Publications:

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Structure-Based Prediction of hERG-Related Cardiotoxicity: A Benchmark Study.

Journal Of Chemical Information And Modeling

Creanza, Teresa Maria TM; Delre, Pietro P; Ancona, Nicola N; Lentini, Giovanni G; Saviano, Michele M; Mangiatordi, Giuseppe Felice GF

Publication Date: 2021-09-27

Variant appearance in text: Kv11.1: M651T

PubMed Link: 34506150

Variant Present in the following documents:

• Main text
• ci1c00744.pdf

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Lipid regulation of hERG1 channel function.

Nature Communications

Miranda, Williams E WE; Guo, Jiqing J; Mesa-Galloso, Haydee H; Corradi, Valentina V; Lees-Miller, James P JP; Tieleman, D Peter DP; Duff, Henry J HJ; Noskov, Sergei Yu SY

Publication Date: 2021-03-03

Variant appearance in text: HERG: M651T

PubMed Link: 33658490

Variant Present in the following documents:

• 41467_2021_Article_21681.pdf

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Allosteric Coupling Between Drug Binding and the Aromatic Cassette in the Pore Domain of the hERG1 Channel: Implications for a State-Dependent Blockade.

Frontiers In Pharmacology

Kudaibergenova, Meruyert M; Guo, Jiqing J; Khan, Hanif M HM; Zahid, Farhan F; Lees-Miller, James J; Noskov, Sergei Yu SY; Duff, Henry J HJ

Publication Date: 2020

Variant appearance in text: HERG: M651T

PubMed Link: 32694995

Variant Present in the following documents:

• fphar-11-00914.pdf

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An Update on the Structure of hERG.

Frontiers In Pharmacology

Butler, Andrew A; Helliwell, Matthew V MV; Zhang, Yihong Y; Hancox, Jules C JC; Dempsey, Christopher E CE

Publication Date: 2019

Variant appearance in text: KCNH2: M651T

PubMed Link: 32038248

Variant Present in the following documents:

• Main text
• fphar-10-01572.pdf

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The Pore-Lipid Interface: Role of Amino-Acid Determinants of Lipophilic Access by Ivabradine to the hERG1 Pore Domain.

Molecular Pharmacology

Perissinotti, Laura L; Guo, Jiqing J; Kudaibergenova, Meruyert M; Lees-Miller, James J; Ol'khovich, Marina M; Sharapova, Angelica A; Perlovich, German L GL; Muruve, Daniel A DA; Gerull, Brenda B; Noskov, Sergei Yu SY; Duff, Henry J HJ

Publication Date: 2019-08

Variant appearance in text: Kv11.1: M651T

PubMed Link: 31182542

Variant Present in the following documents:

• Main text

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Interactions of H562 in the S5 helix with T618 and S621 in the pore helix are important determinants of hERG1 potassium channel structure and function.

Biophysical Journal

Lees-Miller, James P JP; Subbotina, Julia O JO; Guo, Jiqing J; Yarov-Yarovoy, Vladimir V; Noskov, Sergei Y SY; Duff, Henry J HJ

Publication Date: 2009-05-06

Variant appearance in text: HERG: M651T

PubMed Link: 19413965

Variant Present in the following documents:

• Main text

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