, Yifeng Y

Publication Date: 2021-03-16

Variant appearance in text: BRAF: H574Q

PubMed Link: 33726687

Variant Present in the following documents:

• 12885_2021_7942_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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Assessment of Clinical Benefit of Integrative Genomic Profiling in Advanced Solid Tumors.

Jama Oncology

Cobain, Erin F EF; Wu, Yi-Mi YM; Vats, Pankaj P; Chugh, Rashmi R; Worden, Francis F; Smith, David C DC; Schuetze, Scott M SM; Zalupski, Mark M MM; Sahai, Vaibhav V; Alva, Ajjai A; Schott, Anne F AF; Caram, Megan E V MEV; Hayes, Daniel F DF; Stoffel, Elena M EM; Jacobs, Michelle F MF; Kumar-Sinha, Chandan C; Cao, Xuhong X; Wang, Rui R; Lucas, David D; Ning, Yu Y; Rabban, Erica E; Bell, Janice J; Camelo-Piragua, Sandra S; Udager, Aaron M AM; Cieslik, Marcin M; Lonigro, Robert J RJ; Kunju, Lakshmi P LP; Robinson, Dan R DR; Talpaz, Moshe M; Chinnaiyan, Arul M AM

Publication Date: 2021-04-01

Variant appearance in text: BRAF: H574Q

PubMed Link: 33630025

Variant Present in the following documents:

• jamaoncol-e207987-s004.xlsx, sheet 2

View BVdb publication page

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Identification of pathogenic missense mutations using protein stability predictors.

Scientific Reports

Gerasimavicius, Lukas L; Liu, Xin X; Marsh, Joseph A JA

Publication Date: 2020-09-21

Variant appearance in text: BRAF: H574Q

PubMed Link: 32958805

Variant Present in the following documents:

• 41598_2020_72404_MOESM2_ESM.xlsx, sheet 2

View BVdb publication page

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: BRAF: H574Q

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

View BVdb publication page

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Clonal selection confers distinct evolutionary trajectories in BRAF-driven cancers.

Nature Communications

Gopal, Priyanka P; Sarihan, Elif Irem EI; Chie, Eui Kyu EK; Kuzmishin, Gwendolyn G; Doken, Semihcan S; Pennell, Nathan A NA; Raymond, Daniel P DP; Murthy, Sudish C SC; Ahmad, Usman U; Raja, Siva S; Almeida, Francisco F; Sethi, Sonali S; Gildea, Thomas R TR; Peacock, Craig D CD; Adams, Drew J DJ; Abazeed, Mohamed E ME

Publication Date: 2019-11-13

Variant appearance in text: BRAF: H574Q

PubMed Link: 31723142

Variant Present in the following documents:

• 41467_2019_13161_MOESM5_ESM.xlsx, sheet 1
• 41467_2019_Article_13161.pdf

View BVdb publication page

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Estimating dispensable content in the human interactome.

Nature Communications

Ghadie, Mohamed M; Xia, Yu Y

Publication Date: 2019-07-19

Variant appearance in text: BRAF: 1722C>G; His574Gln

PubMed Link: 31324802

Variant Present in the following documents:

• 41467_2019_11180_MOESM8_ESM.xlsx, sheet 4
• 41467_2019_11180_MOESM6_ESM.xlsx, sheet 4

View BVdb publication page

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Primary malignant melanoma of esophagus shared similar genetic characters with both cutaneous and oral mucosal melanoma.

Journal Of Thoracic Disease

Li, Jingjing J; Yan, Shi S; Wu, Nan N

Publication Date: 2018-06

Variant appearance in text: BRAF: H574Q

PubMed Link: 30023129

Variant Present in the following documents:

• Main text

View BVdb publication page

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Unraveling the etiology of primary malignant melanoma of the esophagus.

Journal Of Thoracic Disease

Krauthammer, Michael M

Publication Date: 2018-04

Variant appearance in text: BRAF: H574Q

PubMed Link: 29850187

Variant Present in the following documents:

• Main text

View BVdb publication page

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Bioinformatics Approach for Prediction of Functional Coding/Noncoding Simple Polymorphisms (SNPs/Indels) in Human BRAF Gene.

Advances In Bioinformatics

Hassan, Mohamed M MM; Omer, Shaza E SE; Khalf-Allah, Rahma M RM; Mustafa, Razaz Y RY; Ali, Isra S IS; Mohamed, Sofia B SB

Publication Date: 2016

Variant appearance in text: rs397507481

PubMed Link: 27478437

Variant Present in the following documents:

• Main text
• ABI2016-2632917.pdf

View BVdb publication page

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High-throughput Phenotyping of Lung Cancer Somatic Mutations.

Cancer Cell

Berger, Alice H AH; Brooks, Angela N AN; Wu, Xiaoyun X; Shrestha, Yashaswi Y; Chouinard, Candace C; Piccioni, Federica F; Bagul, Mukta M; Kamburov, Atanas A; Imielinski, Marcin M; Hogstrom, Larson L; Zhu, Cong C; Yang, Xiaoping X; Pantel, Sasha S; Sakai, Ryo R; Watson, Jacqueline J; Kaplan, Nathan N; Campbell, Joshua D JD; Singh, Shantanu S; Root, David E DE; Narayan, Rajiv R; Natoli, Ted T; Lahr, David L DL; Tirosh, Itay I; Tamayo, Pablo P; Getz, Gad G; Wong, Bang B; Doench, John J; Subramanian, Aravind A; Golub, Todd R TR; Meyerson, Matthew M; Boehm, Jesse S JS

Publication Date: 2016-08-08

Variant appearance in text: BRAF: H574Q

PubMed Link: 27478040

Variant Present in the following documents:

• Main text

View BVdb publication page

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PredictSNP2: A Unified Platform for Accurately Evaluating SNP Effects by Exploiting the Different Characteristics of Variants in Distinct Genomic Regions.

Plos Computational Biology

Bendl, Jaroslav J; Musil, Miloš M; Štourač, Jan J; Zendulka, Jaroslav J; Damborský, Jiří J; Brezovský, Jan J

Publication Date: 2016-05

Variant appearance in text: BRAF: H574Q

PubMed Link: 27224906

Variant Present in the following documents:

• pcbi.1004962.s004.xlsx, sheet 1

View BVdb publication page

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Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations.

Molecular Systems Biology

Kiel, Christina C; Serrano, Luis L

Publication Date: 2014-05-06

Variant appearance in text: BRAF: H574Q

PubMed Link: 24803665

Variant Present in the following documents:

• MSB-10-5-727-s13.xls, sheet 1

View BVdb publication page

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