Publications:

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Distinct mutational features across preinvasive and invasive subtypes identified through comprehensive profiling of surgically resected lung adenocarcinoma.

Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc

Xiang, Chan C; Ji, Chunyu C; Cai, Yiran Y; Teng, Haohua H; Wang, Yulu Y; Zhao, Ruiying R; Shang, Zhanxian Z; Guo, Lianying L; Chen, Shengnan S; Lizaso, Analyn A; Lin, Jing J; Wang, Haozhe H; Li, Bing B; Zhang, Zhou Z; Zhao, Jikai J; Wei, Jinzhi J; Liu, Jiaxin J; Zhu, Lei L; Fang, Wentao W; Han, Yuchen Y

Publication Date: 2022-09

Variant appearance in text: BRAF: S365A

PubMed Link: 35641658

Variant Present in the following documents:

• 41379_2022_1076_MOESM1_ESM.pdf

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Role of serine 365 in BRAF V600E sensitivity to RAF inhibition.

Pigment Cell & Melanoma Research

Vido, Michael J MJ; Rock, Justin J; Aplin, Andrew E AE

Publication Date: 2021-07

Variant appearance in text: BRAF: S365A

PubMed Link: 33000894

Variant Present in the following documents:

• Main text

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Structures of BRAF-MEK1-14-3-3 sheds light on drug discovery.

Signal Transduction And Targeted Therapy

Sun, Qiu Q; Wang, Wenjing W

Publication Date: 2019

Variant appearance in text: BRAF: S365A

PubMed Link: 31871776

Variant Present in the following documents:

• Main text

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Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.

Nature

Park, Eunyoung E; Rawson, Shaun S; Li, Kunhua K; Kim, Byeong-Won BW; Ficarro, Scott B SB; Pino, Gonzalo Gonzalez-Del GG; Sharif, Humayun H; Marto, Jarrod A JA; Jeon, Hyesung H; Eck, Michael J MJ

Publication Date: 2019-11

Variant appearance in text: BRAF: S365A

PubMed Link: 31581174

Variant Present in the following documents:

• Main text

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BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS.

Science Advances

Röck, Ruth R; Mayrhofer, Johanna E JE; Torres-Quesada, Omar O; Enzler, Florian F; Raffeiner, Andrea A; Raffeiner, Philipp P; Feichtner, Andreas A; Huber, Roland G RG; Koide, Shohei S; Taylor, Susan S SS; Troppmair, Jakob J; Stefan, Eduard E

Publication Date: 2019-08

Variant appearance in text: BRAF: S365A

PubMed Link: 31453322

Variant Present in the following documents:

• Main text
• aav8463.pdf
• aav8463_SM.pdf

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CRAF mutations in lung cancer can be oncogenic and predict sensitivity to combined type II RAF and MEK inhibition.

Oncogene

Noeparast, Amir A; Giron, Philippe P; Noor, Alfiah A; Bahadur Shahi, Rajendra R; De Brakeleer, Sylvia S; Eggermont, Carolien C; Vandenplas, Hugo H; Boeckx, Bram B; Lambrechts, Diether D; De Grève, Jacques J; Teugels, Erik E

Publication Date: 2019-08

Variant appearance in text: BRAF: S365A

PubMed Link: 31285551

Variant Present in the following documents:

• Main text

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SHOC2 complex-driven RAF dimerization selectively contributes to ERK pathway dynamics.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Boned Del Río, Isabel I; Young, Lucy C LC; Sari, Sibel S; Jones, Greg G GG; Ringham-Terry, Benjamin B; Hartig, Nicole N; Rejnowicz, Ewa E; Lei, Winnie W; Bhamra, Amandeep A; Surinova, Silvia S; Rodriguez-Viciana, Pablo P

Publication Date: 2019-07-02

Variant appearance in text: BRAF: S365A

PubMed Link: 31213532

Variant Present in the following documents:

• Main text

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SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers.

Nature Communications

Jones, Greg G GG; Del Río, Isabel Boned IB; Sari, Sibel S; Sekerim, Aysen A; Young, Lucy C LC; Hartig, Nicole N; Areso Zubiaur, Itziar I; El-Bahrawy, Mona A MA; Hynds, Rob E RE; Lei, Winnie W; Molina-Arcas, Miriam M; Downward, Julian J; Rodriguez-Viciana, Pablo P

Publication Date: 2019-06-10

Variant appearance in text: BRAF: S365A

PubMed Link: 31182717

Variant Present in the following documents:

• Main text

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K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling.

