BRAF c.1685A>G ;(p.Q562R)

Variant ID: 7-140476721-T-C

NM_004333.4(BRAF):c.1685A>G;(p.Q562R)

This variant was identified in 8 publications

View GRCh38 version.




Publications:


Unveiling the Domain-Specific and RAS Isoform-Specific Details of BRAF Regulation.

Biorxiv : The Preprint Server For Biology
Trebino, Tarah T; Markusic, Borna B; Nan, Haihan H; Banerjee, Shrhea S; Wang, Zhihong Z
Publication Date: 2023-04-24

Variant appearance in text: BRAF: Q562R
PubMed Link: 37163002
Variant Present in the following documents:
  • Main text
  • nihpp-2023.04.24.538112v1.pdf
View BVdb publication page



5-Arylidene(chromenyl-methylene)-thiazolidinediones: Potential New Agents against Mutant Oncoproteins K-Ras, N-Ras and B-Raf in Colorectal Cancer and Melanoma.

Medicina (Kaunas, Lithuania)
Nastasă, Cristina C; Tamaian, Radu R; Oniga, Ovidiu O; Tiperciuc, Brîndușa B
Publication Date: 2019-03-31

Variant appearance in text: BRAF: Q562R
PubMed Link: 30935124
Variant Present in the following documents:
  • Main text
  • medicina-55-00085.pdf
View BVdb publication page



N-(7-Cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide (TAK632) Promotes Inhibition of BRAF through the Induction of Inhibited Dimers.

Journal Of Medicinal Chemistry
Grasso, Michael M; Estrada, Michelle A MA; Berrios, Kiara N KN; Winkler, Jeffrey D JD; Marmorstein, Ronen R
Publication Date: 2018-06-14

Variant appearance in text: BRAF: Q562R
PubMed Link: 29727562
Variant Present in the following documents:
  • Main text
View BVdb publication page



RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition.

Nature Communications
Jin, Ting T; Lavoie, Hugo H; Sahmi, Malha M; David, Maud M; Hilt, Christine C; Hammell, Amy A; Therrien, Marc M
Publication Date: 2017-10-31

Variant appearance in text: BRAF: Q562R
PubMed Link: 29084939
Variant Present in the following documents:
  • Main text
  • 41467_2017_Article_1274.pdf
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Chemically Linked Vemurafenib Inhibitors Promote an Inactive BRAFV600E Conformation.

Acs Chemical Biology
Grasso, Michael M; Estrada, Michelle A MA; Ventocilla, Christian C; Samanta, Minu M; Maksimoska, Jasna J; Villanueva, Jessie J; Winkler, Jeffrey D JD; Marmorstein, Ronen R
Publication Date: 2016-10-21

Variant appearance in text: BRAF: Q562R
PubMed Link: 27571413
Variant Present in the following documents:
  • Main text
View BVdb publication page



Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling.

Nature
Dhawan, Neil S NS; Scopton, Alex P AP; Dar, Arvin C AC
Publication Date: 2016-09-01

Variant appearance in text: BRAF: Q562R
PubMed Link: 27556948
Variant Present in the following documents:
  • Main text
  • nihms805461.pdf
View BVdb publication page



Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization.

Nature Chemical Biology
Lavoie, Hugo H; Thevakumaran, Neroshan N; Gavory, Gwenaëlle G; Li, John J JJ; Padeganeh, Abbas A; Guiral, Sébastien S; Duchaine, Jean J; Mao, Daniel Y L DY; Bouvier, Michel M; Sicheri, Frank F; Therrien, Marc M
Publication Date: 2013-07

Variant appearance in text: BRAF: Q562R
PubMed Link: 23685672
Variant Present in the following documents:
  • Main text
  • nihms3965.pdf
View BVdb publication page



Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Tsai, James J; Lee, John T JT; Wang, Weiru W; Zhang, Jiazhong J; Cho, Hanna H; Mamo, Shumeye S; Bremer, Ryan R; Gillette, Sam S; Kong, Jun J; Haass, Nikolas K NK; Sproesser, Katrin K; Li, Ling L; Smalley, Keiran S M KS; Fong, Daniel D; Zhu, Yong-Liang YL; Marimuthu, Adhirai A; Nguyen, Hoa H; Lam, Billy B; Liu, Jennifer J; Cheung, Ivana I; Rice, Julie J; Suzuki, Yoshihisa Y; Luu, Catherine C; Settachatgul, Calvin C; Shellooe, Rafe R; Cantwell, John J; Kim, Sung-Hou SH; Schlessinger, Joseph J; Zhang, Kam Y J KY; West, Brian L BL; Powell, Ben B; Habets, Gaston G; Zhang, Chao C; Ibrahim, Prabha N PN; Hirth, Peter P; Artis, Dean R DR; Herlyn, Meenhard M; Bollag, Gideon G
Publication Date: 2008-02-26

Variant appearance in text: BRAF: Q562R
PubMed Link: 18287029
Variant Present in the following documents:
  • Main text
View BVdb publication page