Publications:

Inhibition of RAF dimers: it takes two to tango.

Biochemical Society Transactions

Cook, Frazer A FA; Cook, Simon J SJ

Publication Date: 2021-02-26

Variant appearance in text: BRAF: R506A

PubMed Link: 33367512

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Design and Synthesis of Type-IV Inhibitors of BRAF Kinase That Block Dimerization and Overcome Paradoxical MEK/ERK Activation.

Journal Of Medicinal Chemistry

Beneker, Chad M CM; Rovoli, Magdalini M; Kontopidis, George G; Röring, Michael M; Galda, Simeon S; Braun, Sandra S; Brummer, Tilman T; McInnes, Campbell C

Publication Date: 2019-04-25

Variant appearance in text: BRAF: R506A

PubMed Link: 30977659

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N-(7-Cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide (TAK632) Promotes Inhibition of BRAF through the Induction of Inhibited Dimers.

Journal Of Medicinal Chemistry

Grasso, Michael M; Estrada, Michelle A MA; Berrios, Kiara N KN; Winkler, Jeffrey D JD; Marmorstein, Ronen R

Publication Date: 2018-06-14

Variant appearance in text: BRAF: R506A

PubMed Link: 29727562

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