Nature Communications

Yin, Qing Q; Han, Tao T; Fang, Bin B; Zhang, Guolin G; Zhang, Chao C; Roberts, Evan R ER; Izumi, Victoria V; Zheng, Mengmeng M; Jiang, Shulong S; Yin, Xiu X; Kim, Minjung M; Cai, Jianfeng J; Haura, Eric B EB; Koomen, John M JM; Smalley, Keiran S M KSM; Wan, Lixin L

Publication Date: 2019-04-23

Variant appearance in text: BRAF: S365A

PubMed Link: 31015455

Variant Present in the following documents:

• Main text
• 41467_2019_Article_9844.pdf
• 41467_2019_9844_MOESM2_ESM.pdf
• 41467_2019_9844_MOESM1_ESM.pdf

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Over-expressed, N-terminally truncated BRAF is detected in the nucleus of cells with nuclear phosphorylated MEK and ERK.

Heliyon

Hey, Fiona F; Andreadi, Catherine C; Noble, Catherine C; Patel, Bipin B; Jin, Hong H; Kamata, Tamihiro T; Straatman, Kees K; Luo, Jinli J; Balmanno, Kathryn K; Jones, David T W DTW; Collins, V Peter VP; Cook, Simon J SJ; Caunt, Christopher J CJ; Pritchard, Catrin C

Publication Date: 2018-12

Variant appearance in text: BRAF: S365A

PubMed Link: 30603699

Variant Present in the following documents:

• mmc1.pdf

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Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism.

Nature Communications

Chen, Ming M; Wan, Lixin L; Zhang, Jiangwen J; Zhang, Jinfang J; Mendez, Lourdes L; Clohessy, John G JG; Berry, Kelsey K; Victor, Joshua J; Yin, Qing Q; Zhu, Yuan Y; Wei, Wenyi W; Pandolfi, Pier Paolo PP

Publication Date: 2018-01-15

Variant appearance in text: BRAF: S365A

PubMed Link: 29335436

Variant Present in the following documents:

• 41467_2017_Article_2272.pdf

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Discrete cytosolic macromolecular BRAF complexes exhibit distinct activities and composition.

The Embo Journal

Diedrich, Britta B; Rigbolt, Kristoffer Tg KT; Röring, Michael M; Herr, Ricarda R; Kaeser-Pebernard, Stephanie S; Gretzmeier, Christine C; Murphy, Robert F RF; Brummer, Tilman T; Dengjel, Jörn J

Publication Date: 2017-03-01

Variant appearance in text: BRAF: S365A

PubMed Link: 28093501

Variant Present in the following documents:

• Main text

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Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles.

Oncotarget

Eisenhardt, Anja E AE; Sprenger, Adrian A; Röring, Michael M; Herr, Ricarda R; Weinberg, Florian F; Köhler, Martin M; Braun, Sandra S; Orth, Joachim J; Diedrich, Britta B; Lanner, Ulrike U; Tscherwinski, Natalja N; Schuster, Simon S; Dumaz, Nicolas N; Schmidt, Enrico E; Baumeister, Ralf R; Schlosser, Andreas A; Dengjel, Jörn J; Brummer, Tilman T

Publication Date: 2016-05-03

Variant appearance in text: BRAF: S365A

PubMed Link: 27034005

Variant Present in the following documents:

• Main text
• oncotarget-07-26628.pdf

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Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling.

The Embo Journal

Röring, Michael M; Herr, Ricarda R; Fiala, Gina J GJ; Heilmann, Katharina K; Braun, Sandra S; Eisenhardt, Anja E AE; Halbach, Sebastian S; Capper, David D; von Deimling, Andreas A; Schamel, Wolfgang W WW; Saunders, Darren N DN; Brummer, Tilman T

Publication Date: 2012-05-30

Variant appearance in text: BRAF: S365A

PubMed Link: 22510884

Variant Present in the following documents:

• Main text

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Differential regulation of B-raf isoforms by phosphorylation and autoinhibitory mechanisms.

Molecular And Cellular Biology

Hmitou, Isabelle I; Druillennec, Sabine S; Valluet, Agathe A; Peyssonnaux, Carole C; Eychène, Alain A

Publication Date: 2007-01

Variant appearance in text: BRAF: S365A

PubMed Link: 17074813

Variant Present in the following documents:

• Main text

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